Article ; Online: Adherence to application technique of inhaled corticosteroid in patients with asthma and COVID-19 improves outcomes.
2024 Volume 11, Issue 1
Abstract: Background: Inhaled corticosteroids have been widely reported as a preventive measure against the development of severe forms of COVID-19 not only in patients with asthma.: Methods: In 654 Czech and Slovak patients with asthma who developed COVID-19, ...
| Abstract | Background: Inhaled corticosteroids have been widely reported as a preventive measure against the development of severe forms of COVID-19 not only in patients with asthma. Methods: In 654 Czech and Slovak patients with asthma who developed COVID-19, we investigated whether the correct use of inhaler containing corticosteroids was associated with a less severe course of COVID-19 and whether this had an impact on the need for hospitalisation, measurable lung functions and quality of life (QoL). Results: Of the studied cohort 51.4% had moderate persistent, 29.9% mild persistent and 7.2% severe persistent asthma. We found a significant adverse effect of poor inhaler adherence on COVID-19 severity (p=0.049). We also observed a lower hospitalisation rate in patients adequately taking the inhaler with OR of 0.83. Vital capacity and forced expiratory lung volume deterioration caused by COVID-19 were significantly reversed, by approximately twofold to threefold, in individuals who inhaled correctly. Conclusion: Higher quality of inhalation technique of corticosteroids measured by adherence to an inhaled medication application technique (A-AppIT) score had a significant positive effect on reversal of the vital capacity and forced expiratory lung volume in 1 s worsening (p=0.027 and p<0.0001, respectively) due to COVID-19. Scoring higher in the A-AppIT was also associated with significantly improved QoL. All measured variables concordantly and without exception showed a positive improvement in response to better adherence. We suggest that corticosteroids provide protection against the worsening of lungs in patients with COVID-19 and that correct and easily assessable adherence to corticosteroids with appropriate inhalation technique play an important role in preventing severe form of COVID-19. |
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| MeSH term(s) | Humans ; Quality of Life ; COVID-19 ; Asthma/drug therapy ; Adrenal Cortex Hormones ; Forced Expiratory Volume |
| Chemical Substances | Adrenal Cortex Hormones |
| Language | English |
| Publishing date | 2024-01-06 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2736454-9 |
| ISSN | 2052-4439 ; 2052-4439 |
| ISSN (online) | 2052-4439 |
| ISSN | 2052-4439 |
| DOI | 10.1136/bmjresp-2023-001874 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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