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  1. AU="Özil, Musa"
  2. AU="Franci, Lorenzo"
  3. AU="Khoobdel, Mehdi"
  4. AU="Ian B Wilkinson"
  5. AU="Sarpün, I.H."
  6. AU="Gums, Jeremiah J"
  7. AU="Petsalaki, Eleni"
  8. AU="Yu, Weichao"
  9. AU="Mertens, Anne Wiebke"
  10. AU="Roitershtein, Alexander"
  11. AU="Deppen, Stephen"
  12. AU="Goliath, Rene"
  13. AU="Emons, Günter"
  14. AU="Sarah S. Barnett"

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  1. Artikel ; Online: Efficient, rapid, and high-yield synthesis of aryl Schiff base derivatives and their in vitro and in silico inhibition studies of hCA I, hCA II, AChE, and BuChE.

    Özil, Musa / Balaydın, Halis T / Dogan, Berna / Şentürk, Murat / Durdagi, Serdar

    Archiv der Pharmazie

    2024  , Seite(n) e2300266

    Abstract: This study reports a rapid and efficient synthesis of four novel aryl Schiff base derivatives. Biological activity and molecular modeling studies were conducted to evaluate the inhibitory effects of these compounds on human carbonic anhydrases (hCA) and ... ...

    Abstract This study reports a rapid and efficient synthesis of four novel aryl Schiff base derivatives. Biological activity and molecular modeling studies were conducted to evaluate the inhibitory effects of these compounds on human carbonic anhydrases (hCA) and cholinesterases. The results indicate that the triazole-ring-containing compounds have strong inhibitory effects on hCA I, hCA II, acetylcholinesterase (AChE), and butyrylcholinesterase (BuChE) targets. Besides comparing the Schiff bases synthesized in our study to reference molecules, we conducted in silico investigations to examine how these compounds interact with their targets. Our studies revealed that these compounds can occupy binding sites and establish interactions with crucial residues, thus inhibiting the functions of the targets. These findings have significant implications as they can be utilized to develop more potent compounds for treating the diseases that these target proteins play crucial roles in or to obtain drug precursors with enhanced efficacy.
    Sprache Englisch
    Erscheinungsdatum 2024-04-09
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 6381-2
    ISSN 1521-4184 ; 0365-6233 ; 1437-1014
    ISSN (online) 1521-4184
    ISSN 0365-6233 ; 1437-1014
    DOI 10.1002/ardp.202300266
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  2. Artikel ; Online: Indenoquinoxaline-phenylacrylohydrazide hybrids as promising drug candidates for the treatment of type 2 diabetes: In vitro and in silico evaluation of enzyme inhibition and antioxidant activity.

    Hameed, Shehryar / Saleem, Faiza / Özil, Musa / Baltaş, Nimet / Salar, Uzma / Ashraf, Sajda / Ul-Haq, Zaheer / Taha, Muhammad / Khan, Khalid Mohammed

    International journal of biological macromolecules

    2024  Band 263, Heft Pt 2, Seite(n) 129517

    Abstract: Existing drugs that are being used to treat type-2 diabetes mellitus are associated with several side effects; thus, exploring potential drug candidates is still an utter need these days. Hybrids of indenoquinoxaline and hydrazide have never been ... ...

    Abstract Existing drugs that are being used to treat type-2 diabetes mellitus are associated with several side effects; thus, exploring potential drug candidates is still an utter need these days. Hybrids of indenoquinoxaline and hydrazide have never been explored as antidiabetic agents. In this study, a series of new indenoquinoxaline-phenylacrylohydrazide hybrids (1-30) were synthesized, structurally characterized, and evaluated for α-amylase and α-glucosidase inhibitory activities, as well as for their antioxidant properties. All scaffolds exhibited varying degrees of inhibitory activity against both enzymes, with IC
    Mesh-Begriff(e) Humans ; Diabetes Mellitus, Type 2/drug therapy ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; alpha-Glucosidases/metabolism ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Glycoside Hydrolase Inhibitors/pharmacology ; Glycoside Hydrolase Inhibitors/therapeutic use ; alpha-Amylases/metabolism ; Molecular Docking Simulation ; Structure-Activity Relationship
    Chemische Substanzen Antioxidants ; alpha-Glucosidases (EC 3.2.1.20) ; Hypoglycemic Agents ; Glycoside Hydrolase Inhibitors ; alpha-Amylases (EC 3.2.1.1)
    Sprache Englisch
    Erscheinungsdatum 2024-01-22
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.129517
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  3. Artikel ; Online: Developing a scaffold for urease inhibition based on benzothiazoles: Synthesis, docking analysis, and therapeutic potential.

