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Article ; Online: The first case: acute abdomen due to gastric gastrointestinal stromal tumor perforation with synchronous renal cell carcinoma.

Omeroglu, Sinan / Gulmez, Selcuk / Bozkurt, Emre

2022 Volume 11

Abstract: Aim: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract and they may coexist with renal cell cancers (RCC). The main treatment method of GIST and RCC is curative elective surgery. Surgery ... ...

Abstract	Aim: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract and they may coexist with renal cell cancers (RCC). The main treatment method of GIST and RCC is curative elective surgery. Surgery followed by oncological treatment with sunitinib is the main treatment option when these tumors coexist. Case report: A 32-year-old male, after a traffic accident applied to the emergency department. A thoraco-abdominopelvic computed tomography was performed, which demonstrated the presence of diffuse hemorrhagic fluid in the abdomen with 11x10 cm exophytic gastric mass and 2 x 2 cm right renal mass. After emergent laparotomy with gastric wedge resection and partial nephrectomy, patient was discharged uneventfully. Conclusions: If the patient's clinical condition is suitable for surgery, both tumors can be removed simultaneously, even in emergency situations. Thus, difficulties and complications that may occur during follow-up and the second operation can be avoided. Key words: Acute Abdomen, Gastrointestinal Stromal Tumor, Renal Cell Carcinoma.
MeSH term(s)	Abdomen, Acute/etiology ; Adult ; Carcinoma, Renal Cell/complications ; Carcinoma, Renal Cell/surgery ; Gastrointestinal Stromal Tumors/complications ; Gastrointestinal Stromal Tumors/pathology ; Gastrointestinal Stromal Tumors/surgery ; Humans ; Kidney Neoplasms/complications ; Kidney Neoplasms/surgery ; Male ; Stomach Neoplasms/surgery ; Sunitinib
Chemical Substances	Sunitinib (V99T50803M)
Language	English
Publishing date	2022-09-20
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	418927-9
ISSN	2239-253X ; 0003-469X
ISSN (online)	2239-253X
ISSN	0003-469X
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Article ; Online: Positive lymph node ratio as a prognostic factor for gastric cancer patients: Is it going to supersede positive lymph node number in guidelines?

Çapkinoğlu, Emir / Tufan, Aydin Eray / Ömeroğlu, Sinan / Tanal, Mert / Güven, Onur / Demir, Uygar

Medicine

2023 Volume 102, Issue 20, Page(s) e33757

Abstract: Gastric malignancies constitute the sixth most common cancer with regards to incidence and have the fifth most mortality rates. Extended lymph-node dissection is the surgical modality of choice while treating advanced stage gastric cancer. It is yet a ... ...

Abstract	Gastric malignancies constitute the sixth most common cancer with regards to incidence and have the fifth most mortality rates. Extended lymph-node dissection is the surgical modality of choice while treating advanced stage gastric cancer. It is yet a topic of debate, whether or not the amount of positive lymph nodes after a pathological examination following the surgical intervention is of prognostic value. In this study, it is aimed to evaluate the prognostic significance of positive lymph nodes following the surgery. A total of 193 patients who underwent curative gastrectomy between January 2011 and December 2015 have been considered for a retrospective data collection. The cases with R1-R2 resections, palliative or emergent surgeries are excluded. Metastatic to total number of lymph nodes, corresponded a ratio which was analyzed in this survey and practiced as a predictive parameter of disease outcome. This survey includes 138 male (71.5%) and 55 female (28.5%) patients treated between 2011 and 2015 in our clinic. The survey follow-up duration of the cases range between 0, 2, and 72 months, corresponding an average of 23.24 ± 16.99 months. We calculated cutoff value of 0.09 with, sensitivity is 76.32% for positive to total number of lymph nodes ratio, whereas specivity applies for 64.10%, positive predictive value for 58% and negative predictive value for 80.6%. Positive lymph node ratio has a prognostic value in terms of predicting the prognosis of the patients with gastric adenocarcinoma following a curative gastrectomy. This might in long term contribute to the prognostic analysis of patients if integrated in the current staging system.
MeSH term(s)	Humans ; Male ; Female ; Prognosis ; Stomach Neoplasms/pathology ; Retrospective Studies ; Neoplasm Staging ; Lymph Node Ratio ; Lymph Node Excision ; Lymph Nodes/surgery ; Lymph Nodes/pathology ; Gastrectomy
Language	English
Publishing date	2023-06-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000033757
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Article: Conservative Approach For The Management Of Bilateral Pneumothorax And Pneumomediastinum After Laparoscopic Totally Extraperitoneal Inguinal Hernia Repair.

