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  1. Book ; Online: Internal Calibration Process Using Chirp Pulses with Application of the Adam Learning Algorithm

    Kweon, Junho / Jung, Chan-Yong / Bae, Kyung-Bin / Park, Seong-Ook

    2020  

    Abstract: ... when sinusoidal signals are used as calibration signals. In regards to the algorithm, the Adam learning algorithm ...

    Abstract We propose a new internal calibration process using chirp pulses. Our method is utilized to mitigate thermal drift, which is unwanted changes and usually occurs in active elements such as a high power amplifier and low noise amplifier. The proposed method has advantages from two distinct aspects: calibration signal and algorithm. In respect to the calibration signal, our method does not contain an additional signal source because chirp pulses, which are normally used for remote sensing, are used as calibration signals. Moreover, our methods solve the ambiguity problem of analyzing a phase shift which occurs when sinusoidal signals are used as calibration signals. In regards to the algorithm, the Adam learning algorithm avoids learning in the wrong direction, unlike the conventional gradient descent. Using our method, mathematical forms of received signals are acquired successfully. Our method shows better effectivity compared to the conventional gradient descent algorithm. After compensation, the maximum differences of gain and phase become 0.06 dB and 2.42 degrees, respectively.

    Comment: This work has been submitted to the IEEE for possible publication. Copyright may be transferred without notice, after which this version may no longer be accessible
    Keywords Electrical Engineering and Systems Science - Signal Processing
    Subject code 518
    Publishing date 2020-12-03
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Preoperative Prognostic Factors After Liver Resection for Non-Colorectal, Non-Neuroendocrine Liver Metastases and Validation of the Adam Score in an Asian Population.

    Sim, Dayna P Y / Goh, Brian K P / Lee, Ser-Yee / Chan, Chung-Yip / Tan, Iain B H / Cheow, Peng-Chung / Jeyaraj, Premaraj / Chow, Pierce K H / Ooi, London L P J / Chung, Alexander Y F

    World journal of surgery

    2017  Volume 42, Issue 4, Page(s) 1073–1084

    Abstract: ... factors of liver resection for NCNN liver metastases and validate the Adam score in an Asian population ... number of nodules were significant predictors of survival. Four of the six components of Adam score were ... free interval and type of a primary tumour. The total Adam score was also a significant predictor ...

    Abstract Background: Historically, the benefit of liver resection for non-colorectal, non-neuroendocrine (NCNN) liver metastases has been controversial. This study aims to determine the preoperative prognostic factors of liver resection for NCNN liver metastases and validate the Adam score in an Asian population.
    Methods: Consecutive patients who underwent liver resection for NCNN liver metastases were identified retrospectively from a prospective liver resection database of the single institution between 2001 and 2014. Univariate Cox regression models were used to identify associations with outcome variables. Recurrence-free interval and overall survival were determined using the Kaplan-Meier method and compared using log-rank test.
    Results: Seventy-eight consecutive patients were identified, which met the study criteria. Univariate analysis demonstrated that adenocarcinoma histology of primary cancer, disease-free interval and number of nodules were significant predictors of survival. Four of the six components of Adam score were significant predictors of survival. These were the presence of extrahepatic metastases, R2 resection, disease-free interval and type of a primary tumour. The total Adam score was also a significant predictor of survival.
    Conclusion: Liver resection for NCNN liver metastases is a safe and viable treatment option in carefully selected patients. Significant preoperative prognostic factors include adenocarcinoma primary tumours, disease-free interval and number of nodules. The total Adam score was a good predictor of overall survival and can be used to risk stratify patients undergoing hepatic resection for NCNN liver metastases.
    MeSH term(s) Adult ; Aged ; Asian Continental Ancestry Group ; Carcinoma/ethnology ; Carcinoma/mortality ; Carcinoma/secondary ; Carcinoma/surgery ; Decision Support Techniques ; Female ; Hepatectomy ; Humans ; Liver Neoplasms/ethnology ; Liver Neoplasms/mortality ; Liver Neoplasms/secondary ; Liver Neoplasms/surgery ; Male ; Melanoma/ethnology ; Melanoma/mortality ; Melanoma/secondary ; Melanoma/surgery ; Middle Aged ; Neoplasm Recurrence, Local/etiology ; Preoperative Period ; Prognosis ; Retrospective Studies ; Survival Analysis
    Language English
    Publishing date 2017-10-17
    Publishing country United States
    Document type Journal Article ; Validation Studies
    ZDB-ID 224043-9
    ISSN 1432-2323 ; 0364-2313
    ISSN (online) 1432-2323
    ISSN 0364-2313
    DOI 10.1007/s00268-017-4208-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Left Atrial Appendage Closure: Novel Cor-Knot Lasso Technique Ensures Complete and Safe Ligation.

