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  1. Book ; Thesis: Transgene Ratten als Modelle des humanen Renin-Angiotensin-Systems

    Bohlender, Jürgen

    Analyse zur Bedeutung von humanem Renin und Angiotensinogen als Risikofaktoren der arteriellen Hypertonie

    2004  

    Author's details von Jürgen Bohlender
    Language German ; English
    Size 248 Bl., Ill., graph. Darst., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Jena, Univ., Habil.-Schr., 2004
    Note Beitr. teilw. dt., teilw. engl. - Enth. 26 Sonderabdr. aus verschiedenen Zeitschr.
    HBZ-ID HT014924513
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2007 E 17 order to use in reading room Magazin

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  2. Book ; Thesis: Schmerz im ischämischen Muskel

    Bohlender, Jürgen

    Untersuchungen zur Physiologie der Schmerzempfindung und experimentellen Algesimetrie

    1991  

    Author's details vorgelegt von Jürgen Bohlender
    Size II, 96 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Würzburg, Univ., Diss., 1991
    HBZ-ID HT003985176
    Database Catalogue ZB MED Medicine, Health

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  3. Article: Unusual circadian hypertension associated with polydipsia.

    Bohlender, Jürgen M / Nussberger, Jürg

    Journal of geriatric cardiology : JGC

    2017  Volume 13, Issue 11, Page(s) 932–934

    Language English
    Publishing date 2017-01-13
    Publishing country China
    Document type Journal Article
    ZDB-ID 2421391-3
    ISSN 1671-5411
    ISSN 1671-5411
    DOI 10.11909/j.issn.1671-5411.2016.11.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Medication adherence during laboratory workup for primary aldosteronism: pilot study.

    Sandbaumhüter, Friederike A / Haschke, Manuel / Vogt, Bruno / Bohlender, Jürgen M

    Patient preference and adherence

    2018  Volume 12, Page(s) 2449–2455

    Abstract: Purpose: Current hypertension guidelines stipulate that all incompatible medications be stopped before performing laboratory screening for aldosteronism, but patient adherence is unclear. We measured plasma drug concentrations to determine drug ... ...

    Abstract Purpose: Current hypertension guidelines stipulate that all incompatible medications be stopped before performing laboratory screening for aldosteronism, but patient adherence is unclear. We measured plasma drug concentrations to determine drug adherence and potential drug bias during biochemical tests.
    Patients and methods: Plasma concentrations of 10 antihypertensive drugs were quantified by mass spectrometry in 24 consecutive ambulatory patients with uncontrolled hypertension routinely evaluated for aldosteronism. Drug screening was done before (first visit), and on the day of biochemical tests (second visit) after stopping all incompatible medications. Concentrations above those expected at trough dosing interval defined same-day dose intake.
    Results: On the first and second visits, 76% vs 77% of prescribed antihypertensive doses could be verified in plasma. A total of 33% of patients were found to be nonadherent and showed divergent plasma drug results relative to prescriptions (21% drugs not detected/13% unprescribed drugs found) on first visit, 25% on the second (0%/25%), and 46% for both. A total of 21% used medication incompatible with the biochemical tests on the second visit. Moreover, 17% of drug concentrations were below expected trough levels on the first vs 15% on the second visit. This analysis revealed additional four (17%) vs three (13%) nonadherent patients who failed same-day dose intake and remained undetected by qualitative drug tests.
    Conclusion: Nonadherence was frequent during laboratory evaluations for aldosteronism advocating cautious interpretation of results. A multicenter study is desirable to set the stage for new screening protocols that should incorporate also incentives and checks of drug adherence.
    Language English
    Publishing date 2018-11-19
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2455848-5
    ISSN 1177-889X
    ISSN 1177-889X
    DOI 10.2147/PPA.S179488
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Pharmacotherapy: Optimal blockade of the renin-angiotensin-aldosterone system.

