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  1. Article: Obesity and insulin resistance are significant predictors of serum leptin levels.

    Beyazıt, Fatma / Ünsal, Mesut A

    Journal of the Turkish German Gynecological Association

    2017  Volume 18, Issue 3, Page(s) 158–159

    Language English
    Publishing date 2017-09-10
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2425806-4
    ISSN 1309-0380 ; 1303-9695 ; 1309-0399
    ISSN (online) 1309-0380 ; 1303-9695
    ISSN 1309-0399
    DOI 10.4274/jtgga.2017.0027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Hepatitis D infection should be taken in mind while evaluating neonatal outcomes related to maternal hepatitis B infection.

    Beyazit, Fatma / Unsal, Mesut A

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

    2017  Volume 32, Issue 4, Page(s) 701

    MeSH term(s) China ; Cohort Studies ; Hepatitis B ; Hepatitis B Surface Antigens ; Hepatitis D ; Humans ; Infant, Newborn
    Chemical Substances Hepatitis B Surface Antigens
    Language English
    Publishing date 2017-09-10
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2077261-0
    ISSN 1476-4954 ; 1057-0802 ; 1476-7058
    ISSN (online) 1476-4954
    ISSN 1057-0802 ; 1476-7058
    DOI 10.1080/14767058.2017.1373086
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: IL18 receptors are required for IL-37-mediated epithelial ovarian tumor progression.

    Beyazit, Fatma / Unsal, Mesut A

    Archives of gynecology and obstetrics

    2017  Volume 295, Issue 6, Page(s) 1301–1302

    MeSH term(s) Biomarkers ; Carcinoma, Ovarian Epithelial ; Female ; Humans ; Interleukin-18 ; Ovarian Neoplasms ; Prognosis ; Receptors, Interleukin-18
    Chemical Substances Biomarkers ; Interleukin-18 ; Receptors, Interleukin-18
    Language English
    Publishing date 2017-04-29
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 896455-5
    ISSN 1432-0711 ; 0932-0067
    ISSN (online) 1432-0711
    ISSN 0932-0067
    DOI 10.1007/s00404-017-4388-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The prevelance of human papillomavirus (HPV) genotypes detected by PCR in women with normal and abnormal cervico-vaginal cytology.

    Beyazit, Fatma / Sılan, Fatma / Gencer, Meryem / Aydin, Buket / Paksoy, Barış / Unsal, Mesut A / Ozdemir, Ozturk

    Ginekologia polska

    2018  Volume 89, Issue 2, Page(s) 62–67

    Abstract: Objectives: Cervical cancer is the second most common type of cancer for women worldwide with a great proportion proved to be related to human papillomavirus (HPV) infection. As infection with HPV is the strongest risk factor for cervical neoplasia, ... ...

    Abstract Objectives: Cervical cancer is the second most common type of cancer for women worldwide with a great proportion proved to be related to human papillomavirus (HPV) infection. As infection with HPV is the strongest risk factor for cervical neoplasia, detection of HPV genotypes in cervical and vaginal specimens of women with normal and abnormal cytology seems to be of paramount importance in cervical cancer screening. The objective of the study is to evaluate the prevalence and HPV genotypes among women with normal or abnormal Pap smear tests.
    Material and methods: This retrospective study was conducted in a tertiary care university hospital in western Turkey. A total of 201 patients in whom both HPV typing and Pap test was performed between 2012 and 2016 in our obstetrics and gynecology department were enrolled in this study. Clinical and laboratory data were obtained for all participants. Cervical smears of the patients were classified by the Bethesda system and HPV analyses were done using the polymerase chain reaction (PCR) method.
    Results: This study included 201 women, 72 of whom had normal and 129 of whom had abnormal Pap smear results. HPV DNA was detected in 91 (45.2%) of the 201 investigated women. Out of 72 patients with normal cervico-vaginal cytology, HPV positivity was detected in 35 (49%) patients, whereas 33 (35%) patients out of 94 with ASCUS , 18 (62%) patients out of 29 with LSIL and 5 (83%) patients out of 6 with HSIL had HPV positivity. Out of 35 HPV positive women that had normal pap test results, 25 (75%) were found to have high risk HPV (HR-HPV) genotypes. In women with ASCUS, LSIL and HSIL, HR-HPV genotype rates were found to be 94%, 89% and 100% respectively. The most common identified HPV types were HPV58, HPV16, HPV31, HPV33, HPV11 and HPV35.
    Conclusions: The frequency of HPV infection was found to be higher in our study compared to previous reports. Moreover, although HR-HPV genotypes were also detected in patients with normal cervical cytology, a majority of patients with HR-HPV genotypes were associated with abnormal cervical smear cytology including high rates of atypical squamous cells of undetermined significance, low-grade squamous intraepithelial lesion, and high-grade squamous intraepithelial lesion.
    MeSH term(s) Adult ; Aged ; Atypical Squamous Cells of the Cervix/virology ; Case-Control Studies ; Female ; Genotype ; Humans ; Middle Aged ; Papillomaviridae/genetics ; Papillomaviridae/isolation & purification ; Papillomavirus Infections/diagnosis ; Papillomavirus Infections/virology ; Polymerase Chain Reaction ; Squamous Intraepithelial Lesions of the Cervix/virology ; Young Adult
    Language English
    Publishing date 2018
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 130894-4
    ISSN 0017-0011
    ISSN 0017-0011
    DOI 10.5603/GP.a2018.0011
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  5. Article ; Online: Intramural leoimyoma without endometrial cavity distortion may negatively affect the ICSI - ET outcome.