    El-Gamel, Adam / Chan, Brian

    The Annals of thoracic surgery

    2022  Volume 114, Issue 5, Page(s) e379–e382

    Abstract: The significance of the left atrial appendage has been well known for a half century. Surgeons used a number of left atrial appendage closure techniques to reduce the risk of stroke without increasing the chance of bleeding from fragile left atrial ... ...

    Abstract The significance of the left atrial appendage has been well known for a half century. Surgeons used a number of left atrial appendage closure techniques to reduce the risk of stroke without increasing the chance of bleeding from fragile left atrial appendage. Removal and oversewing are simple and effective. Current procedures, however, have the disadvantage of 30% to 40% residual appendage. Here, we discuss our innovative lasso technique using a Cor-Knot device for left atrial appendage closure in 50 consecutive patients between January 2018 and January 2019 who underwent mitral valve surgery. This technique ensured complete closure, with no new cerebrovascular events during the 2-year follow-up.
    MeSH term(s) Humans ; Atrial Appendage/surgery ; Atrial Fibrillation/surgery ; Treatment Outcome ; Cardiac Surgical Procedures/methods ; Stroke/etiology ; Stroke/prevention & control
    Language English
    Publishing date 2022-02-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2022.01.046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Female Thumb Carpometacarpal Joint: Motion and Force Changes Due to Arthritis and Surgical Intervention.

    Arnold, Nicole D / Chrzan, Adam J / Chan, Kevin / Bush, Tamara Reid

    Journal of biomechanical engineering

    2024  Volume 146, Issue 6

    Abstract: Thumb carpometacarpal (CMC) osteoarthritis (OA) has been one of the most common locations of hand OA. CMC OA disproportionately occurs in females over males. In severe cases, surgical intervention may be needed. However, to determine the effects of ... ...

    Abstract Thumb carpometacarpal (CMC) osteoarthritis (OA) has been one of the most common locations of hand OA. CMC OA disproportionately occurs in females over males. In severe cases, surgical intervention may be needed. However, to determine the effects of surgical treatment, normative, pre-, and postsurgery function must be understood. The goals of this work were to compare the thumb motion and force abilities of older healthy (OH) females without CMC OA to those of females with CMC OA and who received ligament reconstruction with tendon interposition (LRTI) surgery at time points presurgery, 3- and 6-months postsurgery. On average, CMC OA participants 3- and 6-months postsurgery showed 35.6% and 32.9% less overall metacarpal motion compared to presurgery, 31.9% and 29.1% less than OH, and exhibited altered motion. Metacarpal flexion/extension and abduction/adduction ranges were 51.9 deg and 43.4 deg for OH, 52.9 deg and 40.3 deg presurgery, 39.9 deg and 33.5 deg at 3-months, and 42.6 deg and 32.7 deg at 6-months postsurgery. On average, participants had increased force generation at 6-months postsurgery compared to presurgery, and 20% of participants returned to the level of OH females. These data sets highlight changes in thumb metacarpal movement and thumb force generation due to disease and surgical intervention. This work has the ability to support both surgeons and patients through improved outcome assessments as well as additional data to inform the decision process on intervention.
    MeSH term(s) Male ; Humans ; Female ; Carpometacarpal Joints/surgery ; Thumb/surgery ; Osteoarthritis/surgery ; Tendons ; Motion
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 243094-0
    ISSN 1528-8951 ; 0148-0731
    ISSN (online) 1528-8951
    ISSN 0148-0731
    DOI 10.1115/1.4064551
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Contact-Free, Passive, Electromagnetic Resonant Sensors for Enclosed Biomedical Applications: A Perspective on Opportunities and Challenges.

    Carr, Adam R / Chan, Yee Jher / Reuel, Nigel F

    ACS sensors

    2023  Volume 8, Issue 3, Page(s) 943–955

    Abstract: Inexpensive and accurate tools for monitoring conditions in enclosed environments (through garments, bandages, tissue, etc.) have been a long-standing goal of medicine. Passive resonant sensors are a promising solution for such wearable health sensors as ...

