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Article ; Online: Knock, knock, knocking on Europe

Tunalı, Varol / Özbilgin, Ahmet

Current research in parasitology & vector-borne diseases

2023 Volume 4, Page(s) 100150

Abstract: Leishmaniasis epidemiology is currently undergoing substantial transformations in both Turkey and Europe, signifying potential implications for public health. This review analyzes the evolving patterns within Turkey and their potential ramifications for ... ...

Abstract	Leishmaniasis epidemiology is currently undergoing substantial transformations in both Turkey and Europe, signifying potential implications for public health. This review analyzes the evolving patterns within Turkey and their potential ramifications for Europe. Within Turkey, the dynamics of leishmaniasis are undergoing noteworthy alterations, manifesting in a rise in cutaneous leishmaniasis (CL) cases and the emergence of
Language	English
Publishing date	2023-10-15
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	2667-114X
ISSN (online)	2667-114X
DOI	10.1016/j.crpvbd.2023.100150
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Article: Are Medical Laboratories Ready for the Diagnosis of Parasitic Diseases?

Özbilgin, Ahmet

EJIFCC

2018 Volume 29, Issue 3, Page(s) 171–174

Abstract: Economic instability, destabilisation with armed conflagration, religious and ethnic conflicts are the most important driving factors for migrations towards Europe. Mediterranean countries are important route for refugees who emigrate from the Middle ... ...

Abstract	Economic instability, destabilisation with armed conflagration, religious and ethnic conflicts are the most important driving factors for migrations towards Europe. Mediterranean countries are important route for refugees who emigrate from the Middle East, Africa and Asia. Viral, bacterial, parasitic and fungal diseases carried by these refugees constitute a significant health risk in Mediterranean countries. Parasitic diseases, such as intestinal parasites, pediculosis, scabies, lymphatic filariasis, schistosomiasis, malaria and leishmaniasis, which may reach the Mediterranean region trough migrations, were briefly reviewed and the precautions to be taken were mentioned. It is of utmost importance that laboratories in the Mediterranean countries pay particular attention to parasitic infections, especially by using experienced staff and appropriate diagnostic methods in combating such infections. The diagnosis and screening of all these infections among the refugees can be done by some basic parasitological laboratory methods such as direct methods for stool samples (direct wet smear, concentration methods, permanent stains, special stains), methods for blood samples (thick and thin blood films, blood concentration procedures), direct methods for urogenital specimens, serological methods, molecular methods and rapid diagnosis kits. These methods can be easily learned by laboratory employees. We suggest that migratory related infections study group should be established in Mediterranean countries, which should inform each other by sharing their findings and observations with officials in congresses and symposiums, and should cooperate on this issue and prepare training and workshop programs and health education programs in these countries should be updated about the health and risk factors of refugees.
Language	English
Publishing date	2018-11-07
Publishing country	Italy
Document type	Journal Article
ISSN	1650-3414
ISSN	1650-3414
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Article ; Online: Investigation of Malaria, Leishmaniasis, and Scabies Risk after Earthquakes and Recommendations for Prevention.

Tunalı, Varol / Harman, Mehmet / Özbilgin, Ahmet

Turkiye parazitolojii dergisi

2023 Volume 47, Issue 4, Page(s) 249–255

Abstract: This study examines the risk of malaria, leishmaniasis, and scabies following earthquakes in southeastern Türkiye. The focus is on the impact on the local population and Syrian immigrants. Recommendations for prevention include vector control measures ... ...

Title translation	Depremlerin Ardından Sıtma, Leishmaniasis ve Uyuz Riskinin İncelenmesi ve Korunma Önerileri.
Abstract	This study examines the risk of malaria, leishmaniasis, and scabies following earthquakes in southeastern Türkiye. The focus is on the impact on the local population and Syrian immigrants. Recommendations for prevention include vector control measures such as indoor residual spraying and distribution of insecticidal nets. Surveillance and early detection through rapid diagnostic tests and active case finding are important. Public awareness campaigns and community engagement are crucial for promoting protective measures. Strengthening healthcare infrastructure, providing essential supplies, and capacity building is essential. For leishmaniasis, early detection and treatment, vector control, health education, and community engagement are vital. Scabies outbreaks affect the socioeconomically depressed local population and Syrian immigrants. Early detection, treatment, contact tracing, health education, hygiene promotion, and improved living conditions are necessary. Implementing these interventions and strategies can effectively prevent, control, and manage these diseases. Tailoring approaches to the specific context and needs of affected communities is crucial. By addressing these challenges, we can protect the health and well-being of the affected population.
MeSH term(s)	Animals ; Humans ; Scabies/epidemiology ; Scabies/prevention & control ; Mosquito Control ; Earthquakes ; Mosquito Vectors ; Insecticides ; Malaria/epidemiology ; Malaria/prevention & control ; Leishmaniasis
Chemical Substances	Insecticides
Language	English
Publishing date	2023-12-07
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2651106-X
ISSN	2146-3077 ; 2146-3077
ISSN (online)	2146-3077
ISSN	2146-3077
DOI	10.4274/tpd.galenos.2023.26122
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Article ; Online: Antiprotozoal activity of auranofin on Trypanosoma cruzi, Leishmania tropica and Toxoplasma gondii: in vitro and ex vivo study.

