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  1. Article: Have your competitiveness and eat it too

    Šćepanović, Vera

    Market expansion and social dumping in Europe , p. 190-209

    the pull and limits of cost competition in Hungary and Slovakia

    2015  , Page(s) 190–209

    Author's details Vera Šćepanović
    Language English
    Publisher Routledge
    Publishing place London [u.a.]
    Document type Article
    ISBN 978-1-138-78714-8 ; 1-138-78714-0
    Database ECONomics Information System

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  2. Article: The role of oxidative stress as a risk factor for rupture of posterior inferior cerebellar artery aneurysms

    Šćepanović, V / Borozan, S / Janićijević, A / Mitrović, D / Nikolić, I / Repac, N / Šćepanović, Lj / Šćepanović, R / Šćepanović, T / Stojanović, M / Tasić, G / Todorović, D

    Molecular biology reports. 2018 Dec., v. 45, no. 6

    2018  

    Abstract: Cerebral aneurysm affects 2–5% of the population and posterior inferior cerebellar artery (PICA) aneurysms account for 1–3% of all intracranial aneurysms. Oxidative stress is known to contribute to the progression of cerebrovascular disease and it may be ...

    Abstract Cerebral aneurysm affects 2–5% of the population and posterior inferior cerebellar artery (PICA) aneurysms account for 1–3% of all intracranial aneurysms. Oxidative stress is known to contribute to the progression of cerebrovascular disease and it may be increased by inflammation, a key contributor to cerebral aneurysm development and rupture. The aim of this study was to examine the role of overall oxidative stress as a risk factor for rupture of PICA aneurysms. This study included 29 patients with PICA aneurysms: 18 ruptured and 11 unruptured. We determined catalase, malondialdehyde, myeloperoxidase and carbonyl groups in homogenates of excised aneurysm tissue after surgery and plasma levels of C reactive protein and fibrinogen. The patient’s age and sex, size of aneurysms, multiplicity, history of previous subarachnoidal hemorrhage (SAH) and risk factors for oxidative stress such as hypertension and smoking were compared between unruptured and ruptured aneurysms. Maximal diameter and SAH history were independent predictors for aneurysm rupture. Activity of catalase was decreased while activity of myeloperoxidase, levels of malondialdehyde, carbonyl groups in aneurismal tissue and plasma levels of C reactive protein and fibrinogen were increased in patients with ruptured aneurysms. Plasma levels of C reactive protein and fibrinogen showed positive correlation with myeloperoxidase, malondialdehyde, carbonyl groups and PHASES score and negative correlation with catalase. These findings suggest that oxidative stress may contribute importantly to rupture of PICA aneurysms and plasma levels of C reactive protein and fibrinogen correlate with oxidative stress markers in tissue.
    Keywords aneurysm ; catalase ; cerebellum ; cerebrovascular disorders ; enzyme activity ; fibrinogen ; hemorrhage ; hypertension ; inflammation ; malondialdehyde ; moieties ; myeloperoxidase ; oxidative stress ; patients ; risk factors ; surgery
    Language English
    Dates of publication 2018-12
    Size p. 2157-2165.
    Publishing place Springer Netherlands
    Document type Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-018-4374-6
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  3. Article ; Online: Reconstruction of Moderately and Severely Atrophic Scalp-A Multicentric Experience in Surgical Treatment of Patients Irradiated for Tinea Capitis in Childhood and Surgical Algorithm.

    Nikolić Živanović, Maja / Jurišić, Milana / Marinković, Milana / Grujičić, Danica / Stanimirović, Aleksandar / Šćepanović, Vuk / Milićević, Mihailo / Jovićević, Nikola / Videnović, Goran / Pavlović, Vedrana / Bogunović Stojičić, Sanda / Jovanović, Milan / Jeremić, Jelena / Jović, Marko / Ilić, Rosanda / Stojičić, Milan

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 9

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Humans ; Female ; Male ; Aged ; Scalp/surgery ; Retrospective Studies ; Neoplasm Recurrence, Local ; Tinea Capitis/radiotherapy ; Tinea Capitis/surgery ; Atrophy/surgery ; Algorithms
    Language English
    Publishing date 2023-09-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59091678
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
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  4. Article ; Online: The role of oxidative stress as a risk factor for rupture of posterior inferior cerebellar artery aneurysms.

