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  1. Article: Ketamine, an Old-New Drug: Uses and Abuses.

    Savić Vujović, Katarina / Jotić, Ana / Medić, Branislava / Srebro, Dragana / Vujović, Aleksandar / Žujović, Janko / Opanković, Ana / Vučković, Sonja

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 17, Issue 1

    Abstract: Ketamine as an old-new drug has a variety of clinical implications. In the last 30 years, ketamine has become popular for acute use in humans. Ketamine in standard doses is principally utilized for the induction and maintenance of surgical procedures. ... ...

    Abstract Ketamine as an old-new drug has a variety of clinical implications. In the last 30 years, ketamine has become popular for acute use in humans. Ketamine in standard doses is principally utilized for the induction and maintenance of surgical procedures. Besides its use in anesthesia and analgesia, recent studies have shown that ketamine has found a place in the treatment of asthma, epilepsy, depression, bipolar affective disorders, alcohol and heroin addiction. Ketamine primarily functions as a noncompetitive antagonist targeting the N-methyl-D-aspartate (NMDA) receptor, but its mechanism of action is complex. It is generally regarded as safe, with low doses and short-term use typically not leading to significant adverse effects. Also, ketamine is known as a powerful psychostimulant. During the past decade, ketamine has been one of the commonly abused drugs.
    Language English
    Publishing date 2023-12-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph17010016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Clinical significance of proliferation index and E-cadherin expression in colorectal adenocarcinoma

    Žujović Janko / Vuletić Milena / Stojanović Miroslav / Lazović Ranko / Đorđević Nebojša / Radunović Miodrag / Jančić Snežana / Milošević Velimir

    Srpski Arhiv za Celokupno Lekarstvo, Vol 149, Iss 9-10, Pp 558-

    2021  Volume 565

    Abstract: Introduction/Objective. The aim of this study is to examine the association of E-cadherin expression and high proliferation index (proIDX) with clinical and pathological indicators of colorectal cancer progression. Methods. The biopsy of 72 patients, ... ...

    Abstract Introduction/Objective. The aim of this study is to examine the association of E-cadherin expression and high proliferation index (proIDX) with clinical and pathological indicators of colorectal cancer progression. Methods. The biopsy of 72 patients, obtained by resection of colorectal cancer, was routinely processed at the Institute of Pathology of the Clinical Centre of Montenegro, embedded in paraffin and archived. Based on the archived pathohistological reports, two study groups were formed: the first group (n = 72) consisted of operative biopsies of colorectal cancer, and the control group (n = 72) consisted of biopsies of adjacent non-tumor tissue. Routine hematoxylin-eosin and immunohistochemical avidin-biotin-peroxidase complex method with anti-Ki67 and anti-E-cadherin antibodies was applied on. After quantification of the results for statistical tests, the software package SPSS for Windows (19.0) was used. Results. In colorectal carcinoma, we observed a significant association of proIDX with pT stage, lymph and blood vessel invasion, perineural invasion, lymph node metastases and distant metastases, and Astler–Coller stage tumor disease. We also observed that the absence of E-cadherin was significantly associated with pT stage, lymph and blood vessel invasion, perineural invasion with lymph node metastases, distant metastases, with C2 and D Astler–Coller tumor stage. E-cadherin expression is associated with proIDX with a significantly high, negative correlation coefficient. Conclusion. Our results indicate that it is possible to differentiate patients into groups with a higher or lower risk of developing metastatic disease, based on the expression of Ki67 and E-cadherin.
    Keywords colorectal cancer ; e-cadherin expression ; proliferative index ; clinical significance ; Medicine ; R
    Subject code 610 ; 616
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Serbian Medical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Influence of stathmin 1 (STMN1) expression on neoangiogenesis in colorectal adenocarcinoma.

    Žujović, Janko T / Stojanović, Marko M / Brzački, Vesna M / Kujović, Aleksandar D / Đorđević, Miodrag N / Jančić, Snežana A / Milenković, Sanja M / Milošević, Velimir S

    Pathology, research and practice

    2022  Volume 238, Page(s) 154057

    Abstract: Stathmin1 is a microtubular regulatory protein. The expression disorders of this protein result in significant changes in cell migration, invasion, adhesion and colony formation in many malignant tumors. The aim of our research was to investigate the ... ...

