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  1. Article: Complex decongestive therapy in hidradenitis suppurativa-related genital lymphoedema: a case report.

    Yaman, Ayşegül / Borman, Pınar / Eşme, Pelin / Çalışkan, Ercan

    Journal of wound care

    2024  Volume 33, Issue Sup2a, Page(s) xxviii–xxxi

    Abstract: Genital lymphoedema is a rare but debilitating and disfiguring complication of longstanding hidradenitis suppurativa (HS). Despite the existence of medical and surgical methods that offer varying success rates in a limited number of cases, no data exist ... ...

    Abstract Genital lymphoedema is a rare but debilitating and disfiguring complication of longstanding hidradenitis suppurativa (HS). Despite the existence of medical and surgical methods that offer varying success rates in a limited number of cases, no data exist about the use of complex decongestive therapy (CDT) in HS-related genital lymphoedema. This case report describes the treatment and outcome of a 56-year-old male patient with severe scrotal lymphoedema due to underlying HS (Hurley stage 3). The patient was unresponsive to various topical and systemic antibiotics and biological agents, including adalimumab and certolizumab pegol. When the patient was assessed, ixekizumab treatment for his HS was planned. He had progressive oedema in the genital area for two years with difficulty in wearing trousers and having sexual intercourse, and painful urination. CDT was recommended for three days a week concurrently with ixekizumab treatment. The patient and his wife were also educated about self-drainage techniques and skincare maintenance. After six sessions of CDT over 14 days, the patient demonstrated a significant reduction in scrotal measurements. He achieved a better scrotal contour, the degree of the buried penis was decreased, and urination was easier and painless. The findings of this case report showed that CDT was an easily applicable, practical and promising method that offered a rapid treatment response for HS-related genital lymphoedema.
    MeSH term(s) Humans ; Male ; Middle Aged ; Hidradenitis Suppurativa/therapy ; Hidradenitis Suppurativa/surgery ; Lymphedema/therapy ; Lymphedema/surgery ; Antibodies, Monoclonal, Humanized ; Genitalia
    Chemical Substances Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2024-02-07
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1353951-6
    ISSN 0969-0700
    ISSN 0969-0700
    DOI 10.12968/jowc.2024.33.Sup2a.xxviii
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    Zs.A 4572: Show issues Location:
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  2. Article ; Online: Laser-assisted delivery of imiquimod in Brooke-Spiegler syndrome.

    Botsali, Aysenur / Caliskan, Ercan

    Anais brasileiros de dermatologia

    2022  Volume 97, Issue 4, Page(s) 541–543

    MeSH term(s) Carcinoma, Adenoid Cystic ; Humans ; Imiquimod/therapeutic use ; Lasers ; Neoplastic Syndromes, Hereditary ; Skin Neoplasms
    Chemical Substances Imiquimod (P1QW714R7M)
    Language English
    Publishing date 2022-05-30
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 433655-0
    ISSN 1806-4841 ; 0365-0596
    ISSN (online) 1806-4841
    ISSN 0365-0596
    DOI 10.1016/j.abd.2020.12.014
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    Zs.A 359: Show issues Location:
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    Zs.MO 344: Show issues

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  3. Article: Facial Bier Spots Unresponsive to Botulinum Toxin: A Case Series.

    Esme, Pelin / Beksac, Burcu / Akoglu, Gulsen / Caliskan, Ercan

    Dermatology practical & conceptual

    2023  Volume 13, Issue 1

    Language English
    Publishing date 2023-01-01
    Publishing country Austria
    Document type Letter
    ZDB-ID 2685397-8
    ISSN 2160-9381
    ISSN 2160-9381
    DOI 10.5826/dpc.1301a32
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  4. Article ; Online: Er: YAG Laser Ablation: An Adjuvant Treatment for Medically Resistant Pyoderma Gangrenosum.

    Çalişkan, Ercan

    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.

    2017  Volume 43, Issue 11, Page(s) 1405–1407

    MeSH term(s) Combined Modality Therapy ; Cyclosporine/therapeutic use ; Dermatologic Agents/therapeutic use ; Female ; Humans ; Laser Therapy ; Lasers, Solid-State/therapeutic use ; Middle Aged ; Pyoderma Gangrenosum/pathology ; Pyoderma Gangrenosum/therapy
    Chemical Substances Dermatologic Agents ; Cyclosporine (83HN0GTJ6D)
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1227586-4
    ISSN 1524-4725 ; 1076-0512
    ISSN (online) 1524-4725
    ISSN 1076-0512
    DOI 10.1097/DSS.0000000000001100
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    Zs.A 1212: Show issues Location:
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  5. Article ; Online: Cutaneous leishmaniasis treated with daylight methylene blue photodynamic therapy.

