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  1. Article ; Online: Worldwide antipsychotic drug search intensities: pharmacoepidemological estimations based on Google Trends data.

    Ågren, Richard

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 13136

    Abstract: Prescription patterns of antipsychotic drugs (APDs) are typically sourced from country-specific data. In this study, a digital pharmacoepidemiological approach was used to investigate APD preferences globally. Publicly available data on worldwide web ... ...

    Abstract Prescription patterns of antipsychotic drugs (APDs) are typically sourced from country-specific data. In this study, a digital pharmacoepidemiological approach was used to investigate APD preferences globally. Publicly available data on worldwide web search intensities in Google for 19 typical and 22 atypical APDs were temporally and spatially normalized and correlated with reported prescription data. The results demonstrated an increasing global preference for atypical over typical APDs since 2007, with quetiapine, olanzapine, risperidone, and aripiprazole showing the largest search intensities in 2020. Cross-sectional analysis of 122 countries in 2020 showed pronounced differences in atypical/typical APD preferences that correlated with gross domestic product per capita. In conclusion, the investigation provides temporal and spatial assessments of global APD preferences and shows a trend towards atypical APDs, although with a relative preference for typical APDs in low-income countries. Similar data-sourcing methodologies allow for prospective studies of other prescription drugs.
    MeSH term(s) Antipsychotic Agents/economics ; Antipsychotic Agents/therapeutic use ; Cross-Sectional Studies ; Drug Prescriptions/economics ; Drug Prescriptions/statistics & numerical data ; Drug Utilization/economics ; Drug Utilization/trends ; Global Health/economics ; Global Health/statistics & numerical data ; Humans ; Internet
    Chemical Substances Antipsychotic Agents
    Language English
    Publishing date 2021-06-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-92204-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Neuropathy with Cerebral Features Induced by Nitrous Oxide Abuse-A Case Report.

    Lindeman, Erik / Melin, Sara / Paucar, Martin / Ågren, Richard

    Toxics

    2023  Volume 11, Issue 12

    Abstract: Nitrous oxide abuse may cause functional cobalamin deficiency and subsequent damage to the peripheral nerves, the spinal cord, and the brain, a symptom complex best described by the term cobalamin neuropathy. Here, we report a case of cobalamin ... ...

    Abstract Nitrous oxide abuse may cause functional cobalamin deficiency and subsequent damage to the peripheral nerves, the spinal cord, and the brain, a symptom complex best described by the term cobalamin neuropathy. Here, we report a case of cobalamin neuropathy with uncommon cerebral symptomatology following nitrous oxide intoxication and contextualize the symptomatology. A 22-year-old male with a history of mixed drug dependency presented at the emergency room after inhaling six 615 g cylinders, equal to ~1800 L, of nitrous oxide daily for two weeks. His main complaints were rapidly progressing paresthesias and gait difficulties, but he was also found to suffer from memory impairment and signs of extrapyramidal pathology in the form of dystonic posturing and athetosis. Neuroimaging demonstrated spinal cord hyperintensities consistent with subacute combined degeneration. The patient had low serum cobalamin and high plasma homocysteine, suggesting cobalamin neuropathy. After commencing treatment with parenteral hydroxocobalamin, plasma homocysteine normalized. The extrapyramidal symptoms disappeared during the first days of treatment, whereas the cognitive and peripheral symptoms only partially resolved over the following 20 days. This case highlights how neurological symptoms such as hyperkinetic movements and memory impairment may be associated with chronic nitrous oxide abuse. It is unclear to what extent these and other symptoms of cobalamin neuropathy are reversible, which underscores the public health concern.
    Language English
    Publishing date 2023-11-25
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2733883-6
    ISSN 2305-6304 ; 2305-6304
    ISSN (online) 2305-6304
    ISSN 2305-6304
    DOI 10.3390/toxics11120959
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Evidence for Two Modes of Binding of the Negative Allosteric Modulator SB269,652 to the Dopamine D

    Ågren, Richard / Sahlholm, Kristoffer

    Biomedicines

    2021  Volume 10, Issue 1

    Abstract: SB269,652 has been described as the first negative allosteric modulator (NAM) of the dopamine ... ...

    Abstract SB269,652 has been described as the first negative allosteric modulator (NAM) of the dopamine D
    Language English
    Publishing date 2021-12-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10010022
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  4. Article ; Online: G protein-coupled receptor kinase-2 confers isoform-specific calcium sensitivity to dopamine D

    Ågren, Richard / Sahlholm, Kristoffer

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2021  Volume 35, Issue 11, Page(s) e22013

    Abstract: The dopamine ... ...

