Article ; Online: Determination of albendazole sulfoxide in human plasma by using liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
2016 Volume 1022, Page(s) 1–5
Abstract: A rapid, simple and sensitive method was developed and validated using liquid chromatography-tandem mass spectrometry (LC-MS/MS) for determination of albendazole sulfoxide (ABZOX) in human plasma. The plasma samples were extracted by protein ... ...
| Abstract | A rapid, simple and sensitive method was developed and validated using liquid chromatography-tandem mass spectrometry (LC-MS/MS) for determination of albendazole sulfoxide (ABZOX) in human plasma. The plasma samples were extracted by protein precipitation using albendazole sulfoxide-d3 as internal standard (IS). The chromatographic separation was performed on Waters Xbridge C18Column (100×4.6mm, 3.5μm) with a mobile phase consisting of ammonia solution, water and methanol at a flow rate of 0.70mL/min. ABZOX was detected and identified by mass spectrometry with electrospray ionization (ESI) in positive ion and multiple-reaction monitoring (MRM) mode. The method was linear in the range of 3-1500ng/mL for ABZOX. This method was successfully applied to the bioequivalence study in human plasma samples. |
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| MeSH term(s) | Albendazole/analogs & derivatives ; Albendazole/blood ; Albendazole/chemistry ; Albendazole/pharmacokinetics ; Chromatography, Liquid/methods ; Humans ; Linear Models ; Reproducibility of Results ; Sensitivity and Specificity ; Tandem Mass Spectrometry/methods | |||||
| Chemical Substances | Albendazole (F4216019LN) ; albendazole sulfoxide (J39B52TV34) | |||||
| Language | English | |||||
| Publishing date | 2016-06-01 | |||||
| Publishing country | Netherlands | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 1180823-8 | |||||
| ISSN | 1873-376X ; 0378-4347 ; 1570-0232 ; 1387-2273 | |||||
| ISSN (online) | 1873-376X | |||||
| ISSN | 0378-4347 ; 1570-0232 ; 1387-2273 | |||||
| DOI | 10.1016/j.jchromb.2016.03.024 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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