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Article ; Online: Vitamin D-Related Genes and Thyroid Cancer-A Systematic Review.

Maciejewski, Adam / Lacka, Katarzyna

International journal of molecular sciences

2022 Volume 23, Issue 21

Abstract: Vitamin D, formerly known for its role in calcium-phosphorus homeostasis, was shown to exert a broad influence on immunity and on differentiation and proliferation processes in the last few years. In the field of endocrinology, there is proof of the ... ...

Abstract	Vitamin D, formerly known for its role in calcium-phosphorus homeostasis, was shown to exert a broad influence on immunity and on differentiation and proliferation processes in the last few years. In the field of endocrinology, there is proof of the potential role of vitamin D and vitamin D-related genes in the pathogenesis of thyroid cancer-the most prevalent endocrine malignancy. Therefore, the study aimed to systematically review the publications on the association between vitamin D-related gene variants (polymorphisms, mutations, etc.) and thyroid cancer. PubMed, EMBASE, Scopus, and Web of Science electronic databases were searched for relevant studies. A total of ten studies were found that met the inclusion criteria. Six vitamin D-related genes were analyzed (
MeSH term(s)	Humans ; Genetic Predisposition to Disease ; Polymorphism, Single Nucleotide ; Vitamin D/genetics ; Vitamin D3 24-Hydroxylase/genetics ; Risk Factors ; Receptors, Calcitriol/genetics ; Thyroid Neoplasms/genetics ; Genotype
Chemical Substances	Vitamin D (1406-16-2) ; Vitamin D3 24-Hydroxylase (EC 1.14.15.16) ; Receptors, Calcitriol
Language	English
Publishing date	2022-11-07
Publishing country	Switzerland
Document type	Systematic Review ; Meta-Analysis ; Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms232113661
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Lipomas: genetic basis of common skin lesions and their occurrence in rare diseases.

Marzyńska, Dorota / Żaba, Ryszard / Lacka, Katarzyna

Postepy dermatologii i alergologii

2023 Volume 40, Issue 4, Page(s) 481–486

Abstract: Lipomas are usually sporadic, asymptomatic lesions, and their clinical and histologic presentation does not pose diagnostic difficulties. In ambiguous cases, however, knowledge of genetics is necessary. HMGA2 expression in adipose cells enables the ... ...

Abstract	Lipomas are usually sporadic, asymptomatic lesions, and their clinical and histologic presentation does not pose diagnostic difficulties. In ambiguous cases, however, knowledge of genetics is necessary. HMGA2 expression in adipose cells enables the differentiation of normal adipose tissue from lipoma and liposarcoma. Moreover, lipomas can be associated with genetic diseases, such as multiple endocrine neoplasia type 1, neurofibromatosis type 1, Wilson's disease, or mitochondrial diseases. Lipomas can run in families (familial multiple lipomatosis) or be a part of genetic syndromes such as PTEN hamartoma tumor syndrome, Proteus syndrome, and Pai syndrome. This study aims to present the genetic basis of lipomas and diseases in which these lesions occur in the clinical picture.
Language	English
Publishing date	2023-07-15
Publishing country	Poland
Document type	Journal Article ; Review
ZDB-ID	2596142-1
ISSN	1642-395X
ISSN	1642-395X
DOI	10.5114/ada.2023.129529
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Article: Effect of Growth Hormone and Estrogen Replacement Therapy on Bone Mineral Density in Women with Turner Syndrome: A Meta-Analysis and Systematic Review.

Szybiak, Weronika / Kujawa, Barbara / Miedziaszczyk, Miłosz / Lacka, Katarzyna

Pharmaceuticals (Basel, Switzerland)

2023 Volume 16, Issue 9

Abstract: Osteoporosis is a serious implication of Turner syndrome (TS). Common methods for the treatment of TS are growth hormone (GHT) and estrogen replacement therapy (ERT). We examined the relationship between the treatment of TS and bone mineral density (BMD) ...

Abstract	Osteoporosis is a serious implication of Turner syndrome (TS). Common methods for the treatment of TS are growth hormone (GHT) and estrogen replacement therapy (ERT). We examined the relationship between the treatment of TS and bone mineral density (BMD) of the lumbar spine. The purpose of our study was to show the currency of BMD states among patients with TS for treatment with GHT and ERT. We searched databases for studies published from inception to April 2023. The articles were related to TS, osteoporosis, ERT, GHT, BMD and treatment patients with TS. We applied the selection criteria: lumbar spine values at L1-L4; dual-energy X-ray absorptiometry (DXA); treatment which was applied: one group of articles: ERT and two group of articles: GHT; results performed as means ± SD. In total, 79 articles were analyzed, of which 20 studies were included and 5 were considered for meta-analysis. The total number of women in the articles selected was 71. Based on the results of the meta-analysis, the effect of ERT on BMD demonstrated a significant increase in BMD (the standardized mean difference in the random model was 0.593 g/cm
Language	English
Publishing date	2023-09-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph16091320
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Article ; Online: Pharmacotherapy in Cachexia: A Review of Endocrine Abnormalities and Steroid Pharmacotherapy.

