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Article: The Interplay between Microbiota and Chemotherapy-Derived Metabolites in Breast Cancer.

Plaza-Diaz, Julio / Álvarez-Mercado, Ana Isabel

2023 Volume 13, Issue 6

Abstract: The most common cancer in women is breast cancer, which is also the second leading cause of death in this group. It is, however, important to note that some women will develop or will not develop breast cancer regardless of whether certain known risk ... ...

Abstract	The most common cancer in women is breast cancer, which is also the second leading cause of death in this group. It is, however, important to note that some women will develop or will not develop breast cancer regardless of whether certain known risk factors are present. On the other hand, certain compounds are produced by bacteria in the gut, such as short-chain fatty acids, secondary bile acids, and other metabolites that may be linked to breast cancer development and mediate the chemotherapy response. Modeling the microbiota through dietary intervention and identifying metabolites directly associated with breast cancer and its complications may be useful to identify actionable targets and improve the effect of antiangiogenic therapies. Metabolomics is therefore a complementary approach to metagenomics for this purpose. As a result of the combination of both techniques, a better understanding of molecular biology and oncogenesis can be obtained. This article reviews recent literature about the influence of bacterial metabolites and chemotherapy metabolites in breast cancer patients, as well as the influence of diet.
Language	English
Publishing date	2023-05-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662251-8
ISSN	2218-1989
ISSN	2218-1989
DOI	10.3390/metabo13060703
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Gut Microbiota and Breast Cancer: The Dual Role of Microbes.

Álvarez-Mercado, Ana Isabel / Del Valle Cano, Ana / Fernández, Mariana F / Fontana, Luis

Cancers

2023 Volume 15, Issue 2

Abstract: Breast cancer is the most frequently diagnosed cancer and also one of the leading causes of mortality among women. The genetic and environmental factors known to date do not fully explain the risk of developing this disease. In recent years, numerous ... ...

Abstract	Breast cancer is the most frequently diagnosed cancer and also one of the leading causes of mortality among women. The genetic and environmental factors known to date do not fully explain the risk of developing this disease. In recent years, numerous studies have highlighted the dual role of the gut microbiota in the preservation of host health and in the development of different pathologies, cancer among them. Our gut microbiota is capable of producing metabolites that protect host homeostasis but can also produce molecules with deleterious effects, which, in turn, may trigger inflammation and carcinogenesis, and even affect immunotherapy. The purpose of this review is to describe the mechanisms by which the gut microbiota may cause cancer in general, and breast cancer in particular, and to compile clinical trials that address alterations or changes in the microbiota of women with breast cancer.
Language	English
Publishing date	2023-01-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15020443
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Differential Modulation of Mouse Intestinal Organoids with Fecal Luminal Factors from Obese, Allergic, Asthmatic Children.

Córdova, Samir / Tena-Garitaonaindia, Mireia / Álvarez-Mercado, Ana Isabel / Gámez-Belmonte, Reyes / Gómez-Llorente, Mª Amelia / Sánchez de Medina, Fermín / Martínez-Cañavate, Ana / Martínez-Augustin, Olga / Gómez-Llorente, Carolina

International journal of molecular sciences

2024 Volume 25, Issue 2

Abstract: Asthma is a multifactorial condition that can be associated with obesity. The phenotypes of asthma in lean and obese patients are different, with proinflammatory signatures being further elevated in the latter. Both obesity and asthma are associated with ...

Abstract	Asthma is a multifactorial condition that can be associated with obesity. The phenotypes of asthma in lean and obese patients are different, with proinflammatory signatures being further elevated in the latter. Both obesity and asthma are associated with alterations in intestinal barrier function and immunity, and with the composition of the intestinal microbiota and food consumption. In this study, we aimed to establish an organoid model to test the hypothesis that the intestinal content of lean and obese, allergic, asthmatic children differentially regulates epithelial intestinal gene expression. A model of mouse jejunum intestinal organoids was used. A group of healthy, normal-weight children was used as a control. The intestinal content of asthmatic obese children differentially induced the expression of inflammatory and mitochondrial response genes (
MeSH term(s)	Child ; Animals ; Mice ; Humans ; Pediatric Obesity ; Asthma ; Feces ; Claudin-1 ; Cytochromes b ; NF-kappa B
Chemical Substances	Claudin-1 ; Cytochromes b (9035-37-4) ; NF-kappa B
Language	English
Publishing date	2024-01-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25020866
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Current Knowledge about the Effect of Nutritional Status, Supplemented Nutrition Diet, and Gut Microbiota on Hepatic Ischemia-Reperfusion and Regeneration in Liver Surgery.

