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Article ; Online: Land subsidence risk assessment and protection in mined-out regions

A. Zhao / A. Tang

Proceedings of the International Association of Hydrological Sciences, Vol 372, Pp 145-

2015 Volume 150

Abstract: Land subsidence due to underground mining is an important hazard that causes large damages and threatens to social and economic activities. The China government has started a national project to estimate the risk of land subsidence in the main coal ... ...

Abstract	Land subsidence due to underground mining is an important hazard that causes large damages and threatens to social and economic activities. The China government has started a national project to estimate the risk of land subsidence in the main coal production provinces, such as Heilongjiang, Anhui and Shanxi Provinces. Herein, the investigation methods for land subsidence identification were reported, some types of land settlement are summarized, and some successful engineering measures to mitigate the subsidence are discussed. A Geographical Information System (GIS) for land subsidence risk assessment is developed and is based on site investigations and numerrical simulation of the subsidence process. In this system, maps of mining intensity and risk ranks are developed.
Keywords	Environmental sciences ; GE1-350 ; Geology ; QE1-996.5
Language	English
Publishing date	2015-11-01T00:00:00Z
Publisher	Copernicus Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Factors influencing initial implementation of an online community-based exercise intervention with adults living with HIV

T. Jiancaro / A. M. Bayoumi / F. Ibáñez-Carrasco / B. Torres / K. McDuff / D. A. Brown / S. Chan Carusone / A. Tang / M. Loutfy / S. Cobbing / K. K. O’Brien

Frontiers in Rehabilitation Sciences, Vol

a systems approach

2023 Volume 4

Abstract: IntroductionOnline community-based exercise (CBE) is a digital health intervention and rehabilitation strategy that promotes health among people living with HIV. Our aim was to describe the factors influencing initial implementation of a pilot online CBE ...

Abstract	IntroductionOnline community-based exercise (CBE) is a digital health intervention and rehabilitation strategy that promotes health among people living with HIV. Our aim was to describe the factors influencing initial implementation of a pilot online CBE intervention with adults living with HIV using a systems approach, as recommended by implementation science specialists.MethodsWe piloted the implementation of a 6-month online CBE intervention and 6-month independent exercise follow up, in partnership with the YMCA in Toronto, Canada. We recruited adults living with HIV who identified themselves as safe to engage in exercise. The intervention phase included personalized exercise sessions online with a personal trainer; exercise equipment; access to online exercise classes; and a wireless physical activity monitor. Two researchers documented implementation factors articulated by participants and the implementation team during early implementation, defined as recruitment, screening, equipment distribution, technology orientation, and baseline assessments. Data sources included communication with participants; daily team communication; weekly team discussions; and in-person meetings. We documented implementation factors in meeting minutes, recruitment screening notes, and email communication; and analyzed the data using a qualitative descriptive approach using a systems engineering method called Cognitive Work Analysis.ResultsThirty-three adults living with HIV enrolled in the study (n = 33; median age: 52 years; cis-men: 22, cis-women: 10, non-binary: 1). Fifty-five factors influencing implementation, spanned five layers: (i) Natural, including weather and the COVID-19 virus; (ii) Societal, including COVID-19 impacts (e.g. public transit health risks impacting equipment pick-ups); (iii) Organizational, including information dissemination (e.g. tech support) and logistics (e.g. scheduling); (iv) Personal, including physical setting (e.g. space) and digital setting (e.g. device access); and (v) Human, including ...
Keywords	cognitive work analysis ; systems engineering ; implementation science ; hiv/aids ; physical activity ; exercise. factors influencing initial implementation ; Other systems of medicine ; RZ201-999 ; Medical technology ; R855-855.5
Subject code	796
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Identification of CD38, CD97, and CD278 on the HIV surface using a novel flow virometry screening assay

Jonathan Burnie / Claire Fernandes / Deepa Chaphekar / Danlan Wei / Shubeen Ahmed / Arvin Tejnarine Persaud / Nawrah Khader / Claudia Cicala / James Arthos / Vera A. Tang / Christina Guzzo

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 16

Abstract: Abstract While numerous cellular proteins in the HIV envelope are known to alter virus infection, methodology to rapidly phenotype the virion surface in a high throughput, single virion manner is lacking. Thus, many human proteins may exist on the virion ...