    Abstract The dopamine D
    MeSH term(s) Animals ; Calcium/metabolism ; Cells, Cultured ; Female ; G-Protein-Coupled Receptor Kinase 2/metabolism ; Oocytes/cytology ; Oocytes/metabolism ; Receptors, Dopamine D2/metabolism ; Xenopus laevis ; beta-Arrestin 2/metabolism
    Chemical Substances Receptors, Dopamine D2 ; beta-Arrestin 2 ; G-Protein-Coupled Receptor Kinase 2 (EC 2.7.11.16) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-10-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.202100704RR
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2266: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 296: Show issues

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  5. Article ; Online: Fluorescence-Based Measurements of Membrane-Bound Angiotensin Converting Enzyme 2 Activity Using Xenopus Laevis Oocytes.

    Fast, Luise / Ågren, Richard / Zeberg, Hugo

    Biosensors

    2022  Volume 12, Issue 8

    Abstract: Functional investigations of enzymes involving cellular expression systems are important for pharmacological studies. The precise control of expression is challenging in transiently transfected mammalian cell lines. Here, we explored the ability of ... ...

    Abstract Functional investigations of enzymes involving cellular expression systems are important for pharmacological studies. The precise control of expression is challenging in transiently transfected mammalian cell lines. Here, we explored the ability of Xenopus laevis oocytes to express a membrane-bound enzyme for functional characterization using standard 96-well plates and a fluorescence-based plate reader assay. We microinjected oocytes with cRNA encoding the angiotensin converting enzyme 2 (ACE2) and measured the enzymatic activity in single oocytes using a commercial fluorescence-based assay. The injected oocytes showed up to a 50-fold increase in fluorescence compared to uninjected oocytes. This fluorescence intensity was dose-dependent on the amount of
    MeSH term(s) Angiotensin-Converting Enzyme 2 ; Animals ; Fluorescence ; Mammals ; Oocytes/metabolism ; RNA, Complementary/metabolism ; Xenopus laevis
    Chemical Substances RNA, Complementary ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Language English
    Publishing date 2022-08-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662125-3
    ISSN 2079-6374 ; 2079-6374
    ISSN (online) 2079-6374
    ISSN 2079-6374
    DOI 10.3390/bios12080601
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Voltage-Dependent Dopamine Potency at D

    Ågren, Richard / Sahlholm, Kristoffer

    Frontiers in pharmacology

    2020  Volume 11, Page(s) 581151

    Abstract: In recent years, transmembrane voltage has been found to modify agonist potencies at several G protein-coupled receptors (GPCRs). Whereas the voltage sensitivities of the ... ...

    Abstract In recent years, transmembrane voltage has been found to modify agonist potencies at several G protein-coupled receptors (GPCRs). Whereas the voltage sensitivities of the Gα
    Language English
    Publishing date 2020-10-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2020.581151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Low-Resistance silver bromide electrodes for recording fast ion channel kinetics under voltage clamp conditions.

    Ågren, Richard / Zeberg, Hugo

    Journal of neuroscience methods

    2020  Volume 348, Page(s) 108984

    Abstract: Background: Two-electrode voltage clamp is a widely used technique for studying ionic currents. However, fast activation kinetics of ion channels are disguised by the capacitive transient during voltage clamp of Xenopus oocytes. The limiting factors of ... ...

    Abstract Background: Two-electrode voltage clamp is a widely used technique for studying ionic currents. However, fast activation kinetics of ion channels are disguised by the capacitive transient during voltage clamp of Xenopus oocytes. The limiting factors of clamp performance include, but are not limited to, amplifier gain, membrane capacitance, and micropipette resistance. Previous work has focused on increasing amplifier gain (e.g.; high performing two-electrode amplifiers) or reducing the membrane capacitance (e.g.; the cut-open technique).
    New method: The use of an Ag-AgBr electrode with saturated KBr solution to reduce micropipette resistance.
    Results: The conductivity of 4 M KBr was 37 % higher compared to 3 M KCl and the micropipette resistance was reduced by 19 % when 4 M KBr was used, compared to the standard 3 M KCl solution. Micropipette resistances correlated positively with capacitive transient durations. Neither the current-voltage relationship of the voltage-gated sodium channel, Nav1.7, nor Xenopus oocyte stability were affected by bromide ions.
    Comparison with existing methods: The de facto standard for two-electrode voltage clamp is 3 M KCl and Ag-AgCl electrodes, which are associated an unnecessarily high micropipette resistance. Elsewise, cut-open voltage clamp techniques are technically demanding and require manipulation of the intracellular environment.
    Conclusions: The use of an Ag-AgBr electrode with saturated KBr as micropipette solution reduces the capacitive transient in two-electrode voltage clamp recordings. Moreover, the exchange of chloride against bromide ions does not seem to affect oocyte physiology and ion channel kinetics.
    MeSH term(s) Bromides ; Electrodes ; Ion Channels ; Kinetics ; Oocytes ; Silver Compounds
    Chemical Substances Bromides ; Ion Channels ; Silver Compounds ; silver bromide (NHQ37BJZ2Z)
    Language English
    Publishing date 2020-10-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282721-9
    ISSN 1872-678X ; 0165-0270
    ISSN (online) 1872-678X
    ISSN 0165-0270
    DOI 10.1016/j.jneumeth.2020.108984
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1486: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Voxel-Based Morphometry of Cerebellar Lobules in Essential Tremor.

