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Article: Effect of different voxel sizes on the accuracy of CBCT measurements of trabecular bone microstructure: A comparative micro-CT study.

Tayman, Mahmure Ayşe / Kamburoğlu, Kıvanç / Ocak, Mert / Özen, Doğukan

2022 Volume 52, Issue 2, Page(s) 171–179

Abstract: Purpose: The aim of this study was to assess the accuracy of cone-beam computed tomographic (CBCT) images obtained using different voxel sizes in measuring trabecular bone microstructure in comparison to micro-CT.: Materials and methods: Twelve human ...

Abstract	Purpose: The aim of this study was to assess the accuracy of cone-beam computed tomographic (CBCT) images obtained using different voxel sizes in measuring trabecular bone microstructure in comparison to micro-CT. Materials and methods: Twelve human skull bones containing posterior-mandibular alveolar bone regions were analyzed. CBCT images were obtained at voxel sizes of 0.075 mm (high: HI) and 0.2 mm (standard: Std), while micro-CT imaging used voxel sizes of 0.06 mm (HI) and 0.12 mm (Std). Analyses were performed using CTAn software with the standardized automatic global threshold method. Intraclass correlation coefficients were used to evaluate the consistency and agreement of paired measurements for bone volume (BV), percent bone volume (BV/TV), bone surface (BS), trabecular thickness (TbTh), trabecular separation (TbSp), trabecular number (TbN), trabecular pattern factor (TbPf), and structure model index (SMI). Results: When compared to micro-CT, CBCT images had higher BV, BV/TV, and TbTh values, while micro-CT images had lower BS, TbSp, TbN, TbPf, and SMI values ( Conclusion: This study demonstrated the potential of high-resolution CBCT imaging for quantitative bone morphometry assessment.
Language	English
Publishing date	2022-04-28
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2631801-5
ISSN	2233-7830 ; 2233-7822
ISSN (online)	2233-7830
ISSN	2233-7822
DOI	10.5624/isd.20220025
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Article: A Mixed-Methods Survey of Veterinary Ethics Teaching in Turkey.

Gölcü, Berfin Melikoğlu / Ünsal Adaca, Aytaç / Yerlikaya, Nigar / Özen, Doğukan / Başağaç Gül, R Tamay

Journal of veterinary medical education

2023 , Page(s) e20220077

Abstract: With the growth of interest in veterinary ethics, the teaching of ethics to veterinary students has become more important. This study collects comprehensive data about ethics education at veterinary faculties in Turkey to contribute to the international ... ...

Abstract	With the growth of interest in veterinary ethics, the teaching of ethics to veterinary students has become more important. This study collects comprehensive data about ethics education at veterinary faculties in Turkey to contribute to the international literature. A cross-sectional descriptive survey design is used to collect data via questionnaire. Of the 31 faculty members actively teaching ethics at 24 of the 29 veterinary faculties in Turkey (as of the end of 2021), 30 responded to the survey. By the end of 2021, ethics courses in 24 veterinary faculties in Turkey were conducted between the 7th and 10th semesters with similar content across the examined institutions. Of the 31 faculty members responsible for ethics education, 22 were ethicists. Theoretical lectures and multiple-choice tests were the most preferred methods for teaching and assessment. The most preferred learning outcome to be gained by students was ethical awareness. Integrity by ethicists and morality by faculty members from other departments were considered the most important virtues. The collected qualitative data regarding the strengths of ethics education and areas for improvement were varied and controversial. Ethics training should be an ongoing process throughout veterinary education. Applied ethics education should be comprehensively included in the curricula and carried out with the cooperation of faculty members working in clinical fields.
Language	English
Publishing date	2023-04-04
Publishing country	Canada
Document type	Journal Article
ISSN	0748-321X
ISSN	0748-321X
DOI	10.3138/jvme-2022-0077
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Article: Investigation of Factors Influencing Thoroughbred Horses' Racing Career Length in Turkey

Özen, Doğukan / Kaya, Ufuk / Özen, Hülya / Ambarcioğlu, Pınar / Ünal, Necmettin / Gürcan, İsmayil Safa

Journal of equine veterinary science. 2021 Dec., v. 107

2021

Abstract: The aim of this research was to determine the average length of a Thoroughbred horse's racing career in Turkey using survival functions of Thoroughbred horses with various characteristics. In addition, the aim was to identify risk factors that could ... ...