Abstract	Abstract While numerous cellular proteins in the HIV envelope are known to alter virus infection, methodology to rapidly phenotype the virion surface in a high throughput, single virion manner is lacking. Thus, many human proteins may exist on the virion surface that remain undescribed. Herein, we developed a novel flow virometry screening assay to discover new proteins on the surface of HIV particles. By screening a CD4+ T cell line and its progeny virions, along with four HIV isolates produced in primary cells, we discovered 59 new candidate proteins in the HIV envelope that were consistently detected across diverse HIV isolates. Among these discoveries, CD38, CD97, and CD278 were consistently present at high levels on virions when using orthogonal techniques to corroborate flow virometry results. This study yields new discoveries about virus biology and demonstrates the utility and feasibility of a novel flow virometry assay to phenotype individual virions.
Keywords	Medicine ; R ; Science ; Q
Subject code	570
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Scale effect in macroscopic permeability of jointed rock mass using a coupled stress–damage–flow method

Yang, T / C.A. Tang / H.Y. Liu

Engineering geology. 2017 Oct. 13, v. 228

2017

Abstract: The scale effect holds true for both the strength and permeability of a rock mass, especially for a jointed rock mass. Thus, the size of a rock mass structure must be considered during design, and the rock mass permeability obtained in laboratory must be ...

Abstract	The scale effect holds true for both the strength and permeability of a rock mass, especially for a jointed rock mass. Thus, the size of a rock mass structure must be considered during design, and the rock mass permeability obtained in laboratory must be modified against the scale effect before being applied in engineering practice. Based on the progressive failure process analysis and the fluid–solid coupled theory, this paper reproduces variations of macroscopic permeability of jointed rock masses with various sizes using numerical methods. The relationship between the observation scale and the seepage directionality or randomicity is presented, and the sensitivity of the scale effects of rock mass strength and permeability is compared. The results from this study reveal that for jointed rock masses with randomly distributed orthogonal joints, as the observation scale increases, the macroscopic permeability increases following a negative exponential equation. The variation of permeability along different directions gradually attenuates, and the rock mass permeability tends to be isotropic at the macroscopic level. When the observation scale approaches the characteristic size, the macroscopic permeability becomes stable and isotropic. Moreover, it is found that the rock mass strength is more sensitive to the scale effect than the permeability, and the characteristic size corresponding to strength is smaller than that for permeability. Furthermore, the rock mass permeability suddenly increases as the rock mass fails under compression, which is caused by coalescence of the seepage channels. In this case, the scale effect becomes less important. Thus, during the design of rock structures, it is necessary to comprehensively consider the scale effects of both rock mass strength and permeability, and the parameters shall be calibrated according to the laboratory test results.
Keywords	engineering ; equations ; isotropy ; laboratory experimentation ; permeability ; seepage
Language	English
Dates of publication	2017-1013
Size	p. 121-136.
Publishing place	Elsevier B.V.
Document type	Article
ISSN	0013-7952
DOI	10.1016/j.enggeo.2017.07.009
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Breaking Earth’s shell into a global plate network

C. A. Tang / A. A. G. Webb / W. B. Moore / Y. Y. Wang / T. H. Ma / T. T. Chen

Nature Communications, Vol 11, Iss 1, Pp 1-

2020 Volume 6

Abstract: How Earth’s lithosphere first divided into tectonic plates remains uncertain. Here, the authors use 3D spherical shell models to demonstrate that anticipated warming of the early lithosphere should lead to thermal expansion and the initiation of a global ...

Abstract	How Earth’s lithosphere first divided into tectonic plates remains uncertain. Here, the authors use 3D spherical shell models to demonstrate that anticipated warming of the early lithosphere should lead to thermal expansion and the initiation of a global network of rifts, dividing the lithosphere into tectonic plates.
Keywords	Science ; Q
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Effect of injection rate on hydraulic fracturing in naturally fractured shale formations: a numerical study

Wang, Y / X. Li / C. A. Tang

Environmental earth sciences. 2016 June, v. 75, no. 11

2016

Abstract: This paper studies the effect of fluid injection rate on hydraulic fracturing in pre-existing discrete fracture network (DFN) formations. A flowâstressâdamage coupling approach has been used in an initial attempt toward how reservoir responses to ... ...

