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Article ; Online: Anti-IL-5 and anti-IL-5R biologics for severe asthma. Are there any differences in their effects?

Granda, Paula / Villamañán, Elena / Carpio, Carlos / Laorden, Daniel / Quirce, Santiago / Álvarez-Sala, Rodolfo

The Journal of asthma : official journal of the Association for the Care of Asthma

2024 , Page(s) 1–10

Abstract: Objective: The aim of this retrospective multicentre study is to describe the clinical characteristics of patients diagnosed with severe eosinophilic asthma receiving anti-IL-5/anti-IL-5Rα therapies and to compare their effectiveness.: Methods: We ... ...

Abstract	Objective: The aim of this retrospective multicentre study is to describe the clinical characteristics of patients diagnosed with severe eosinophilic asthma receiving anti-IL-5/anti-IL-5Rα therapies and to compare their effectiveness. Methods: We collected and analysed results separately for anti-IL-5 and anti-IL-5Rα therapies from January 2016 until December 2021 in multidisciplinary severe asthma units. We collected demographic and clinical data, treatment with previous anti-IgE and/or anti-IL-5 agents, and comorbidities. We compared the number of exacerbations and admissions to the hospital, daily oral corticosteroid intake, pulmonary function tests, and Asthma Control Test scores before and after 12 months of therapy. 261 patients were included: 176 patients in the anti-IL-5 group and 85 in the anti-IL-5Rα group. Results: Both groups led to statistically significant reductions in asthma exacerbations, hospital admissions, and visits to the Emergency Room. Although both groups showed a significant reduction in blood eosinophiliccount, we found a difference, although not significant, in the magnitude of reduction as benralizumab was able to decrease eosinophil counts to zero. Patients in the anti-IL-5 group achieved higher ACT scores after treatment, although this improvement was seen in both treatment groups. Conclusion: The anti-IL-5 and anti-IL-5Rα biologics have shown similar effectiveness despite having different mechanisms of action. The anti-IL-5 group appeared to be better than benralizumab at improving ACT scores and FEV1/FVC and at reducing the number of inhalers. Although these differences were not statistically significant, it is not clear whether they may have clinical relevance and they might highlight the need for further head-to-head studies comparing these treatments.
Language	English
Publishing date	2024-01-24
Publishing country	England
Document type	Journal Article
ZDB-ID	603816-5
ISSN	1532-4303 ; 0277-0903
ISSN (online)	1532-4303
ISSN	0277-0903
DOI	10.1080/02770903.2024.2308684
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Article ; Online: Successful Long-Term Treatment Combining Omalizumab and Anti-IL-5 Biologics in Allergic Bronchopulmonary Aspergillosis.

Laorden, Daniel / Zamarrón, Ester / Domínguez-Ortega, Javier / Romero, David / Quirce, Santiago / Álvarez-Sala, Rodolfo

Archivos de bronconeumologia

2022 Volume 58, Issue 8, Page(s) 624–626

MeSH term(s)	Aspergillosis, Allergic Bronchopulmonary/drug therapy ; Aspergillus fumigatus ; Biological Products/therapeutic use ; Humans ; Immunoglobulin E ; Omalizumab/therapeutic use
Chemical Substances	Biological Products ; Omalizumab (2P471X1Z11) ; Immunoglobulin E (37341-29-0)
Language	Spanish
Publishing date	2022-01-07
Publishing country	Spain
Document type	Case Reports
ZDB-ID	733126-5
ISSN	1579-2129 ; 0300-2896
ISSN (online)	1579-2129
ISSN	0300-2896
DOI	10.1016/j.arbres.2021.12.005
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Article ; Online: Impact of systemic corticosteroids on length of hospitalization among patients with COVID-19.

Zamarrón, Ester / Carpio, Carlos / Villamañán, Elena / Álvarez-Sala, Rodolfo / Borobia, Alberto M / Gómez-Carrera, Luis / Buño, Antonio / Prados, M Concepción

Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria

2023 Volume 47, Issue 2, Page(s) T55–T63

Abstract: Objective: The COVID-19 pandemic has posed a threat to hospital capacity due to the high number of admissions, which has led to the development of various strategies to release and create new hospital beds. Due to the importance of systemic ... ...

