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  1. Article: Hematological Alterations after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy.

    Pintado, Maria Consuelo / Lasa Unzúe, Inmaculada / Gómez Sanz, Remedios / Diez Alonso, Manuel / Ortega, Miguel A / Álvarez de Mon, Melchor / Nevado Losada, Emilio / Gutierrez Calvo, Alberto

    Journal of clinical medicine

    2023  Volume 12, Issue 13

    Abstract: Background: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have benefits for survival in some cancers with peritoneal metastasis. Hematologic toxicity described rate is 2 to 38%.: Methods: Patients admitted to an ... ...

    Abstract Background: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have benefits for survival in some cancers with peritoneal metastasis. Hematologic toxicity described rate is 2 to 38%.
    Methods: Patients admitted to an intensive care unit (ICU) after CRS and HIPEC over 78 months. The data recorded were demographic characteristics, the severity of illness, complete blood samples, the type of cancer and extension, HIPEC drug and temperature, ICU and hospital stay and mortality, bleeding, and the need for transfusion of blood products.
    Results: Of the 96 patients included, 77.1% presented hematological complications: 8.3% leukopenia (<4000/mm
    Conclusions: In our study, 77.1% of patients treated with CRS and HIPEC developed hematological complications during the postoperative period; the majority of them were not severe and resolved spontaneously, without an effect on mortality or hospital stay.
    Language English
    Publishing date 2023-06-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12134323
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Nutrition, Epigenetics, and Major Depressive Disorder: Understanding the Connection.

    Ortega, Miguel A / Fraile-Martínez, Óscar / García-Montero, Cielo / Alvarez-Mon, Miguel Angel / Lahera, Guillermo / Monserrat, Jorge / Llavero-Valero, Maria / Mora, Fernando / Rodríguez-Jiménez, Roberto / Fernandez-Rojo, Sonia / Quintero, Javier / Alvarez De Mon, Melchor

    Frontiers in nutrition

    2022  Volume 9, Page(s) 867150

    Abstract: Major depressive disorder (MDD) is a complex, multifactorial disorder of rising prevalence and incidence worldwide. Nearly, 280 million of people suffer from this leading cause of disability in the world. Moreover, patients with this condition are ... ...

    Abstract Major depressive disorder (MDD) is a complex, multifactorial disorder of rising prevalence and incidence worldwide. Nearly, 280 million of people suffer from this leading cause of disability in the world. Moreover, patients with this condition are frequently co-affected by essential nutrient deficiency. The typical scene with stress and hustle in developed countries tends to be accompanied by eating disorders implying overnutrition from high-carbohydrates and high-fat diets with low micronutrients intake. In fact, currently, coronavirus disease 2019 (COVID-19) pandemic has drawn more attention to this underdiagnosed condition, besides the importance of the nutritional status in shaping immunomodulation, in which minerals, vitamins, or omega 3 polyunsaturated fatty acids (ω-3 PUFA) play an important role. The awareness of nutritional assessment is greater and greater in the patients with depression since antidepressant treatments have such a significant probability of failing. As diet is considered a crucial environmental factor, underlying epigenetic mechanisms that experience an adaptation or consequence on their signaling and expression mechanisms are reviewed. In this study, we included metabolic changes derived from an impairment in cellular processes due to lacking some essential nutrients in diet and therefore in the organism. Finally, aspects related to nutritional interventions and recommendations are also addressed.
    Language English
    Publishing date 2022-05-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2022.867150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Mindfulness, Resilience, and Burnout Subtypes in Primary Care Physicians: The Possible Mediating Role of Positive and Negative Affect.

    Montero-Marin, Jesús / Tops, Mattie / Manzanera, Rick / Piva Demarzo, Marcelo M / Álvarez de Mon, Melchor / García-Campayo, Javier

    Frontiers in psychology

    2015  Volume 6, Page(s) 1895

    Abstract: Purpose: Primary care health professionals suffer from high levels of burnout. The aim of the present study was to evaluate the associations of mindfulness and resilience with the features of the burnout types (overload, lack of development, neglect) in ...