Yıldırım, Ahmet / Özbilgin, Ahmet / Yereli, Kor

Transactions of the Royal Society of Tropical Medicine and Hygiene

2023 Volume 117, Issue 10, Page(s) 733–740

Abstract: Background: Three obligate intracellular protozoan parasite species, which are responsible for significant morbidity and mortality and settle in macrophage cells, affect more than one-half of the world's population, namely, Trypanosoma cruzi, Leishmania ...

Abstract	Background: Three obligate intracellular protozoan parasite species, which are responsible for significant morbidity and mortality and settle in macrophage cells, affect more than one-half of the world's population, namely, Trypanosoma cruzi, Leishmania tropica and Toxoplasma gondii, which are causative agents of Chagas disease, leishmaniasis and toxoplasmosis, respectively. In the current study, it was aimed to investigate the in vitro and ex vivo antiprotozoal activity of auranofin on T. cruzi, L. tropica and T. gondii. Methods: The in vitro drug efficacy (IC50) of auranofin was investigated by haemocytometry and the CellTiter-Glo assay methods and the ex vivo drug efficacy (IC50) by light microscopic examination of Giemsa-stained slides. Also, the cytotoxic activity (CC50) of auranofin was examined by the CellTiter-Glo assay. The selectivity index (SI) was calculated for auranofin. Results: According to IC50, CC50 and SI data, auranofin did not exhibit cytotoxic activity on Vero cells, but exhibited antiprotozoal activity on epimastigotes and intracellular amastigotes of T. cruzi, promastigotes and intracellular amastigotes of L. tropica and intracellular tachyzoites of T. gondii (p<0.05). Conclusions: The detection antiprotozoal activity of auranofin on T. cruzi, L. tropica and T. gondii according to the IC50, CC50 and SI values is considered an important and promising development. This is significant because auranofin may be an effective alternative treatment for Chagas disease, leishmaniasis and toxoplasmosis in the future.
MeSH term(s)	Humans ; Animals ; Chlorocebus aethiops ; Trypanosoma cruzi ; Toxoplasma ; Leishmania tropica ; Auranofin/pharmacology ; Auranofin/therapeutic use ; Vero Cells ; Chagas Disease/parasitology ; Toxoplasmosis ; Leishmaniasis ; Antiprotozoal Agents/pharmacology ; Antiprotozoal Agents/therapeutic use
Chemical Substances	Auranofin (3H04W2810V) ; Antiprotozoal Agents
Language	English
Publishing date	2023-06-28
Publishing country	England
Document type	Journal Article
ZDB-ID	441375-1
ISSN	1878-3503 ; 0035-9203
ISSN (online)	1878-3503
ISSN	0035-9203
DOI	10.1093/trstmh/trad040
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Article: Sıtma Modelinde Cinnamaldehyde, Cannabidiol ve Eravacycline’in Etkinliğinin Araştırılması.

Özel, Yener / Çavuş, İbrahim / Ünlü, Mehmet / Özbilgin, Ahmet

Mikrobiyoloji bulteni

2023 Volume 57, Issue 4, Page(s) 608–624

Abstract: In this study, it was aimed to investigate the antimalarial activity of cinnamaldehyde (CIN) and cannabidiol (CBD) which have shown various biological activities such as potent antimicrobial activity and eravacycline (ERA), a new generation tetracycline ... ...