    Guven, Suleyman / Kart, Cavit / Unsal, Mesut A / Odaci, Ersan

    Reproductive biology and endocrinology : RB&E

    2013  Volume 11, Page(s) 102

    Abstract: Background: To assess the impact of intramural fibroids on the intracytoplasmic sperm injection-embryo transfer (ICSI-ET) cycle outcome, when there is no compression of the endometrial cavity.: Methods: In this retrospective, matched control study, ... ...

    Abstract Background: To assess the impact of intramural fibroids on the intracytoplasmic sperm injection-embryo transfer (ICSI-ET) cycle outcome, when there is no compression of the endometrial cavity.
    Methods: In this retrospective, matched control study, the ICSI-ET outcome of sixty-two patients (Group I) with intramural fibroid (mean diameter <7 cm) and normal endometrial cavity demonstrated by office hysteroscopy was compared with matched-control group of patients (n = 301) with no fibroid (Group II). The diagnosis of fibroids was done by transvaginal ultrasonography.
    Results: The mean age in fibroid group was 32.66 +/- 5.30 while this figure was 32.95 +/- 3.98 in control group. The clinical pregnancy rate was significantly lower in the fibroid group although fibroids not distorting the uterine cavity (25.8% vs. 39.9%, p = 0.04). In fibroid group the implantation rate was significantly lower than control group (20.97 +/- 37.93 vs.32.89 +/- 43.18%, p = 0.04). However, spontaneous abortion rate was higher in fibroid group but it did not reach the significant level (12.5% vs. 9.2%, p > 0.05).
    Conclusion: Women having intramural leiomyomas not encroaching on the uterine cavity have unfavorable ICSI/ET outcomes comparable to those of women without such leiomyomas. Therefore, myomectomy may be a good option for such patients with intramural fibroids even they do not have any endometrial distortion.
    MeSH term(s) Female ; Humans ; Infertility, Female/complications ; Infertility, Female/therapy ; Leiomyoma/complications ; Leiomyoma/diagnostic imaging ; Pregnancy ; Pregnancy Outcome ; Pregnancy Rate ; Retrospective Studies ; Sperm Injections, Intracytoplasmic ; Ultrasonography ; Uterus/diagnostic imaging
    Language English
    Publishing date 2013-10-29
    Publishing country England
    Document type Journal Article
    ISSN 1477-7827
    ISSN (online) 1477-7827
    DOI 10.1186/1477-7827-11-102
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  6. Article ; Online: Endometrial injury may increase the clinical pregnancy rate in normoresponders undergoing long agonist protocol ICSI cycles with single embryo transfer.

    Guven, Suleyman / Kart, Cavit / Unsal, Mesut A / Yildirim, Ozkan / Odaci, Ersan / Yulug, Esin

    European journal of obstetrics, gynecology, and reproductive biology

    2014  Volume 173, Page(s) 58–62

    Abstract: Objective: To investigate the effect of endometrial injury on the clinical pregnancy rate in normoresponders undergoing long agonist protocol intracytoplasmic sperm injection (ICSI) cycles with single embryo transfer.: Study design: Prospective case- ... ...

