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  1. Article: Editorial: Molecular mechanisms underlying obesity and their links with other comorbidities.

    Plaza-Diaz, Julio / Álvarez-Mercado, Ana I / Yu, Bilian / Sungthong, Rungroch

    Frontiers in molecular biosciences

    2024  Volume 10, Page(s) 1334024

    Language English
    Publishing date 2024-01-25
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2023.1334024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Editorial: Interplay between gut microbiota and the immune system in liver surgery and liver diseases.

    Plaza-Díaz, Julio / Fontana, Luis / Álvarez-Mercado, Ana I

    Frontiers in cellular and infection microbiology

    2023  Volume 13, Page(s) 1188092

    MeSH term(s) Humans ; Gastrointestinal Microbiome ; Liver ; Liver Diseases/surgery ; Immune System
    Language English
    Publishing date 2023-03-27
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2023.1188092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Dietary Polysaccharides as Modulators of the Gut Microbiota Ecosystem: An Update on Their Impact on Health.

    Álvarez-Mercado, Ana I / Plaza-Diaz, Julio

    Nutrients

    2022  Volume 14, Issue 19

    Abstract: A polysaccharide is a macromolecule composed of more than ten monosaccharides with a wide distribution and high structural diversity and complexity in nature. Certain polysaccharides are immunomodulators and play key roles in the regulation of immune ... ...

    Abstract A polysaccharide is a macromolecule composed of more than ten monosaccharides with a wide distribution and high structural diversity and complexity in nature. Certain polysaccharides are immunomodulators and play key roles in the regulation of immune responses during the progression of some diseases. In addition to stimulating the growth of certain intestinal bacteria, polysaccharides may also promote health benefits by modulating the gut microbiota. In the last years, studies about the triad gut microbiota-polysaccharides-health have increased exponentially. In consequence, in the present review, we aim to summarize recent knowledge about the function of dietary polysaccharides on gut microbiota composition and how these effects affect host health.
    MeSH term(s) Dietary Carbohydrates ; Ecosystem ; Gastrointestinal Microbiome ; Health Promotion ; Monosaccharides ; Polysaccharides/pharmacology
    Chemical Substances Dietary Carbohydrates ; Monosaccharides ; Polysaccharides
    Language English
    Publishing date 2022-10-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14194116
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Dietary Polysaccharides and Gut Microbiota Ecosystem.

    Álvarez-Mercado, Ana I / Plaza-Diaz, Julio

    Nutrients

    2022  Volume 14, Issue 20

    Abstract: The intestinal microbiota is a community of microorganisms that subsists within the gastrointestinal ecosystem [ ... ]. ...

    Abstract The intestinal microbiota is a community of microorganisms that subsists within the gastrointestinal ecosystem [...].
    MeSH term(s) Gastrointestinal Microbiome ; Polysaccharides ; Ecosystem ; Gastrointestinal Tract ; Dietary Carbohydrates
    Chemical Substances Polysaccharides ; Dietary Carbohydrates
    Language English
    Publishing date 2022-10-14
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14204285
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Editorial: Molecular and cellular aspects of regulatory and subjacent mechanisms in host/microbiota association and its involvement in cancer.

    Álvarez-Mercado, Ana I / Sáez-Lara, María José / Plaza-Diaz, Julio

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 989208

    Language English
    Publishing date 2022-08-29
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.989208
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Nutrition and cellular senescence in obesity-related disorders

    Rubio-Tomás, Teresa / Rueda-Robles, Ascensión / Plaza-Díaz, Julio / Álvarez-Mercado, Ana I.

    Journal of nutritional biochemistry. 2022 Jan., v. 99

    2022  

    Abstract: Adequate nutrition is vital for immune homeostasis. However, the incidence of obesity is increasing worldwide due to the adoption of the Western diet and a sedentary lifestyle. Obesity is associated with chronic inflammation which alters the function of ... ...

