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Article: The evaluation of Candida-related central line-related bloodstream infections in pediatric cancer patients: A pre- and post-intervention study.

Devrim, İlker / Celebi, Miray Yılmaz / Karakaya, Nurgul / Sahinkaya, Sahika / Acar, Sultan Okur / Cem, Ela / Demirağ, Bengü / Oruc, Yeliz / Kara, Aybuke Akaslan / Oymak, Yesim / Karapınar, Tuba Hilkay / Bayram, Nuri

Journal of infection prevention

2023 Volume 24, Issue 5, Page(s) 219–222

Abstract: Aim/objections: The purpose of this study was to assess the efficacy of a central line maintenance bundle in preventing catheter-related (implanted venous access devices, port) Candida bloodstream infections.: Methods: The study encompassed two ... ...

Abstract	Aim/objections: The purpose of this study was to assess the efficacy of a central line maintenance bundle in preventing catheter-related (implanted venous access devices, port) Candida bloodstream infections. Methods: The study encompassed two distinct time periods, namely, pre-bundle and bundle. The number of catheter-related bloodstream infections (CRBSI) episodes per catheter days for each timeframe was determined. Findings/results: Upon implementation of the central line bundle, the rate of CRBSI reduced significantly from 4.27 per 1000 central line days in the pre-bundle period to 1.0 per 1000 central line days in the bundle period ( Discussion: Using a central line bundle to avoid CRBSIs in pediatric cancer patients with ports led to a significant decrease in Candida species-related CRBSIs.
Language	English
Publishing date	2023-08-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2595000-9
ISSN	1757-1782 ; 1757-1774
ISSN (online)	1757-1782
ISSN	1757-1774
DOI	10.1177/17571774231191334
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Article ; Online: Rehospitalization indications of children hospitalized for COVID-19 infections after discharge: Should we suspect long COVID?

Cem, Ela / Kıymet, Elif / Böncüoğlu, Elif / Şahinkaya, Şahika / Çelebi, Miray Yılmaz / Gülderen, Mustafa / Kara, Aybüke Akaslan / Özenen, Gizem Güner / Bayram, Nuri / Devrim, İlker

The Turkish journal of pediatrics

2023 Volume 65, Issue 4, Page(s) 583–591

Abstract: Background: Complications that may develop in children after coronavirus disease 2019 (COVID-19) infections are unknown. The `Long COVID` syndrome is a new process that can also be identified in children. Therefore, in this study, the conditions that ... ...

Abstract	Background: Complications that may develop in children after coronavirus disease 2019 (COVID-19) infections are unknown. The `Long COVID` syndrome is a new process that can also be identified in children. Therefore, in this study, the conditions that may develop in children after COVID-19 infection were discussed, and the indications for rehospitalizations were reviewed. Methods: This retrospective cohort study was conducted in a tertiary children`s hospital in İzmir, Türkiye. All children who were rehospitalized in the study center after discharge, and the indications for readmissions were screened. Results: Since the beginning of the pandemic, 777 children with COVID-19 infection were hospitalized, including 98 (12.6%) cases rehospitalized for any indication. Fifty-five (56.1%) patients were male, and 43 (43.9%) were female. The mean age of the study population was 79.3±63.5 months (1 month to 17 years). Among these 98 patients, 76 (77.6%) were rehospitalized because of the presence of their primary underlying disease, nonspecific infectious diseases unrelated to COVID-19, and the need to perform certain surgical procedures. The remaining 22 (22.4%) patients presented with symptoms such as fatigue, fever, abdominal pain, and myalgia after the COVID-19 infection. No other underlying cause was detected in approximately one-third of the patients, whose manifestations were found to be consistent with long COVID syndrome. Conclusions: The findings of acute COVID-19 infection are well characterized, but there is still limited data on its long-term outcomes. The majority of the study population that had no underlying disease were thought to have complications from the COVID-19 infection. Therefore, although the incidence rate of long COVID syndrome in childhood has not been revealed so far, it should be kept in mind among relevant differential diagnoses.
MeSH term(s)	Humans ; Child ; Female ; Male ; Post-Acute COVID-19 Syndrome ; COVID-19/complications ; Patient Readmission ; Patient Discharge ; Retrospective Studies
Language	English
Publishing date	2023-09-04
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	123487-0
ISSN	2791-6421 ; 0041-4301
ISSN (online)	2791-6421
ISSN	0041-4301
DOI	10.24953/turkjped.2022.829
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Article ; Online: The impact of central line bundles on the timing of catheter-associated bloodstream infections and their microbiological distribution in critically ill children.