    Abstract Objective: To investigate the effect of endometrial injury on the clinical pregnancy rate in normoresponders undergoing long agonist protocol intracytoplasmic sperm injection (ICSI) cycles with single embryo transfer.
    Study design: Prospective case-control study.
    Methods: One hundred and eighteen women (age <35 years, normoresponders with Grade I or II embryos for transfer) were included. Women in the intervention group (n=56) underwent endometrial biopsy on Day 3 of the menstrual cycle following downregulation. Women in the control group (n=62) did not undergo endometrial biopsy.
    Results: The clinical and embryological characteristics were comparable in the two groups, and no significant difference was found in the fertilization rates (66.32% in the intervention group vs. 70.23% in the control group). The clinical pregnancy rate was 48.2% in the intervention group and 29.0% in the control group (p=0.025). Endometrial injury may increase the clinical pregnancy rate (odds ratio 2.27). The 'take home baby' rates were 33.9% and 17.7% in the intervention and control groups, respectively (p=0.035).
    Conclusion: Assisted reproductive technology treatment that is preceded by endometrial injury may increase the clinical pregnancy rate in women undergoing long agonist protocol ICSI cycles with single embryo transfer.
    MeSH term(s) Adult ; Biopsy ; Case-Control Studies ; Endometrium/injuries ; Female ; Fertilization in Vitro/methods ; Humans ; Pregnancy ; Pregnancy Rate ; Prospective Studies ; Single Embryo Transfer/methods ; Sperm Injections, Intracytoplasmic/methods
    Language English
    Publishing date 2014-02
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2013.11.005
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  7. Article ; Online: Brenner tumor of the ovary revealed by cyst aspiration in a patient undergoing in vitro fertilization.

    Guven, Suleyman / Kart, Cavit / Cobanoglu, Umit / Guven, Emine S Guvendag / Unsal, Mesut A

    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

    2013  Volume 121, Issue 3, Page(s) 278–279

    MeSH term(s) Adult ; Brenner Tumor/diagnosis ; Brenner Tumor/pathology ; Female ; Fertilization in Vitro/methods ; Humans ; Ovarian Cysts/therapy ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/pathology ; Suction
    Language English
    Publishing date 2013-06
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80149-5
    ISSN 1879-3479 ; 0020-7292
    ISSN (online) 1879-3479
    ISSN 0020-7292
    DOI 10.1016/j.ijgo.2013.01.009
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  8. Article ; Online: Failed labor induction in nulliparous women at term: the role of pelvic floor muscle strength.

    Aran, Turhan / Osmanagaoglu, Mehmet A / Kart, Cavit / Guven, Suleyman / Sahin, Mustafa / Unsal, Mesut A

    International urogynecology journal

    2012  Volume 23, Issue 8, Page(s) 1105–1110

    Abstract: Introduction and hypothesis: The prolongation, protraction or complete cessation of labor is called failed labor. It is one of the leading indications for cesarean delivery. The goal of this study was to measure pelvic floor muscle strength and ... ...

    Abstract Introduction and hypothesis: The prolongation, protraction or complete cessation of labor is called failed labor. It is one of the leading indications for cesarean delivery. The goal of this study was to measure pelvic floor muscle strength and investigate its effect on labor in nulliparous pregnant women.
    Methods: A total of 88 patients were included in the study. The study was conducted in nulliparous pregnant women with a low Bishop score (≤ 7). A low-dose intravenous oxytocin protocol was used for labor induction in all patients. Evaluation of pelvic floor muscle (PFM) strength was performed using a vaginal pressure measurement device just before labor induction. The duration of labor stages and the rate of failed labor were considered the main outcomes. The study group consisted of patients whose labor failed and who subsequently underwent cesarean delivery. The control group consisted of patients who delivered vaginally. The pelvic floor muscle strength and main outcome measures of the two groups were compared.
    Results: No differences were found in age, weight, height, body mass index (BMI), and neonatal birth weight between the study and control groups. The mean resting and maximum squeeze pressures in the study group were 29.6 ± 9.8 and 56.4 ± 12.1 cm H(2)O respectively, significantly higher than in the control group. The best predictor of failed labor was a maximum squeeze pressure value of 59 cm H(2)0 (51.6% sensitivity and 87.7% specificity).
    Conclusions: Pelvic floor muscle strength appears to play a role in predicting failed labor.
    MeSH term(s) Adult ; Cesarean Section ; Delivery, Obstetric ; Dose-Response Relationship, Drug ; Female ; Humans ; Labor, Induced ; Muscle Strength/physiology ; Oxytocin ; Parity/physiology ; Pelvic Floor/physiology ; Predictive Value of Tests ; Pregnancy ; Term Birth/physiology
    Chemical Substances Oxytocin (50-56-6)
    Language English
    Publishing date 2012-04-14
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 1050631-7
    ISSN 1433-3023 ; 0937-3462
    ISSN (online) 1433-3023
    ISSN 0937-3462
    DOI 10.1007/s00192-012-1754-7
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  9. Article ; Online: Carbon dioxide pneumoperitoneum induces systemic oxidative stress: a clinical study.