Abstract	The aim of this research was to determine the average length of a Thoroughbred horse's racing career in Turkey using survival functions of Thoroughbred horses with various characteristics. In addition, the aim was to identify risk factors that could influence the duration of a Thoroughbred horse's racing career and develop a survival model that took these factors into account. A total of 11,721 Thoroughbred horses born in 2007 and later were included in the study population. The horses involved in the study were followed for a minimum of 1 year. Kaplan-Meier analysis was used to calculate the average length of racing career for each factor studied. Extended Cox regression analysis was used to determine the risk factors upon time of career ending and to create a survival model. Results showed that, the mean career length of Thoroughbred horses was 17.79 months (95% CI: 17.41–18.13). Also, "starting age of the race," "number of starts," "type of track where the race started," "racing on a single type racetrack" and "earning status" were found risk factors that affect the length of the racing career. Earnings was the top relative contributor to the established model, and its sole adjusted effect showed that being in the lowest earning group increased the hazard of career ending 2.28 times (95% CI:1.98–2.61) compared to horses with highest earning group. In conclusion, clear differences upon the length of racing career was observed for each investigated factor. Future studies should be considerate of these differences when analyzing population data.
Keywords	Thoroughbred ; horses ; models ; regression analysis ; veterinary medicine
Language	English
Dates of publication	2021-12
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	2102631-2
ISSN	1542-7412 ; 0737-0806
ISSN (online)	1542-7412
ISSN	0737-0806
DOI	10.1016/j.jevs.2021.103782
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Article: Investigation of Factors Influencing Thoroughbred Horses' Racing Career Length in Turkey.

Özen, Doğukan / Kaya, Ufuk / Özen, Hülya / Ambarcioğlu, Pınar / Ünal, Necmettin / Gürcan, İsmayil Safa

Journal of equine veterinary science

2021 Volume 107, Page(s) 103782

Abstract	The aim of this research was to determine the average length of a Thoroughbred horse's racing career in Turkey using survival functions of Thoroughbred horses with various characteristics. In addition, the aim was to identify risk factors that could influence the duration of a Thoroughbred horse's racing career and develop a survival model that took these factors into account. A total of 11,721 Thoroughbred horses born in 2007 and later were included in the study population. The horses involved in the study were followed for a minimum of 1 year. Kaplan-Meier analysis was used to calculate the average length of racing career for each factor studied. Extended Cox regression analysis was used to determine the risk factors upon time of career ending and to create a survival model. Results showed that, the mean career length of Thoroughbred horses was 17.79 months (95% CI: 17.41-18.13). Also, "starting age of the race," "number of starts," "type of track where the race started," "racing on a single type racetrack" and "earning status" were found risk factors that affect the length of the racing career. Earnings was the top relative contributor to the established model, and its sole adjusted effect showed that being in the lowest earning group increased the hazard of career ending 2.28 times (95% CI:1.98-2.61) compared to horses with highest earning group. In conclusion, clear differences upon the length of racing career was observed for each investigated factor. Future studies should be considerate of these differences when analyzing population data.
MeSH term(s)	Animals ; Horses ; Kaplan-Meier Estimate ; Physical Conditioning, Animal ; Running ; Turkey
Language	English
Publishing date	2021-10-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2102631-2
ISSN	1542-7412 ; 0737-0806
ISSN (online)	1542-7412
ISSN	0737-0806
DOI	10.1016/j.jevs.2021.103782
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Article: An ex vivo comparative study of occlusal and proximal caries using terahertz and X-ray imaging.

Kamburoğlu, Kıvanç / Karagöz, Burcu / Altan, Hakan / Özen, Doĝukan

Dento maxillo facial radiology

2018 Volume 48, Issue 2, Page(s) 20180250

Abstract: Objectives:: To examine the effectiveness of terahertz (THz) pulsed imaging (TPI) in comparison to intraoral photostimulable phosphor late (PSP) and cone beam CT (CBCT) for the detection of dental caries ex vivo.: Methods:: Newly extracted 32 human ... ...