    Nussberger, Jürg / Bohlender, Jürgen

    Nature reviews. Cardiology

    2013  Volume 10, Issue 4, Page(s) 183–184

    Abstract: Inhibition of the renin–angiotensin–aldosterone system (RAAS) is a successful therapy for hypertension, heart failure, and renal insufficiency. Overdosing of RAAS inhibitors is occasionally observed when several agents are used together, and can cause ... ...

    Abstract Inhibition of the renin–angiotensin–aldosterone system (RAAS) is a successful therapy for hypertension, heart failure, and renal insufficiency. Overdosing of RAAS inhibitors is occasionally observed when several agents are used together, and can cause adverse events such as hypotension, hyperkalaemia, and renal failure. We advocate optimal, rather than complete, RAAS blockade.
    MeSH term(s) Angiotensin II Type 1 Receptor Blockers/adverse effects ; Angiotensin II Type 1 Receptor Blockers/therapeutic use ; Angiotensin-Converting Enzyme Inhibitors/adverse effects ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Antihypertensive Agents/adverse effects ; Antihypertensive Agents/therapeutic use ; Blood Pressure/drug effects ; Drug Therapy, Combination ; Heart Failure/drug therapy ; Heart Failure/physiopathology ; Humans ; Hypertension/drug therapy ; Hypertension/physiopathology ; Hypokalemia/chemically induced ; Hypotension/chemically induced ; Hypotension/physiopathology ; Meta-Analysis as Topic ; Renal Insufficiency/chemically induced ; Renal Insufficiency/physiopathology ; Renin/antagonists & inhibitors ; Renin/metabolism ; Renin-Angiotensin System/drug effects ; Treatment Outcome
    Chemical Substances Angiotensin II Type 1 Receptor Blockers ; Angiotensin-Converting Enzyme Inhibitors ; Antihypertensive Agents ; Renin (EC 3.4.23.15)
    Language English
    Publishing date 2013-03-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2490375-9
    ISSN 1759-5010 ; 1759-5002
    ISSN (online) 1759-5010
    ISSN 1759-5002
    DOI 10.1038/nrcardio.2013.28
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Reply: Optimal renin-angiotensin-aldosterone system blockade--wish fulfilled.

    Nussberger, Jürg / Bohlender, Jürgen

    Nature reviews. Cardiology

    2013  Volume 10, Issue 8, Page(s) 486

    MeSH term(s) Angiotensin II Type 1 Receptor Blockers/therapeutic use ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Antihypertensive Agents/therapeutic use ; Heart Failure/drug therapy ; Humans ; Hypertension/drug therapy ; Renin/antagonists & inhibitors ; Renin-Angiotensin System/drug effects
    Chemical Substances Angiotensin II Type 1 Receptor Blockers ; Angiotensin-Converting Enzyme Inhibitors ; Antihypertensive Agents ; Renin (EC 3.4.23.15)
    Language English
    Publishing date 2013-07-02
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2490375-9
    ISSN 1759-5010 ; 1759-5002
    ISSN (online) 1759-5010
    ISSN 1759-5002
    DOI 10.1038/nrcardio.2013.28-c2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Angiotensinergic Innervation of the Human Right Atrium: Implications for Cardiac Reflexes.

    Bohlender, Jürgen M / Nussberger, Jürg / Tevaearai, Hendrik / Imboden, Hans

    American journal of hypertension

    2017  Volume 31, Issue 2, Page(s) 188–196

    Abstract: Background: The right atrium is densely innervated and provides sensory input to important cardiocirculatory reflexes controlling cardiac output and blood pressure. Its angiotensin (Ang) II-expressing innervation may release Ang II as a neuropeptide ... ...