    Abstract Inexpensive and accurate tools for monitoring conditions in enclosed environments (through garments, bandages, tissue, etc.) have been a long-standing goal of medicine. Passive resonant sensors are a promising solution for such wearable health sensors as well as off-body diagnostics. They are simple circuits with inherent inductance and capacitance (LC tank) that have a measurable resonant frequency. Changes in local parameters, e.g., permittivity or geometry, effect inductance and capacitance which cause a resonant frequency shift response. This signal transduction has been applied to several biomedical applications such as intracranial pressure, hemodynamics, epidermal hydration, etc. Despite these many promising applications presented in the literature, resonant sensors still do not see widespread adoption in biomedical applications, especially as wearable or embedded sensing devices. This perspective highlights some of the current challenges facing LC resonant sensors in biomedical applications, such as positional sensitivity, and potential strategies that have been developed to overcome them. An outlook on adoption in medicine and health monitoring is presented, and a perspective is given on next steps for research in this field.
    MeSH term(s) Bandages ; Electric Capacitance
    Language English
    Publishing date 2023-03-13
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 2379-3694
    ISSN (online) 2379-3694
    DOI 10.1021/acssensors.2c02552
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: WRN Is a Promising Synthetic Lethal Target for Cancers with Microsatellite Instability (MSI).

    Chan, Edmond M / Foster, Kyla J / Bass, Adam J

    Cancer treatment and research

    2023  Volume 186, Page(s) 313–328

    Abstract: Microsatellite instability (MSI), a type of genetic hypermutability arising from impaired DNA mismatch repair (MMR), is observed in approximately 3% of all cancers. Preclinical work has identified the RecQ helicase WRN as a promising synthetic lethal ... ...

    Abstract Microsatellite instability (MSI), a type of genetic hypermutability arising from impaired DNA mismatch repair (MMR), is observed in approximately 3% of all cancers. Preclinical work has identified the RecQ helicase WRN as a promising synthetic lethal target for patients with MSI cancers. WRN depletion substantially impairs the viability of MSI, but not microsatellite stable (MSS), cells. Experimental evidence suggests that this synthetic lethal phenotype is driven by numerous TA dinucleotide repeats that undergo expansion mutations in the setting of long-standing MMR deficiency. The lengthening of TA repeats increases their propensity to form secondary DNA structures that require WRN to resolve. In the absence of WRN helicase activity, these unresolved DNA secondary structures stall DNA replication forks and induce catastrophic DNA damage.
    MeSH term(s) Humans ; Microsatellite Instability ; Microsatellite Repeats ; Colorectal Neoplasms ; DNA Mismatch Repair ; DNA ; Werner Syndrome Helicase/genetics
    Chemical Substances DNA (9007-49-2) ; WRN protein, human (EC 3.6.4.12) ; Werner Syndrome Helicase (EC 3.6.4.12)
    Language English
    Publishing date 2023-11-17
    Publishing country United States
    Document type Journal Article
    ISSN 0927-3042
    ISSN 0927-3042
    DOI 10.1007/978-3-031-30065-3_17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Cognitive function among women with breast cancer receiving endocrine therapy: what are the impacts?

    Fardell, Joanna E / Walker, Adam / Chan, Raymond J / Vardy, Janette L

    JNCI cancer spectrum

    2023  Volume 7, Issue 2

    MeSH term(s) Humans ; Female ; Breast Neoplasms/drug therapy ; Breast Neoplasms/psychology ; Tamoxifen/adverse effects ; Postmenopause ; Cognition
    Chemical Substances Tamoxifen (094ZI81Y45) ; exemestane (NY22HMQ4BX)
    Language English
    Publishing date 2023-03-25
    Publishing country England
    Document type Editorial ; Comment
    ISSN 2515-5091
    ISSN (online) 2515-5091
    DOI 10.1093/jncics/pkad026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Sustained Mild Inflammation in Cancer Survivors: Where to from Here?

    Walker, Adam K / Chan, Raymond J / Vardy, Janette L

    JNCI cancer spectrum

    2022  Volume 6, Issue 4

    MeSH term(s) Biomarkers ; Breast Neoplasms ; Cancer Survivors ; Female ; Humans ; Inflammation ; Survivors
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-08-12
    Publishing country England
    Document type Editorial ; Comment
    ISSN 2515-5091
    ISSN (online) 2515-5091
    DOI 10.1093/jncics/pkac054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Transcatheter mitral edge-to-edge repair - Age is only one parameter among others.

    Messika-Zeitoun, David / Chan, Vincent / Al-Atassi, Talal / Dryden, Adam / Burwash, Ian G / Labinaz, Marino

    The Canadian journal of cardiology

    2024  

    Language English
    Publishing date 2024-03-16
    Publishing country England
    Document type Editorial
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2024.03.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Exploring the relationship between pericoronary inflammation and microvascular function.

    Thakkar, Harsh V / Chan, Jasmine / Comella, Andrea / Ihdayhid, Abdul R / Michail, Michael / Nerlekar, Nitesh / Brown, Adam J

    Journal of cardiovascular computed tomography

    2024  

    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Letter
    ZDB-ID 2394360-9
    ISSN 1876-861X ; 1934-5925
    ISSN (online) 1876-861X
    ISSN 1934-5925
    DOI 10.1016/j.jcct.2024.04.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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