Devrim, İlker / Sandal, Ozlem Sarac / Çelebi, Miray Yılmaz / Hepduman, Pınar / Gönüllü, Ahmet / Atakul, Gülhan / Kara, Aybüke Akaslan / Oruç, Yeliz / Gülfidan, Gamze / Bayram, Nuri / Ağın, Hasan

European journal of pediatrics

2023 Volume 182, Issue 10, Page(s) 4625–4632

Abstract: Catheter-associated bloodstream infection, also known as CLABSI, is the most serious consequence of central venous access devices. These infections increase the risk of mortality and morbidity. The use of central line bundles in clinical settings is ... ...

Abstract	Catheter-associated bloodstream infection, also known as CLABSI, is the most serious consequence of central venous access devices. These infections increase the risk of mortality and morbidity. The use of central line bundles in clinical settings is increasing worldwide with the purpose of lowering the risk of catheter-associated bloodstream infections. In this study, we investigated the effect of implementing a central line bundle for the prevention of CLABSIs, the distribution of pathogens, and the duration of time it took for CLABSIs to develop in patients who had subclavian-inserted central venous catheters. This research project was a cross-sectional study investigation carried out in a pediatric tertiary teaching hospital. Participants consisted of children who had been admitted to the pediatric critical care unit with subclavian catheters during a period of 13 years. We compared the prebundle period with the bundle period for CLABSI specifically focusing on the time to infection, the number of polymicrobial infections, the proportion of Candida parapsilosis, and the percentage of Coagulase-negative staphylococci (CoNS). The "prebundle period" included the period from May 2007 to May 2013, and the "bundle period" included the period from June 2013 to June 2020. Throughout the course of the study, a total of 286 cases of CLABSI were documented. Among these patients, 141 (49.3%) had CLABSIs associated with subclavian catheters. During the prebundle period, 55 CLABSIs were diagnosed in 5235 central line days, with an overall rate of 10.5 CLABSIs per 1000 central line days; after the implementation of central line bundle, 86 CLABSIs were diagnosed in 12,450 CL days, with an overall rate of 3.6 CLABSIs per 1000 CL days. This showed a statistically significantly lower rate in the bundle period (p = 0.0126). In the prebundle period, the mean time to develop CLABSI was 15 days, whereas during the bundle period, the mean time to develop CLABSI was 27.9 days, a significantly longer time to onset (p = 0.001). While the percentage of other microorganisms was not statistically different between the prebundle and bundle periods (p > 0.05), the percentage of C. parapsilosis was significantly higher in the prebundle period (p = 0.001). Conclusion: The results of this study imply that the use of central line bundles not only reduces the incidence of CLABSI but also delays the time to which CLABSI patients acquire an infection. In addition, as a direct consequence of the CLB, the number of CLABSIs caused by gram-positive cocci did not increase, while the proportion of CLABSIs caused by C. parapsilosis decreased. What is Known: • The most significant negative consequence of central venous access devices is catheter-associated bloodstream infections. • "Care bundles" for CLABSI prevention have been reported to reduce the CLABSI rate. What is New: • Consider what would happen if the "Care bundle" failed to prevent CLABSI. • The findings of this study imply that using central line bundles not only reduces the risk of CLABSI but also extends the time it takes for patients to develop CLABSI. While the number of CLABSIs caused by gram-positive cocci did not increase as a direct result of CLB, the rate of CLABSIs caused by C. parapsilosis, which has recently become a major problem, has decreased.
MeSH term(s)	Humans ; Child ; Central Venous Catheters/adverse effects ; Catheterization, Central Venous/adverse effects ; Cross-Sectional Studies ; Critical Illness/therapy ; Catheter-Related Infections/epidemiology ; Catheter-Related Infections/prevention & control ; Catheter-Related Infections/microbiology ; Sepsis/etiology ; Hospitals, Teaching ; Bacteremia/epidemiology ; Bacteremia/etiology ; Bacteremia/prevention & control
Language	English
Publishing date	2023-08-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	194196-3
ISSN	1432-1076 ; 0340-6199 ; 0943-9676
ISSN (online)	1432-1076
ISSN	0340-6199 ; 0943-9676
DOI	10.1007/s00431-023-05141-7
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Article ; Online: A retrospective comparative analysis of factors affecting the decision and outcome of initial intravenous immunoglobulin alone or intravenous immunoglobulin plus methylprednisolone use in children with the multisystem inflammatory syndrome.

