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  1. Article ; Online: Can Alpha-1 Antitrypsin Levels be Used to Predict the Prognosis of COVID-19 Therapy?

    Aras Atik, Elif / Özdemir, Nesligül / Demirkan, Kutay

    Turkish journal of pharmaceutical sciences

    2021  Volume 17, Issue 6, Page(s) 576–577

    Language English
    Publishing date 2021-01-02
    Publishing country Turkey
    Document type Journal Article
    ISSN 2148-6247
    ISSN (online) 2148-6247
    DOI 10.4274/tjps.galenos.2020.20727
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Factors associated with intention of clinical pharmacists and candidates to provide pharmaceutical care: application of theory planned behaviour.

    Tecen-Yucel, Kamer / Ozdemir, Nesligul / Kara, Emre / Demirkan, Kutay / Sancar, Mesut / Okuyan, Betul

    BMC medical education

    2023  Volume 23, Issue 1, Page(s) 682

    Abstract: Background: Postgraduate education programs in clinical pharmacy have become widespread in Türkiye. This study aimed to identify factors associated with the intention of Turkish clinical pharmacists and candidates (who were graduates and students of ... ...

    Abstract Background: Postgraduate education programs in clinical pharmacy have become widespread in Türkiye. This study aimed to identify factors associated with the intention of Turkish clinical pharmacists and candidates (who were graduates and students of postgraduate clinical pharmacy programs) to provide pharmaceutical care.
    Methods: This prospective observational study was conducted between June 2021 and May 2022. After searching relevant studies, an expert panel discussion, translation, cultural adaptation, and a pilot study developed a 52-item Turkish scale based on the Theory of Planned Behavior (TBP). Cronbach alpha for each construct was calculated after an explanatory factor and test-retest reliability analysis. An online survey link was sent to all graduates or candidates of postgraduate clinical pharmacy programs in Türkiye. After univariate regression analysis, the multiple linear regression model was performed.
    Results: One hundred fifty-six participants completed the survey (response rate: 59.1%). The Cronbach's alpha for attitude (9 items), subjective norm (6 items), perceived behavioural control (5 items), self-efficacy (6 items), intention (11 items) and past behaviour (15 items) were 0.945, 0.720, 0.751, 0.864, 0.934 and 0.955 respectively. The multiple linear regression analysis found a higher score of the subjective norm (p = 0.016), a higher score of self-efficacy (p < 0.001), younger age (p < 0.001) and having PhD (p = 0.038) were associated with increased intention score.
    Conclusions: It was shown that higher self efficacy and positive beliefs of their peers and other healthcare professionals were associated with their higher intention score for providing pharmaceutical care. Younger age and having a PhD were other factors associated with their intention to provide pharmaceutical care.
    MeSH term(s) Humans ; Pharmacists ; Intention ; Pilot Projects ; Reproducibility of Results ; Pharmacy Service, Hospital
    Language English
    Publishing date 2023-09-20
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 2044473-4
    ISSN 1472-6920 ; 1472-6920
    ISSN (online) 1472-6920
    ISSN 1472-6920
    DOI 10.1186/s12909-023-04658-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The effect of the COVID-19 pandemic on routine adult vaccination in cancer patients.

    Ozdemir, Nesligul / Bayraktar-Ekincioglu, Aygin / Kilickap, Saadettin

    Medical oncology (Northwood, London, England)

    2021  Volume 38, Issue 6, Page(s) 62

    MeSH term(s) Adult ; COVID-19/epidemiology ; Cross-Sectional Studies ; Female ; Humans ; Male ; Neoplasms/epidemiology ; Pandemics/prevention & control ; Pneumococcal Vaccines/administration & dosage ; Turkey/epidemiology ; Vaccination/trends
    Chemical Substances Pneumococcal Vaccines
    Language English
    Publishing date 2021-04-23
    Publishing country United States
    Document type Letter
    ZDB-ID 1201189-7
    ISSN 1559-131X ; 0736-0118 ; 1357-0560
    ISSN (online) 1559-131X
    ISSN 0736-0118 ; 1357-0560
    DOI 10.1007/s12032-021-01512-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Evaluation of medication errors in pediatric patients using antibiotics.