Omeroglu, Sinan / Guven, Onur / Kostek, Mehmet / Tufan, Aydin Eray / Baran, Elif

JPMA. The Journal of the Pakistan Medical Association

2023 Volume 73, Issue 7, Page(s) 1527–1529

Abstract: Laparoscopic totally extraperitoneal inguinal hernia repair is considered a common and safe procedure. Here, we present the case of a 31-year-old male with right indirect inguinal hernia and no medical history. The patient underwent laparoscopic totally ... ...

Abstract	Laparoscopic totally extraperitoneal inguinal hernia repair is considered a common and safe procedure. Here, we present the case of a 31-year-old male with right indirect inguinal hernia and no medical history. The patient underwent laparoscopic totally extraperitoneal inguinal hernia repair and the operation was completed successfully. During extubation, subcutaneous emphysema was noted at the neck, chest, and above the nipples. Tracheal injury was excluded by the anaesthesiologists and otorhinolaryngologists. On arterial blood gas, the patient's oxygen saturation was 95% with nasal oxygen support. The patient was followed-up closely in the general surgery inpatient clinic. Computed tomography was performed, on which bilateral pneumothorax and pneumomediastinum were noted. Conservative management was planned and the patient was discharged on the fourth postoperative day. Laparoscopic totally extraperitoneal inguinal hernia repair is considered a routinely applied safe procedure, however, appropriate care should be taken to avoid possible complications.
MeSH term(s)	Male ; Humans ; Adult ; Hernia, Inguinal/surgery ; Hernia, Inguinal/complications ; Laparoscopy/adverse effects ; Mediastinal Emphysema/diagnostic imaging ; Mediastinal Emphysema/etiology ; Mediastinal Emphysema/therapy ; Pneumothorax/therapy ; Pneumothorax/surgery ; Subcutaneous Emphysema/therapy ; Subcutaneous Emphysema/complications ; Herniorrhaphy/adverse effects ; Herniorrhaphy/methods
Language	English
Publishing date	2023-05-22
Publishing country	Pakistan
Document type	Case Reports
ZDB-ID	603873-6
ISSN	0030-9982
ISSN	0030-9982
DOI	10.47391/JPMA.6951
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Article ; Online: Management of Gastric Tumor Perforation with Conservative Treatment during Neoadjuvant Chemotherapy.

Bozkurt, Emre / Omeroglu, Sinan / Capkinoglu, Emir / Guven, Onur / Mihmanli, Mehmet

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

2021 Volume 32, Issue 1, Page(s) 117–118

Abstract: Perioperative chemotherapy provides advantage for gastric cancer patients in terms of survival. A 56-year male with a diagnosis of locally advanced gastric carcinoma presented with complaints of acute abdominal pain; and was diagnosed as gastric tumor ... ...

Abstract	Perioperative chemotherapy provides advantage for gastric cancer patients in terms of survival. A 56-year male with a diagnosis of locally advanced gastric carcinoma presented with complaints of acute abdominal pain; and was diagnosed as gastric tumor perforation during neoadjuvant therapy. Gastric perforation may occur during neoadjuvant chemotherapy for gastric cancer. While the treatment of choice for these perforations was surgery in the past, it is now shifting towards a minimally invasive or non-invasive approach. We used the minimally invasive treatment approach with nasogastric drainage, intravenous antibiotics and proton pump inhibitors, which was effective in the treatment of perforation. Althrough, conservative treatment approach may be an effective management option in selected patients with gastric cancer perforation. Key Words: Gastric cancer, Neoadjuvant chemotherapy, Perforation.
MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Chemotherapy, Adjuvant ; Conservative Treatment ; Humans ; Male ; Neoadjuvant Therapy ; Stomach Neoplasms/drug therapy
Language	English
Publishing date	2021-12-20
Publishing country	Pakistan
Document type	Case Reports
ZDB-ID	2276646-7
ISSN	1681-7168 ; 1022-386X
ISSN (online)	1681-7168
ISSN	1022-386X
DOI	10.29271/jcpsp.2022.01.117
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Article: Clinical significance of the histopathological metastatic largest lymph node size in colorectal cancer patients.