Abstract	Objectives:: To examine the effectiveness of terahertz (THz) pulsed imaging (TPI) in comparison to intraoral photostimulable phosphor late (PSP) and cone beam CT (CBCT) for the detection of dental caries ex vivo. Methods:: Newly extracted 32 human permanent teeth surfaces (16 with caries and 16 without caries) were serially sectioned mesiodistally and imaged by using four image sets as follows: (1) CBCT; (2) PSP; (3) THz movie video; and (4) THz static images. All images were evaluated twice separately by two calibrated observers for the presence/absence of caries using a 5-grade rating/confidence scale. Weighted κ coefficients were calculated. Different image sets were compared with the histological gold-standard using the receiver operating characteristic and area under curves for each image set were compared using χ Results:: Intra- and interobserverκ-values for all image sets were almost excellent ranging between 0.777 and 0.988. Mean Az values of observers and readings were 0.898 for CBCT, 0.888 for PSP images, 0.853 for THz static images and 0.781 for THz video movie. No statistically significant differences (p > 0.05) were found between Az values for the different image sets. When observer scores were evaluated according to caries location again no statistically significant differences (p > 0.05) were found between Az values for the occlusal and proximal caries for the four image sets. Conclusions:: Terahertz pulsed imaging was found to be successful for the detection of dental caries ex vivo.
MeSH term(s)	Dental Caries/diagnostic imaging ; Humans ; Observer Variation ; ROC Curve ; Radiography, Dental, Digital ; X-Rays
Language	English
Publishing date	2018-11-07
Publishing country	England
Document type	Journal Article
ZDB-ID	221323-0
ISSN	1476-542X ; 0250-832X ; 0349-490X
ISSN (online)	1476-542X
ISSN	0250-832X ; 0349-490X
DOI	10.1259/dmfr.20180250
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Article: In vitro comparison of high-definition US, CBCT and periapical radiography in the diagnosis of proximal and recurrent caries.

Şeker, Oya / Kamburoğlu, Kıvanç / Şahin, Cihan / Eratam, Nejlan / Çakmak, Esra Ece / Sönmez, Gül / Özen, Doğukan

Dento maxillo facial radiology

2021 Volume 50, Issue 8, Page(s) 20210026

Abstract: Objective: To assess the : Methods: A total of 240 molar teeth were divided into eight groups each comprised of 30 teeth. Control groups consisted of teeth without caries (Group 1-4; : Results: Intraobserver agreement for both readings for the ... ...

Abstract	Objective: To assess the Methods: A total of 240 molar teeth were divided into eight groups each comprised of 30 teeth. Control groups consisted of teeth without caries (Group 1-4; Results: Intraobserver agreement for both readings for the four observers ranged between 0.848 and 0.988 for CBCT (0.075 mm) images; 0.658 and 0.952 for CBCT (0.2 mm) images; 0.555 and 0.810 for periapical images; 0.427 and 0.676 for US images. Highest AUC values were found for CBCT (0.075 mm) images and lowest for US images. Statistically significant differences were found among CBCT (0.075 mm) images and US images ( Conclusion: Periapical and CBCT images outperformed HD US imaging in the detection of proximal dental caries.
MeSH term(s)	Cone-Beam Computed Tomography ; Dental Caries/diagnostic imaging ; Dental Caries Susceptibility ; Humans ; Observer Variation ; Radiography ; Radiography, Dental, Digital ; Spiral Cone-Beam Computed Tomography
Language	English
Publishing date	2021-05-12
Publishing country	England
Document type	Journal Article
ZDB-ID	221323-0
ISSN	1476-542X ; 0250-832X ; 0349-490X
ISSN (online)	1476-542X
ISSN	0250-832X ; 0349-490X
DOI	10.1259/dmfr.20210026
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Article ; Online: Immunohistochemical and qPCR determination of the expression and serum level of anti-Müllerian hormone in pre-pubertal, intact and ovarian remnant syndrome detected bitches.