    Šćepanović, V / Tasić, G / Repac, N / Nikolić, I / Janićijević, A / Todorović, D / Stojanović, M / Šćepanović, R / Mitrović, D / Šćepanović, T / Borozan, S / Šćepanović, Lj

    Molecular biology reports

    2018  Volume 45, Issue 6, Page(s) 2157–2165

    Abstract: Cerebral aneurysm affects 2-5% of the population and posterior inferior cerebellar artery (PICA) aneurysms account for 1-3% of all intracranial aneurysms. Oxidative stress is known to contribute to the progression of cerebrovascular disease and it may be ...

    Abstract Cerebral aneurysm affects 2-5% of the population and posterior inferior cerebellar artery (PICA) aneurysms account for 1-3% of all intracranial aneurysms. Oxidative stress is known to contribute to the progression of cerebrovascular disease and it may be increased by inflammation, a key contributor to cerebral aneurysm development and rupture. The aim of this study was to examine the role of overall oxidative stress as a risk factor for rupture of PICA aneurysms. This study included 29 patients with PICA aneurysms: 18 ruptured and 11 unruptured. We determined catalase, malondialdehyde, myeloperoxidase and carbonyl groups in homogenates of excised aneurysm tissue after surgery and plasma levels of C reactive protein and fibrinogen. The patient's age and sex, size of aneurysms, multiplicity, history of previous subarachnoidal hemorrhage (SAH) and risk factors for oxidative stress such as hypertension and smoking were compared between unruptured and ruptured aneurysms. Maximal diameter and SAH history were independent predictors for aneurysm rupture. Activity of catalase was decreased while activity of myeloperoxidase, levels of malondialdehyde, carbonyl groups in aneurismal tissue and plasma levels of C reactive protein and fibrinogen were increased in patients with ruptured aneurysms. Plasma levels of C reactive protein and fibrinogen showed positive correlation with myeloperoxidase, malondialdehyde, carbonyl groups and PHASES score and negative correlation with catalase. These findings suggest that oxidative stress may contribute importantly to rupture of PICA aneurysms and plasma levels of C reactive protein and fibrinogen correlate with oxidative stress markers in tissue.
    MeSH term(s) Aged ; Aneurysm, Ruptured/metabolism ; Arteries ; Biomarkers/blood ; C-Reactive Protein/analysis ; Catalase/analysis ; Cerebellum ; Female ; Fibrinogen/analysis ; Humans ; Intracranial Aneurysm/metabolism ; Male ; Malondialdehyde/analysis ; Middle Aged ; Oxidative Stress/physiology ; Peroxidase/analysis ; Risk Factors ; Serbia ; Subarachnoid Hemorrhage ; Tomography, X-Ray Computed
    Chemical Substances Biomarkers ; Malondialdehyde (4Y8F71G49Q) ; Fibrinogen (9001-32-5) ; C-Reactive Protein (9007-41-4) ; Catalase (EC 1.11.1.6) ; Peroxidase (EC 1.11.1.7)
    Language English
    Publishing date 2018-09-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-018-4374-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1140: Show issues Location:
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  5. Article ; Conference proceedings: Aneurysm Inclination Angle as the Predisposing Factor for the Occurrence of Rupture

    Nikolić, I. / Repac, N. / Janićijević, A. / Šćepanović, V. / Rasulić, L. / Tasić, G.

    Journal of Neurological Surgery Part A: Central European Neurosurgery

    2015  

    Abstract: Introduction: Natural course of aneurysms that occur on blood vessels of the brain singles out the need for understanding the mechanism of the occurrence of aneurysm wall rupture and identification of anatomic characteristics as predictive factors for ... ...