Devrim, İlker / Böncüoğlu, Elif / Kıymet, Elif / Şahinkaya, Şahika / Çelebi, Miray Yılmaz / Cem, Ela / Düzgöl, Mine / Arıkan, Kamile Ötiken / Kara, Aybüke Akaslan / Besin, Dorukhan / Vuran, Gamze / Seven, Pınar / Meşe, Timur / Ağın, Hasan / Bayram, Nuri

Pediatric rheumatology online journal

2022 Volume 20, Issue 1, Page(s) 69

Abstract: Background: For children with the multisystem inflammatory syndrome(MIS-C), intravenous immunoglobulins (IVIG) with or without methylprednisolone are the most effective treatment. In this study, IVIG combined with methylprednisolone was compared to IVIG ...

Abstract	Background: For children with the multisystem inflammatory syndrome(MIS-C), intravenous immunoglobulins (IVIG) with or without methylprednisolone are the most effective treatment. In this study, IVIG combined with methylprednisolone was compared to IVIG used alone in children with MIS-C. Methods: This retrospective cohort study was carried out between April 1, 2020, and November 1, 2021. This study covered all children with MIS-C. According to whether they received IVIG alone or IVIG with methylprednisolone as an initial treatment for MIS-C, the patients were split into two groups. The IVIG dosage for the patients in group I was 2 gr/kg, whereas the IVIG dosage for the patients in group II was 2 gr/kg + 2 mg/kg/day of methylprednisolone. These two groups were contrasted in terms of the frequency of fever, length of hospital stay, and admission to the pediatric intensive care unit. Results: The study comprised 91 patients who were diagnosed with MIS-C and were under the age of 18. 42 (46.2%) of these patients were in the IVIG alone group (group I), and 49 (53.8%) were in the IVIG + methylprednisolone group (group II). Patients in group II had a severe MIS-C ratio of 36.7%, which was substantially greater than the rate of severe MIS-C patients in group I (9.5%) (p 0.01). When compared to group I (9.5%), the rate of hypotension was considerably higher in group II (30.6%) (p = 0.014). Additionally, patients in group II had considerably higher mean serum levels of C-reactive protein. The incidence of fever recurrence was 26.5% in group II and 33.3% in group I, however the difference was not statistically significant (p > 0.05). Conclusions: The choice of treatment for patients with MIS-C should be based on an individual evaluation. In MIS-C children with hypotension and/or with an indication for a pediatric intensive care unit, a combination of IVIG and methylprednisolone may be administered. For the treatment modalities of children with MIS-C, however, randomized double-blind studies are necessary.
MeSH term(s)	COVID-19/complications ; Child ; Fever/drug therapy ; Fever/etiology ; Humans ; Hypotension ; Immunoglobulins, Intravenous ; Infusions, Intravenous ; Methylprednisolone/adverse effects ; Retrospective Studies ; Systemic Inflammatory Response Syndrome
Chemical Substances	Immunoglobulins, Intravenous ; Methylprednisolone (X4W7ZR7023)
Language	English
Publishing date	2022-08-20
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2279468-2
ISSN	1546-0096 ; 1546-0096
ISSN (online)	1546-0096
ISSN	1546-0096
DOI	10.1186/s12969-022-00726-2
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Article ; Online: Comparison of the pediatric hospitalizations due to COVID-19 and H1N1pdm09 virus infections during the pandemic period.

Devrim, İlker / Böncüoğlu, Elif / Kıymet, Elif / Şahinkaya, Şahika / Çelebi, Miray Yılmaz / Cem, Ela / Düzgöl, Mine / Arıkan, Kamile Ötiken / Kara, Aybüke Akaslan / Devrim, Fatma / Ağın, Hasan / Bayram, Nuri

Journal of medical virology

2022 Volume 94, Issue 5, Page(s) 2055–2059

Abstract: There are two major pandemics in the new millennium, including the pandemic of swine influenza and the COVID-19 pandemic. These two pandemics affected children as well as the adult population. In this case-control study, we compared children with COVID- ... ...