Title translation	[Artículo traducido] Impacto de los corticoides sistémicos en el tiempo de hospitalización en pacientes con COVID-19.
Abstract	Objective: The COVID-19 pandemic has posed a threat to hospital capacity due to the high number of admissions, which has led to the development of various strategies to release and create new hospital beds. Due to the importance of systemic corticosteroids in this disease, we assessed their efficacy in reducing the length of stay (LOS) in hospitals and compared the effect of 3 different corticosteroids on this outcome. MéTHOD: We conducted a real-world, controlled, retrospective cohort study that analysed data from a hospital database that included 3934 hospitalised patients diagnosed with COVID-19 in a tertiary hospital from April to May 2020. Hospitalised patients who received systemic corticosteroids (CG) were compared with a propensity score control group matched by age, sex and severity of disease who did not receive systemic corticosteroids (NCG). The decision to prescribe CG was at the discretion of the primary medical team. Results: A total of 199 hospitalized patients in the CG were compared with 199 in the NCG. The LOS was shorter for the CG than for the NCG (median=3 [interquartile range=0-10] vs. 5 [2-8.5]; p=0.005, respectively), showing a 43% greater probability of being hospitalised ≤4 days than >4 days when corticosteroids were used. Moreover, this difference was only noticed in those treated with dexamethasone (76.3% hospitalised ≤4 days vs. 23.7% hospitalised >4 days [p<0.001]). Serum ferritin levels, white blood cells and platelet counts were higher in the CG. No differences in mortality or intensive care unit admission were observed. Conclusions: Treatment with systemic corticosteroids is associated with reduced LOS in hospitalised patients diagnosed with COVID-19. This association is significant in those treated with dexamethasone, but no for methylprednisolone and prednisone.
MeSH term(s)	Humans ; COVID-19 ; Retrospective Studies ; Pandemics ; SARS-CoV-2 ; Adrenal Cortex Hormones/therapeutic use ; Hospitalization ; Dexamethasone/therapeutic use
Chemical Substances	Adrenal Cortex Hormones ; Dexamethasone (7S5I7G3JQL)
Language	Spanish
Publishing date	2023-02-07
Publishing country	Spain
Document type	Journal Article
ZDB-ID	1122680-8
ISSN	2171-8695 ; 1130-6343
ISSN (online)	2171-8695
ISSN	1130-6343
DOI	10.1016/j.farma.2023.02.001
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Article ; Online: Influenza vaccination mitigates severe complications in hospitalized patients: A ten-year observational study, Spain, 2009-2019.

Mangas-Moro, Alberto / Zamarrón, Ester / Carpio, Carlos / Álvarez-Sala, Rodolfo / Arribas-López, José R / Prados, Concepción

American journal of infection control

2023 Volume 52, Issue 5, Page(s) 563–569

Abstract: Background: Influenza epidemics annually impact a substantial portion of adults worldwide, leading to numerous hospitalizations and fatalities. While the primary goal of vaccination is to prevent influenza virus infection, breakthrough infections can ... ...

Abstract	Background: Influenza epidemics annually impact a substantial portion of adults worldwide, leading to numerous hospitalizations and fatalities. While the primary goal of vaccination is to prevent influenza virus infection, breakthrough infections can still occur despite vaccination. Evaluating the vaccine effectiveness in preventing severe cases among hospitalized patients is crucial for enhancing vaccination strategies. Methods: This single-center, observational, cross-sectional, and retrospective study analyzed data from 1,357 patients admitted to La Paz University Hospital for influenza infection between 2009 and 2019. Patients' demographics, clinical variables, comorbidities, vaccination status, and influenza-related outcomes were assessed. Logistic regression analysis was performed to determine the vaccine-independent protective effects. Results: Influenza vaccination independently prevented severe complications, including pneumonia, bacterial superinfection, acute respiratory distress syndrome, and multiple organ failure in hospitalized patients (odds ratio = 0.61, 95% confidence interval: 0.47-0.76). Vaccinated patients had significantly lower intensive care unit admission rates (odds ratio = 0.42, 95% confidence interval: 0.18-0.92). However, there were no significant differences in mortality rates between vaccinated and unvaccinated patients (P = .385). Conclusions: Our study provides robust evidence supporting the influenza vaccine protective effect against severe outcomes in hospitalized patients during epidemic flu. Vaccination is associated with a significant reduction in severe complications and intensive care unit admissions, emphasizing its importance as a preventive measure. Improving vaccination coverage, especially in specific comorbidities and age groups, could further enhance the vaccine effectiveness in preventing severe influenza cases.
Language	English
Publishing date	2023-11-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	392362-9
ISSN	1527-3296 ; 0196-6553
ISSN (online)	1527-3296
ISSN	0196-6553
DOI	10.1016/j.ajic.2023.11.009
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Article ; Online: Evaluation of FEOS score and super-responder criteria in a real-life cohort treated with anti-IL5/IL5R.