Karakas Alkan, Kubra / Ceylan, Ahmet / Alkan, Hasan / Ozen, Dogukan / Bayraktaroglu, Alev Gurol / Kaymaz, Mustafa

Reproduction in domestic animals = Zuchthygiene

2019 Volume 54, Issue 7, Page(s) 979–986

Abstract: The aim of this study was to determine the serum concentrations, ovarian presence and expression of anti-Müllerian hormone (AMH) in pre-pubertal, bitches with signs of ovarian remnant syndrome (ORS) and intact bitches. In addition, we aimed to verify the ...

Abstract	The aim of this study was to determine the serum concentrations, ovarian presence and expression of anti-Müllerian hormone (AMH) in pre-pubertal, bitches with signs of ovarian remnant syndrome (ORS) and intact bitches. In addition, we aimed to verify the suitability of serum AMH concentrations for diagnostic purposes in sterilized bitches and/or in suspected cases of ORS in the field of veterinary medicine. For this purpose, 36 healthy female dogs divided into six groups: proestrus, oestrus, dioestrus, anoestrus, pre-pubertal and ORS. Serum AMH concentrations were determined by electrochemiluminescence immunoassay, and ovarian presence and distribution of AMH was confirmed by immunohistochemical and qPCR techniques. According to the results of qPCR, while the expression values of AMH were at the highest concentrations in the proestrus and oestrus, there was a statistically significant decrease in these values at the later stages of the cycle (p < 0.05). According to hormone analysis, the serum AMH values of the ORS group had decreased significantly compared with the proestrus and oestrus (p < 0.05). Although serum AMH levels of ORS group were increased compared with anestrus and pre-pubertal groups, this increase was statistically non-significant (p > 0.05). Immunohistochemically, AMH expression was first observed in the granulosa cells of primordial follicles in folliculogenesis. Expression values were the highest in the proestrous and oestrus groups, but values from bitches in later stages of the cycle were statistically significant decrease in comparison with these groups (p < 0.05). As a result, AMH concentration and expression were found to be higher in proestrus and oestrus than in other periods (p < 0.05). In addition, the measurable level of AMH concentration in bitches with ORS is an indication that it can be used in the diagnosis of ORS.
MeSH term(s)	Animals ; Anti-Mullerian Hormone/blood ; Anti-Mullerian Hormone/genetics ; Anti-Mullerian Hormone/metabolism ; Dog Diseases/blood ; Dog Diseases/diagnosis ; Dogs ; Estrous Cycle/genetics ; Estrous Cycle/metabolism ; Female ; Immunohistochemistry/veterinary ; Ovarian Diseases/blood ; Ovarian Diseases/diagnosis ; Ovarian Diseases/veterinary ; Ovary/metabolism
Chemical Substances	Anti-Mullerian Hormone (80497-65-0)
Language	English
Publishing date	2019-05-18
Publishing country	Germany
Document type	Comparative Study ; Journal Article
ZDB-ID	1015187-4
ISSN	1439-0531 ; 0936-6768
ISSN (online)	1439-0531
ISSN	0936-6768
DOI	10.1111/rda.13451
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Article ; Online: Effect of trabeculectomy and Ahmed glaucoma valve implantation surgery on corneal biomechanical changes.

Kaderli, Ahmet / Demirok, Gülizar / Tamer Kaderli, Sema / Öktem, Çağlar / Karnaz, Ali / Özen, Doğukan / Ekşioğlu, Ümit

International ophthalmology

2020 Volume 40, Issue 8, Page(s) 1941–1947

Abstract: Purpose: To evaluate alterations in corneal biomechanical properties before and 6 months after conventional trabeculectomy (TRAB) and Ahmed glaucoma valve (AGV) implantation.: Methods: Thirty-nine eyes of 39 patients were evaluated retrospectively. ... ...

