Article ; Online: ARID5B, CEBPE and PIP4K2A Germline Genetic Polymorphisms and Risk of Childhood Acute Lymphoblastic Leukemia in Mexican Patients: A MIGICCL Study.
2017 Volume 47, Issue 8, Page(s) 623–628
Abstract: Background and aims: Childhood acute lymphoblastic leukemia (ALL) is the leading cause of childhood cancer-related deaths worldwide. Multiples studies have shown that ALL seems to be originated by an interaction between environmental and genetic ... ...
| Abstract | Background and aims: Childhood acute lymphoblastic leukemia (ALL) is the leading cause of childhood cancer-related deaths worldwide. Multiples studies have shown that ALL seems to be originated by an interaction between environmental and genetic susceptibility factors. The ARID5B polymorphisms are among the most reproducible ALL associated-risk alleles in different populations. The aim of the present study was to examine the contribution of ARID5B, CEBPE, and PIP4K2 risk alleles for the development of ALL in children from Mexico City and Yucatan, Mexico. Methods: A study was conducted with a total of 761 unrelated subjects. Two hundred eighty five ALL cases (111 from Yucatan and 174 from Mexico City) and 476 healthy subjects. Genotyping included the rs7088318 (PIP4K2A), rs10821936 (ARID5B), rs7089424 (ARID5B) and rs2239633 (CEBPE) polymorphisms. Results: Associations between ALL and rs10821936 and rs7089424 ARID5B SNPs were found (OR = 1.9, 95% CI (1.5-2.4) and OR = 2.0, 95% CI (1.6-2.5), respectively). Moreover, a higher risk was observed in the homozygous risk genotypes of carriers from Mexico City (OR = 3.1, 95% CI (2.0-4.9) and OR 3.1, CI 95% (2.0-4.8), respectively). Otherwise, the rs7088318 (PIP4K2A) and rs2239633 (CEBPE) polymorphisms were not associated with ALL risk. Conclusions: Our analysis suggests that ARID5B confers risk for childhood ALL in a Mexican population. |
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| MeSH term(s) | Adolescent ; Alleles ; CCAAT-Enhancer-Binding Proteins/genetics ; Case-Control Studies ; Child ; Child, Preschool ; DNA-Binding Proteins/genetics ; Female ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genotype ; Heterozygote ; Humans ; Infant ; Male ; Mexico ; Phosphotransferases (Alcohol Group Acceptor)/genetics ; Polymorphism, Single Nucleotide ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Risk ; Transcription Factors/genetics |
| Chemical Substances | ARID5B protein, human ; CCAAT-Enhancer-Binding Proteins ; DNA-Binding Proteins ; Transcription Factors ; CEBPE protein, human (142805-41-2) ; PIP4K2A protein, human (EC 2.7.1.-) ; Phosphotransferases (Alcohol Group Acceptor) (EC 2.7.1.-) |
| Language | English |
| Publishing date | 2017-05-04 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 1156844-6 |
| ISSN | 1873-5487 ; 0188-4409 ; 0188-0128 |
| ISSN (online) | 1873-5487 |
| ISSN | 0188-4409 ; 0188-0128 |
| DOI | 10.1016/j.arcmed.2016.12.003 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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