    Event/congress Presentation Abstracts, Hotel Bristol, Sarajevo, Bosnia and Herzegovina, 2015
    Abstract Introduction: Natural course of aneurysms that occur on blood vessels of the brain singles out the need for understanding the mechanism of the occurrence of aneurysm wall rupture and identification of anatomic characteristics as predictive factors for hemorrhage to occur.
    Aim: In this study, we comparatively present results of our researches and experimental models on animals.
    Material and Methods: We made a comparative analysis of anatomical characteristics of blood vessels of the brain and aneurysms obtained on the basis of digital subtraction angiography and intraoperative finding. In this article, we review recent research in the anatomic characteristics of intracranial aneurysms and parent blood vessels.
    Results: We present a series of 185 aneurysms (ruptured and unruptured) dissected at the Neurosurgical Clinic of Clinical Center of Serbia in Belgrade. Inclination angle may be considered as the vital predisposing factor for intracranial aneurysm rupture. In aneurysms that ruptured, it was 139.748 ± 27.242 degrees, while in unruptured aneurysms it was considerably smaller and amounted to 100.882 ± 22.001 degrees ( p  < 0.01).
    Conclusion: Inclination angle may be regarded as the vital predisposing factor because it differs considerably in unruptured and ruptured aneurysms. Aneurysms with blood stream angle smaller than 115 degrees have very small probability of rupture, while blood stream angle bigger than 150 degrees presents a high risk of rupture.
    Keywords: intracranial aneurysm; inclination angle; rupture
    Language English
    Publishing date 2015-10-19
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2651663-9
    ISSN 2193-6323 ; 2193-6315
    ISSN (online) 2193-6323
    ISSN 2193-6315
    DOI 10.1055/s-0035-1566394
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.130: Show issues Location:
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  6. Article ; Conference proceedings: Spontaneous Intracerebral Brain Hemorrhage Localized in the Basal Ganglia

    Milošević, A. / Nikolić, I / Repac, N. / Janićijević, A. / Šćepanović, V. / Rasulić, L. / Tasić, G.

    Journal of Neurological Surgery Part A: Central European Neurosurgery

    2015  

    Abstract: Introduction: The study included 39 patients treated in a special hospital for the prevention and treatment of cerebrovascular diseases “Sveti Sava” in Belgrade in the period from October 2010 to January 2012. The criteria for inclusion in the study is ... ...

    Event/congress Presentation Abstracts, Hotel Bristol, Sarajevo, Bosnia and Herzegovina, 2015
    Abstract Introduction: The study included 39 patients treated in a special hospital for the prevention and treatment of cerebrovascular diseases “Sveti Sava” in Belgrade in the period from October 2010 to January 2012. The criteria for inclusion in the study is the moment of diagnosis of spontaneous intracerebral hemorrhage (ICH) in the basal ganglia of the brain (BG).
    Results: We analyzed 25 male patients and 14 female patients, aged 54 to 95 years. In deceased group, 22 (56.4%) and 20 (90.9%) were in the age group 60 to 80 years; GCS: 3–5, 12 patients (54.5%) died, GCS: 6–8, 10 patients (45.5%), 20 patients (90.9%) also had intracerebral and intraventricular hemorrhage complicated by acute hydrocephalus.
    Conclusion: Predisposing factors for mortality within 1 year in patients with spontaneous intracerebral hemorrhage in the basal ganglia of the brain are males older than 60 years, unregulated hypertension, and penetration of blood in the chamber system.
    Keywords: HIC; basal ganglia
    Language English
    Publishing date 2015-10-19
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2651663-9
    ISSN 2193-6323 ; 2193-6315
    ISSN (online) 2193-6323
    ISSN 2193-6315
    DOI 10.1055/s-0035-1566390
    Database Thieme publisher's database

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  7. Article: Determination of Predictive Anatomic Parameters for Bleeding of Brain Arteriovenous Malformations by Multidetector CT Angiography.

    Milatović, Biljana / Tasić, Goran / Nikolić, Igor / Đorić, Igor / Repac, Nikola / Šćepanović, Vuk / Janićijević, Aleksandar / Rotim, Krešimir / Rasulić, Lukas

    Acta clinica Croatica

    2018  Volume 56, Issue 4, Page(s) 728–732

    Abstract: Patients with brain arteriovenous malformation (AVM) have a certain risk to bleed, and the goal of this study was to examine the effect of radiological and clinical predictive characteristics of AVM hemorrhage using multidetector computed tomographic ( ... ...