Abstract	This paper studies the effect of fluid injection rate on hydraulic fracturing in pre-existing discrete fracture network (DFN) formations. A flowâstressâdamage coupling approach has been used in an initial attempt toward how reservoir responses to injection rate under different DFN connected configuration states. The simulation results show that injection rate has an significant influence on the hydraulic fractures (HF) and DFN interaction and hydraulic fracturing effectiveness, which can be characterized by the total interaction area, stimulated DFN length, stimulated HF length and leak-off ratio. For the sparse DFN model, stimulated HF length increases with increasing injection rate and the stimulated DFN length decreases with the increasing injection rate. For the medium DFN model, stimulated HF and DFN length both increase with increasing of injection rate. For the dense DFN model, length of stimulated HF deceases with increasing injection rate; however, the stimulated DFN length increases with the increasing injection rate. The effect of injection rate on hydraulic fracturing is closely related to formation characteristics, which are strongly affected by the DFN connected configuration. For the studied fracture network, the sparse DFN model gets the optimal hydraulic fracturing effectiveness with lower injection rate; however, the dense DFN model has the best hydraulic fracturing effectiveness with higher injection rate. This work strongly links the production technology and hydraulic fracturing effectiveness evaluation and aids in the understanding and optimization of hydraulic fracturing simulations in naturally fractured reservoirs.
Keywords	models ; production technology ; shale
Language	English
Dates of publication	2016-06
Size	p. 935.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	2493699-6
ISSN	1866-6299 ; 1866-6280
ISSN (online)	1866-6299
ISSN	1866-6280
DOI	10.1007/s12665-016-5308-z
Database	NAL-Catalogue (AGRICOLA)

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Article: Predicted global warming scenarios impact on the mother plant to alter seed dormancy and germination behaviour in Arabidopsis

Huang, Z / S. Footitt / A. Tang / W.E. FinchâSavage

Plant, cell and environment. 2018 Jan., v. 41, no. 1

2018

Abstract: Seed characteristics are key components of plant fitness that are influenced by temperature in their maternal environment, and temperature will change with global warming. To study the effect of such temperature changes, Arabidopsis thaliana plants were ... ...

Abstract	Seed characteristics are key components of plant fitness that are influenced by temperature in their maternal environment, and temperature will change with global warming. To study the effect of such temperature changes, Arabidopsis thaliana plants were grown to produce seeds along a uniquely designed polyethylene tunnel having a thermal gradient reflecting local global warming predictions. Plants therefore experienced the same variations in temperature and light conditions but different mean temperatures. A range of seedârelated plant fitness estimates were measured. There were dramatic nonâlinear temperature effects on the germination behaviour in two contrasting ecotypes. Maternal temperatures lower than 15â16Â Â°C resulted in significantly greater primary dormancy. In addition, the impact of nitrate in the growing media on dormancy was shown only by seeds produced below 15â16Â Â°C. However, there were no consistent effects on seed yield, number, or size. Effects on germination behaviour were shown to be a species characteristic responding to temperature and not time of year. Elevating temperature above this critical value during seed development has the potential to dramatically alter the timing of subsequent seed germination and the proportion entering the soil seed bank. This has potential consequences for the whole plant life cycle and species fitness.
Keywords	Arabidopsis thaliana ; buried seeds ; ecotypes ; global warming ; growing media ; nitrates ; polyethylene ; prediction ; seed characteristics ; seed development ; seed dormancy ; seed germination ; seed yield ; temperature
Language	English
Dates of publication	2018-01
Size	p. 187-197.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	391893-2
ISSN	1365-3040 ; 0140-7791
ISSN (online)	1365-3040
ISSN	0140-7791
DOI	10.1111/pce.13082
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Single-Particle Discrimination of Retroviruses from Extracellular Vesicles by Nanoscale Flow Cytometry

Vera A. Tang / Tyler M. Renner / Anna K. Fritzsche / Dylan Burger / Marc-André Langlois

Scientific Reports, Vol 7, Iss 1, Pp 1-

2017 Volume 15

Abstract: Abstract Retroviruses and small EVs overlap in size, buoyant densities, refractive indices and share many cell-derived surface markers making them virtually indistinguishable by standard biochemical methods. This poses a significant challenge when ... ...

Abstract	Abstract Retroviruses and small EVs overlap in size, buoyant densities, refractive indices and share many cell-derived surface markers making them virtually indistinguishable by standard biochemical methods. This poses a significant challenge when purifying retroviruses for downstream analyses or for phenotypic characterization studies of markers on individual virions given that EVs are a major contaminant of retroviral preparations. Nanoscale flow cytometry (NFC), also called flow virometry, is an adaptation of flow cytometry technology for the analysis of individual nanoparticles such as extracellular vesicles (EVs) and retroviruses. In this study we systematically optimized NFC parameters for the detection of retroviral particles in the range of 115–130 nm, including viral production, sample labeling, laser power and voltage settings. By using the retroviral envelope glycoprotein as a selection marker, and evaluating a number of fluorescent dyes and labeling methods, we demonstrate that it is possible to confidently distinguish retroviruses from small EVs by NFC. Our findings make it now possible to individually phenotype genetically modified retroviral particles that express a fluorescent envelope glycoprotein without removing EV contaminants from the sample.
Keywords	Medicine ; R ; Science ; Q
Subject code	500
Language	English
Publishing date	2017-12-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Novel Semiconductor-Based Flow Cytometer with Enhanced Light-Scatter Sensitivity for the Analysis of Biological Nanoparticles

George C. Brittain / Yong Q. Chen / Edgar Martinez / Vera A. Tang / Tyler M. Renner / Marc-André Langlois / Sergei Gulnik

Scientific Reports, Vol 9, Iss 1, Pp 1-

2019 Volume 13

Abstract: Abstract The CytoFLEX is a novel semiconductor-based flow cytometer that utilizes avalanche photodiodes, wavelength-division multiplexing, enhanced optics, and diode lasers to maximize light capture and minimize optical and electronic noise. Due to an ... ...