Abstract	Purpose: To evaluate alterations in corneal biomechanical properties before and 6 months after conventional trabeculectomy (TRAB) and Ahmed glaucoma valve (AGV) implantation. Methods: Thirty-nine eyes of 39 patients were evaluated retrospectively. Complete ophthalmological examinations including evaluation of corneal biomechanical properties using the Ocular Response Analyzer were performed before and after 6 months postoperatively. A mean of four measurements for corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann correlated intraocular pressure (IOPg), and corneal compensated intraocular pressure (IOPcc) was recorded. The participants had undergone trabeculectomy or shunt surgery as the first surgical procedure for glaucoma treatment of uncontrolled IOP with maximum antiglaucoma eyedrops. Results: There were 20 eyes of 20 patients in trabeculectomy group and 19 eyes of 19 patients in AGV implantation group. There was no significant difference between two groups in terms of sex, age, eye laterality, lens status, antiglaucoma drug usage, preoperatively measured Mean Deviation of Humphrey Visual Field Analyzer, CH, CRF, IOPcc, and IOPg (p > 0.05). CH and CRF increased significantly after shunt surgery (p < 0.001). CH increased in trabeculectomy group postoperatively (p < 0.001); however, CRF showed a small amount of decrease, but this reduction was not statistically significant (p > 0.05). CH and CRF showed higher increase after AGV surgery than trabeculectomy surgery (p < 0.05). There was no significant correlation between IOP changes and CH-CRF changes in both TRAB and AGV groups (p > 0.05). Conclusion: According to our results, surgical technique differences may have an impact on postoperative corneal biomechanical outcomes. AGV surgery offers better corneal biomechanical results than standard trabeculectomy in 6-month follow-up.
MeSH term(s)	Biomechanical Phenomena ; Cornea/surgery ; Glaucoma/surgery ; Humans ; Intraocular Pressure ; Retrospective Studies ; Tonometry, Ocular ; Trabeculectomy
Language	English
Publishing date	2020-04-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	800087-6
ISSN	1573-2630 ; 0165-5701
ISSN (online)	1573-2630
ISSN	0165-5701
DOI	10.1007/s10792-020-01367-8
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Article: Immunohistochemical and qPCR determination of the expression and serum level of anti‐Müllerian hormone in pre‐pubertal, intact and ovarian remnant syndrome detected bitches

Karakas Alkan, Kubra / Ceylan, Ahmet / Alkan, Hasan / Ozen, Dogukan / Bayraktaroglu, Alev Gurol / Kaymaz, Mustafa

Reproduction in domestic animals. 2019 July, v. 54, no. 7

2019

Abstract: The aim of this study was to determine the serum concentrations, ovarian presence and expression of anti‐Müllerian hormone (AMH) in pre‐pubertal, bitches with signs of ovarian remnant syndrome (ORS) and intact bitches. In addition, we aimed to verify the ...

Abstract	The aim of this study was to determine the serum concentrations, ovarian presence and expression of anti‐Müllerian hormone (AMH) in pre‐pubertal, bitches with signs of ovarian remnant syndrome (ORS) and intact bitches. In addition, we aimed to verify the suitability of serum AMH concentrations for diagnostic purposes in sterilized bitches and/or in suspected cases of ORS in the field of veterinary medicine. For this purpose, 36 healthy female dogs divided into six groups: proestrus, oestrus, dioestrus, anoestrus, pre‐pubertal and ORS. Serum AMH concentrations were determined by electrochemiluminescence immunoassay, and ovarian presence and distribution of AMH was confirmed by immunohistochemical and qPCR techniques. According to the results of qPCR, while the expression values of AMH were at the highest concentrations in the proestrus and oestrus, there was a statistically significant decrease in these values at the later stages of the cycle (p < 0.05). According to hormone analysis, the serum AMH values of the ORS group had decreased significantly compared with the proestrus and oestrus (p < 0.05). Although serum AMH levels of ORS group were increased compared with anestrus and pre‐pubertal groups, this increase was statistically non‐significant (p > 0.05). Immunohistochemically, AMH expression was first observed in the granulosa cells of primordial follicles in folliculogenesis. Expression values were the highest in the proestrous and oestrus groups, but values from bitches in later stages of the cycle were statistically significant decrease in comparison with these groups (p < 0.05). As a result, AMH concentration and expression were found to be higher in proestrus and oestrus than in other periods (p < 0.05). In addition, the measurable level of AMH concentration in bitches with ORS is an indication that it can be used in the diagnosis of ORS.
Keywords	anestrus ; anti-Mullerian hormone ; bitches ; blood serum ; diestrus ; electrochemiluminescence ; estrus ; follicular development ; granulosa cells ; immunoassays ; immunohistochemistry ; proestrus ; puberty ; quantitative polymerase chain reaction ; veterinary medicine
Language	English
Dates of publication	2019-07
Size	p. 979-986.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	1015187-4
ISSN	1439-0531 ; 0936-6768
ISSN (online)	1439-0531
ISSN	0936-6768
DOI	10.1111/rda.13451
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Article ; Online: Intratumoral recombinant human interferon alpha-2a and vincristine combination therapy in canine transmissible venereal tumour.