    Abstract Patients with brain arteriovenous malformation (AVM) have a certain risk to bleed, and the goal of this study was to examine the effect of radiological and clinical predictive characteristics of AVM hemorrhage using multidetector computed tomographic (MDCT) angiography. The study included a series of 57 patients, mean age 35.46 years, who were diagnosed during their hospitalization at Clinical Department of Neurosurgery, Clinical Center of Serbia, in the period from January 2008 to March 2016. In all patients, the diagnosis was made using MDCT angiography. Two groups of patients were observed. The first group included patients who did not initially present with hemorrhage, while the second group initially presented with hemorrhage. Both groups were treated with medical therapy or a combination of medical therapy with embolization/surgery/radiotherapy. Deep venous drainage (p<0.05), combined arterial supply from different basins (p<0.05) with a length <60 mm, venous dilatation present in the drainage vein (p<0.01), and the angle of casting sup-ply arteries in the nidus (p<0.01) carry a risk of repeated bleeding. In the group of patients who had initial hemorrhage, the mean value of the casting angle size was 130°, while in the group that did not have initial bleeding the mean value of the measured angle size was 103.81° with standard deviation of 17.21° (p<0.01). In conclusion, AVMs with deep venous drainage from the carotid and vertebrobasilar basin, the length of the feeding arteries <60 mm, the angle of the casting feeding arteries in the nidus ≥130° and dilatation and/or venous aneurysm of drainage vessel are predictive for clinical presenting by hemorrhage.
    MeSH term(s) Adult ; Cerebral Hemorrhage/etiology ; Computed Tomography Angiography ; Humans ; Intracranial Arteriovenous Malformations/complications ; Intracranial Arteriovenous Malformations/diagnostic imaging ; Serbia
    Language English
    Publishing date 2018-03-28
    Publishing country Croatia
    Document type Journal Article
    ZDB-ID 1478635-7
    ISSN 0353-9466
    ISSN 0353-9466
    DOI 10.20471/acc.2017.56.04.21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5057: Show issues Location:
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  8. Article: Adult Brainstem Gliomas: Retrospective Analysis of 51 Patients.

    Tasic, Goran / Repac, Nikola / Nikolic, Igor / Bogosavljevic, Vojislav / Scepanovic, Vuk / Janicijevic, Aleksandar / Eric-Nikolic, Aleksandra / Rasulic, Lukas

    Turkish neurosurgery

    2017  Volume 27, Issue 4, Page(s) 558–562

    Abstract: Aim: Brainstem gliomas (BSG) constitute less than 2% of brain tumors in adults. Therapeutic options are limited and BSG are associated with a high morbidity and mortality.: Material and methods: We reviewed the records of 51 patients with BSG treated ...

    Abstract Aim: Brainstem gliomas (BSG) constitute less than 2% of brain tumors in adults. Therapeutic options are limited and BSG are associated with a high morbidity and mortality.
    Material and methods: We reviewed the records of 51 patients with BSG treated at the Institute of Neurosurgery, Clinical Center of Serbia in Belgrade between 1998 and 2012. We recorded demographic and clinical variables as well as radiological findings and survival.
    Results: Of the 51 patients, 62.7% were male and 37.3% were female. The mean age was 30.6±19.3 years. High grade glioma (Astrocytoma grade III and IV) was most common at the age of 38.2±17.9 years (t=.481, p=0.017) while low grade glioma (Astrocytoma grade I and II) was common in younger age as 25.4±17.4 years (X2=4.013; p=0.045), with localization in the pons (X2=5.299; p=0.021) and exophytic presentation (X2=3.862; p=0.049). Ataxia, as initial symptom, was a predictor of poor outcome (HR:5.546, p=0.012).
    Conclusion: Due to its specific localization, BSG present a major challenge for neurosurgery, because of the necessity of safe approach for radical resection. Histological verification of BSG determines the need for additional therapeutic procedures such as radiotherapy and chemotherapy. Benefit from correct diagnosis is reflected in the avoidance of potentially adverse effects of treatment.
    Language English
    Publishing date 2017
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 1203779-5
    ISSN 1019-5149
    ISSN 1019-5149
    DOI 10.5137/1019-5149.JTN.16488-15.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4081: Show issues Location:
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  9. Article: Effects of subchronic methionine stimulation on oxidative status and morphological changes in the rat ileum.

    Todorovic, Dušan / Stojanovic, Marija / Scepanovic, Ljiljana / Mitrovic, Dušan / Scepanovic, Vuk / Scepanovic, Radomir / Scepanovic, Teja / Labudovic-Borovic, Milica / Dragutinovic, Vesna / Borozan, Nevena / Djuric, Dragan

    General physiology and biophysics

    2019  Volume 38, Issue 6, Page(s) 535–544

    Abstract: This study was conducted to explore the effects of sulfur containing amino acids on redox status and morphological parameters in the rat ileum tissue. Male Wistar albino rats were randomly divided into the following groups: Group K (saline (1 ml/day, i.p. ...