    Özdemir, Nesligül / Kara, Emre / Büyükçam, Ayşe / Aykaç, Kübra / Çeliker, Ayçe / Demirkan, Kutay / Kara, Ateş

    The Turkish journal of pediatrics

    2022  Volume 63, Issue 6, Page(s) 970–977

    Abstract: Background: Medication errors are frequently seen in pediatric patients. Medication error studies on pediatric cases were found to not only be limited but also the collaboration of clinical pharmacists and physicians on this topic was not published in ... ...

    Abstract Background: Medication errors are frequently seen in pediatric patients. Medication error studies on pediatric cases were found to not only be limited but also the collaboration of clinical pharmacists and physicians on this topic was not published in Turkey. This study aimed to identify drug-related problems, especially in antibiotics.
    Methods: This study was a point prevalence study with pediatric inpatients that used at least one antibiotic at a pediatric tertiary care reference hospital on November 16, 2016. Medications of patients were evaluated by clinical pharmacists in terms of drug-related problems and by physicians in terms of correct indications.
    Results: Eighty-nine hospitalized patients were using antibiotics at the time of the study. The median age was 42 months (range: 1-226 months), and 49 (55.1%) of the patients were male. Clinical pharmacists detected a total of 210 potential drug-drug interactions in 46 (51.7%) patients. Approximately 48.5% of the patients in pediatric wards and 52.4% of the patients in surgical wards had at least one potential drug-drug interaction. A total of 39 medication errors were identified in 36 patients` drug orders. Most of the errors (51.3%) were due to dosing and administration time errors (35.9%). The number of errors per patient in surgical services was higher (0.47) than the pediatric services (0.42). Forty-three percent of errors were antimicrobial-related, and 70.5% of them were classified as dosing errors.
    Conclusions: Evaluation of patients` drug usage by a clinical pharmacist in terms of drug-related problems such as drug interactions, side effects and prescribing errors leads to better pharmaceutical care.
    MeSH term(s) Adolescent ; Anti-Bacterial Agents/adverse effects ; Child ; Child, Preschool ; Drug-Related Side Effects and Adverse Reactions ; Female ; Humans ; Infant ; Male ; Medication Errors ; Pharmacists ; Pharmacy Service, Hospital
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-01-13
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 123487-0
    ISSN 2791-6421 ; 0041-4301
    ISSN (online) 2791-6421
    ISSN 0041-4301
    DOI 10.24953/turkjped.2021.06.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Can antibiotics affect the clinical features of patients with candidemia? The retrospective evaluation of 5 years of data in an intensive care unit.

    Durmuş, Mefküre / Kalkan, Serkan / Güzel Karahan, Sena / Biçakcioğlu, Murat / Özdemir, Nesligül / Gün, Zeynep Ülkü / Özer, Ayşe Belin

    European journal of hospital pharmacy : science and practice

    2023  

    Abstract: Background: Candidemia is an opportunistic infection of intensive care units (ICUs) and causes morbidity and mortality. Multiple antibiotic exposure was found to be an independent risk factor for mortality and non-albicans candidemia (NAC) in candidemia ...

    Abstract Background: Candidemia is an opportunistic infection of intensive care units (ICUs) and causes morbidity and mortality. Multiple antibiotic exposure was found to be an independent risk factor for mortality and non-albicans candidemia (NAC) in candidemia patients.
    Aim: The aim of this study was to determine the relationship between antibiotics and clinical features of patients with candidemia, and to determine the independent risk factors for hospital stay >50 days, 30-day mortality in hospital, candidemia types, and septic shock in candidemia patients.
    Methods: Patients were evaluated retrospectively for 5 years. A total of 148 candidemia cases were detected and included in the study. Characteristics of cases were defined and recorded. The relationship between qualitative data was determined by the χ
    Results: The incidence of candidemia for 5 years was 4.5%.
    Conclusions: This study concluded that many antibiotics were safe for candidemia patients. However, clinicians should pay attention when prescribing linezolid or piperacillin-tazobactam and flouroquinolons concomitantly or sequentially for patients with candidemia risk factors.
    Language English
    Publishing date 2023-04-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2650179-X
    ISSN 2047-9964 ; 2047-9956
    ISSN (online) 2047-9964
    ISSN 2047-9956
    DOI 10.1136/ejhpharm-2022-003673
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Impact of pharmacist-led educational intervention on pneumococcal vaccination rates in cancer patients: a randomized controlled study.