Celichowska, Magdalena / Miedziaszczyk, Miłosz / Lacka, Katarzyna

Journal of pain & palliative care pharmacotherapy

2022 Volume 36, Issue 2, Page(s) 117–131

Abstract: Cachexia is a state of increased metabolism associated with high morbidity and mortality. Dysregulation of cytokines and hormone activity causes reduced protein synthesis and excessive protein breakdown. various treatments are available, depending on the ...

Abstract	Cachexia is a state of increased metabolism associated with high morbidity and mortality. Dysregulation of cytokines and hormone activity causes reduced protein synthesis and excessive protein breakdown. various treatments are available, depending on the primary disease and the patient's state. Besides pharmacological treatment, crucial is nutritional support as well as increasing physical activity. The main purpose of pharmacological treatment is to diminish inflammation, improve appetite and decrease muscle wasting. Therefore a lot of medications aim at proinflammatory cytokines such as Interferon-α or Tumor Necrosis Factor-β, but because of the complicated mechanism of cachexia, the range of targets is very wide. in cachexia treatment, use of corticosteroids is common, which improve appetite, diminish inflammation, inhibit prostaglandin metabolism, Interleukin-1 activity. They can also decrease protein synthesis and increase protein degradation, which can be prevented by resveratrol. Estrogen analogs, progesterone analogs, testosterone analogs, Selective Androgen Receptor Modulators (SARM), Angiotensin-Converting-Enzyme Inhibitors (ACEI), Nonsteroidal anti-inflammatory drugs (NSAIDs), thalidomide, melatonin, Growth Hormone Releasing Peptide-2 (GHRP-2) may play important role in wasting syndrome treatment as well. However, for the usage of some of them, evidence-based recommendations are not available. This review highlights current therapeutic options for cachexia with a specific focus on steroid therapy.
MeSH term(s)	Appetite ; Cachexia/drug therapy ; Cachexia/etiology ; Cachexia/metabolism ; Cytokines/therapeutic use ; Humans ; Inflammation ; Steroids/therapeutic use
Chemical Substances	Cytokines ; Steroids
Language	English
Publishing date	2022-06-27
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2078852-6
ISSN	1536-0539 ; 1536-0288
ISSN (online)	1536-0539
ISSN	1536-0288
DOI	10.1080/15360288.2022.2063469
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Article ; Online: Effects of Isoflavonoid and Vitamin D Synergism on Bone Mineral Density-A Systematic and Critical Review.

Miedziaszczyk, Miłosz / Maciejewski, Adam / Idasiak-Piechocka, Ilona / Karczewski, Marek / Lacka, Katarzyna

Nutrients

2023 Volume 15, Issue 24

Abstract: Phytoestrogens are non-steroidal plant compounds, which bind to α and β estrogen receptors, thereby causing specific effects. The best-known group of phytoestrogens are flavonoids, including isoflavonoids-genistein and daidzein. They play a role in the ... ...

Abstract	Phytoestrogens are non-steroidal plant compounds, which bind to α and β estrogen receptors, thereby causing specific effects. The best-known group of phytoestrogens are flavonoids, including isoflavonoids-genistein and daidzein. They play a role in the metabolism of bone tissue, improving its density and preventing bone loss, which contributes to reducing the risk of fractures. Vitamin D is found in the form of cholecalciferol (vitamin D3) and ergocalciferol (vitamin D2) and is traditionally recognized as a regulator of bone metabolism. The aim of this review was to evaluate the synergistic effect of isoflavonoids and vitamin D on bone mineral density (BMD). The MEDLINE (PubMed), Scopus and Cochrane databases were searched independently by two authors. The search strategy included controlled vocabulary and keywords. Reference publications did not provide consistent data regarding the synergistic effect of isoflavonoids on BMD. Some studies demonstrated a positive synergistic effect of these compounds, whereas in others, the authors did not observe any significant differences. Therefore, further research on the synergism of isoflavonoids and vitamin D may contribute to a significant progress in the prevention and treatment of osteoporosis.
MeSH term(s)	Vitamin D/pharmacology ; Bone Density ; Phytoestrogens/pharmacology ; Vitamins/pharmacology ; Cholecalciferol/pharmacology
Chemical Substances	Vitamin D (1406-16-2) ; Phytoestrogens ; Vitamins ; Cholecalciferol (1C6V77QF41)
Language	English
Publishing date	2023-12-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15245014
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Article: Insulin Resistance in Patients with Acne Vulgaris.