Cornide-Petronio, María Eugenia / Álvarez-Mercado, Ana Isabel / Jiménez-Castro, Mónica B / Peralta, Carmen

Nutrients

2020 Volume 12, Issue 2

Abstract: Ischemia-reperfusion (I/R) injury is an unresolved problem in liver resection and transplantation. The preexisting nutritional status related to the gut microbial profile might contribute to primary non-function after surgery. Clinical studies evaluating ...

Abstract	Ischemia-reperfusion (I/R) injury is an unresolved problem in liver resection and transplantation. The preexisting nutritional status related to the gut microbial profile might contribute to primary non-function after surgery. Clinical studies evaluating artificial nutrition in liver resection are limited. The optimal nutritional regimen to support regeneration has not yet been exactly defined. However, overnutrition and specific diet factors are crucial for the nonalcoholic or nonalcoholic steatohepatitis liver diseases. Gut-derived microbial products and the activation of innate immunity system and inflammatory response, leading to exacerbation of I/R injury or impaired regeneration after resection. This review summarizes the role of starvation, supplemented nutrition diet, nutritional status, and alterations in microbiota on hepatic I/R and regeneration. We discuss the most updated effects of nutritional interventions, their ability to alter microbiota, some of the controversies, and the suitability of these interventions as potential therapeutic strategies in hepatic resection and transplantation, overall highlighting the relevance of considering the extended criteria liver grafts in the translational liver surgery.
MeSH term(s)	Diet/methods ; Dietary Supplements ; Gastrointestinal Microbiome ; Hepatectomy/adverse effects ; Humans ; Liver/blood supply ; Liver/physiology ; Liver/surgery ; Liver Regeneration/physiology ; Nutritional Status ; Reperfusion Injury/etiology ; Reperfusion Injury/microbiology ; Reperfusion Injury/prevention & control
Language	English
Publishing date	2020-01-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu12020284
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Current Knowledge about the Effect of Nutritional Status, Supplemented Nutrition Diet, and Gut Microbiota on Hepatic Ischemia-Reperfusion and Regeneration in Liver Surgery

Cornide-Petronio, María Eugenia / Álvarez-Mercado, Ana Isabel / Jiménez-Castro, Mónica B / Peralta, Carmen

Nutrients. 2020 Jan. 21, v. 12, no. 2

2020

Abstract	Ischemia-reperfusion (I/R) injury is an unresolved problem in liver resection and transplantation. The preexisting nutritional status related to the gut microbial profile might contribute to primary non-function after surgery. Clinical studies evaluating artificial nutrition in liver resection are limited. The optimal nutritional regimen to support regeneration has not yet been exactly defined. However, overnutrition and specific diet factors are crucial for the nonalcoholic or nonalcoholic steatohepatitis liver diseases. Gut-derived microbial products and the activation of innate immunity system and inflammatory response, leading to exacerbation of I/R injury or impaired regeneration after resection. This review summarizes the role of starvation, supplemented nutrition diet, nutritional status, and alterations in microbiota on hepatic I/R and regeneration. We discuss the most updated effects of nutritional interventions, their ability to alter microbiota, some of the controversies, and the suitability of these interventions as potential therapeutic strategies in hepatic resection and transplantation, overall highlighting the relevance of considering the extended criteria liver grafts in the translational liver surgery.
Keywords	clinical trials ; diet ; fatty liver ; inflammation ; innate immunity ; intestinal microorganisms ; knowledge ; liver ; nutrients ; nutritional intervention ; optimal nutrition ; resection ; starvation
Language	English
Dates of publication	2020-0121
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-light
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu12020284
Database	NAL-Catalogue (AGRICOLA)

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Article: New Insights Into the Role of Autophagy in Liver Surgery in the Setting of Metabolic Syndrome and Related Diseases.

Álvarez-Mercado, Ana Isabel / Rojano-Alfonso, Carlos / Micó-Carnero, Marc / Caballeria-Casals, Albert / Peralta, Carmen / Casillas-Ramírez, Araní

Frontiers in cell and developmental biology

2021 Volume 9, Page(s) 670273

Abstract: Visceral obesity is an important component of metabolic syndrome, a cluster of diseases that also includes diabetes and insulin resistance. A combination of these metabolic disorders damages liver function, which manifests as non-alcoholic fatty liver ... ...