Omeroglu, Sinan / Gulmez, Selcuk / Uzun, Orhan / Senger, Aziz Serkan / Bostanci, Ozgur / Guven, Onur / Polat, Erdal / Duman, Mustafa

Frontiers in oncology

2023 Volume 13, Page(s) 1120753

Abstract: Background: The metastatic lymph nodes (MLN) are interpreted to be correlated with prognosis of the colorectal cancers (CRC). The present retrospective study aimed to investigate the clinical significance of the largest MLN size in terms of ... ...

Abstract	Background: The metastatic lymph nodes (MLN) are interpreted to be correlated with prognosis of the colorectal cancers (CRC). The present retrospective study aimed to investigate the clinical significance of the largest MLN size in terms of postoperative outcomes and its predictive value in the prognosis of the patients with stage III CRC. Methods: Between May 2013 and December 2018, a total of 101 patients who underwent curative resection for stage III CRC retrospectively reviewed. All patients were divided into two groups regarding cut-off value (<1.05 cm and ≥1.05 cm) of maximum MLN diameter measured histopathologically. A comparative analysis of demographic and clinicopathological characteristics of the patients and their postoperative outcomes were performed. Results: Two groups carried similar demographic data and preoperative laboratory variables except the lymphocyte count, hematocrit (HCT) ratio, hemoglobin level and mean corpuscular volume (MCV) value (p<0.05). The patients with MLN diameter ≥1.05 cm (n=46) needed more erythrocyte suspension and were hospitalized longer than the patients with a diameter <1.05 cm (n=55) (p=0.006 and 0.0294, respectively). Patients with MLN diameter < 1.05 cm had a significantly longer overall survival than patients with MLN diameter ≥ 1.05 cm (75,29 Conclusion: The size of MLN larger than 1.05 cm may be predictive for a poor prognosis and lower survival of stage III CRC patients. The largest MLN size may be a proper alternative factor to the number of MLNs in predicting prognosis or in staging CRC patients.
Language	English
Publishing date	2023-03-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1120753
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Article ; Online: Surgical Repair of a 13-cm Infrarenal Abdominal Aortic Aneurysm with Aortocaval Fistula in a 63-Year-Old Tuba Player.

Bitargil, Macit / Bektas, Nilufer / Omeroglu, Sinan / Koramaz, Ismail

Texas Heart Institute journal

2019 Volume 46, Issue 1, Page(s) 36–40

Abstract: Infrarenal abdominal aortic aneurysm with aortocaval fistula, a rare condition, can be fatal without prompt intervention. The clinical symptoms are complex and varied, so diagnosis is typically confirmed by use of contrast-enhanced multidetector computed ...

Abstract	Infrarenal abdominal aortic aneurysm with aortocaval fistula, a rare condition, can be fatal without prompt intervention. The clinical symptoms are complex and varied, so diagnosis is typically confirmed by use of contrast-enhanced multidetector computed tomography. We report our surgical repair of a 13-cm-diameter infrarenal abdominal aortic aneurysm and aortocaval fistula in a 63-year-old orchestral tuba player who had 2 classic symptoms of the condition. The unruptured aneurysm and fistula were complicated by acutely angled vessels, so we performed surgery rather than endovascular repair. The patient recovered fully and was discharged from the hospital. This infrarenal aneurysm with aortocaval fistula is perhaps the largest to have been treated successfully by means of open surgery. In addition to our patient's case, we discuss the history and treatment considerations of this rare combined condition.
MeSH term(s)	Aorta, Abdominal/abnormalities ; Aorta, Abdominal/surgery ; Aortic Aneurysm, Abdominal/complications ; Aortic Aneurysm, Abdominal/diagnosis ; Aortic Aneurysm, Abdominal/surgery ; Aortography ; Arteriovenous Fistula/diagnosis ; Arteriovenous Fistula/etiology ; Arteriovenous Fistula/surgery ; Blood Vessel Prosthesis Implantation/methods ; Endovascular Procedures/methods ; Humans ; Male ; Middle Aged ; Multidetector Computed Tomography ; Music ; Phlebography ; Vena Cava, Inferior/abnormalities ; Vena Cava, Inferior/surgery
Language	English
Publishing date	2019-02-01
Publishing country	United States
Document type	Case Reports
ZDB-ID	604761-0
ISSN	1526-6702 ; 0730-2347
ISSN (online)	1526-6702
ISSN	0730-2347
DOI	10.14503/THIJ-17-6370
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Article ; Online: The rapid effects of sleeve gastrectomy on glucose homeostasis and resolution of diabetes mellitus.