    Abstract Purpose: Primary care health professionals suffer from high levels of burnout. The aim of the present study was to evaluate the associations of mindfulness and resilience with the features of the burnout types (overload, lack of development, neglect) in primary care physicians, taking into account the potential mediating role of negative and positive affect.
    Methods: A cross-sectional design was used. Six hundred and twenty-two Spanish primary care physicians were recruited from an online survey. The Mindful Attention Awareness Scale (MAAS), Connor-Davidson Resilience Scale (CD-RISC), Positive and Negative Affect Schedule (PANAS), and Burnout Clinical Subtype Questionnaire (BCSQ-12) questionnaires were administered. Polychoric correlation matrices were calculated. The unweighted least squares (ULS) method was used for developing structural equation modeling.
    Results: Mindfulness and resilience presented moderately high associations (φ = 0.46). Links were found between mindfulness and overload (γ = -0.25); resilience and neglect (γ = -0.44); mindfulness and resilience, and negative affect (γ = -0.30 and γ = -0.35, respectively); resilience and positive affect (γ = 0.70); negative affect and overload (β = 0.36); positive affect and lack of development (β = -0.16). The links between the burnout types reached high and positive values between overload and lack of development (β = 0.64), and lack of development and neglect (β = 0.52). The model was a very good fit to the data (GFI = 0.96; AGFI = 0.96; RMSR = 0.06; NFI = 0.95; RFI = 0.95; PRATIO = 0.96).
    Conclusions: Interventions addressing both mindfulness and resilience can influence burnout subtypes, but their impact may occur in different ways, potentially mediated by positive and negative affect. Both sorts of trainings could constitute possible tools against burnout; however, while mindfulness seems a suitable intervention for preventing its initial stages, resilience may be more effective for treating its advanced stages.
    Language English
    Publishing date 2015-12-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2015.01895
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Linfocitos TCD8+ autorreactivos en pacientes con leucemia mieloide crónica en asociación con HLA e infección con adenovirus.

    Rivera, Sergio E / Echeverría, Miriam / Salcedo, Pedro / Márquez, Georgina / Carrillo, Zuhey / Parra, Yennis / Cipriani, Ana María / Núñez, José R / Álvarez de Mon, Melchor / Farruco, Atilio

    Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)

    2016  Volume 63, Issue 2, Page(s) 163–168

    Abstract: Background: A possible interaction between a specific HLA type and Adenovirus has been postulated as a promoter in leukemia clonal evolution. The HLA-DRB1*14, specifically DRB1*14:21, 14:22, 14:45, 14:26, 14:33, 14:51, 14:35 subtypes was the most ... ...

    Title translation Autoreactive TCD8+ lymphocytes in patients with chronic myeloid leukemia in association with HLA and adenovirus infection.
    Abstract Background: A possible interaction between a specific HLA type and Adenovirus has been postulated as a promoter in leukemia clonal evolution. The HLA-DRB1*14, specifically DRB1*14:21, 14:22, 14:45, 14:26, 14:33, 14:51, 14:35 subtypes was the most frequent in CML Venezuelan patients.
    Objectives: It is interesting to evaluate the molecular mimicry between the Adenovirus and the DRB1*14 subtypes which exhibit the same change in the amino acid position of the DR53 epitope. This mimicked segment has been identified as a LLERRRA polypeptide.
    Material and method: Experimental research conducted in the IHO Venezuela, in peripheral blood samples of patients with ALL, CML and healthy controls. Mixed culture, serology, lymphocyte proliferation and cytofluorometry were performed.
    Results: DRB1*14 patient's lymphocytes reacted in 48 hours mixed culture against DRB1*14 promoters lymphocytes exhibiting increased CD8+T lymphocytes. CML patients show a different serological profile against Adenovirus. Only CML patients reacted to LLERRRA peptide, increasing CD8+ T cells.
    Conclusion: It is established that the relationship CML, HLADRB1* 14, autoreactive CD8+ T memory cell and CD8+T specific response from Adenovirus could be at the origin of the CML in Venezuelan patients.
    MeSH term(s) Adenoviridae Infections/immunology ; CD8-Positive T-Lymphocytes/immunology ; Case-Control Studies ; HLA-DRB1 Chains/immunology ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/immunology ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/virology ; Molecular Mimicry ; Venezuela
    Chemical Substances HLA-DRB1 Chains
    Language Spanish
    Publishing date 2016-04-29
    Publishing country Mexico
    Document type Journal Article
    ZDB-ID 639125-4
    ISSN 0002-5151
    ISSN 0002-5151
    DOI 10.29262/ram.v63i2.149
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: HLA DRB1*, DQB1*, DPA1* y DPB1* y su asociación con la patogénesis de las leucemias en población venezolana.