Kanca, Halit / Tez, Gizem / Bal, Kazim / Ozen, Dogukan / Alcigir, Eray / Atalay Vural, Sevil

Veterinary medicine and science

2018 Volume 4, Issue 4, Page(s) 364–372

Abstract: Canine transmissible venereal tumour (CTVT) is a naturally occurring contagious neoplasm of dogs located mainly on the external genitalia of both sexes. The course of vincristine chemotherapy, the most effective and practical therapy, is affected by the ... ...

Abstract	Canine transmissible venereal tumour (CTVT) is a naturally occurring contagious neoplasm of dogs located mainly on the external genitalia of both sexes. The course of vincristine chemotherapy, the most effective and practical therapy, is affected by the immune status of the host. The aim was to investigate recombinant human interferon alpha-2a (rhIFNα-2a) and vincristine for treatment of CTVT. A total of 21 female dogs were included. In group I (n = 9), vincristine (0.025 mg/kg, IV) was administered weekly. In group II (n = 6), dogs were injected intratumorally weekly with 1.5 million IU rhIFNα-2a. In group III (n = 6), rhIFNα-2a and vincristine were combined. No tumour regression was observed after three injections of rhIFNα-2a in group II and weekly vincristine was administered. The number of tumour infiltrating lymphocytes (TILs), mitotic figures and apoptotic cells were counted in subsequent incisional tumour biopsies. The Kaplan-Meier Method was used to analyse survival using complete tumour regression as the outcome and Breslow Test was used for comparison of survival curves. Differences in TILs, cell proliferation and apoptosis between groups were assessed by analysis of covariance. Complete regression was observed in all animals included. Mean duration of vincristine treatment for complete regression was shorter in group II (3.50 weeks, 95% CI, 3.06-3.94, P < 0.05) and group III (3.17 weeks, 95% CI, 2.84-3.49, P < 0.01) compared to group I (5.11 weeks, 95% CI, 4.42-5.80). Vincristine and rhIFNα-2a combination increased TILs in CTVT biopsies compared to vincristine treatment (P = 0.017) and vincristine treatment after rhIFNα-2a (P = 0.049). Vincristine treatment after rhIFNα-2a (Group II; P < 0.001) and rhIFNα-2a and vincristine combination (Group III; P < 0.001) decreased apoptosis. The results indicate that intratumoral rhIFNα-2a treatment alone is not effective in CTVT. However, combination of rhIFNα-2a and vincristine shortens the duration of treatment compared to vincristine therapy.
MeSH term(s)	Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/therapeutic use ; Dog Diseases/drug therapy ; Dogs ; Drug Therapy, Combination ; Female ; Interferon alpha-2/administration & dosage ; Interferon alpha-2/therapeutic use ; Venereal Tumors, Veterinary/drug therapy ; Vincristine/administration & dosage ; Vincristine/therapeutic use
Chemical Substances	Antineoplastic Agents ; Interferon alpha-2 ; Vincristine (5J49Q6B70F)
Language	English
Publishing date	2018-08-17
Publishing country	England
Document type	Clinical Trial, Veterinary ; Journal Article
ZDB-ID	2819409-3
ISSN	2053-1095 ; 2053-1095
ISSN (online)	2053-1095
ISSN	2053-1095
DOI	10.1002/vms3.119
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