    Özil, Musa / Tuzcuoğlu, Özge / Emirik, Mustafa / Baltaş, Nimet

    Archiv der Pharmazie

    2021  Band 354, Heft 12, Seite(n) e2100200

    Abstract: The synthesis, in silico molecular docking, and in vitro urease inhibition studies of a novel series of benzothiazole derivatives are reported. The title compounds in the two series, namely, 2-({5-[(benzothiazol-2-ylthio)methyl]-1,3,4-oxadiazol-2-yl}thio) ...

    Abstract The synthesis, in silico molecular docking, and in vitro urease inhibition studies of a novel series of benzothiazole derivatives are reported. The title compounds in the two series, namely, 2-({5-[(benzothiazol-2-ylthio)methyl]-1,3,4-oxadiazol-2-yl}thio)-1-(4-substituted-phenyl)ethan-1-one and 2-(benzothiazol-2-ylthio)-1-(4-substituted-phenyl)ethan-1-one oxime, were synthesized by the reaction of benzo[d]thiazole-2-thiol with different kinds of intermediates in several steps using both conventional and microwave techniques. All compounds were found to have an excellent degree of urease-inhibitory potential ranging between 16.16 ± 0.54 and 105.32 ± 2.10 µM when compared with the standard inhibitor acetohydroxamic acid with IC
    Mesh-Begriff(e) Benzothiazoles/chemical synthesis ; Benzothiazoles/chemistry ; Benzothiazoles/pharmacology ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Hydroxamic Acids/pharmacology ; Inhibitory Concentration 50 ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Structure-Activity Relationship ; Urease/antagonists & inhibitors
    Chemische Substanzen Benzothiazoles ; Enzyme Inhibitors ; Hydroxamic Acids ; acetohydroxamic acid (4RZ82L2GY5) ; Urease (EC 3.5.1.5)
    Sprache Englisch
    Erscheinungsdatum 2021-09-21
    Erscheinungsland Germany
    Dokumenttyp Comparative Study ; Journal Article
    ZDB-ID 6381-2
    ISSN 1521-4184 ; 0365-6233 ; 1437-1014
    ISSN (online) 1521-4184
    ISSN 0365-6233 ; 1437-1014
    DOI 10.1002/ardp.202100200
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  4. Artikel ; Online: Synthesis of 5-methyl-2,4-dihydro-3H-1,2,4-triazole-3-one's aryl Schiff base derivatives and investigation of carbonic anhydrase and cholinesterase (AChE, BuChE) inhibitory properties.

    Özil, Musa / Balaydın, Halis Türker / Şentürk, Murat

    Bioorganic chemistry

    2019  Band 86, Seite(n) 705–713

    Abstract: Carbonic anhydrase enzymes (EC 4.2.1.1, CAs) are metalloenzyme families that catalyze the rapid conversion of ... ...