    Rivera-Pirela, Sergio E / Echeverría, Miriam / Salcedo, Pedro / Márquez, Georgina / Carrillo, Zuhey / Parra, Yennis / Cipriani, Ana María / Núñez, José R / Álvarez de Mon, Melchor

    Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)

    2016  Volume 63, Issue 3, Page(s) 237–251

    Abstract: Background: The HLA complex involved is a factor in the pathogenesis of leukemia.: Objectives: The presence of class II HLA alleles DRB1 *, DQB1 *, DPA1 *, and DPB1 * was evaluated in 47 patients with acute lymphoblastic leukemia (ALL) and 48 with ... ...

    Title translation HLA DRB1*, DQB1*, DPA1*, and DPB1* and their association with the pathogenesis of leukemia in the population of Venezuela.
    Abstract Background: The HLA complex involved is a factor in the pathogenesis of leukemia.
    Objectives: The presence of class II HLA alleles DRB1 *, DQB1 *, DPA1 *, and DPB1 * was evaluated in 47 patients with acute lymphoblastic leukemia (ALL) and 48 with chronic myeloid leukemia (CML) for comparison with 48 healthy volunteers in Zulia, Venezuela, and to evaluate potential associations of HLA with leukemia.
    Methods: Low- and high-resolution PCR-SSP was used for class II HLA regions DRB1 *, DQB1 *, DPA1 *, and DPB1 * following the instructions of KIT Olerup SSP Genovision.
    Results: Alleles HLA-DRB1*14, especially DRB1*14:21, -DPA1*1:06, -DPA1*01:03,-DPA1*02:01, and the haplotypes HLA-DPA1*01:03-DPB1*04:01, DPA1*01:03-DPB1*02:01, DPA1*01:03-DPB1*99:01, -DRB1*14-DPA1*01:03, -DRB1*15-DPA1*01:03 were associated with CML (RR > 3); alleles HLA-DRB1*13, -DQB1*02, -DPA1*01:05, -DPA1*01:09 and the haplotypes HLA-DPA1*01:09-DPB1*02:01, DPA1*01:09-DPB1*04:01 were protective (RR < 1). Alleles HLA-DQB1*04, -DQB1*05, -DPA1*1:06, -DPA1*01:07, -DPA1*1:08 had a positive association with ALL. Alleles HLA-DPA1*01:09, -DPA1*02:01, -DPB1*02:01, -DPB1*03:01 and the haplotypes HLA-DPA1*01:03-DPB1*04:02, -DPA1*01:09-DPB1*02:01, -DPA1*01:09-DPB1*04:01, -DPA1*02:01-DPB1*04:02 were negatively associated.
    Conclusions: The other association patterns identified suggest marked differences in the pathogenesis of leukemia, which suggests possible deficiencies in antigen presentation for ALL or potential effects of molecular mimicry in CML.
    MeSH term(s) Alleles ; HLA-D Antigens/genetics ; HLA-D Antigens/immunology ; HLA-DQ beta-Chains/immunology ; HLA-DRB1 Chains/genetics ; HLA-DRB1 Chains/immunology ; Haplotypes ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/immunology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/immunology ; Venezuela
    Chemical Substances HLA-D Antigens ; HLA-DQ beta-Chains ; HLA-DQbeta antigen ; HLA-DRB1 Chains
    Language Spanish
    Publishing date 2016-08-23
    Publishing country Mexico
    Document type Journal Article
    ZDB-ID 639125-4
    ISSN 0002-5151
    ISSN 0002-5151
    DOI 10.29262/ram.v63i3.147
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 488: Show issues Location:
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  6. Article: Biological effect of nutritional recovery on serum concentrations of inflammation cytokines in the malnourished child.

