Article ; Online: CCBE1 Is Essential for Epicardial Function during Myocardium Development.
International journal of molecular sciences
2022 Volume 23, Issue 20
Abstract: The epicardium is a single cell layer of mesothelial cells that plays a critical role during heart development contributing to different cardiac cell types of the developing heart through epithelial-to-mesenchymal transition (EMT). Moreover, the ... ...
| Abstract | The epicardium is a single cell layer of mesothelial cells that plays a critical role during heart development contributing to different cardiac cell types of the developing heart through epithelial-to-mesenchymal transition (EMT). Moreover, the epicardium is a source of secreted growth factors that promote myocardial growth. CCBE1 is a secreted extracellular matrix protein expressed by epicardial cells that is required for the formation of the primitive coronary plexus. However, the role of CCBE1 during epicardial development was still unknown. Here, using a |
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| MeSH term(s) | Mice ; Animals ; Heart/physiology ; Organogenesis ; Pericardium/metabolism ; Myocardium/metabolism ; Epithelial-Mesenchymal Transition/genetics ; Mice, Knockout ; Collagen/metabolism |
| Chemical Substances | Collagen (9007-34-5) |
| Language | English |
| Publishing date | 2022-10-20 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ZDB-ID | 2019364-6 |
| ISSN | 1422-0067 ; 1422-0067 ; 1661-6596 |
| ISSN (online) | 1422-0067 |
| ISSN | 1422-0067 ; 1661-6596 |
| DOI | 10.3390/ijms232012642 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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