    Abstract Adequate nutrition is vital for immune homeostasis. However, the incidence of obesity is increasing worldwide due to the adoption of the Western diet and a sedentary lifestyle. Obesity is associated with chronic inflammation which alters the function of adipose tissue, liver, pancreas, and the nervous system. Inflammation is related to cellular senescence, distinguished by irreversible cell cycle arrest. Senescent cells secrete the senescence-associated secretory phenotype (SASP) which contains pro-inflammatory factors. Targeting processes in senescence might have a salutary approach to obesity. The present review highlights the impact of an unhealthy diet on tissues affected by obesity, and the mechanisms that promote the consequent inflammation and senescence.
    Keywords Western diets ; adipose tissue ; biochemistry ; cell cycle checkpoints ; cell senescence ; homeostasis ; inflammation ; liver ; nervous system ; obesity ; pancreas ; phenotype ; sedentary lifestyle
    Language English
    Dates of publication 2022-01
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 1014929-6
    ISSN 1873-4847 ; 0955-2863
    ISSN (online) 1873-4847
    ISSN 0955-2863
    DOI 10.1016/j.jnutbio.2021.108861
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 5044: Show issues

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  7. Article: From Non-Alcoholic Fatty Liver Disease to Liver Cancer: Microbiota and Inflammation as Key Players.

    Rodríguez-Lara, Avilene / Rueda-Robles, Ascensión / Sáez-Lara, María José / Plaza-Diaz, Julio / Álvarez-Mercado, Ana I

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 7

    Abstract: It is estimated that 25% of the world's population has non-alcoholic fatty liver disease. This disease can advance to a more severe form, non-alcoholic steatohepatitis (NASH), a disease with a greater probability of progression to cirrhosis and ... ...

    Abstract It is estimated that 25% of the world's population has non-alcoholic fatty liver disease. This disease can advance to a more severe form, non-alcoholic steatohepatitis (NASH), a disease with a greater probability of progression to cirrhosis and hepatocellular carcinoma (HCC). NASH could be characterized as a necro-inflammatory complication of chronic hepatic steatosis. The combination of factors that lead to NASH and its progression to HCC in the setting of inflammation is not clearly understood. The portal vein is the main route of communication between the intestine and the liver. This allows the transfer of products derived from the intestine to the liver and the hepatic response pathway of bile and antibody secretion to the intestine. The intestinal microbiota performs a fundamental role in the regulation of immune function, but it can undergo changes that alter its functionality. These changes can also contribute to cancer by disrupting the immune system and causing chronic inflammation and immune dysfunction, both of which are implicated in cancer development. In this article, we address the link between inflammation, microbiota and HCC. We also review the different in vitro models, as well as recent clinical trials addressing liver cancer and microbiota.
    Language English
    Publishing date 2023-07-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12070940
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Impact of Dietary Patterns on H. pylori Infection and the Modulation of Microbiota to Counteract Its Effect. A Narrative Review

    Rueda-Robles, Ascensión / Rubio-Tomás, Teresa / Plaza-Diaz, Julio / Álvarez-Mercado, Ana I.

    Pathogens. 2021 July 10, v. 10, no. 7

    2021  

    Abstract: Helicobacter pylori (H. pylori) is a Gram-negative bacterium that colonizes the stomach and can induce gastric disease and intra-gastric lesions, including chronic gastritis, peptic ulcers, gastric adenocarcinoma, and mucosa-associated lymphoid tissue ... ...

    Abstract Helicobacter pylori (H. pylori) is a Gram-negative bacterium that colonizes the stomach and can induce gastric disease and intra-gastric lesions, including chronic gastritis, peptic ulcers, gastric adenocarcinoma, and mucosa-associated lymphoid tissue lymphoma. This bacterium is responsible for long-term complications of gastric disease. The conjunction of host genetics, immune response, bacterial virulence expression, diet, micronutrient availability, and microbiome structure influence the disease outcomes related to chronic H. pylori infection. In this regard, the consumption of unhealthy and unbalanced diets can induce microbial dysbiosis, which infection with H. pylori may contribute to. However, to date, clinical trials have reported controversial results and current knowledge in this field is inconclusive. Here, we review preclinical studies concerning the changes produced in the microbiota that may be related to H. pylori infection, as well as the involvement of diet. We summarize and discuss the last approaches based on the modulation of the microbiota to improve the negative impact of H. pylori infection and their potential translation from bench to bedside.
    Keywords Gram-negative bacteria ; Helicobacter pylori ; adenocarcinoma ; diet ; dysbiosis ; gastritis ; immune response ; lymphoma ; microbiome ; nutrient availability ; stomach ; virulence
    Language English
    Dates of publication 2021-0710
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens10070875
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: Effect of Probiotics on Host-Microbiota in Bacterial Infections