Gruszczyńska, Michalina / Sadowska-Przytocka, Anna / Szybiak, Weronika / Więckowska, Barbara / Lacka, Katarzyna

Biomedicines

2023 Volume 11, Issue 8

Abstract: Acne vulgaris presents multifactorial pathogenesis, which may include insulin resistance. To investigate whether insulin resistance is a causative factor in acne vulgaris development, this cohort study and a systematic review were conducted. A cohort of ... ...

Abstract	Acne vulgaris presents multifactorial pathogenesis, which may include insulin resistance. To investigate whether insulin resistance is a causative factor in acne vulgaris development, this cohort study and a systematic review were conducted. A cohort of 41 acne vulgaris patients and 47 healthy BMI-matched controls were recruited. Glucose and insulin fasting serum levels were obtained and the HOMA-IR was calculated; insulin resistance was diagnosed in cases with a HOMA-IR value over 2.1. The mean ± SD values for glucose fasting serum level were as follows: 94.88 ± 7.731 (mg/dL) in the study group and 79.51 ± 7.175 (mg/dL) in the controls (
Language	English
Publishing date	2023-08-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11082294
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Article ; Online: Is There a Link between Thyroid Peroxidase Gene Promoter Polymorphisms and Autoimmune Thyroiditis in the Polish Population?

Lacka, Katarzyna / Maciejewski, Adam / Jarecki, Piotr / Herman, Waldemar / Lacki, Jan K / Żaba, Ryszard / Kowalczyk, Michał J

International journal of molecular sciences

2024 Volume 25, Issue 6

Abstract: 1) Autoimmune thyroiditis (AIT) is the most common cause of primary hypothyroidism and one of the most frequent organ-specific autoimmune diseases. Its pathogenesis is polygenic and still requires further research. The aim of the study was to assess, ... ...

Abstract	(1) Autoimmune thyroiditis (AIT) is the most common cause of primary hypothyroidism and one of the most frequent organ-specific autoimmune diseases. Its pathogenesis is polygenic and still requires further research. The aim of the study was to assess, for the first time in the Caucasian population, the role of selected
MeSH term(s)	Humans ; Autoantibodies ; Hashimoto Disease/genetics ; Iodide Peroxidase/genetics ; Poland ; Polymorphism, Single Nucleotide ; Thyroiditis, Autoimmune/genetics
Chemical Substances	Autoantibodies ; Iodide Peroxidase (EC 1.11.1.8) ; TPO protein, human (EC 1.11.1.7)
Language	English
Publishing date	2024-03-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25063312
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Article: Hiponatremia w świetle najnowszych wytycznych – diagnostyka i różnicowanie.

Wiśniewski, Oskar Wojciech / Łącka, Katarzyna

Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego

2018 Volume 45, Issue 268, Page(s) 168–172

Abstract: Hyponatremia is still considered as a challenge of today's medicine. It is an independent factor responsible for the increased mortality among hyponatremic population and its clinical expression might be made up of threatening neurological symptoms, e.g. ...

Title translation	Hyponatremia in the light of the most recent guidelines - diagnostics and differential diagnosis.
Abstract	Hyponatremia is still considered as a challenge of today's medicine. It is an independent factor responsible for the increased mortality among hyponatremic population and its clinical expression might be made up of threatening neurological symptoms, e.g. brain oedema. Moreover, inappropriate treatment of hyponatremia may be followed with grievous consequences in the form of osmotic demyelination syndrome. Hyponatremia could also arise from iatrogenic origins. Thus, education concerning issues related to hyponatremia as the most frequent, though often underestimated, waterelectrolyte imbalance seems to be fundamental. This paper is a review of the current state of knowledge about hyponatremia with regard to its causes, diagnostics and differential diagnosis based on the prevailing guidelines elaborated by American and European experts independently.
MeSH term(s)	Diagnosis, Differential ; Humans ; Hyponatremia/diagnosis ; Hyponatremia/etiology ; Practice Guidelines as Topic
Language	Polish
Publishing date	2018-10-29
Publishing country	Poland
Document type	Journal Article ; Review
ZDB-ID	1388406-2
ISSN	1426-9686
ISSN	1426-9686
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4780: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: The Comparison of Predictive Value Among Chemerin, IL-18 and Hormonal Parameters in Assessing the Risk of Metabolic Syndrome in Men.