    Abstract Background: The right atrium is densely innervated and provides sensory input to important cardiocirculatory reflexes controlling cardiac output and blood pressure. Its angiotensin (Ang) II-expressing innervation may release Ang II as a neuropeptide cotransmitter to modulate reflexes but has not yet been characterized.
    Methods: Intraoperative surgical biopsies from human right atria (n = 7) were immunocytologically stained for Ang II, tyrosine hydroxylase (TH), and synaptophysin (SYN). Tissue angiotensins were extracted and quantified by radioimmunoassay.
    Results: Angiotensinergic fibers were frequent in epicardial nerves and around vessels with variable TH co-localization (none to >50%/bundle). Fibers were also widely distributed between cardiomyocytes and in the endocardium where they were typically nonvaricose, TH/SYN-negative and usually accompanied by varicose catecholaminergic fibers. In the endocardium, some showed large varicosities and were partially TH or SYN-positive. A few endocardial regions showed scattered nonvaricose Ang fibers ending directly between endothelial cells. Occasional clusters of thin varicose terminals co-localizing SYN or TH were located underneath, or protruded into, the endothelium. Endocardial density of Ang and TH-positive fibers was 30-300 vs. 200-450/mm2. Atrial Ang II, III, and I concentrations were 67, 16, and 5 fmol/g (median) while Ang IV and V were mostly undetectable.
    Conclusions: The human right atrium harbors an abundant angiotensinergic innervation and a novel potential source of atrial Ang II. Most peripheral fibers were noncatecholaminergic afferents or preterminal vagal efferents and a minority was presumably sympathetic. Neuronal Ang II release from these fibers may modulate cardiac and circulatory reflexes independently from plasma and tissue Ang II sources.
    MeSH term(s) Aged ; Angiotensin I/analysis ; Angiotensin II/analogs & derivatives ; Angiotensin II/analysis ; Angiotensin III/analysis ; Angiotensins/analysis ; Autonomic Nervous System/chemistry ; Heart Atria/innervation ; Humans ; Male ; Middle Aged ; Nerve Fibers/chemistry ; Peptide Fragments/analysis ; Reflex ; Synaptophysin/analysis ; Tyrosine 3-Monooxygenase/analysis
    Chemical Substances Angiotensins ; Peptide Fragments ; SYP protein, human ; Synaptophysin ; Angiotensin II (11128-99-7) ; Angiotensin III (12687-51-3) ; angiotensin II, des-Asp(1)-des-Arg(2)-Ile(5)- (23025-68-5) ; angiotensin pentapeptide (52530-60-6) ; Angiotensin I (9041-90-1) ; Tyrosine 3-Monooxygenase (EC 1.14.16.2)
    Language English
    Publishing date 2017-10-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639383-4
    ISSN 1941-7225 ; 1879-1905 ; 0895-7061
    ISSN (online) 1941-7225 ; 1879-1905
    ISSN 0895-7061
    DOI 10.1093/ajh/hpx163
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    Zs.A 2329: Show issues Location:
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  8. Article ; Online: Salt and Blood Pressure: Cutting Through the Scientific Fog.

    Rexhaj, Emrush / Messerli, Franz H / Cerny, David / Bohlender, Juergen

    Current hypertension reports

    2017  Volume 19, Issue 6, Page(s) 47

    Language English
    Publishing date 2017-06-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057367-4
    ISSN 1534-3111 ; 1522-6417
    ISSN (online) 1534-3111
    ISSN 1522-6417
    DOI 10.1007/s11906-017-0747-9
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  9. Article ; Online: Resetting of renal tissular renin-angiotensin and bradykinin-kallikrein systems after unilateral kidney denervation in rats.

    Bohlender, Jürgen M / Nussberger, Jürg / Birkhäuser, Frédéric / Grouzmann, Eric / Thalmann, George N / Imboden, Hans

    Histochemistry and cell biology

    2017  Volume 147, Issue 5, Page(s) 585–593

    Abstract: The renal tissular renin-angiotensin and bradykinin-kallikrein systems control kidney function together with the renal sympathetic innervation but their interaction is still unclear. To further elucidate this relationship, we investigated these systems ... ...