Abstract	There are two major pandemics in the new millennium, including the pandemic of swine influenza and the COVID-19 pandemic. These two pandemics affected children as well as the adult population. In this case-control study, we compared children with COVID-19 infection and those with H1N1pdm09 virus infection. We also compared the demographic factors, underlying disease, and the requirement for intensive care admission between the hospitalized children with COVID-19 infection and children with H1N1pdm09 virus infection who were hospitalized during the 2009 H1N1 pandemic. In this study, we evaluated 103 patients with H1N1pdm09 virus infection and 392 patients with COVID-19 infection. The age was significantly higher in the COVID-19 patients' group compared to the pandemic influenza group (p < 0.001). The ratio of the children ≥12 years was 10.7% (n = 11) in the H1N1pdm09 virus infection and 36.2% (n = 142) in the COVID-19 group. The rate of underlying disease was significantly higher in the patients with H1N1pdm09 virus infections (p = 0.02). The prevalence of underlying disease in patients requiring PICU hospitalization was 69.2% (n = 9/13) compared to 25.7% (n = 124/482) in patients who did not require PICU hospitalization. The rate of underlying disease was significantly higher in the PICU group regardless of COVID-19 or H1N1pdm09 virus (p = 0.002). Our results suggest that older children were more hospitalized for COVID-19 infections compared to pandemic influenza. In addition, regardless of the type of pandemic infection, the underlying disease is an important factor for pediatric intensive care unit admission. This finding is important for developing strategies for the protection of children with the underlying disease in the upcoming pandemics.
MeSH term(s)	Adolescent ; COVID-19/epidemiology ; Case-Control Studies ; Child ; Hospitalization ; Humans ; Influenza A Virus, H1N1 Subtype ; Influenza, Human/epidemiology ; Orthomyxoviridae Infections/epidemiology ; Pandemics
Language	English
Publishing date	2022-01-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.27589
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Article ; Online: A Comparative Study of Children with MIS-C between Admitted to the Pediatric Intensive Care Unit and Pediatric Ward: A One-Year Retrospective Study.

Kıymet, Elif / Böncüoğlu, Elif / Şahinkaya, Şahika / Cem, Ela / Çelebi, Miray Yılmaz / Düzgöl, Mine / Kara, Aybüke Akaslan / Arıkan, Kamile Ötiken / Vuran, Gamze Talay / Yılmazer, Murat Muhtar / Sandal, Özlem Saraç / Ağın, Hasan / Pirinç, Neslihan / Bayram, Nuri / Devrim, İlker

Journal of tropical pediatrics

2022 Volume 67, Issue 6

Abstract: Objectives: This descriptive study aimed to compare the clinical and laboratory features of the children with the multisystem inflammatory syndrome in children (MIS-C), requiring pediatric intensive care unit (PICU), admission with the MIS-C patients ... ...

Abstract	Objectives: This descriptive study aimed to compare the clinical and laboratory features of the children with the multisystem inflammatory syndrome in children (MIS-C), requiring pediatric intensive care unit (PICU), admission with the MIS-C patients who did not require PICU admission. Patients and methods: This study was conducted between March 2020 and February 2021 at the University of Health Sciences Dr. Behçet Uz Children's Hospital, a referral center for pediatric infectious diseases in the Aegean Region of Turkey. All hospitalized patients aged 18 years old or less with MIS-C according to the definition of the universal guidelines were included in the study. Data of the patients with the diagnosis of MIS-C were recorded and collected from the electronic medical records of the hospital. The data included demographic characteristics, presenting signs and symptoms, laboratory findings and clinical data. Results: A total of 58 patients with MIS-C were included in this study. Thirty-eight (65.5%) patients were male. The median age was 6 years (2 months-16 years). The patients admitted to PICU were 15 (25.9%). The rate of pulmonary involvement was 81.3% (n = 13) in the PICU group. The median procalcitonin, C-reactive protein, erythrocyte sedimentation rate, D-Dimer and ferritin values were significantly higher in the PICU group compared to non-PICU group (p < 0.001, p = 0.02, p < 0.001, p = 0.006 and p = 0.031). Conclusions: Besides the depressing cardiac functions reported before, the pulmonary involvement and signs of shock are important factors for PICU admission in children with MIS-C.
MeSH term(s)	Adolescent ; COVID-19/complications ; Child ; Hospitals, Pediatric ; Humans ; Intensive Care Units, Pediatric ; Male ; Retrospective Studies ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome
Language	English
Publishing date	2022-01-06
Publishing country	England
Document type	Journal Article
ZDB-ID	800065-7
ISSN	1465-3664 ; 0449-3281 ; 0142-6338
ISSN (online)	1465-3664
ISSN	0449-3281 ; 0142-6338
DOI	10.1093/tropej/fmab104
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Article ; Online: Frequency and safety of COVID-19 vaccination in children with multisystem inflammatory syndrome: a telephonic interview-based analysis.