    Abstract Carbonic anhydrase enzymes (EC 4.2.1.1, CAs) are metalloenzyme families that catalyze the rapid conversion of H
    Mesh-Begriff(e) Acetylcholinesterase/metabolism ; Animals ; Butyrylcholinesterase/metabolism ; Carbonic Anhydrase Inhibitors/chemical synthesis ; Carbonic Anhydrase Inhibitors/chemistry ; Carbonic Anhydrase Inhibitors/pharmacology ; Carbonic Anhydrases/metabolism ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemistry ; Cholinesterase Inhibitors/pharmacology ; Dose-Response Relationship, Drug ; Electrophorus ; Horses ; Humans ; Isoenzymes/antagonists & inhibitors ; Isoenzymes/metabolism ; Microwaves ; Molecular Structure ; Schiff Bases/chemical synthesis ; Schiff Bases/chemistry ; Schiff Bases/pharmacology ; Structure-Activity Relationship ; Triazoles/chemical synthesis ; Triazoles/chemistry ; Triazoles/pharmacology
    Chemische Substanzen 5-methyl-2,4-dihydro-3H-1,2,4-triazole-3-one ; Carbonic Anhydrase Inhibitors ; Cholinesterase Inhibitors ; Isoenzymes ; Schiff Bases ; Triazoles ; Acetylcholinesterase (EC 3.1.1.7) ; Butyrylcholinesterase (EC 3.1.1.8) ; Carbonic Anhydrases (EC 4.2.1.1)
    Sprache Englisch
    Erscheinungsdatum 2019-02-22
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120080-x
    ISSN 1090-2120 ; 0045-2068
    ISSN (online) 1090-2120
    ISSN 0045-2068
    DOI 10.1016/j.bioorg.2019.02.045
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  5. Artikel ; Online: Synthesis and glutathione reductase inhibitory properties of 5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one's aryl Schiff base derivatives.

    Balaydın, Halis Türker / Özil, Musa / Şentürk, Murat

    Archiv der Pharmazie

    2018  , Seite(n) e1800086

    Abstract: Glutathione reductase (GR) is responsible for the existence of the reduced glutathione (GSH) molecule, a crucial antioxidant against oxidative stress reagents. The antimalarial activities of some redox active compounds are attributed to their inhibition ... ...

    Abstract Glutathione reductase (GR) is responsible for the existence of the reduced glutathione (GSH) molecule, a crucial antioxidant against oxidative stress reagents. The antimalarial activities of some redox active compounds are attributed to their inhibition of antioxidant flavoenzyme GR, and inhibitors are therefore expected to be useful for the treatment of malaria. In this work, a fast and effective synthesis and the GR inhibitory properties of 5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one's aryl Schiff base derivatives are reported. For this aim, the triazol nucleus was obtained, which was substituted with identical groups: ester, hydrazide, and Schiff base system at the N-2 and N-4 nitrogen atoms. The majority of the reactions were carried out by utilizing both microwave and conventional methods in order to compare their yields and reaction times. Beside this, the occuring E/Z geometrical isomers from the CN double bond and the cis/trans amide conformers at the CONH single bond were studied. In the biological activity section of this work, it was found that all synthesized compounds have better inhibitory activity than N,N-bis(2-chloroethyl)-N-nitrosourea against GR; especially, two molecules, 6e and 6f, are the best among them. The evidence indicates that these Schiff base derivatives, with triazole ring, are strong GR inhibitors and novel antimalaria candidates.
    Sprache Englisch
    Erscheinungsdatum 2018-06-08
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 6381-2
    ISSN 1521-4184 ; 0365-6233 ; 1437-1014
    ISSN (online) 1521-4184
    ISSN 0365-6233 ; 1437-1014
    DOI 10.1002/ardp.201800086
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  6. Artikel ; Online: Hydrazinyl thiazole linked indenoquinoxaline hybrids: Potential leads to treat hyperglycemia and oxidative stress; Multistep synthesis, α-amylase, α-glucosidase inhibitory and antioxidant activities.

    Hameed, Shehryar / Khan, Khalid Mohammed / Salar, Uzma / Özil, Musa / Baltaş, Nimet / Saleem, Faiza / Qureshi, Urooj / Taha, Muhammad / Ul-Haq, Zaheer

    International journal of biological macromolecules

    2022  Band 221, Seite(n) 1294–1312

    Abstract: A library of hydrazinyl thiazole-linked indenoquinoxaline hybrids 1-36 were synthesized via a multistep reaction scheme. All synthesized compounds were characterized by various spectroscopic techniques including EI-MS (electron ionization mass ... ...