Title translation	Investigation of the Efficacy of Cinnamaldehyde, Cannabidiol and Eravacycline in a Malaria Model.
Abstract	In this study, it was aimed to investigate the antimalarial activity of cinnamaldehyde (CIN) and cannabidiol (CBD) which have shown various biological activities such as potent antimicrobial activity and eravacycline (ERA), a new generation tetracycline derivative, in an in vivo malaria model. The cytotoxic activities of the active substances were determined by the MTT method against L929 mouse fibroblasts and their antimalarial activity were determined by the four-day test in an in vivo mouse model. In this study, five groups were formed: the CIN group, the CBD group, the ERA group, the chloroquine group (CQ) and the untreated group (TAG). 2.5 x 107 parasites/mL of P.berghei-infected erythrocyte suspension was administered IP to all mice. The determined doses of active substances were given to the mice by oral gavage in accordance with the four-day test and the parasitemia status in the mice was controlled for 21 days with smear preparations made from the blood taken from the tail end of the mice. The IC50 values, which express the cytotoxic activity values of the active substances were determined as 27.55 μg/mL, 16.40 μM and 48.82 μg/mL for CIN, CBD and ERA, respectively. The mean parasitemia rate in untreated mice was 33% on day nine and all mice died on day 11. On the ninth day, when compared with the TAG group, no parasites were observed in the CIN group, while the average parasitemia was 0.08% in the CBD group and 17.8% in the ERA group. Compared to the mice in the TAG group, the life expectancy of the other groups was prolonged by eight days in the CIN group, 12 days in the CBD group and eight days in the ERA group. It has been determined that all three active subtances tested in this study suppressed the development of Plasmodium parasites in an in vivo mouse model and prolonged the life span of the mice. It is thought that the strong antimalarial activity of CIN and CBD shown in the study and the possible positive effect of ERA on the clinical course can be improved by combining them with the existing and potential antimalarial molecules.
MeSH term(s)	Animals ; Mice ; Antimalarials/pharmacology ; Antimalarials/therapeutic use ; Cannabidiol/pharmacology ; Cannabidiol/therapeutic use ; Parasitemia/drug therapy ; Parasitemia/parasitology ; Plasmodium berghei ; Plant Extracts/pharmacology ; Malaria/drug therapy ; Malaria/parasitology ; Tetracycline/pharmacology ; Tetracycline/therapeutic use
Chemical Substances	Antimalarials ; eravacycline (07896928ZC) ; Cannabidiol (19GBJ60SN5) ; cinnamaldehyde (SR60A3XG0F) ; Plant Extracts ; Tetracycline (F8VB5M810T)
Language	Turkish
Publishing date	2023-10-27
Publishing country	Turkey
Document type	English Abstract ; Journal Article
ZDB-ID	985146-x
ISSN	0374-9096
ISSN	0374-9096
DOI	10.5578/mb.20239949
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Article ; Online: An Update on the Imported Cutaneous Leishmaniasis in Europe.

Kurt, Özgür / Özbilgin, Ahmet / Petersen, Eskild / Ergönül, Önder

Infectious diseases & clinical microbiology

2023 Volume 5, Issue 1, Page(s) 59–62

Language	English
Publishing date	2023-03-11
Publishing country	Turkey
Document type	Journal Article
ISSN	2667-646X
ISSN (online)	2667-646X
DOI	10.36519/idcm.2023.202
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Article: Comparative proteomic analysis of Leishmania parasites isolated from visceral and cutaneous leishmaniasis patients

Dinç, Melike / Yalçın, Talat / Çavuş, İbrahim / Özbilgin, Ahmet

Parasitology. 2022 Mar., v. 149, no. 3

2022

Abstract: Leishmaniasis is an infectious disease in which different clinical manifestations are classified into three primary forms: visceral, cutaneous and mucocutaneous. These disease forms are associated with parasite species of the protozoan genus Leishmania. ... ...

Abstract	Leishmaniasis is an infectious disease in which different clinical manifestations are classified into three primary forms: visceral, cutaneous and mucocutaneous. These disease forms are associated with parasite species of the protozoan genus Leishmania. For instance, Leishmania infantum and Leishmania tropica are typically linked with visceral (VL) and cutaneous (CL) leishmaniasis, respectively; however, these two species can also cause other form to a lesser extent. What is more alarming is this characteristic, which threatens current medical diagnosis and treatment, is started to be acquired by other species. Our purpose was to address this issue; therefore, gel-based and gel-free proteomic analyses were carried out on the species L. infantum to determine the proteins differentiating between the parasites caused VL and CL. In addition, L. tropica parasites representing the typical cases for CL were included. According to our results, electrophoresis gels of parasites caused to VL were distinguishable regarding the repetitive down-regulation on some specific locations. In addition, a distinct spot of an antioxidant enzyme, superoxide dismutase, was shown up only on the gels of CL samples regardless of the species. In the gel-free approach, 37 proteins that were verified with a second database search using a different search engine, were recognized from the comparison between VL and CL samples. Among them, 31 proteins for the CL group and six proteins for the VL group were determined differentially abundant. Two proteins from the gel-based analysis, pyruvate kinase and succinyl-coA:3-ketoacid-coenzyme A transferase analysis were encountered in the protein list of the CL group.
Keywords	Leishmania infantum ; Leishmania tropica ; antioxidant enzymes ; cutaneous leishmaniasis ; databases ; electrophoresis ; infectious diseases ; parasites ; parasitology ; proteomics ; pyruvate kinase ; superoxide dismutase
Language	English
Dates of publication	2022-03
Size	p. 298-305.
Publishing place	Cambridge University Press
Document type	Article
ZDB-ID	207627-5
ISSN	1469-8161 ; 0031-1820
ISSN (online)	1469-8161
ISSN	0031-1820
DOI	10.1017/S0031182021001967
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Increasing the Sensitivity of

Nalçacı, Muhammed / Karakuş, Mehmet / Özbel, Yusuf / Özbilgin, Ahmet / Töz, Seray

Turkiye parazitolojii dergisi

2022 Volume 46, Issue 2, Page(s) 86–90

Abstract: Objective: Leishmania: Methods: In this study, LRV2+ three : Results: We observed lower Ct values in amplicons with the modified version than with the classical kit protocol for cDNA synthesis, in all of the strains used in the study. The addition ...