Abstract	Abstract The CytoFLEX is a novel semiconductor-based flow cytometer that utilizes avalanche photodiodes, wavelength-division multiplexing, enhanced optics, and diode lasers to maximize light capture and minimize optical and electronic noise. Due to an increasing interest in the use of extracellular vesicles (EVs) as disease biomarkers, and the growing desire to use flow cytometry for the analyses of biological nanoparticles, we assessed the light-scatter sensitivity of the CytoFLEX for small-particle detection. We found that the CytoFLEX can fully resolve 70 nm polystyrene and 98.6 nm silica beads by violet side scatter (VSSC). We further analyzed the detection limit for biological nanoparticles, including viruses and EVs, and show that the CytoFLEX can detect viruses down to 81 nm and EVs at least as small as 65 nm. Moreover, we could immunophenotype EV surface antigens, including directly in blood and plasma, demonstrating the double labeling of platelet EVs with CD61 and CD9, as well as triple labeling with CD81 for an EV subpopulation in one donor. In order to assess the refractive indices (RIs) of the viruses and EVs, we devised a new method to inversely calculate the RIs using the intensity vs. size data together with Mie-theory scatter efficiencies scaled to reference-particle measurements. Each of the viruses tested had an equivalent RI, approximately 1.47 at 405 nm, which suggests that flow cytometry can be more broadly used to easily determine virus sizes. We also found that the RIs of EVs increase as the particle diameters decrease below 150 nm, increasing from 1.37 for 200 nm EVs up to 1.61 for 65 nm EVs, expanding the lower range of EVs that can be detected by light scatter. Overall, we demonstrate that the CytoFLEX has an unprecedented level of sensitivity compared to conventional flow cytometers. Accordingly, the CytoFLEX can be of great benefit to virology and EV research, and will help to expand the use of flow cytometry for minimally invasive liquid biopsies by allowing for the direct analysis of antigen expression on biological nanoparticles within patient samples, including blood, plasma, urine and bronchoalveolar lavages.
Keywords	Medicine ; R ; Science ; Q
Subject code	500
Language	English
Publishing date	2019-11-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Affimer-mediated locking of p21-activated kinase 5 in an intermediate activation state results in kinase inhibition

Heather L. Martin / Amy L. Turner / Julie Higgins / Anna A. Tang / Christian Tiede / Thomas Taylor / Sitthinon Siripanthong / Thomas L. Adams / Iain W. Manfield / Sandra M. Bell / Ewan E. Morrison / Jacquelyn Bond / Chi H. Trinh / Carolyn D. Hurst / Margaret A. Knowles / Richard W. Bayliss / Darren C. Tomlinson

Cell Reports, Vol 42, Iss 10, Pp 113184- (2023)

2023

Abstract: Summary: Kinases are important therapeutic targets, and their inhibitors are classified according to their mechanism of action, which range from blocking ATP binding to covalent inhibition. Here, a mechanism of inhibition is highlighted by capturing p21- ... ...

Abstract	Summary: Kinases are important therapeutic targets, and their inhibitors are classified according to their mechanism of action, which range from blocking ATP binding to covalent inhibition. Here, a mechanism of inhibition is highlighted by capturing p21-activated kinase 5 (PAK5) in an intermediate state of activation using an Affimer reagent that binds in the P+1 pocket. PAK5 was identified from a non-hypothesis-driven high-content imaging RNAi screen in urothelial cancer cells. Silencing of PAK5 resulted in reduced cell number, G1/S arrest, and enlargement of cells, suggesting it to be important in urothelial cancer cell line survival and proliferation. Affimer reagents were isolated to identify mechanisms of inhibition. The Affimer PAK5-Af17 recapitulated the phenotype seen with siRNA. Co-crystallization revealed that PAK5-Af17 bound in the P+1 pocket of PAK5, locking the kinase into a partial activation state. This mechanism of inhibition indicates that another class of kinase inhibitors is possible.
Keywords	CP: Cell biology ; Biology (General) ; QH301-705.5
Subject code	500
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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