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  1. Book ; Thesis: Immunantwort nach der Grundimmunisierung mit mRNA-1273 und der Einfluss des GNB3 c.825C>T Polymorphismus auf die Immunantwort nach der Impfung

    Čiučiulkaitė, Ieva / Siffert, Winfried

    2023  

    Institution Universität Duisburg-Essen
    Author's details vorgelegt von Ieva Čiučiulkaitė ; 1. Gutachter: Herr Univ,-Prof. Dr. med. W. Siffert ; 2. Gutachterin: Frau Priv.-Doz. Dr. med. St. Klenke
    Language German
    Size 82 Seiten, Illustrationen
    Publishing place Duisburg ; Essen
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität Duisburg-Essen, 2023
    HBZ-ID HT030390862
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2024 E 28 order for loan Magazin

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  2. Article: Influence of the Single Nucleotide Polymorphisms rs12252 and rs34481144 in

    Čiučiulkaitė, Ieva / Siffert, Winfried / Elsner, Carina / Dittmer, Ulf / Wichert, Marc / Wagner, Bernd / Volbracht, Lothar / Mosel, Frank / Möhlendick, Birte

    Vaccines

    2023  Volume 11, Issue 7

    Abstract: The COVID-19 mRNA vaccine is the first mRNA vaccine approved for human administration by both the U.S. Food and Drug Administration and the European Medicines Agency. Studies have shown that the immune response and the decay of immunity after vaccination ...

    Abstract The COVID-19 mRNA vaccine is the first mRNA vaccine approved for human administration by both the U.S. Food and Drug Administration and the European Medicines Agency. Studies have shown that the immune response and the decay of immunity after vaccination with the COVID-19 vaccines are variable within a population. Host genetic factors probably contribute to this variability. In this study, we investigated the effect of the single-nucleotide polymorphisms rs12252 and rs34481144 in the
    Language English
    Publishing date 2023-07-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11071257
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: GNB3

    Čiučiulkaitė, Ieva / Möhlendick, Birte / Thümmler, Laura / Fisenkci, Neslinur / Elsner, Carina / Dittmer, Ulf / Siffert, Winfried / Lindemann, Monika

    Frontiers in genetics

    2022  Volume 13, Page(s) 932043

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-08-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2022.932043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Antibody responses elicited by mRNA vaccination in firefighters persist six months and correlate inversely with age and directly with BMI

    Holtkamp, Caroline / Schöler, Lara / Anastasiou, Olympia E. / Brune, Bastian / Fessmann, Kai / Elsner, Carina / Möhlendick, Birte / Čiučiulkaitė, Ieva / Dudda, Marcel / Trilling, Mirko / Dittmer, Ulf / Spors, Jörg / Le-Trilling, Vu Thuy Khanh

    Heliyon. 2023 Jan., v. 9, no. 1 p.e12746-

    2023  

    Abstract: Knowledge regarding the sustainability of immune responses after COVID-19 vaccination is important, e.g., to decide whom and when to booster. Thus, we analyzed antibody titers in firefighters six months after vaccination with the mRNA-based vaccine ... ...

    Abstract Knowledge regarding the sustainability of immune responses after COVID-19 vaccination is important, e.g., to decide whom and when to booster. Thus, we analyzed antibody titers in firefighters six months after vaccination with the mRNA-based vaccine Comirnaty. SARS-CoV-2 spike-binding antibodies (bAb) were quantified and compared to peak responses determined in healthcare workers (HCW). For the firefighters, neutralizing antibodies (nAb) were also analyzed. Six months after the second vaccine dose, all analyzed firefighters had detectable bAb, and 91% exhibited nAb titers above 1:16. However, actual titers six months after vaccination were over 12-fold lower than in the HCW control group four weeks after vaccination. bAb and nAb responses showed a significant correlation, and age correlated inversely with antibody responses. Unexpectedly, participants with a body mass index over 25 had higher neutralization titers after six months. All participants with very low neutralization titers were offered booster vaccination. The booster vaccination improved the extent and sustainability of antibody responses.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; antibodies ; body mass index ; health services ; neutralization ; secondary immunization ; vaccination ; vaccines ; COVID-19 ; SARS-CoV-2 ; Firefighters ; Body mass index (BMI) ; mRNA vaccine ; BMI
    Language English
    Dates of publication 2023-01
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2022.e12746
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Individuals With Weaker Antibody Responses After Booster Immunization Are Prone to Omicron Breakthrough Infections.

    Möhlendick, Birte / Čiučiulkaitė, Ieva / Elsner, Carina / Anastasiou, Olympia E / Trilling, Mirko / Wagner, Bernd / Zwanziger, Denise / Jöckel, Karl-Heinz / Dittmer, Ulf / Siffert, Winfried

    Frontiers in immunology

    2022  Volume 13, Page(s) 907343

    Abstract: Background: Despite the high level of protection against severe COVID-19 provided by the currently available vaccines some breakthrough infections occur. Until now, there is no information whether a potential risk of a breakthrough infection can be ... ...

    Abstract Background: Despite the high level of protection against severe COVID-19 provided by the currently available vaccines some breakthrough infections occur. Until now, there is no information whether a potential risk of a breakthrough infection can be inferred from the level of antibodies after booster vaccination.
    Methods: Levels of binding antibodies and neutralization capacity after the first, one and six month after the second, and one month after the third (booster) vaccination against COVID-19 were measured in serum samples from 1391 healthcare workers at the University Hospital Essen. Demographics, vaccination scheme, pre-infection antibody titers and neutralization capacity were compared between individuals with and without breakthrough infections.
    Results: The risk of developing an Omicron breakthrough infection was independent of vaccination scheme, sex, body mass index, smoking status or pre-existing conditions. In participants with low pre-infection anti-spike antibodies (≤ 2641.0 BAU/ml) and weaker neutralization capacity (≤ 65.9%) against Omicron one month after the booster vaccination the risk for developing an Omicron infection was 10-fold increased (
    Conclusion: Routine testing of anti-SARS-CoV-2 IgG antibodies and surrogate virus neutralization can quantify vaccine-induced humoral immune response and may help to identify subjects who are at risk for a breakthrough infection. The establishment of thresholds for SARS-CoV-2 IgG antibody levels identifying "non"-, "low" and "high"-responders may be used as an indication for re-vaccination.
    MeSH term(s) Antibodies, Viral ; Antibody Formation ; COVID-19/prevention & control ; Humans ; Immunization, Secondary ; SARS-CoV-2
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2022-06-23
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.907343
    Database MEDical Literature Analysis and Retrieval System OnLINE

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