Bozkurt, Emre / Kaya, Cemal / Ömeroğlu, Sinan / Güven, Onur / Mihmanlı, Mehmet

Endocrinology, diabetes & metabolism

2020 Volume 4, Issue 2, Page(s) e00182

Abstract: Aims: Type 2 diabetes caused by obesity is increasing globally. Bariatric surgical procedures are known to have positive effects on glucose homeostasis through neurohormonal action mechanisms. In the present study, we aimed to investigate the factors ... ...

Abstract	Aims: Type 2 diabetes caused by obesity is increasing globally. Bariatric surgical procedures are known to have positive effects on glucose homeostasis through neurohormonal action mechanisms. In the present study, we aimed to investigate the factors influencing glucose homeostasis independent of weight loss after the laparoscopic sleeve gastrectomy (LSG). Methods: Patients who underwent LSG for morbid obesity in a 3-year period were evaluated. Data on demographics, clinical characteristics (duration of diabetes, resected gastric volume, antral resection margin) and laboratory parameters (preoperative and postoperative blood glucose on fasting, preoperative HbA1c levels and first-year HbA1c levels) were retrospectively reviewed. Effect of patients' body mass index (<50 kg/m Results: Total of 61 patients constituted the study group. There were 40 female and 21 male patients with an average age of 43.8 ± 10.5 years (19-67 years). Preoperatively, mean BMI, blood glucose levels and HbA1c were 48.8 ± 8.5 kg/m Conclusions: It is noteworthy that LSG can control blood glucose levels in short term after surgery regardless of weight loss. Therefore, LSG should be preferred at earlier stages in the treatment of obesity-related T2DM in order to prevent T2DM-related complications.
MeSH term(s)	Adult ; Aged ; Biomarkers/blood ; Blood Glucose/metabolism ; Diabetes Complications/etiology ; Diabetes Complications/prevention & control ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/etiology ; Diabetes Mellitus, Type 2/surgery ; Female ; Gastrectomy/methods ; Glycated Hemoglobin ; Homeostasis ; Humans ; Laparoscopy/methods ; Male ; Middle Aged ; Obesity, Morbid/complications ; Obesity, Morbid/surgery ; Retrospective Studies ; Treatment Outcome ; Young Adult
Chemical Substances	Biomarkers ; Blood Glucose ; Glycated Hemoglobin A ; hemoglobin A1c protein, human
Language	English
Publishing date	2020-08-30
Publishing country	England
Document type	Journal Article
ISSN	2398-9238
ISSN (online)	2398-9238
DOI	10.1002/edm2.182
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Article ; Online: Prognostic effect of perineural invasion in successive years in patients with locally advanced gastric cancer.

Uzun, Orhan / Gülmez, Selçuk / Senger, Aziz Serkan / Ömeroğlu, Sinan / Polat, Erdal / Duman, Mustafa

Indian journal of pathology & microbiology

2021 Volume 64, Issue 3, Page(s) 479–483

Abstract: Aim: The present study evaluates the prognostic significance of perineural invasion (PNI) on 2-year, 5-year, and overall survival in patients undergoing gastrectomy and D2 lymphadenectomy due to locally advanced gastric cancer.: Materials and methods!# ...

Abstract	Aim: The present study evaluates the prognostic significance of perineural invasion (PNI) on 2-year, 5-year, and overall survival in patients undergoing gastrectomy and D2 lymphadenectomy due to locally advanced gastric cancer. Materials and methods: Included in the study were 231 patients who underwent surgery between November 2006 and October 2018 due to stage 1B and over locally advanced gastric cancer, whose records were reviewed retrospectively. Statistical analysis: The variables in the presence or absence of PNI were compared between the two groups with a Chi-square test, a Fisher's exact test, a likelihood ratio, and a Mann-Whitney U test. Overall survival data were evaluated with a Kaplan-Meier test. Prognostic factors were evaluated with a stepwise Cox regression analysis. Results: PNI was identified in 167 (72.3%) of the patients. The 2-year, 5-year, and overall survival rates at the end of the follow-up period were 85.9%, 70.3%, and 64.1% in those without PNI, and 52.7%, 38.3%, and 36.5% in those with PNI, respectively. In a multivariate analysis, PNI appeared to be a significant prognostic factor for 2-year survival (P = 0.04) but had no effect on 5-year and overall survival. Conclusions: Survival was shorter in patients with PNI than in patients without PNI, and PNI had no effect on overall survival, although it was found to be of prognostic significance for 2-year survival.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Disease-Free Survival ; Female ; Gastrectomy/statistics & numerical data ; Humans ; Kaplan-Meier Estimate ; Lymph Node Excision/statistics & numerical data ; Male ; Middle Aged ; Multivariate Analysis ; Neoplasm Invasiveness/pathology ; Prognosis ; Retrospective Studies ; Stomach Neoplasms/mortality ; Stomach Neoplasms/surgery ; Survival Rate ; Time Factors
Language	English
Publishing date	2021-08-01
Publishing country	India
Document type	Journal Article
ZDB-ID	197621-7
ISSN	0974-5130 ; 0377-4929
ISSN (online)	0974-5130
ISSN	0377-4929
DOI	10.4103/IJPM.IJPM_612_20
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Article ; Online: Management of Nonocclusive Mesenteric Ischemia in Patients with Cardiac Failure.

