Article ; Online: Cyclosporin A in combination with corticosteroids as a treatment for immunoglobulin A vasculitis nephritis in children.
2023
Abstract: Background: Immunoglobulin A vasculitis is the most common vasculitis in children. It is usually a self-limiting condition, and the long-term prognosis depends on the severity of renal involvement. Although cyclosporin A is not generally recommended for ...
| Abstract | Background: Immunoglobulin A vasculitis is the most common vasculitis in children. It is usually a self-limiting condition, and the long-term prognosis depends on the severity of renal involvement. Although cyclosporin A is not generally recommended for the management of moderate immunoglobulin A vasculitis nephritis, a few previous reports showed its efficacy. Our aim was to determine whether the treatment with cyclosporin A in combination with corticosteroids is safe and effective for moderate pediatric immunoglobulin A vasculitis nephritis. Methods: Nine children underwent treatment. Mean follow-up was 3.1±1.6 (1.4-5.8) years. Results: All children (seven females and two males) reached complete remission (65.8±27.6 [24-99]) days. No patient had relapse, one patient had slightly impaired kidney function (glomerular filtration rate 84.4 mL/min/1.73 m Conclusions: Cyclosporin A in combination with corticosteroids seems to be a safe and effective treatment for moderate immunoglobulin A vasculitis nephritis. More studies with cyclosporin A should be conducted to better determine the best therapeutic approach. |
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| Language | English |
| Publishing date | 2023-04-06 |
| Publishing country | Italy |
| Document type | Journal Article |
| ZDB-ID | 3062664-X |
| ISSN | 2724-5780 |
| ISSN (online) | 2724-5780 |
| DOI | 10.23736/S2724-5276.23.07057-X |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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