Aykac, Kubra / Ozturk, Kubra / Demir, Osman Oguz / Gumus, Dilan Demir / Aslan, Sevgi / Cem, Ela / Celebi, Miray Yilmaz / Karabacak, Mustafa Dogan / Alkan, Gulsum / Aksoy, Fatma Dilsad / Yayla, Burcu Ceylan Cura / Kepenekli, Eda / Celebi, Solmaz / Emiroglu, Melike / Devrim, Ilker / Cengiz, Ali Bulent / Ceyhan, Mehmet / Ozsurekci, Yasemin

World journal of pediatrics : WJP

2022 Volume 18, Issue 10, Page(s) 700–705

MeSH term(s)	COVID-19/complications ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Child ; Connective Tissue Diseases ; Humans ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome ; Vaccination/adverse effects
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2022-08-16
Publishing country	Switzerland
Document type	Letter
ZDB-ID	2236681-7
ISSN	1867-0687 ; 1708-8569
ISSN (online)	1867-0687
ISSN	1708-8569
DOI	10.1007/s12519-022-00604-7
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Article ; Online: Distribution of spreading viruses during COVID-19 pandemic: Effect of mitigation strategies.

Kıymet, Elif / Böncüoğlu, Elif / Şahinkaya, Şahika / Cem, Ela / Çelebi, Miray Yılmaz / Düzgöl, Mine / Kara, Aybüke Akaslan / Arıkan, Kamile Ötiken / Aydın, Tuğçe / İşgüder, Rana / Yılmazer, Murat Muhtar / Ayhan, Yüce / Gülfidan, Gamze / Bayram, Arzu / Bayram, Nuri / Çelik, Tanju / Alp, Yaşar Tamer / Devrim, İlker

American journal of infection control

2021 Volume 49, Issue 9, Page(s) 1142–1145

Abstract: Background: The study aimed to evaluate the distribution of circulating respiratory viral pathogens other than severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) during the first year of the coronavirus disease-2019 (COVID-19) pandemic with ... ...

Abstract	Background: The study aimed to evaluate the distribution of circulating respiratory viral pathogens other than severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) during the first year of the coronavirus disease-2019 (COVID-19) pandemic with especially focusing on the effects of the national-based mitigation strategies. Methods: This single-center study was conducted between March 11, 2020-March 11, 2021. All children who were tested by polymerase chain reaction on nasopharyngeal swabs for SARS-CoV-2 and other common respiratory viral pathogens were included in the study. Results: A total of 995 children with suspected COVID-19 admitted to the study center. Of these, 513 patients who were tested by polymerase chain reaction for both SARS-CoV-2 and common respiratory viral pathogens were included in the final analysis. Two hundred ninety-five patients were (57.5%) male. The median age was 3 years of age (27 days-17 years). A total of 321 viral pathogens identified in 310 (n: 310/513, 60.4%) patients, and 11 of them (n: 11/310, 3.5%) had co-detection with more than 1 virus. The most common detected virus was rhinovirus (n: 156/513, 30.4%), and SARS-CoV-2 (n: 122/513, 23.8%) followed by respiratory syncytial virus (n: 18/513, 3.5%). The influenza virus was detected in 2 patients (0.4%). A total of 193 patients were negative for both SARS-CoV-2 and other pathogens. Conclusions: There is a decline in the frequency of all viral pathogens like SARS-CoV-2 in correlation with the national-based mitigation strategies against COVID-19 during the pandemic.
MeSH term(s)	Adolescent ; COVID-19/transmission ; Child ; Child, Preschool ; Coinfection/epidemiology ; Humans ; Infant ; Infant, Newborn ; Male ; Pandemics ; Virus Diseases/transmission ; Viruses
Language	English
Publishing date	2021-06-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	392362-9
ISSN	1527-3296 ; 0196-6553
ISSN (online)	1527-3296
ISSN	0196-6553
DOI	10.1016/j.ajic.2021.06.002
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Article ; Online: Impact of Prophylactic Continuous Positive Airway Pressure on Transient Tachypnea of the Newborn and Neonatal Intensive Care Admission in Newborns Delivered by Elective Cesarean Section.