    Abstract The renal tissular renin-angiotensin and bradykinin-kallikrein systems control kidney function together with the renal sympathetic innervation but their interaction is still unclear. To further elucidate this relationship, we investigated these systems in rats 6 days after left kidney denervation (DNX, n = 8) compared to sham-operated controls (CTR, n = 8). Plasma renin concentration was unchanged in DNX vs. CTR (p = NS). Kidney bradykinin (BK) and angiotensin (Ang) I and II concentrations decreased bilaterally in DNX vs. CTR rats (~20 to 40%, p < 0.05) together with Ang IV and V concentrations that were extremely low (p = NS). Renin, Ang III and dopamine concentrations decreased by ~25 to 50% and norepinephrine concentrations by 99% in DNX kidneys (p < 0.05) but were unaltered in opposite kidneys. Ang II/I and KA were comparable in DNX, contralateral and CTR kidneys. Ang III/II increased in right vs. DNX or CTR kidneys (40-50%, p < 0.05). Ang II was mainly located in tubular epithelium by immunocytological staining and its cellular distribution was unaffected by DNX. Moreover, the angiotensinergic and catecholaminergic innervation of right kidneys was unchanged vs. CTR. We found an important dependency of tissular Ang and BK levels on the renal innervation that may contribute to the resetting of kidney function after DNX. The DNX-induced peptide changes were not readily explained by kidney KA, renin or plasma Ang I generation. However, tissular peptide metabolism and compartmentalization may have played a central role. The mechanisms behind the concentration changes remain unclear and deserve further clarification.
    Language English
    Publishing date 2017-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1222930-1
    ISSN 1432-119X ; 0301-5564 ; 0948-6143
    ISSN (online) 1432-119X
    ISSN 0301-5564 ; 0948-6143
    DOI 10.1007/s00418-017-1543-y
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  10. Article ; Online: Angiotensinergic innervation of the kidney: present knowledge and its significance.

    Bohlender, Jürgen / Nussberger, Jürg / Imboden, Hans

    Current hypertension reports

    2012  Volume 15, Issue 1, Page(s) 10–16

    Abstract: Intrarenal neurotransmission implies the co-release of neuropeptides at the neuro-effector junction with direct influence on parameters of kidney function. The presence of an angiotensin (Ang) II-containing phenotype in catecholaminergic postganglionic ... ...

    Abstract Intrarenal neurotransmission implies the co-release of neuropeptides at the neuro-effector junction with direct influence on parameters of kidney function. The presence of an angiotensin (Ang) II-containing phenotype in catecholaminergic postganglionic and sensory fibers of the kidney, based on immunocytological investigations, has only recently been reported. These angiotensinergic fibers display a distinct morphology and intrarenal distribution, suggesting anatomical and functional subspecialization linked to neuronal Ang II-expression. This review discusses the present knowledge concerning these fibers, and their significance for renal physiology and the pathogenesis of hypertension in light of established mechanisms. The data suggest a new role of Ang II as a co-transmitter stimulating renal target cells or modulating nerve traffic from or to the kidney. Neuronal Ang II is likely to be an independent source of intrarenal Ang II. Further physiological experimentation will have to explore the role of the angiotensinergic renal innervation and integrate it into existing concepts.
    MeSH term(s) Angiotensin II/physiology ; Animals ; Autonomic Nervous System/physiology ; Endothelium, Vascular/physiology ; Humans ; Hypertension/metabolism ; Immunohistochemistry ; Kidney/innervation ; Kidney/metabolism ; Kidney/physiology ; Neuroeffector Junction/physiology ; Neurons/chemistry ; Neuropeptides/physiology ; Synaptic Transmission/physiology
    Chemical Substances Neuropeptides ; Angiotensin II (11128-99-7)
    Language English
    Publishing date 2012-11-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2057367-4
    ISSN 1534-3111 ; 1522-6417
    ISSN (online) 1534-3111
    ISSN 1522-6417
    DOI 10.1007/s11906-012-0322-3
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