    Abstract A library of hydrazinyl thiazole-linked indenoquinoxaline hybrids 1-36 were synthesized via a multistep reaction scheme. All synthesized compounds were characterized by various spectroscopic techniques including EI-MS (electron ionization mass spectrometry) and
    Mesh-Begriff(e) Humans ; alpha-Glucosidases/metabolism ; alpha-Amylases/chemistry ; Antioxidants/pharmacology ; Antioxidants/metabolism ; Molecular Docking Simulation ; Thiazoles/chemistry ; Kinetics ; Hyperglycemia ; Oxidative Stress ; Glycoside Hydrolase Inhibitors/pharmacology ; Glycoside Hydrolase Inhibitors/chemistry ; Structure-Activity Relationship
    Chemische Substanzen alpha-Glucosidases (EC 3.2.1.20) ; alpha-Amylases (EC 3.2.1.1) ; Antioxidants ; Thiazoles ; Glycoside Hydrolase Inhibitors
    Sprache Englisch
    Erscheinungsdatum 2022-09-13
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2022.09.102
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  7. Artikel: Hydrazinyl thiazole linked indenoquinoxaline hybrids: Potential leads to treat hyperglycemia and oxidative stress; Multistep synthesis, α-amylase, α-glucosidase inhibitory and antioxidant activities

    Hameed, Shehryar / Khan, Khalid Mohammed / Salar, Uzma / Özil, Musa / Baltaş, Nimet / Saleem, Faiza / Qureshi, Urooj / Taha, Muhammad / Ul-Haq, Zaheer

    International journal of biological macromolecules. 2022 Nov. 30, v. 221

    2022  

    Abstract: A library of hydrazinyl thiazole-linked indenoquinoxaline hybrids 1–36 were synthesized via a multistep reaction scheme. All synthesized compounds were characterized by various spectroscopic techniques including EI-MS (electron ionization mass ... ...

    Abstract A library of hydrazinyl thiazole-linked indenoquinoxaline hybrids 1–36 were synthesized via a multistep reaction scheme. All synthesized compounds were characterized by various spectroscopic techniques including EI-MS (electron ionization mass spectrometry) and ¹H NMR (nuclear magnetic resonance spectroscopy). Compounds 1–36 were evaluated for their inhibitory potential against α-amylase, and α-glucosidase enzymes. Among thirty-six, compounds 2, 9, 10, 13, 15, 17, 21, 22, 31, and 36 showed excellent inhibition against α-amylase (IC₅₀ = 0.3–76.6 μM) and α-glucosidase (IC₅₀ = 1.1–92.2 μM). Results were compared to the standard acarbose (IC₅₀ = 13.5 ± 0.2 μM). All compounds were also evaluated for their DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity and compounds 2, 9, 10, 17, 21, 31, and 36 showed (SC₅₀ = 7.58–125.86 μM) as compared to the standard ascorbic acid (SC₅₀ = 21.50 ± 0.18 μM). Among this library, compounds 9 and 10 with a hydroxy group on the phenyl rings and thiosemicarbazide bearing intermediate 21 were identified as the most potent inhibitors against α-amylase, and α-glucosidase enzymes. The remaining compounds were found to be moderately active. The molecular docking studies were conducted to understand the binding mode of active inhibitors and kinetic studies of the active compounds followed competitive modes of inhibition.
    Schlagwörter 2,2-diphenyl-1-picrylhydrazyl ; acarbose ; alpha-amylase ; antioxidants ; ascorbic acid ; hyperglycemia ; mass spectrometry ; nuclear magnetic resonance spectroscopy ; oxidative stress ; thiazoles
    Sprache Englisch
    Erscheinungsverlauf 2022-1130
    Umfang p. 1294-1312.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2022.09.102
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  8. Artikel ; Online: Multicomponent diastereoselective synthesis of tetrahydropyridines as α-amylase and α-glucosidase enzymes inhibitors.

    Saleem, Faiza / Shamim, Fariha / Özil, Musa / Baltaş, Nimet / Salar, Uzma / Ashraf, Sajda / Ul-Haq, Zaheer / Taha, Muhammad / Solangi, Mehwish / Khan, Khalid Mohammed

    Future medicinal chemistry

    2023  Band 15, Heft 15, Seite(n) 1343–1368

    Abstract: Background: ...