    Ozdemir, Nesligul / Aktas, Burak Y / Gulmez, Ahmet / Inkaya, Ahmet C / Bayraktar-Ekincioglu, Aygin / Kilickap, Saadettin / Unal, Serhat

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2023  Volume 31, Issue 3, Page(s) 194

    Abstract: Purpose: This study aimed to evaluate clinical pharmacist's contribution to the pneumococcal vaccination rate by providing education to cancer patients in hospital settings.: Methods: This study was conducted in 2 tertiary-care hospitals' medical ... ...

    Abstract Purpose: This study aimed to evaluate clinical pharmacist's contribution to the pneumococcal vaccination rate by providing education to cancer patients in hospital settings.
    Methods: This study was conducted in 2 tertiary-care hospitals' medical oncology outpatient clinics. Patients over 18 years of age and diagnosed with cancer for less than 2 years, in remission stage, and have not previously received the pneumococcal vaccine were included. Patients were randomized to intervention and control groups. The intervention group was provided vaccination education and recommended to receive the PCV13 vaccine. The control group received routine care. Patients' knowledge about pneumonia/pneumococcal vaccine, Vaccine Attitude Examination Scale (VAX) score, and vaccination rates were evaluated at baseline and 3 months after the education.
    Results: A total of 235 patients (intervention: 117, control: 118) were included. The mean age ± SD was 57.86 ± 11.88 years in the control and 60.68 ± 11.18 years in the intervention groups. The numbers of correct answers about pneumonia/pneumococcal vaccine (p = 0.482) and VAX scores (p = 0.244) of the groups were similar at baseline. After the intervention, the median (IQR) number of correct answers in intervention group [10(3)] was higher than control group [8(4)] (p < 0.001). After the education, the total VAX score (mean ± SD) was less in intervention group (33.09 ± 7.018) than the control group (36.07 ± 6.548) (p = 0.007). Three months after the education, 20.2% of the patients in the intervention and 6.1% in the control groups were vaccinated with pneumococcal vaccine (p = 0.003).
    Conclusions: The pneumococcal vaccination rate in cancer patients has increased significantly by the education provided by a clinical pharmacist in hospital settings.
    MeSH term(s) Humans ; Adolescent ; Adult ; Pharmacists ; Research Design ; Vaccination ; Neoplasms ; Pneumococcal Vaccines
    Chemical Substances Pneumococcal Vaccines
    Language English
    Publishing date 2023-03-01
    Publishing country Germany
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-023-07652-3
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  7. Article ; Online: Potential drug-drug interactions with psychotropic drugs in paediatric inpatients: A cross-sectional study.

    Yalçın, Nadir / Özdemir, Nesligül / Çak Esen, Halime Tuna / Çengel Kültür, Sadriye Ebru / Demirkan, Kutay

    International journal of clinical practice

    2021  Volume 75, Issue 6, Page(s) e14107

    Abstract: Aims: Polypharmacy and drug-drug interactions (DDIs) are important problems that necessitate more attention in paediatric inpatients. This study aimed to determine and evaluate DDIs in paediatric inpatients using psychotropic drugs.: Methods: It was ... ...

