Article ; Online: Chelation of Mitochondrial Iron as an Antiparasitic Strategy.
ACS infectious diseases
2024 Volume 10, Issue 2, Page(s) 676–687
Abstract: Iron, as an essential micronutrient, plays a crucial role in host-pathogen interactions. In order to limit the growth of the pathogen, a common strategy of innate immunity includes withdrawing available iron to interfere with the cellular processes of ... ...
| Abstract | Iron, as an essential micronutrient, plays a crucial role in host-pathogen interactions. In order to limit the growth of the pathogen, a common strategy of innate immunity includes withdrawing available iron to interfere with the cellular processes of the microorganism. Against that, unicellular parasites have developed powerful strategies to scavenge iron, despite the effort of the host. Iron-sequestering compounds, such as the approved and potent chelator deferoxamine (DFO), are considered a viable option for therapeutic intervention. Since iron is heavily utilized in the mitochondrion, targeting iron chelators in this organelle could constitute an effective therapeutic strategy. This work presents mitochondrially targeted DFO, mitoDFO, as a candidate against a range of unicellular parasites with promising in vitro efficiency. Intracellular |
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| MeSH term(s) | Iron ; Deferoxamine/chemistry ; Antiparasitic Agents/pharmacology ; Iron Chelating Agents/pharmacology ; Iron Chelating Agents/therapeutic use ; Mitochondria ; Anti-Infective Agents |
| Chemical Substances | Iron (E1UOL152H7) ; Deferoxamine (J06Y7MXW4D) ; Antiparasitic Agents ; Iron Chelating Agents ; Anti-Infective Agents |
| Language | English |
| Publishing date | 2024-01-30 |
| Publishing country | United States |
| Document type | Journal Article |
| ISSN | 2373-8227 |
| ISSN (online) | 2373-8227 |
| DOI | 10.1021/acsinfecdis.3c00529 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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