    Pereira, Nayda / Echeverría-Velasquez, Miriam / Nuñez-Gonzalez, José R / Molano, Nelly / Atencio, Teresa / Amel, Anilsa / Gil, Luis / Álvarez de Mon, Melchor

    Investigacion clinica

    2015  Volume 56, Issue 4, Page(s) 356–366

    Title translation Efecto biológico de la recuperación nutricional en las concentraciones séricas de citocinas inflamatorias en el niño desnutrido grave.
    MeSH term(s) Cytokines/blood ; Humans ; Infant ; Infant Nutrition Disorders/blood ; Infant Nutrition Disorders/therapy ; Inflammation/blood ; Longitudinal Studies ; Malnutrition/blood ; Malnutrition/therapy ; Nutrition Therapy ; Prospective Studies
    Chemical Substances Cytokines
    Language Spanish
    Publishing date 2015-12
    Publishing country Venezuela
    Document type Journal Article
    ZDB-ID 969078-5
    ISSN 0535-5133
    ISSN 0535-5133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2092: Show issues Location:
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  7. Article ; Online: Increased cytokine/chemokines in serum from asthmatic and non-asthmatic patients with viral respiratory infection.

    Giuffrida, María J / Valero, Nereida / Mosquera, Jesús / Alvarez de Mon, Melchor / Chacín, Betulio / Espina, Luz Marina / Gotera, Jennifer / Bermudez, John / Mavarez, Alibeth

    Influenza and other respiratory viruses

    2013  Volume 8, Issue 1, Page(s) 116–122

    Abstract: Background: Respiratory viral infections can induce different cytokine/chemokine profiles in lung tissues and have a significant influence on patients with asthma. There is little information about the systemic cytokine status in viral respiratory- ... ...

    Abstract Background: Respiratory viral infections can induce different cytokine/chemokine profiles in lung tissues and have a significant influence on patients with asthma. There is little information about the systemic cytokine status in viral respiratory-infected asthmatic patients compared with non-asthmatic patients.
    Objectives: The aim of this study was to determine changes in circulating cytokines (IL-1β, TNF-α, IL-4, IL-5) and chemokines (MCP1: monocyte chemoattractant protein-1 and RANTES: regulated on activation normal T cell expressed and secreted) in patients with an asthmatic versus a non-asthmatic background with respiratory syncytial virus, parainfluenza virus or adenovirus respiratory infection. In addition, human monocyte cultures were incubated with respiratory viruses to determine the cytokine/chemokine profiles.
    Patients/methods: Patients with asthmatic (n = 34) and non-asthmatic (n = 18) history and respiratory infections with respiratory syncytial virus, parainfluenza, and adenovirus were studied. Healthy individuals with similar age and sex (n = 10) were used as controls. Cytokine/chemokine content in blood and culture supernatants was determined by ELISA. Monocytes were isolated by Hystopaque gradient and cocultured with each of the above-mentioned viruses.
    Results: Similar increased cytokine concentrations were observed in asthmatic and non-asthmatic patients. However, higher concentrations of chemokines were observed in asthmatic patients. Virus-infected monocyte cultures showed similar cytokine/chemokine profiles to those observed in the patients.
    Conclusions: Circulating cytokine profiles induced by acute viral lung infection were not related to asthmatic status, except for chemokines that were already increased in the asthmatic status. Monocytes could play an important role in the increased circulating concentration of cytokines found during respiratory viral infections.
    MeSH term(s) Adenoviridae/immunology ; Adenoviridae Infections/immunology ; Adenoviridae Infections/pathology ; Adolescent ; Adult ; Aged ; Asthma/complications ; Cells, Cultured ; Child ; Cytokines/blood ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Male ; Middle Aged ; Monocytes/immunology ; Paramyxoviridae Infections/immunology ; Paramyxoviridae Infections/pathology ; Respiratory Syncytial Virus Infections/immunology ; Respiratory Syncytial Virus Infections/pathology ; Respiratory Syncytial Viruses/immunology ; Respiratory Tract Infections/immunology ; Respiratory Tract Infections/pathology ; Respirovirus/immunology ; Serum/chemistry ; Young Adult
    Chemical Substances Cytokines
    Keywords covid19
    Language English
    Publishing date 2013-08-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2274538-5
    ISSN 1750-2659 ; 1750-2640
    ISSN (online) 1750-2659
    ISSN 1750-2640
    DOI 10.1111/irv.12155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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