Abstract	Visceral obesity is an important component of metabolic syndrome, a cluster of diseases that also includes diabetes and insulin resistance. A combination of these metabolic disorders damages liver function, which manifests as non-alcoholic fatty liver disease (NAFLD). NAFLD is a common cause of abnormal liver function, and numerous studies have established the enormously deleterious role of hepatic steatosis in ischemia-reperfusion (I/R) injury that inevitably occurs in both liver resection and transplantation. Thus, steatotic livers exhibit a higher frequency of post-surgical complications after hepatectomy, and using liver grafts from donors with NAFLD is associated with an increased risk of post-surgical morbidity and mortality in the recipient. Diabetes, another MetS-related metabolic disorder, also worsens hepatic I/R injury, and similar to NAFLD, diabetes is associated with a poor prognosis after liver surgery. Due to the large increase in the prevalence of MetS, NAFLD, and diabetes, their association is frequent in the population and therefore, in patients requiring liver resection and in potential liver graft donors. This scenario requires advancement in therapies to improve postoperative results in patients suffering from metabolic diseases and undergoing liver surgery; and in this sense, the bases for designing therapeutic strategies are in-depth knowledge about the molecular signaling pathways underlying the effects of MetS-related diseases and I/R injury on liver tissue. A common denominator in all these diseases is autophagy. In fact, in the context of obesity, autophagy is profoundly diminished in hepatocytes and alters mitochondrial functions in the liver. In insulin resistance conditions, there is a suppression of autophagy in the liver, which is associated with the accumulation of lipids, being this is a risk factor for NAFLD. Also, oxidative stress occurring in hepatic I/R injury promotes autophagy. The present review aims to shed some light on the role of autophagy in livers undergoing surgery and also suffering from metabolic diseases, which may lead to the discovery of effective therapeutic targets that could be translated from laboratory to clinical practice, to improve postoperative results of liver surgeries when performed in the presence of one or more metabolic diseases.
Language	English
Publishing date	2021-06-01
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2021.670273
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Impact of Exercise on Gut Microbiota in Obesity.

Aragón-Vela, Jerónimo / Solis-Urra, Patricio / Ruiz-Ojeda, Francisco Javier / Álvarez-Mercado, Ana Isabel / Olivares-Arancibia, Jorge / Plaza-Diaz, Julio

Nutrients

2021 Volume 13, Issue 11

Abstract: Physical activity, exercise, or physical fitness are being studied as helpful nonpharmacological therapies to reduce signaling pathways related to inflammation. Studies describing changes in intestinal microbiota have stated that physical activity could ... ...

Abstract	Physical activity, exercise, or physical fitness are being studied as helpful nonpharmacological therapies to reduce signaling pathways related to inflammation. Studies describing changes in intestinal microbiota have stated that physical activity could increase the microbial variance and enhance the ratio of Firmicutes/Bacteroidetes, and both actions could neutralize the obesity progression and diminish body weight. The aim of this review is to provide an overview of the literature describing the relationship between physical activity profiles and gut microbiota and in obesity and some associated comorbidities. Promoting physical activity could support as a treatment to maintain the gut microbiota composition or to restore the balance toward an improvement of dysbiosis in obesity; however, these mechanisms need to be studied in more detail. The opportunity to control the microbiota by physical activity to improve health results and decrease obesity and related comorbidities is very attractive. Nevertheless, several incompletely answered questions need to be addressed before this strategy can be implemented.
MeSH term(s)	Bacteroidetes ; Body Weight ; Dysbiosis ; Exercise ; Firmicutes ; Gastrointestinal Microbiome ; Humans ; Inflammation ; Noncommunicable Diseases ; Obesity/metabolism
Language	English
Publishing date	2021-11-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13113999
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Impact of Exercise on Gut Microbiota in Obesity

Aragón-Vela, Jerónimo / Solis-Urra, Patricio / Ruiz-Ojeda, Francisco Javier / Álvarez-Mercado, Ana Isabel / Olivares-Arancibia, Jorge / Plaza-Diaz, Julio

Nutrients. 2021 Nov. 10, v. 13, no. 11

2021

Abstract	Physical activity, exercise, or physical fitness are being studied as helpful nonpharmacological therapies to reduce signaling pathways related to inflammation. Studies describing changes in intestinal microbiota have stated that physical activity could increase the microbial variance and enhance the ratio of Firmicutes/Bacteroidetes, and both actions could neutralize the obesity progression and diminish body weight. The aim of this review is to provide an overview of the literature describing the relationship between physical activity profiles and gut microbiota and in obesity and some associated comorbidities. Promoting physical activity could support as a treatment to maintain the gut microbiota composition or to restore the balance toward an improvement of dysbiosis in obesity; however, these mechanisms need to be studied in more detail. The opportunity to control the microbiota by physical activity to improve health results and decrease obesity and related comorbidities is very attractive. Nevertheless, several incompletely answered questions need to be addressed before this strategy can be implemented.
Keywords	Bacteroidetes ; Firmicutes ; dysbiosis ; exercise ; inflammation ; intestinal microorganisms ; obesity ; physical fitness ; variance
Language	English
Dates of publication	2021-1110
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13113999
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Effects of Gut Metabolites and Microbiota in Healthy and Marginal Livers Submitted to Surgery.