Laorden, Daniel / Zamarrón, Ester / Romero, David / Domínguez-Ortega, Javier / Villamañán, Elena / Losantos, Itsaso / Gayá, Francisco / Quirce, Santiago / Álvarez-Sala, Rodolfo

Respiratory medicine

2023 Volume 211, Page(s) 107216

MeSH term(s)	Humans ; Anti-Asthmatic Agents/therapeutic use ; Asthma/drug therapy
Chemical Substances	Anti-Asthmatic Agents
Language	English
Publishing date	2023-03-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1003348-8
ISSN	1532-3064 ; 0954-6111
ISSN (online)	1532-3064
ISSN	0954-6111
DOI	10.1016/j.rmed.2023.107216
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Article ; Online: Impact of systemic corticosteroids on hospital length of stay among patients with COVID-19.

Zamarrón, Ester / Carpio, Carlos / Villamañán, Elena / Álvarez-Sala, Rodolfo / Borobia, Alberto M / Gómez-Carrera, Luis / Buño, Antonio / Prados, Concepción

Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria

2022 Volume 47, Issue 2, Page(s) 55–63

Abstract: Background and objective: The COVID-19 pandemic has posed a threat to hospital capacity due to the high number of admissions, which has led to the development of various strategies to release and create new hospital beds. Due to the importance of ... ...

Abstract	Background and objective: The COVID-19 pandemic has posed a threat to hospital capacity due to the high number of admissions, which has led to the development of various strategies to release and create new hospital beds. Due to the importance of systemic corticosteroids in this disease, we assessed their efficacy in reducing the length of stay (LOS) in hospitals and compared the effect of 3 different corticosteroids on this outcome. Methods: We conducted a real-world, controlled, retrospective cohort study that analysed data from a hospital database that included 3934 hospitalised patients diagnosed with COVID-19 in a tertiary hospital from April to May 2020. Hospitalised patients who received systemic corticosteroids (CG) were compared with a propensity score control group matched by age, sex and severity of disease who did not receive systemic corticosteroids (NCG). The decision to prescribe CG was at the discretion of the primary medical team. Results: A total of 199 hospitalized patients in the CG were compared with 199 in the NCG. The LOS was shorter for the CG than for the NCG (median = 3 [interquartile range = 0-10] vs. 5 [2-8.5]; p = 0.005, respectively), showing a 43% greater probability of being hospitalised ≤ 4 days than > 4 days when corticosteroids were used. Moreover, this difference was only noticed in those treated with dexamethasone (76.3% hospitalised ≤ 4 days vs. 23.7% hospitalised > 4 days [p < 0.001]). Serum ferritin levels, white blood cells and platelet counts were higher in the CG. No differences in mortality or intensive care unit admission were observed. Conclusions: Treatment with systemic corticosteroids is associated with reduced LOS in hospitalised patients diagnosed with COVID-19. This association is significant in those treated with dexamethasone, but no for methylprednisolone and prednisone.
MeSH term(s)	Humans ; COVID-19 ; Length of Stay ; Retrospective Studies ; Pandemics ; SARS-CoV-2 ; Adrenal Cortex Hormones/therapeutic use ; Hospitals ; Dexamethasone/therapeutic use
Chemical Substances	Adrenal Cortex Hormones ; Dexamethasone (7S5I7G3JQL)
Language	Spanish
Publishing date	2022-12-14
Publishing country	Spain
Document type	Journal Article
ZDB-ID	1122680-8
ISSN	2171-8695 ; 1130-6343
ISSN (online)	2171-8695
ISSN	1130-6343
DOI	10.1016/j.farma.2022.11.003
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Article ; Online: Adherence to inhalers in patients with severe asthma treated with anti-interleukin-5 biologics.

Granda, Paula / Villamañán, Elena / Carpio, Carlos / Laorden, Daniel / Sobrino, Carmen / Herrero, Alicia / Quirce, Santiago / Álvarez-Sala, Rodolfo

Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria

2022 Volume 46, Issue 4, Page(s) 203–207

Abstract: Objective: Given poor medication adherence in severe asthma is difficult to evaluate in daily practice, using at least two methods concurrently is recommended. We aimed to determine the prevalence of nonadherence to inhalers using the Test of ... ...