Title translation	Leishmania
Abstract	Objective: Leishmania Methods: In this study, LRV2+ three Results: We observed lower Ct values in amplicons with the modified version than with the classical kit protocol for cDNA synthesis, in all of the strains used in the study. The addition of pre-denaturation step at 95 °C showed lower Ct values meaning the sensitivity increased. Different parasite dilutions showed similar results. Conclusion: It is important to increase the sensitivity especially with the aim for detecting LRV in clinical samples obtained from patients probably have less number of parasites. The presence and burden of the virus can help to understand the relationship between the clinical findings and the pathogenicity of the parasite which may lead to changes in the course of treatment.
MeSH term(s)	DNA Primers ; DNA, Complementary ; Humans ; Leishmania ; Leishmania tropica/genetics ; Leishmaniasis, Cutaneous/parasitology ; Leishmaniavirus/genetics ; RNA Viruses/genetics
Chemical Substances	DNA Primers ; DNA, Complementary
Language	English
Publishing date	2022-05-03
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2651106-X
ISSN	2146-3077 ; 2146-3077
ISSN (online)	2146-3077
ISSN	2146-3077
DOI	10.4274/tpd.galenos.2022.30074
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Article ; Online: Imported Malaria: A

Öncel, Koray / Karaağaç, Leman / Özbilgin, Ahmet

Turkiye parazitolojii dergisi

2021 Volume 45, Issue 3, Page(s) 216–219

Abstract: Malaria is an important public health problem, with about 219 million cases, which account for 435 thousand deaths of children in Africa in 2017. The infection is transmitted by female anopheles mosquito, ... ...

Title translation	İmport Sıtma: Nadir Görülen Kan Evreleri ile Türkiye’de Bir
Abstract	Malaria is an important public health problem, with about 219 million cases, which account for 435 thousand deaths of children in Africa in 2017. The infection is transmitted by female anopheles mosquito, including
MeSH term(s)	Adult ; Female ; Humans ; Malaria ; Malaria, Falciparum/diagnosis ; Malaria, Vivax/diagnosis ; Male ; Plasmodium falciparum ; Turkey
Language	English
Publishing date	2021-08-04
Publishing country	Turkey
Document type	Case Reports ; Journal Article
ZDB-ID	2651106-X
ISSN	2146-3077 ; 2146-3077
ISSN (online)	2146-3077
ISSN	2146-3077
DOI	10.4274/tpd.galenos.2021.7003
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Article ; Online: Growth of

Özel, Yener / Yılmaz, Umut / Ünlü, Gülhan / Özbilgin, Ahmet / Ünlü, Mehmet

Turkiye parazitolojii dergisi

2022 Volume 46, Issue 1, Page(s) 7–13

Abstract: Objective: Trichomonas vaginalis: Methods: In this study, four media, namely, thioglucholate medium (THIO), brain heart infusion medium (BHI), tryptic soy broth medium (TSB), and Brucella broth medium (BRB) were modified and tested. Trypticase-yeast ... ...

Title translation	Rutin Mikrobiyoloji Laboratuvarlarında Bulunan Temel Besiyerlerinde
Abstract	Objective: Trichomonas vaginalis Methods: In this study, four media, namely, thioglucholate medium (THIO), brain heart infusion medium (BHI), tryptic soy broth medium (TSB), and Brucella broth medium (BRB) were modified and tested. Trypticase-yeast extract-maltose (TYM) medium was used as a reference medium. Each medium tested was enriched with three different serum additives. Results: Trichomonas vaginalis grew extremely well on THIO, BHI, and TSB media but not on BRB media. The time and number of parasites peaked were determined as 100×10 Conclusion: The rich content of THIO, TSB, and BHI media, which are widely available in routine microbiology laboratories, may allow
MeSH term(s)	Animals ; Culture Media ; Laboratories ; Trichomonas Vaginitis/diagnosis ; Trichomonas Vaginitis/parasitology ; Trichomonas vaginalis ; Trophozoites
Chemical Substances	Culture Media
Language	English
Publishing date	2022-02-12
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2651106-X
ISSN	2146-3077 ; 2146-3077
ISSN (online)	2146-3077
ISSN	2146-3077
DOI	10.4274/tpd.galenos.2021.29290
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