Jarecki, Piotr / Herman, Waldemar A / Losy, Jacek / Lacka, Katarzyna

American journal of men's health

2021 Volume 15, Issue 4, Page(s) 15579883211034984

Abstract: Chemerin (CHEM) is a new proinflammatory adipokine involved in the immune, metabolic and reproductive processes. Low-grade state inflammation (LGSI) is a key element in the pathogenesis of metabolic syndrome (MS). Low SHBG is a good marker of male ... ...

Abstract	Chemerin (CHEM) is a new proinflammatory adipokine involved in the immune, metabolic and reproductive processes. Low-grade state inflammation (LGSI) is a key element in the pathogenesis of metabolic syndrome (MS). Low SHBG is a good marker of male hypogonadism in MS. This study evaluated the prognostic value of selected adipokine, LGSI, and androgenic parameters in predicting the risk of MS among men. One hundred thirty-two random men aged 40 to 70 years old were enrolled. Measurements of anthropometric indices, blood pressure, and laboratory tests were carried out. A total of 62 men (47%) were diagnosed with MS. Chemerin concentrations were higher in men diagnosed with MS compared to healthy: 89.48 (78.12-112.10) vs. 77.9 (65.12-98.64) ng/mL;
MeSH term(s)	Adult ; Aged ; Androgens/blood ; Case-Control Studies ; Chemokines/blood ; Humans ; Interleukin-18/blood ; Male ; Metabolic Syndrome/blood ; Metabolic Syndrome/diagnosis ; Metabolic Syndrome/epidemiology ; Middle Aged ; Predictive Value of Tests ; Testosterone/blood ; Waist Circumference
Chemical Substances	Androgens ; Chemokines ; IL18 protein, human ; Interleukin-18 ; RARRES2 protein, human ; Testosterone (3XMK78S47O)
Language	English
Publishing date	2021-07-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2275106-3
ISSN	1557-9891 ; 1557-9883
ISSN (online)	1557-9891
ISSN	1557-9883
DOI	10.1177/15579883211034984
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Severe hyponatremia as the first sign of late-onset Schmidt's syndrome: A case report.

Wiśniewski, Oskar Wojciech / Matuszak, Paulina / Kasprzak, Agnieszka / Łącka, Katarzyna

Caspian journal of internal medicine

2021 Volume 12, Issue Suppl 2, Page(s) S392–S396

Abstract: Background: Schmidt's syndrome (SS) is a rare endocrine disorder (14-20:1000000), which consists of autoimmune thyroiditis (AIT) and autoimmune Addison's disease (aAD), and usually occurs in young adults. Here, we report a unique case of late-onset SS ... ...

Abstract	Background: Schmidt's syndrome (SS) is a rare endocrine disorder (14-20:1000000), which consists of autoimmune thyroiditis (AIT) and autoimmune Addison's disease (aAD), and usually occurs in young adults. Here, we report a unique case of late-onset SS manifesting initially with isolated severe hyponatremia and present the hazardous outcomes of preliminary misdiagnosis. Case presentation: A 78-year-old female presented to the emergency department with a two-day history of diarrhea, emesis and disturbances in consciousness. She also reported general fatigue and increasing weakness in the last month. Urgent laboratory findings revealed isolated severe hyponatremia (serum sodium=108 mmol/l) and initial treatment with active sodium infusions was started, although with no improvement in the patient's neurological status after 5 days (serum sodium=127 mmol/l). Meanwhile, the patient developed recurring episodes of hypoglycemia and symptoms portending adrenal crisis (blood pressure=105/58 mmHg, heart rate=96 bpm, severe whole-body muscle pain, two loose stools), which required immediate i.e. hydrocortisone treatment. Reduced blood cortisol, elevated adrenocorticotropic hormone (ACTH) and atrophic morphology of the adrenal glands in computed tomography imaging contributed to the final diagnosis of aAD and SS consequently, since the patient had a past medical history of AIT. Conclusion: Isolated severe hyponatremia should not be underestimated as the first sign of aAD. Appropriate cause-specific treatment is crucial in managing hyponatremia.
Language	English
Publishing date	2021-10-21
Publishing country	Iran
Document type	Case Reports
ZDB-ID	2971933-1
ISSN	2008-6172 ; 2008-6164
ISSN (online)	2008-6172
ISSN	2008-6164
DOI	10.22088/cjim.12.0.392
Database	MEDical Literature Analysis and Retrieval System OnLINE

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