Title translation	Adherencia a los inhaladores en pacientes con asma grave tratados con biológicos anti interleucina 5.
Abstract	Objective: Given poor medication adherence in severe asthma is difficult to evaluate in daily practice, using at least two methods concurrently is recommended. We aimed to determine the prevalence of nonadherence to inhalers using the Test of Adherence to Inhalers questionnaire and the medication possession ratio obtained from the pharmacy refill data in patients with severe asthma treated with anti-interleukin-5 biologics and to evaluate their concordance. Method: This was a cross-sectional retrospective observational study of 53 patients with severe asthma recruited from the severe asthma unit of a tertiary hospital in Madrid from June to December 2020. We registered demographic data, comorbidities and concomitant therapy for sthma. Nonadherence was defined as pharmacy refill data < 80% and/or Test of Adherence to Inhalers questionnaire results < 50. Concordance was assessed by determining the Cohen's kappa statistic. Results: The median age was 61 years (interquartile range 51.8-67.0), and 33 (61%) were women. According to the pharmacy refill data lack of adherence to the primary inhaler was 58.5%. However, when using the Test of Adherence to Inhalers questionnaire, it was 22.6%. Combining both methods, 17% of patients were considered to have nonadherence to inhalers. Likewise, when identifying nonadherence by either of these methods, it reached a prevalence of 64.2%. The pharmacy refill data and Test of Adherence to Inhalers questionnaire agreed in 53.1% and disagreed in 46.9% of patients (k = 0.137; 95% confidence interval -0.057 to 0.331; p = 0.318). Conclusions: We observed a higher prevalence of non-adherence to inhalers in patients with severe asthma treated with anti-interleukin-5 biologics. The agreement between the Test of Adherence to Inhalers questionnaire and the pharmacy refill data is lower when evaluating nonadherence in patients with severe asthma treated with anti-interleukin-5 biologics. The pharmacy refill data detect a higher proportion of nonadherence compared with the Test of Adherence to Inhalers questionnaire.
MeSH term(s)	Asthma/drug therapy ; Biological Products/therapeutic use ; Cross-Sectional Studies ; Female ; Humans ; Male ; Medication Adherence ; Middle Aged ; Nebulizers and Vaporizers
Chemical Substances	Biological Products
Language	English
Publishing date	2022-05-19
Publishing country	Spain
Document type	Journal Article ; Observational Study
ZDB-ID	1122680-8
ISSN	2171-8695 ; 1130-6343
ISSN (online)	2171-8695
ISSN	1130-6343
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Article ; Online: Long COVID outcomes in an asthmatic cohort and its implications for asthma control.

Laorden, Daniel / Domínguez-Ortega, Javier / Carpio, Carlos / Barranco, Pilar / Villamañán, Elena / Romero, David / Quirce, Santiago / Álvarez-Sala, Rodolfo

Respiratory medicine

2022 Volume 207, Page(s) 107092

MeSH term(s)	Humans ; Post-Acute COVID-19 Syndrome ; COVID-19 ; Asthma/complications ; Asthma/epidemiology ; Asthma/drug therapy ; Anti-Asthmatic Agents/therapeutic use ; Administration, Inhalation ; Adrenal Cortex Hormones/therapeutic use
Chemical Substances	Anti-Asthmatic Agents ; Adrenal Cortex Hormones
Language	English
Publishing date	2022-12-16
Publishing country	England
Document type	Journal Article
ZDB-ID	1003348-8
ISSN	1532-3064 ; 0954-6111
ISSN (online)	1532-3064
ISSN	0954-6111
DOI	10.1016/j.rmed.2022.107092
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Article ; Online: Air pollution exposure and its effects on idiopathic pulmonary fibrosis: clinical worsening, lung function decline, and radiological deterioration.

Mariscal-Aguilar, Pablo / Gómez-Carrera, Luis / Bonilla, Gema / Díaz-Almirón, Mariana / Gayá, Francisco / Carpio, Carlos / Zamarrón, Ester / Fernández-Velilla, María / Torres, Isabel / Esteban, Isabel / Regojo, Rita / Villamañán, Elena / Prados, Concepción / Álvarez-Sala, Rodolfo

Frontiers in public health

2024 Volume 11, Page(s) 1331134

Abstract: Introduction: Major urban pollutants have a considerable influence on the natural history of lung disease. However, this effect is not well known in idiopathic pulmonary fibrosis (IPF).: Aim: This study aimed to investigate the effects of air ... ...