    Aran, Turhan / Unsal, Mesut A / Guven, Suleyman / Kart, Cavit / Cetin, Esra Can / Alver, Ahmet

    European journal of obstetrics, gynecology, and reproductive biology

    2012  Volume 161, Issue 1, Page(s) 80–83

    Abstract: Objective: To investigate the effect of carbon dioxide pneumoperitoneum on systemic oxidative stress by using serum oxidative stress markers (ischemia modified albumin (IMA), malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status ( ... ...

    Abstract Objective: To investigate the effect of carbon dioxide pneumoperitoneum on systemic oxidative stress by using serum oxidative stress markers (ischemia modified albumin (IMA), malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI)) and to compare their effectiveness at clinically accepted safe intra-abdominal pressure levels (<12 mmHg).
    Study design: A total of 33 consecutive patients who had a unilateral ovarian cyst were enrolled for this prospective clinical study. All women underwent a laparoscopic ovarian cystectomy procedure. Venous blood was collected from patients preoperatively, 10 min after induction of anesthesia and 30 min after insufflation. Preoperative, 10(min), and 30(min) serum IMA, MDA, TOS, OSI and TAS levels were compared.
    Results: The mean age was 29.3 ± 6.4 and the range of operation time was 45-80 min. The mean serum IMA levels showed a significant increase 30 min later from CO(2) insufflation (p<0.05). Significant alterations were not observed in serum MDA, TOS, OSI or TAS levels.
    Conclusions: Laparoscopic surgery causes systemic ischemia and this ischemic effect can be revealed by measuring serum ischemia modified albumin. IMA is more sensitive than MDA, TOS, OSI and TAS in early detection of systemic oxidative stress.
    MeSH term(s) Adult ; Antioxidants ; Biomarkers/blood ; Carbon Dioxide ; Female ; Humans ; Insufflation ; Laparoscopy/adverse effects ; Laparoscopy/methods ; Malondialdehyde/blood ; Oxidants/blood ; Oxidative Stress ; Pneumoperitoneum, Artificial/adverse effects ; Serum Albumin ; Serum Albumin, Human
    Chemical Substances Antioxidants ; Biomarkers ; Oxidants ; Serum Albumin ; ischemia-modified albumin ; Carbon Dioxide (142M471B3J) ; Malondialdehyde (4Y8F71G49Q) ; Serum Albumin, Human (ZIF514RVZR)
    Language English
    Publishing date 2012-03
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2011.11.027
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  10. Article ; Online: Serum ischemia-modified albumin as a novel marker of ovarian torsion: an experimental study.

    Aran, Turhan / Guven, Suleyman / Unsal, Mesut A / Alver, Ahmet / Mentese, Ahmet / Yulug, Esin

    European journal of obstetrics, gynecology, and reproductive biology

    2010  Volume 150, Issue 1, Page(s) 72–75

    Abstract: Objective: To evaluate the effect of ovarian torsion on serum levels of ischemia-modified albumin (IMA) in an experimental model.: Study design: Sixteen female adult Sprague-Dawley rats were involved in the study. Rats were allocated randomly to ... ...

    Abstract Objective: To evaluate the effect of ovarian torsion on serum levels of ischemia-modified albumin (IMA) in an experimental model.
    Study design: Sixteen female adult Sprague-Dawley rats were involved in the study. Rats were allocated randomly to group I or group II on the day of the experiment. Group I (eight rats) comprised the control (sham operated) group. In group II (eight rats), a torsion model was created by using atraumatic vascular clips just above and below the right ovary. At the end of a 3-h period of ischemia, the ovaries were removed. Blood was sampled before and after operation to assess serum IMA levels. Serum IMA levels (absorbance units) and histopathologic damage scores were evaluated.
    Results: Initial serum IMA levels were similar in both groups. After the operation, significant elevation was observed in group II in contrast to group I (0.191+/-0.034 and 0.277+/-0.089 ABSU, p=0.05). Histologic specimens of the ovaries in group II had higher scores of follicular cell degeneration, vascular congestion, hemorrhage and inflammatory cell infiltration than those in group I (p<0.001).
    Conclusions: The elevated serum IMA levels observed in the ovarian torsion model seem to have a potential role as a serum marker in the early diagnosis of ovarian torsion.
    MeSH term(s) Animals ; Biomarkers/blood ; Disease Models, Animal ; Female ; Ischemia/pathology ; Ischemia/physiopathology ; Ovarian Diseases/diagnosis ; Ovarian Diseases/pathology ; Ovary/blood supply ; Ovary/pathology ; Rats ; Rats, Sprague-Dawley ; Serum Albumin/metabolism ; Torsion Abnormality/diagnosis ; Torsion Abnormality/pathology
    Chemical Substances Biomarkers ; Serum Albumin
    Language English
    Publishing date 2010-05
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2010.01.006
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