    Ågren, Richard / Awad, Amar / Blomstedt, Patric / Fytagoridis, Anders

    Frontiers in aging neuroscience

    2021  Volume 13, Page(s) 667854

    Abstract: Background: The extent of neurodegeneration underlying essential tremor (ET) remains a matter of debate. Despite various extents of cerebellar atrophy on structural magnetic resonance imaging (MRI), previous studies have shown substantial heterogeneity ... ...

    Abstract Background: The extent of neurodegeneration underlying essential tremor (ET) remains a matter of debate. Despite various extents of cerebellar atrophy on structural magnetic resonance imaging (MRI), previous studies have shown substantial heterogeneity and included a limited number of patients. Novel automated pipelines allow detailed segmentation of cerebellar lobules based on structural MRI.
    Objective: To compare the volumes of cerebellar lobules in ET patients with those in healthy controls (HCs) using an automated segmentation pipeline.
    Methods: Structural MRI scans of ET patients eligible for deep brain stimulation (
    Results: Total brain tissue volumes did not differ between the ET and HC groups. ET patients demonstrated reduced volumes of lobules I-II, left Crus II, left VIIB, and an increased volume of right X when compared with the HC group.
    Conclusion: A large cohort of ET patients demonstrated subtle signs of decreased cerebellar lobule volumes. These findings oppose the hypothesis of localized atrophy in cerebellar motor areas in ET, but not the possibility of cerebellar pathophysiology in ET. Prospective investigations using alternative neuroimaging modalities may further elucidate the pathophysiology of ET and provide insights into diagnostic and therapeutic approaches.
    Language English
    Publishing date 2021-06-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2021.667854
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  9. Article ; Online: Major Genetic Risk Factors for Dupuytren's Disease Are Inherited From Neandertals.

    Ågren, Richard / Patil, Snehal / Zhou, Xiang / Sahlholm, Kristoffer / Pääbo, Svante / Zeberg, Hugo

    Molecular biology and evolution

    2023  Volume 40, Issue 6

    Abstract: Dupuytren's disease is characterized by fingers becoming permanently bent in a flexed position. Whereas people of African ancestry are rarely afflicted by Dupuytren's disease, up to ∼30% of men over 60 years suffer from this condition in northern Europe. ...

    Abstract Dupuytren's disease is characterized by fingers becoming permanently bent in a flexed position. Whereas people of African ancestry are rarely afflicted by Dupuytren's disease, up to ∼30% of men over 60 years suffer from this condition in northern Europe. Here, we meta-analyze 3 biobanks comprising 7,871 cases and 645,880 controls and find 61 genome-wide significant variants associated with Dupuytren's disease. We show that 3 of the 61 loci harbor alleles of Neandertal origin, including the second and third most strongly associated ones (P = 6.4 × 10-132 and P = 9.2 × 10-69, respectively). For the most strongly associated Neandertal variant, we identify EPDR1 as the causal gene. Dupuytren's disease is an example of how admixture with Neandertals has shaped regional differences in disease prevalence.
    MeSH term(s) Animals ; Humans ; Male ; Alleles ; Dupuytren Contracture/genetics ; Neanderthals/genetics ; Risk Factors
    Language English
    Publishing date 2023-06-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 998579-7
    ISSN 1537-1719 ; 0737-4038
    ISSN (online) 1537-1719
    ISSN 0737-4038
    DOI 10.1093/molbev/msad130
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2137: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: An E280K Missense Variant in

    Ågren, Richard / Geerdink, Niels / Brunner, Han G / Paucar, Martin / Kamsteeg, Erik-Jan / Sahlholm, Kristoffer

    International journal of molecular sciences

    2023  Volume 24, Issue 13

    Abstract: A five-year-old girl presented with headache attacks, clumsiness, and a history of transient gait disturbances. She and her father, mother, twin sister, and brother underwent neurological evaluation, neuroimaging, and exome sequencing covering 357 genes ... ...

    Abstract A five-year-old girl presented with headache attacks, clumsiness, and a history of transient gait disturbances. She and her father, mother, twin sister, and brother underwent neurological evaluation, neuroimaging, and exome sequencing covering 357 genes associated with movement disorders. Sequencing revealed the new variant
    MeSH term(s) Male ; Female ; Humans ; Spinocerebellar Degenerations/genetics ; Shal Potassium Channels/genetics ; Mutation, Missense ; Mutation ; Cerebellar Ataxia ; Ataxia
    Chemical Substances Shal Potassium Channels ; KCND3 protein, human
    Language English
    Publishing date 2023-06-30
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241310924
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