Celebi, Miray Yilmaz / Alan, Serdar / Kahvecioglu, Dilek / Cakir, Ufuk / Yildiz, Duran / Erdeve, Omer / Arsan, Saadet / Atasay, Begum

American journal of perinatology

2016 Volume 33, Issue 1, Page(s) 99–106

Abstract: Objective: This study aims to evaluate the effect of the prophylactic continuous positive airway pressure (CPAP) administration in the delivery room to newborns who were delivered by elective cesarean section (CS).: Study design: Inborn infants with ... ...

Abstract	Objective: This study aims to evaluate the effect of the prophylactic continuous positive airway pressure (CPAP) administration in the delivery room to newborns who were delivered by elective cesarean section (CS). Study design: Inborn infants with gestational age between 34(0/7) to 38(6/7) and born by elective CS were prospectively randomized to receive either prophylactic CPAP for 20 minutes via face mask or standardized care without CPAP in the delivery room. Primary outcomes were the incidence of transient tachypnea of the newborn (TTN) and neonatal intensive care unit (NICU) admission due to respiratory distress. Results: A total of 259 infants with a mean gestational age of 37.7 ± 0.8 weeks and birth weight of 3,244 ± 477 g were included. A total of 134 infants received prophylactic CPAP and 125 received control standard care. The rate of NICU admission was significantly lower in prophylactic CPAP group (p = 0.045). Although the rate of TTN was lower in the prophylactic CPAP group, the difference was not statistically significant (p = 0.059). The rate of NICU admission due to respiratory distress was significantly higher in late-preterm cohort than early-term cohort (p < 0.0001). Conclusion: Prophylactic CPAP administration decreases the rate of NICU admission without any side effect in late-preterm and early-term infants delivered by elective CS.
MeSH term(s)	Cesarean Section ; Continuous Positive Airway Pressure ; Delivery Rooms/organization & administration ; Female ; Gestational Age ; Humans ; Infant, Newborn ; Intensive Care, Neonatal/standards ; Logistic Models ; Male ; Pregnancy ; Prospective Studies ; Transient Tachypnea of the Newborn/therapy ; Turkey
Language	English
Publishing date	2016-01
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	605671-4
ISSN	1098-8785 ; 0735-1631
ISSN (online)	1098-8785
ISSN	0735-1631
DOI	10.1055/s-0035-1560041
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Article: Impact of Prophylactic Continuous Positive Airway Pressure on Transient Tachypnea of the Newborn and Neonatal Intensive Care Admission in Newborns Delivered by Elective Cesarean Section

Celebi, Miray Yilmaz / Alan, Serdar / Kahvecioglu, Dilek / Cakir, Ufuk / Yildiz, Duran / Erdeve, Omer / Arsan, Saadet / Atasay, Begum

American Journal of Perinatology

2015 Volume 02, Issue 01, Page(s) 99–106

Abstract	Objective: This study aims to evaluate the effect of the prophylactic continuous positive airway pressure (CPAP) administration in the delivery room to newborns who were delivered by elective cesarean section (CS). Study Design: Inborn infants with gestational age between 34 0/7 to 38 6/7 and born by elective CS were prospectively randomized to receive either prophylactic CPAP for 20 minutes via face mask or standardized care without CPAP in the delivery room. Primary outcomes were the incidence of transient tachypnea of the newborn (TTN) and neonatal intensive care unit (NICU) admission due to respiratory distress. Results: A total of 259 infants with a mean gestational age of 37.7 ± 0.8 weeks and birth weight of 3,244 ± 477 g were included. A total of 134 infants received prophylactic CPAP and 125 received control standard care. The rate of NICU admission was significantly lower in prophylactic CPAP group ( p = 0.045). Although the rate of TTN was lower in the prophylactic CPAP group, the difference was not statistically significant ( p = 0.059). The rate of NICU admission due to respiratory distress was significantly higher in late-preterm cohort than early-term cohort ( p < 0.0001). Conclusion: Prophylactic CPAP administration decreases the rate of NICU admission without any side effect in late-preterm and early-term infants delivered by elective CS.
Keywords	continuous positive airway pressure ; late preterm ; early term ; delivery room ; transient tachypnea of the newborn
Language	English
Publishing date	2015-08-21
Publisher	Thieme Medical Publishers
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	605671-4
ISSN	1098-8785 ; 0735-1631
ISSN (online)	1098-8785
ISSN	0735-1631
DOI	10.1055/s-0035-1560041
Database	Thieme publisher's database

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