    Çalişkan, Ercan / Uncu, Hüma B / Akoğlu, Gülşen

    International journal of dermatology

    2023  Volume 63, Issue 2, Page(s) e65–e67

    MeSH term(s) Humans ; Methylene Blue/therapeutic use ; Photochemotherapy/adverse effects ; Leishmaniasis, Cutaneous/diagnosis ; Leishmaniasis, Cutaneous/drug therapy ; Photosensitizing Agents/therapeutic use
    Chemical Substances Methylene Blue (T42P99266K) ; Photosensitizing Agents
    Language English
    Publishing date 2023-12-13
    Publishing country England
    Document type Letter
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.16977
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  6. Article ; Online: Combination of Full-Field and Fractional Erbium: YAG Laser for Nonhealing Wounds.

    Caliskan, Ercan / Botsali, Aysenur

    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.

    2021  Volume 48, Issue 1, Page(s) 114–119

    Abstract: Background: To evaluate the outcomes of a heterogeneous group of patients with chronic ulcer receiving a combination regimen of full-field and fractional erbium-doped yttrium aluminum garnet (erbium: YAG) laser applications.: Methods: Enrolled in ... ...

    Abstract Background: To evaluate the outcomes of a heterogeneous group of patients with chronic ulcer receiving a combination regimen of full-field and fractional erbium-doped yttrium aluminum garnet (erbium: YAG) laser applications.
    Methods: Enrolled in this study were patients with chronic ulcer who had received at least 2 erbium: YAG laser sessions. Fractional applications followed the initial full-field application for debridement. The therapeutic outcomes were evaluated by serial photographs. The primary outcome measure was the proportion of patients achieving complete re-epithelialization at the first year.
    Results: Forty-three treatment regions from 23 patients between 40 and 90 years (F: M = 11:12; age: 60.3 ± 15.5 years, mean ± SD) were eligible. The ulcers' median duration was 24 months (min-max: 2-240 months). The median number of laser sessions was 5 (min-max: 2-12). Of arterial (n = 13), immunologic (n = 9), venous (n = 8), diabetic (n = 8), and mechanical ulcers (n = 5), the primary outcome measure was achieved in 69%, 77.7%, 75%, 88.8%, and 100% of the groups, respectively.
    Conclusion: Full-field erbium: YAG laser applications preserve the vascular architecture and enable delicate debridement. Ongoing maintenance fractional laser sessions promote wound healing. Similar to the previous reports of erbium: YAG laser in venous and diabetic ulcers, arterial ulcers, and ulcers of immunologic origin demonstrated an objective treatment response along with different adjuvant approaches.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Chronic Disease/therapy ; Female ; Humans ; Laser Therapy/instrumentation ; Laser Therapy/methods ; Lasers, Solid-State/therapeutic use ; Male ; Middle Aged ; Re-Epithelialization/radiation effects ; Retrospective Studies ; Skin Ulcer/therapy ; Treatment Outcome ; Wound Healing/radiation effects
    Language English
    Publishing date 2021-09-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1227586-4
    ISSN 1524-4725 ; 1076-0512
    ISSN (online) 1524-4725
    ISSN 1076-0512
    DOI 10.1097/DSS.0000000000003292
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  7. Article ; Online: Safety and Efficacy of High-Dose Fractional Erbium: Yttrium Aluminium Garnet Laser in Stable Vitiligo.

    Botsali, Aysenur / Caliskan, Ercan

    Photobiomodulation, photomedicine, and laser surgery

    2021  Volume 39, Issue 9, Page(s) 600–606

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Aluminum ; Combined Modality Therapy ; Erbium ; Humans ; Lasers, Solid-State/adverse effects ; Ultraviolet Therapy ; Vitiligo/drug therapy ; Yttrium
    Chemical Substances Yttrium (58784XQC3Y) ; Erbium (77B218D3YE) ; Aluminum (CPD4NFA903)
    Language English
    Publishing date 2021-10-21
    Publishing country United States
    Document type Journal Article
    ISSN 2578-5478
    ISSN (online) 2578-5478
    DOI 10.1089/photob.2021.0016
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  8. Article: An Anti-Interleukin-17A Monoclonal Antibody, Ixekizumab, in the Treatment of Resistant Hidradenitis Suppurativa: A Case Series.

    Esme, Pelin / Botsali, Aysenur / Akoglu, Gulsen / Caliskan, Ercan

    Skin appendage disorders

    2022  Volume 8, Issue 4, Page(s) 342–345

    Abstract: Introduction: Although adalimumab is the only approved biologic for the treatment of hidradenitis suppurativa (HS), the treatment response may not be satisfactory in all patients. Recently, many other biological agents, including interleukin 17 ... ...