Ömeroğlu, Sinan / Tanal, Mert / Beyaz, Metin Onur / Güven, Onur / Demir, Ibrahim / Kabul Gürbulak, Esin / Demir, Uygar

The heart surgery forum

2022 Volume 25, Issue 5, Page(s) E649–E651

Abstract: Aim: This study aimed to evaluate the surgical procedures, outcomes, and prognostic factors in patients with ischemic heart disease who were operated on due to nonocclusive mesenteric ischemia (NOMI).: Material and methods: This research contains all ...

Abstract	Aim: This study aimed to evaluate the surgical procedures, outcomes, and prognostic factors in patients with ischemic heart disease who were operated on due to nonocclusive mesenteric ischemia (NOMI). Material and methods: This research contains all patients diagnosed with congestive heart failure and NOMI between January 2011 to January 2020. The patients who had angiography or CT that showed occlusion of more than 50% in any of the main branches of the mesenteric artery or patients who presented with symptoms in correlation with a total occlusion were excluded from the study. Patients who underwent coronary heart surgery but were not diagnosed with congestive heart failure and those with atrial fibrillation also were excluded from the study. Patients divided into two groups, according to a medical database. Results: A significant difference was found between the surviving and non-survivor groups in minutes, in terms of median time to segmenter intestinal resection (P = 0.042). Conclusion: An early diagnosis and surgical segmental intestinal resection before peritonitis worsens can be the key to better prognosis for NOMI patients.
MeSH term(s)	Humans ; Mesenteric Ischemia/diagnosis ; Mesenteric Ischemia/surgery ; Cardiac Surgical Procedures ; Heart Failure ; Prognosis
Language	English
Publishing date	2022-09-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2069188-9
ISSN	1522-6662 ; 1098-3511
ISSN (online)	1522-6662
ISSN	1098-3511
DOI	10.1532/hsf.4879
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Article: Clinical significance of the largest histopathological metastatic lymph node size for postoperative course of patients undergoing surgery for gastric cancer.

Omeroglu, Sinan / Gulmez, Selcuk / Yazici, Pinar / Demir, Uygar / Guven, Onur / Capkinoglu, Emir / Uzun, Orhan / Senger, Aziz Serkan / Polat, Erdal / Duman, Mustafa

Frontiers in surgery

2023 Volume 10, Page(s) 1105189

Abstract: Aim: The aim of this study was to investigate the effect of the largest metastatic lymph node (MLN) size on postoperative outcomes of patients with stage II-III gastric cancer (GC).: Methods: A total of 163 patients with stage II/III GC who underwent ...

Abstract	Aim: The aim of this study was to investigate the effect of the largest metastatic lymph node (MLN) size on postoperative outcomes of patients with stage II-III gastric cancer (GC). Methods: A total of 163 patients with stage II/III GC who underwent curative surgery were included in this single-center retrospective study. The lymph nodes were counted, each lymph node was analyzed for metastatic involvement by histopathological examination, and the diameter of the largest metastatic lymph node was recorded. The severity of postoperative complications was assessed by Clavien-Dindo classification system. Two groups of 163 patients were defined according to ROC analysis with cut-off value of histopathologically maximum MLN diameter. A comparative analysis of demographic and clinicopathological characteristics of the patients and their postoperative outcomes were performed. Results: The median hospital stay was significantly longer in patients with major complications compared to patients without major complications [18 days (IQR: 13-24) vs. 8 days (IQR: 7-11); ( Conclusions: The largest metastatic lymph node size had a significant association with survival outcomes. Particularly, MLN size over 1.05 cm was associated with worse survival outcomes. However, the largest MLN was not shown to have any effect on major complications. Further prospective and large-scale studies are required to draw more precise conclusions.
Language	English
Publishing date	2023-02-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2023.1105189
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