    Abstract Stathmin1 is a microtubular regulatory protein. The expression disorders of this protein result in significant changes in cell migration, invasion, adhesion and colony formation in many malignant tumors. The aim of our research was to investigate the effects of Stathmin1 expression on neoangiogenesis in colorectal adenocarcinoma. Biopsy material that was obtained by the resection of colorectal carcinoma was used. The experimental group consisted of operative biopsies of colorectal cancer (n = 72), and the control group (n = 72) consisted of biopsies of adjacent non-tumor colon tissue. The biopsy material was taken from an operative preparation submitted to the Department of Pathology. After histopathological treatment, classical Hematoxylin- Eosin and immunohistochemical ABC methods with anti-Stathmin1, anti-VEGF and anti CD105 antibodies were applied on 4 µm thick sections. High expression of Stathmin1 is associated with severe (91.9%) and moderate (8.1%) expression of VEGF in a significantly high number of cases. This relation is defined by a highly significant correlation coefficient (r = 0.768; p = 0.000). High expression of Stathmin1 is associated with a high microvascular density index (mvdIDX) in a significant number of cases (73.0%) while low expression of Stathmin1 is in relation with low mvdIDX in a significant 73.7% of cases. This relationship is also defined by a highly significant correlation coefficient (r = 0.566; p = 0.000). ROC analysis showed that the sensitivity for Stathmin1 was 97.4% and the specificity was 91.4%. Based on Stathmin1 expression, it is possible to differentiate patients with increased risk for metastatic disease. The highly significant association of Stathmin1 expression with VEGF expression and microvascular density (MVD) suggests that Stathmin1 may be a serious candidate for therapeutic target.
    Language English
    Publishing date 2022-08-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 391889-0
    ISSN 1618-0631 ; 0344-0338
    ISSN (online) 1618-0631
    ISSN 0344-0338
    DOI 10.1016/j.prp.2022.154057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud III Zs.20: Show issues Location:
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  4. Article ; Online: Clinical significance of Leptin receptor (LEPR) and Endoglin (CD105) expressions in colorectal adenocarcinoma.

    S Vuletic, Milena / S Milosevic, Velimir / A Jancic, Snezana / T Zujovic, Janko / S Krstic, Miljan / C Vukmirovic, Filip

    Journal of B.U.ON. : official journal of the Balkan Union of Oncology

    2020  Volume 24, Issue 6, Page(s) 2448–2457

    Abstract: Purpose: Carcinoma of the colon occurs quite more often in obese than in healthy people. The key molecule in the development of obesity is leptin, a product of Ob gene that expresses its effects through a specific receptor (LEPR), so our goal was to ... ...

    Abstract Purpose: Carcinoma of the colon occurs quite more often in obese than in healthy people. The key molecule in the development of obesity is leptin, a product of Ob gene that expresses its effects through a specific receptor (LEPR), so our goal was to investigate the expression of LEPR in colorectal carcinoma and the association of their expression with neoangiogenesis, with local/regional and distant metastases and with tumor stage according to the Astler-Coller classification.
    Methods: In the paraffin blocks taken from 75 patients treated for colorectal cancer, 3-4 μm thick cuts were made using routine hematoxylin-eosin (HE) and immunohistochemical ABC methods with anti-LEPR and anti-CD105 antibodies. After quantitative analysis of LEPR expression, the microvascular density per mm2 was calculated stereometrically. For the statistical processing, the SPSS software (version 13.0) was used.
    Results: Pronounced expression of LEPR in stages B1 and B2 was present in 9.1% and in 16% of the cases. In the C2 and D stages, pronounced LEPR expression was found in 51.6%, i.e. 57.1% of the cases, which was significantly higher than in the stages B1 and B2. In the C2 and D stages, a high neoangiogenesis index was found in a significantly higher number of cases (67.7% and 100%) than in stages B1 and B2. LEPR expression had a highly significant correlation coefficient associated with tumor stage, neoangiogenesis index, metastases in the lymph nodes and with distant metastases.
    Conclusion: The increase of LEPR expression was accompanied by increased neoangiogenesis and an increase in the metastatic potential of colorectal cancer.
    MeSH term(s) Adenocarcinoma/metabolism ; Adenocarcinoma/secondary ; Aged ; Biomarkers, Tumor/metabolism ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Endoglin/metabolism ; Female ; Follow-Up Studies ; Humans ; Lymphatic Metastasis ; Male ; Middle Aged ; Neovascularization, Pathologic/metabolism ; Neovascularization, Pathologic/pathology ; Phosphorylation ; Prognosis ; Receptors, Leptin/metabolism ; Signal Transduction
    Chemical Substances Biomarkers, Tumor ; ENG protein, human ; Endoglin ; LEPR protein, human ; Receptors, Leptin
    Language English
    Publishing date 2020-01-21
    Publishing country Cyprus
    Document type Journal Article
    ZDB-ID 2040386-0
    ISSN 2241-6293 ; 1107-0625
    ISSN (online) 2241-6293
    ISSN 1107-0625
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5438: Show issues Location:
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