    Abstract This study was conducted to explore the effects of sulfur containing amino acids on redox status and morphological parameters in the rat ileum tissue. Male Wistar albino rats were randomly divided into the following groups: Group K (saline (1 ml/day, i.p.)), Group M (methionine (0.8 mmol/kg/day, i.p.)), Group C (methionine (0.8 mmol/kg/day) + L-cysteine (7 mg/kg/day), i.p.) and Group N (methionine (0.8 mmol/kg/day) + N-acetyl-L-cysteine (50 mg/kg/day), i.p.). Activities of antioxidant enzymes in the ileum were analyzed to profile oxidative status. Morphometric analysis included measurement of villus height (μm), tunica mucosa thickness (μm), tunica muscularis thickness (μm), the total thickness of the ileal wall (μm) and the number of cells in the lamina propria (per 0.1 mm2 of tissue). Results showed that methionine treatment reduced the activity of antioxidant enzymes (SOD, GPx, CAT) and the GSH content compared to the control group (p > 0.05). The application of methionine reduced the following parameters statistically significant compared to the control group: length of the ileal villi (p < 0.01), tunica mucosa thickness (p < 0.01), and ileal wall thickness (p < 0.01). We concluded that methionine induced the changes in the gut redox status, which implied oxidative stress occurrence. L-cysteine and N-acetyl-L-cysteine both exhibited antioxidant properties.
    MeSH term(s) Animals ; Ileum ; Male ; Methionine ; Oxidation-Reduction ; Oxidative Stress ; Rats ; Rats, Wistar
    Chemical Substances Methionine (AE28F7PNPL)
    Language English
    Publishing date 2019-12-11
    Publishing country Slovakia
    Document type Journal Article
    ZDB-ID 791184-1
    ISSN 0231-5882
    ISSN 0231-5882
    DOI 10.4149/gpb_2019033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Conference proceedings: Use of the Direct Electrostimulation in the Prevention of Motor Deficit in Surgical Treatment of Glioblastoma Multiforme Tumors Localized in the Motor Zone of the Brain

    Repac, N. / Nikolić, I. / Erić-Nikolić, A. / Janićijević, A. / Šćepanović, V. / Rasulić, L. / Tasić, G.

    Journal of Neurological Surgery Part A: Central European Neurosurgery

    2015  

    Abstract: Introduction: Glioblastoma multiforme localized in the motor area is the surgical challenge because of the need for more radical resection to extend the life of the patient, and the other due to the risk that radicalism could lead to additional- ... ...

    Event/congress Presentation Abstracts, Hotel Bristol, Sarajevo, Bosnia and Herzegovina, 2015
    Abstract Introduction: Glioblastoma multiforme localized in the motor area is the surgical challenge because of the need for more radical resection to extend the life of the patient, and the other due to the risk that radicalism could lead to additional-crippling neurological deficit.
    Material and Methods: We present a series of 26 patients with glioblastoma multiforme localized in and around the motor area in front of the central sulcus who were hospitalized from October 2004 to February 2009. During all operations, we conducted cortical electrostimulation on displayed area of the brain, to the anatomical location of M1 segment of the motor cortex.
    Results: Distance of the central sulcus in relation to the coronary suture, measured by magnetic resonance imaging (MRI), was 18.38 mm ± 9.564 mm. The volume of electricity required for a motor response was 9.26 ± 1.286 mA (min.: 7 mA, max.: 11 mA), with increasing distance from the coronary suture the amperage required to explicit motor responses decreased ( p  < 0.01).
    Conclusion: The method of direct cerebral cortex electrostimulation is simple and safe method and a binding protocol to the patient's safe operation glioblastoma multiforme localized in the motor area of the brain.
    Keywords: glioblastoma multiforme; motor area; direct electrostimulation
    Language English
    Publishing date 2015-10-19
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2651663-9
    ISSN 2193-6323 ; 2193-6315
    ISSN (online) 2193-6323
    ISSN 2193-6315
    DOI 10.1055/s-0035-1566401
    Database Thieme publisher's database

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