    Abstract Aims: Polypharmacy and drug-drug interactions (DDIs) are important problems that necessitate more attention in paediatric inpatients. This study aimed to determine and evaluate DDIs in paediatric inpatients using psychotropic drugs.
    Methods: It was conducted as a retrospective cross-sectional study. Inpatients consulted by child and adolescent psychiatrists (CAPs) and had at least one psychotropic drug-using between January 2016 and September 2017 were retrospectively included. To determine the clinical significance of DDIs by Micromedex
    Results: During the study period, 564 patients' records were reviewed and 200 patients were considered eligible and included in the study. The median (min-max) age was 13.70 (1.5-17.83) years. The mean (SD) number of psychotropics used during hospitalisation was 1.29 (0.55) and the total number of drugs was 7.39 (4.45). A total of 336 potential DDIs were detected (2.19 DDIs/patient) in all patients. The most common potential outcome of psychotropic DDIs was drug-induced QTc prolongation (67.56%). While 92.85% of the potential DDIs were "contraindicated" or "major," only 18.46% had a "good" or "excellent" strength of evidence. The risk of psychotropic polypharmacy (OR:0.73, 95% CI 0.59-0.92; p:0.006) and DDIs (OR:0.69, 95% CI 0.35-0.76; p:0.033) was significantly higher in patients without primary psychiatric disorders. When the total number of drugs and the total number of potential DDIs were compared amongst all inpatient units, significant differences were found between paediatric hematology-general paediatrics (mean difference: 2.002; P < .001) and paediatric hematology-paediatric ICU (mean difference: 1.650; P = .012), respectively.
    Conclusion: Psychotropic drug-related DDI is a major problem in the paediatric population and the clinical significance of the potential DDIs' risk should be determined in patient-centred care and managed by the multidisciplinary team.
    MeSH term(s) Adolescent ; Child ; Cross-Sectional Studies ; Drug Interactions ; Humans ; Inpatients ; Pediatrics ; Pharmaceutical Preparations ; Psychotropic Drugs/adverse effects ; Retrospective Studies
    Chemical Substances Pharmaceutical Preparations ; Psychotropic Drugs
    Language English
    Publishing date 2021-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 1386246-7
    ISSN 1742-1241 ; 1368-5031
    ISSN (online) 1742-1241
    ISSN 1368-5031
    DOI 10.1111/ijcp.14107
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  8. Article ; Online: Knowledge, attitudes, and practices regarding vaccination among community pharmacists.

    Ozdemir, Nesligul / Kara, Emre / Bayraktar-Ekincioglu, Aygin / Buyukcam, Ayse / Celiker, Ayce / Demirkan, Kutay / Kara, Ates

    Primary health care research & development

    2022  Volume 23, Page(s) e38

    Abstract: Background: Healthcare professionals' vaccine recommendation is the most effective method to increase vaccination rates of the community. The vaccine counseling and recommendation behavior of pharmacists, who are among the easily accessible healthcare ... ...

    Abstract Background: Healthcare professionals' vaccine recommendation is the most effective method to increase vaccination rates of the community. The vaccine counseling and recommendation behavior of pharmacists, who are among the easily accessible healthcare professionals, are influenced by their knowledge and attitudes about vaccines.
    Aim: It was aimed to investigate community pharmacists' knowledge, attitudes, and practices regarding commonly used vaccines.
    Methods: A cross-sectional study was conducted as an online survey with a sample of 1100 community pharmacists in Turkey. Pharmacists were invited to participate in the study by phone calls. A structured survey, which consists of 40 questions to assess the knowledge, attitudes, and practices regarding vaccines, was sent to the e-mail addresses of pharmacists who volunteered to participate in the study.
    Findings: A total of 430 pharmacists completed the survey. Thirty percent of pharmacists had lack of knowledge about vaccination during pregnancy, whereas 52.2% and 31.4% of pharmacists believed that tetanus and influenza vaccines should be provided during pregnancy, respectively. Nearly 89% of pharmacists recommended vaccines to patients, mainly for influenza vaccine (83.9%). Only 31.5% of pharmacists had been vaccinated against influenza in the last season, whereas 50.5% had never been vaccinated. Pharmacists who had been vaccinated with influenza vaccine had a high rate of recommending influenza vaccines to the patients.
    Conclusion: The present study found that vaccination among pharmacists in Turkey and their knowledge on vaccination during pregnancy were low. Further education of pharmacists to improve their knowledge and attitudes toward vaccines is needed.
    MeSH term(s) Cross-Sectional Studies ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Influenza Vaccines ; Pharmacists/psychology ; Pregnancy ; Surveys and Questionnaires ; Vaccination/psychology
    Chemical Substances Influenza Vaccines
    Language English
    Publishing date 2022-07-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2027892-5
    ISSN 1477-1128 ; 1477-1128
    ISSN (online) 1477-1128
    ISSN 1477-1128
    DOI 10.1017/S1463423622000330
    Database MEDical Literature Analysis and Retrieval System OnLINE

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