Micó-Carnero, Marc / Rojano-Alfonso, Carlos / Álvarez-Mercado, Ana Isabel / Gracia-Sancho, Jordi / Casillas-Ramírez, Araní / Peralta, Carmen

International journal of molecular sciences

2020 Volume 22, Issue 1

Abstract: Microbiota is defined as the collection of microorganisms within the gastrointestinal ecosystem. These microbes are strongly implicated in the stimulation of immune responses. An unbalanced microbiota, termed dysbiosis, is related to the development of ... ...

Abstract	Microbiota is defined as the collection of microorganisms within the gastrointestinal ecosystem. These microbes are strongly implicated in the stimulation of immune responses. An unbalanced microbiota, termed dysbiosis, is related to the development of several liver diseases. The bidirectional relationship between the gut, its microbiota and the liver is referred to as the gut-liver axis. The translocation of bacterial products from the intestine to the liver induces inflammation in different cell types such as Kupffer cells, and a fibrotic response in hepatic stellate cells, resulting in deleterious effects on hepatocytes. Moreover, ischemia-reperfusion injury, a consequence of liver surgery, alters the microbiota profile, affecting inflammation, the immune response and even liver regeneration. Microbiota also seems to play an important role in post-operative outcomes (i.e., liver transplantation or liver resection). Nonetheless, studies to determine changes in the gut microbial populations produced during and after surgery, and affecting liver function and regeneration are scarce. In the present review we analyze and discuss the preclinical and clinical studies reported in the literature focused on the evaluation of alterations in microbiota and its products as well as their effects on post-operative outcomes in hepatic surgery.
MeSH term(s)	Animals ; Dysbiosis/metabolism ; Dysbiosis/microbiology ; Dysbiosis/physiopathology ; Gastrointestinal Microbiome/physiology ; Gastrointestinal Tract/metabolism ; Gastrointestinal Tract/microbiology ; Hepatectomy/methods ; Humans ; Liver/physiology ; Liver Diseases/physiopathology ; Liver Diseases/surgery ; Liver Transplantation/methods ; Reperfusion Injury/metabolism ; Reperfusion Injury/microbiology ; Reperfusion Injury/physiopathology
Language	English
Publishing date	2020-12-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22010044
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Role of Adipokines in Surgical Procedures Requiring Both Liver Regeneration and Vascular Occlusion.

Álvarez-Mercado, Ana Isabel / Bujaldon, Esther / Gracia-Sancho, Jordi / Peralta, Carmen

International journal of molecular sciences

2018 Volume 19, Issue 11

Abstract: Liver regeneration is a perfectly calibrated mechanism crucial to increase mass recovery of small size grafts from living donor liver transplantation, as well as in other surgical procedures including hepatic resections and liver transplantation from ... ...

Abstract	Liver regeneration is a perfectly calibrated mechanism crucial to increase mass recovery of small size grafts from living donor liver transplantation, as well as in other surgical procedures including hepatic resections and liver transplantation from cadaveric donors. Regeneration involves multiple events and pathways in which several adipokines contribute to their orchestration and drive hepatocytes to proliferate. In addition, ischemia-reperfusion injury is a critical factor in hepatic resection and liver transplantation associated with liver failure or graft dysfunction post-surgery. This review aims to summarize the existing knowledge in the role of adipokines in surgical procedures requiring both liver regeneration and vascular occlusion, which increases ischemia-reperfusion injury and regenerative failure. We expose and discuss results in small-for-size liver transplantation and hepatic resections from animal studies focused on the modulation of the main adipokines associated with liver diseases and/or regeneration published in the last five years and analyze future perspectives and their applicability as potential targets to decrease ischemia-reperfusion injury and improve regeneration highlighting marginal states such as steatosis. In our view, adipokines means a promising approach to translate to the bedside to improve the recovery of patients subjected to partial hepatectomy and to increase the availability of organs for transplantation.
MeSH term(s)	Adipokines/metabolism ; Arterial Occlusive Diseases/metabolism ; Arterial Occlusive Diseases/pathology ; Hepatectomy ; Humans ; Liver/metabolism ; Liver/pathology ; Liver Regeneration ; Liver Transplantation ; Reperfusion Injury/metabolism ; Reperfusion Injury/pathology
Chemical Substances	Adipokines
Language	English
Publishing date	2018-10-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms19113395
Database	MEDical Literature Analysis and Retrieval System OnLINE

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