    Rueda-Robles, Ascensión / Rodríguez-Lara, Avilene / Meyers, Matthew S. / Sáez-Lara, María José / Álvarez-Mercado, Ana I.

    Pathogens. 2022 Aug. 29, v. 11, no. 9

    2022  

    Abstract: Diseases caused by bacteria cause millions of deaths every year. In addition, the problem of resistance to antibiotics is so serious that it threatens the achievements of modern medicine. This is a very important global problem as some bacteria can also ... ...

    Abstract Diseases caused by bacteria cause millions of deaths every year. In addition, the problem of resistance to antibiotics is so serious that it threatens the achievements of modern medicine. This is a very important global problem as some bacteria can also develop persistence. Indeed, the persistence of pathogenic bacteria has evolved as a potent survival strategy to overcome host organisms’ defense mechanisms. Additionally, chronic or persistent infections may be caused by persisters which could facilitate antibiotic resistance. Probiotics are considered good bacteria. It has been described that the modulation of gut microbiota by probiotics could have a great potential to counteract the deleterious impact and/or regulate gut microbiota after bacterial infection. Probiotics might provide health benefits through the inhibition of pathogen growth or the replacement of pathogenic bacteria. Bearing in mind that current strategies to avoid bacterial persistence and prevent antibiotic resistance are not effective, other strategies need to be assessed. We have carried out a comprehensive review, which included the reported literature between 2016 and 2021, highlighting the clinical trials that reported the probiotics’ potential to regulate gut microbiota after bacterial infection and focusing in particular on the context of antibiotic resistance and persister cells.
    Keywords antibiotic resistance ; bacterial infections ; intestinal microorganisms ; medicine ; pathogens ; probiotics
    Language English
    Dates of publication 2022-0829
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens11090986
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  10. Article: Functions of SMYD proteins in biological processes: What do we know? An updated review

    Rueda-Robles, Ascensión / Audano, Matteo / Álvarez-Mercado, Ana I. / Rubio-Tomás, Teresa

    Archives of biochemistry and biophysics. 2021 Nov. 15, v. 712

    2021  

    Abstract: Epigenetic modifiers, such as methyltransferases, play crucial roles in the regulation of many biological processes, including development, cancer and multiple physiopathological conditions.The Su(Var)3–9, Enhancer-of-zeste and Trithorax (SET) and ... ...

    Abstract Epigenetic modifiers, such as methyltransferases, play crucial roles in the regulation of many biological processes, including development, cancer and multiple physiopathological conditions.The Su(Var)3–9, Enhancer-of-zeste and Trithorax (SET) and Myeloid, Nervy, and DEAF-1 (MYND) domain-containing (SMYD) protein family consists of five members in humans and mice (i.e. SMYD1, SMYD2, SMYD3, SMYD4 and SMYD5), which are known or predicted to have methyltransferase activity on histone and non-histone substrates. The abundance of information concerning SMYD2 and SMYD3 is of note, whereas the other members of the SMYD family have not been so thoroughly studiedHere we review the literature regarding SMYD proteins published in the last five years, including basic molecular biology mechanistic studies using in vitro systems and animal models, as well as human studies with a more translational or clinical approach.
    Keywords biophysics ; epigenetics ; histones ; humans ; methyltransferases ; molecular biology
    Language English
    Dates of publication 2021-1115
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 523-x
    ISSN 1096-0384 ; 0003-9861
    ISSN (online) 1096-0384
    ISSN 0003-9861
    DOI 10.1016/j.abb.2021.109040
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    In stock of ZB MED Bonn / Germany

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