    Abstract Introduction: Although adalimumab is the only approved biologic for the treatment of hidradenitis suppurativa (HS), the treatment response may not be satisfactory in all patients. Recently, many other biological agents, including interleukin 17 inhibitors such as ixekizumab, have shown promise.
    Case presentations: Five severe HS (Hurley stage III) patients resistant to conventional treatments and adalimumab for at least 3 months were recruited. Patients were prescribed ixekizumab with a scheme approved for psoriasis (160 mg once, followed by 80 mg at weeks 2, 4, 6, 8, 10, and 12.) The primary outcome measure was achieving the Hidradenitis Suppurativa Clinical Response (HiSCR) score following 12 weeks. Secondary outcome measures included the patient-reported Dermatology Life Quality Index (DLQI) and visual analog scale (VAS). Four of 5 patients (80%) achieved HiSCR. While improvement was observed in the VAS and DLQI scores of 4 patients, the decline was limited in 1 patient. No adverse event was recorded related to ixekizumab.
    Conclusion: The result of our observation suggests that ixekizumab may be effective for HS, especially in challenging cases.
    Language English
    Publishing date 2022-02-09
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2806972-9
    ISSN 2296-9160 ; 2296-9195
    ISSN (online) 2296-9160
    ISSN 2296-9195
    DOI 10.1159/000521860
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  9. Article ; Online: Comparison of fractional erbium:YAG laser-assisted tranexamic acid delivery alone and in combination with oral tranexamic acid in melasma.

    Botsali, Aysenur / Esme, Pelin / Erbil, Hakan / Caliskan, Ercan

    Lasers in medical science

    2022  Volume 37, Issue 7, Page(s) 2823–2830

    Abstract: Tranexamic acid (TA) emerged as a promising agent for melasma. However, due to its hydrophilic structure, topical TA should be combined with a penetration-enhancing strategy to augment efficacy. To evaluate the efficacy of fractional erbium:YAG laser- ... ...

    Abstract Tranexamic acid (TA) emerged as a promising agent for melasma. However, due to its hydrophilic structure, topical TA should be combined with a penetration-enhancing strategy to augment efficacy. To evaluate the efficacy of fractional erbium:YAG laser-assisted delivery (LAD) of topical TA 5% either with or without oral TA treatment in recalcitrant melasma patients. The authors retrospectively assessed the treatment outcomes of melasma patients treated by fractional erbium:YAG LAD of topical TA 5%. Patients receiving a standard protocol including four biweekly laser sessions were eligible. The study included two groups: group 1 patients received oral TA and LAD of topical TA 5%, and group 2 patients received only LAD of topical TA 5%. Two blinded dermatologists reported pre-treatment and post-treatment modified MASI (mMASI) scores. Mean mMASI scores in both group 1 (n = 15) and group 2 (n = 19) were significantly lower at the end of the treatment than baseline values (p = 0.001; p = 0.022, respectively). The decrease of mMASI scores were higher in group 1 (median = 2.1) (64.7%) than in group 2 (median = 1.2) (41.8%) (p = 0.027). Fractional erbium:YAG LAD of topical TA 5% is an efficient treatment regimen for melasma patients recalcitrant to conventional treatment approaches. The implementation of oral TA to this regimen improves the therapeutic outcomes.
    MeSH term(s) Erbium ; Humans ; Lasers, Solid-State/therapeutic use ; Melanosis/drug therapy ; Retrospective Studies ; Tranexamic Acid ; Treatment Outcome
    Chemical Substances Tranexamic Acid (6T84R30KC1) ; Erbium (77B218D3YE)
    Language English
    Publishing date 2022-03-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 632808-8
    ISSN 1435-604X ; 0268-8921
    ISSN (online) 1435-604X
    ISSN 0268-8921
    DOI 10.1007/s10103-022-03547-7
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    Zs.A 2148: Show issues Location:
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  10. Article ; Online: Role of exosomes in skin diseases.

    Kose, Osman / Botsali, Aysenur / Caliskan, Ercan

    Journal of cosmetic dermatology

    2022  Volume 21, Issue 8, Page(s) 3219–3225

    Abstract: Background: Exosomes, as a family member of extracellular vesicles, are cell-secreted nanoscale structures that play pivotal roles in regulating physiological and pathophysiological processes of the skin. Exosomes induce communication between cells and ... ...

    Abstract Background: Exosomes, as a family member of extracellular vesicles, are cell-secreted nanoscale structures that play pivotal roles in regulating physiological and pathophysiological processes of the skin. Exosomes induce communication between cells and are responsible for transporting cellular components such as microRNAs, mRNAs, DNA, lipids, metabolites, and cell-surface proteins. Numerous preclinical and clinical trials searched the contribution of exosomes to skin functions and disorders. Thus, exosomes are gaining increasing attention within investigational dermatology. In advance, stem-cell-derived exosomes were integrated into the functional cosmetics industry nominated as cell-free regenerative medicine.
    Objective: This review aims to demonstrate the roles of exosomes in inflammatory skin disorders, stem cell, and tumor biology through a comprehensive evaluation of the diagnostic, prognostic, and therapeutic perspectives.
    Methods: A comprehensive literature search was performed using electronic online databases "PubMed" and "Google Scholar" using key words ''exosomes'', ''skin'', ''wound healing''.
    Conclusion: Exosomes are regarded as promising diagnostic and prognostic biomarkers for various skin diseases. Future prospects are repurposing exosomes to treat skin disorders, either as drug carriers or drugs themselves.
    MeSH term(s) Exosomes/metabolism ; Humans ; MicroRNAs ; Skin Diseases/diagnosis ; Skin Diseases/metabolism ; Skin Diseases/therapy ; Stem Cells/metabolism ; Wound Healing/physiology
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2022-06-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.15152
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