Abstract	Introduction: Major urban pollutants have a considerable influence on the natural history of lung disease. However, this effect is not well known in idiopathic pulmonary fibrosis (IPF). Aim: This study aimed to investigate the effects of air pollution on clinical worsening, lung function, and radiological deterioration in patients with IPF. Methods: This exploratory retrospective cohort study included 69 patients with IPF, monitored from 2011 to 2020. Data on air pollution levels, including carbon monoxide (CO), nitrogen dioxide (NO Results: There was an association between higher O Conclusion: This study suggests that air pollution, specifically O
MeSH term(s)	Humans ; Nitrogen Dioxide/adverse effects ; Retrospective Studies ; Air Pollution/adverse effects ; Idiopathic Pulmonary Fibrosis ; Lung/diagnostic imaging
Chemical Substances	Nitrogen Dioxide (S7G510RUBH)
Language	English
Publishing date	2024-01-10
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.1331134
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Article ; Online: Psycho-demographic profile in severe asthma and effect of emotional mood disorders and hyperventilation syndrome on quality of life.

Dafauce, Lucía / Romero, David / Carpio, Carlos / Barga, Paula / Quirce, Santiago / Villasante, Carlos / Bravo, María Fe / Álvarez-Sala, Rodolfo

BMC psychology

2021 Volume 9, Issue 1, Page(s) 3

Abstract: Background: Severe asthma affects a small population but carries a high psychopathological risk. Therefore, the psychodemographic profile of these patients is of interest. A substantial prevalence of anxiety, depression, alexithymia and hyperventilation ...

Abstract	Background: Severe asthma affects a small population but carries a high psychopathological risk. Therefore, the psychodemographic profile of these patients is of interest. A substantial prevalence of anxiety, depression, alexithymia and hyperventilation syndrome in severe asthma is known, but contradictory results have been observed. These factors can also affect patients' quality of life. For this reasons, our purpose is to evaluate the psychodemographic profile of patients with severe asthma and assess the prevalence of anxiety, depression, alexithymia and hyperventilation syndrome and their impact on the quality of life of patients with severe asthma. Methods: A cross-sectional study of 63 patients with severe asthma. Their psychodemographic profile was evaluated using the Hospital Anxiety and Depression Scale (HADS), Toronto Alexithymia Scale (TAS-20), Nijmegen questionnaire and Asthma Control Test (ACT) to determine the state of anxiety and depression, alexithymia, hyperventilation syndrome and control of asthma, respectively. Quality of life was assessed with the Mini Asthma Quality of Life Questionnaire (Mini-AQLQ). Results: The mean age was 60 ± 13.6 years. Personal psychopathological histories were found in 65.1% of participants, and 8% reported previous suicidal attempts. The rate of anxiety and/or depression (HADS ≥ 11) was 68.3%. These patients present higher scores on the TAS-20 (p < 0.001) for the level of dyspnea (p = 0.021), and for emotional function (p = 0.017) on the Mini-AQLQ, compared with patients without anxiety or depression. Alexithymia (TAS-20 ≥ 61) was observed in 42.9% of patients; these patients were older (p = 0.037) and had a higher HADS score (p = 0.019) than patients with asthma without alexithymia. On the other hand, patients with hyperventilation syndrome (Nijmegen ≥ 23) scored higher on the HADS (p < 0.05), on the Mini-AQLQ (p = 0.002) and on the TAS-20 (p = 0.044) than the group without hyperventilation syndrome. Quality of life was related to anxiety-depression symptomatology (r = - 0.302; p = 0.016) and alexithymia (r = - 0.264; p = 0.036). Finally, the Mini-AQLQ total score was associated with the Nijmegen questionnaire total score (r = - 0.317; p = 0.011), and the activity limitation domain of the Mini-AQLQ correlated with the ACT total score (r = 0.288; p = 0.022). Conclusions: The rate of anxiety, depression, alexithymia and hyperventilation syndrome is high in patients with severe asthma. Each of these factors is associated with a poor quality of life.
MeSH term(s)	Adult ; Affective Symptoms/epidemiology ; Affective Symptoms/psychology ; Aged ; Anxiety/epidemiology ; Anxiety/psychology ; Asthma/epidemiology ; Asthma/psychology ; Cross-Sectional Studies ; Humans ; Hyperventilation/epidemiology ; Hyperventilation/psychology ; Middle Aged ; Mood Disorders/epidemiology ; Mood Disorders/psychology ; Quality of Life/psychology
Language	English
Publishing date	2021-01-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2705921-2
ISSN	2050-7283 ; 2050-7283
ISSN (online)	2050-7283
ISSN	2050-7283
DOI	10.1186/s40359-020-00498-y
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