    Abstract Background:
    Mesh-Begriff(e) Humans ; alpha-Amylases/antagonists & inhibitors ; alpha-Glucosidases/metabolism ; Diabetes Mellitus ; Glycoside Hydrolase Inhibitors/chemistry ; Kinetics ; Molecular Docking Simulation ; Structure-Activity Relationship
    Chemische Substanzen alpha-Amylases (EC 3.2.1.1) ; alpha-Glucosidases (EC 3.2.1.20) ; Glycoside Hydrolase Inhibitors
    Sprache Englisch
    Erscheinungsdatum 2023-08-31
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1756-8927
    ISSN (online) 1756-8927
    DOI 10.4155/fmc-2023-0073
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Indole-pyridine carbonitriles: multicomponent reaction synthesis and bio-evaluation as potential hits against diabetes mellitus.

    Solangi, Mehwish / Khan, Khalid Mohammed / Ji, Xingyue / Özil, Musa / Baltaş, Nimet / Salar, Uzma / Khan, Alamgir / Haq, Zaheer Ul / Meghwar, Herchand / Taha, Muhammad

    Future medicinal chemistry

    2023  Band 15, Heft 21, Seite(n) 1943–1965

    Abstract: Background: ...

    Abstract Background:
    Mesh-Begriff(e) Humans ; Molecular Docking Simulation ; Glycoside Hydrolase Inhibitors/chemistry ; Diabetes Mellitus/drug therapy ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Hypoglycemic Agents/chemistry ; Pyridines/chemistry ; Indoles/pharmacology ; Indoles/therapeutic use ; Structure-Activity Relationship ; Molecular Structure
    Chemische Substanzen Glycoside Hydrolase Inhibitors ; Hypoglycemic Agents ; Pyridines ; Indoles
    Sprache Englisch
    Erscheinungsdatum 2023-11-06
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1756-8927
    ISSN (online) 1756-8927
    DOI 10.4155/fmc-2023-0087
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: A simple and efficient synthesis of benzimidazoles containing piperazine or morpholine skeleton at C-6 position as glucosidase inhibitors with antioxidant activity.

    Özil, Musa / Parlak, Cansu / Baltaş, Nimet

    Bioorganic chemistry

    2017  Band 76, Seite(n) 468–477

    Abstract: A novel 2-(aryl)-6-morpholin-4-yl(or 4-methylpiperazin-1-yl)-1H-benzimidazole derivatives were designed and expeditiously synthesized starting from 5-morpholin-4-yl(or 4-methylpiperazin-1-yl)-2-nitroaniline with various aldehydes which were preliminarily ...

    Abstract A novel 2-(aryl)-6-morpholin-4-yl(or 4-methylpiperazin-1-yl)-1H-benzimidazole derivatives were designed and expeditiously synthesized starting from 5-morpholin-4-yl(or 4-methylpiperazin-1-yl)-2-nitroaniline with various aldehydes which were preliminarily screened for in vitro antioxidant activities and glucosidase inhibitors. The benzimidazoles were effectively synthesized by a rapid 'onepot' nitro reductive cyclization reaction using sodium hydrosulfite as a reagent. All reactions were conducted using both the microwave and conventional methods to compare yields and reaction times. Antioxidant activities of the synthesized compounds were clarified using various in vitro antioxidant assays including Cupric Reducing Antioxidant Capacity (CUPRAC, ranging from 5.511 to 19.703 mM Trolox/mg compound) and Ferric Reducing Antioxidant Power (FRAP) (1.141-12.943 mM FeSO
    Mesh-Begriff(e) Acarbose/chemistry ; Benzimidazoles/chemical synthesis ; Benzimidazoles/chemistry ; Cyclization ; Enzyme Assays ; Free Radical Scavengers/chemical synthesis ; Free Radical Scavengers/chemistry ; Glycoside Hydrolase Inhibitors/chemical synthesis ; Glycoside Hydrolase Inhibitors/chemistry ; Molecular Structure ; Morpholines/chemical synthesis ; Morpholines/chemistry ; Piperazines/chemical synthesis ; Piperazines/chemistry
    Chemische Substanzen Benzimidazoles ; Free Radical Scavengers ; Glycoside Hydrolase Inhibitors ; Morpholines ; Piperazines ; Acarbose (T58MSI464G)
    Sprache Englisch
    Erscheinungsdatum 2017-12-16
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120080-x
    ISSN 1090-2120 ; 0045-2068
    ISSN (online) 1090-2120
    ISSN 0045-2068
    DOI 10.1016/j.bioorg.2017.12.019
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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