LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 6 of total 6

Search options

  1. Article ; Online: Neurogenic inflammation

    A. N. Kucher

    Бюллетень сибирской медицины, Vol 19, Iss 2, Pp 171-

    biochemical markers, genetic control and diseases

    2020  Volume 181

    Abstract: Neurogenic inflammation is a pathological process based on bidirectional interactions between cells of the nervous and immune systems as well as on a wide range of biologically active substances.Aim. Basing on scientific publications and information ... ...

    Abstract Neurogenic inflammation is a pathological process based on bidirectional interactions between cells of the nervous and immune systems as well as on a wide range of biologically active substances.Aim. Basing on scientific publications and information provided in databases, to analyze markers of neurogenic inflammation (biochemical, genetic) and characterize their involvement in the pathogenesis of diseases of various organ systems.Results. Neurogenic inflammation that occurs during the development of various diseases (asthma, urticaria, atopic dermatitis, psoriasis, rheumatoid arthritis, pain syndrome, interstitial cystitis, colitis, etc.) is characterized by common stages and pathophysiologically active substances. Mediators released by nerve cells (substance P, calcitonin gene-related peptide, vasoactive peptide), acting on specific receptors, contribute to mast cell degranulation with the release of a complex of biologically active substances (histamine, tryptase, nerve growth factor, etc.), which activate inflammatory processes. Biologically active substances and receptors significant for the development of neurogenic inflammation are under genetic control. At the same time, there are overlaps of the spectrum of diseases for which importance in the pathogenesis of neurogenic inflammation is proved and an association between variants of neurogenic inflammation genes. This makes it possible to conclude that the course of neurogenic inflammation will depend not only on the etiological factors, but also on the genetic features of key molecules involved in neurogenic inflammation processes. The similarity of the pathogenetic links of neurogenic inflammation (at the genetic and biochemical levels) in various pathologies may underlie the formation of comorbid conditions.Conclusion. Understanding the biochemical and genetic components of the development of neurogenic inflammation is of interest for prevention and treatment of diseases (including comorbid ones) based on this pathological process.
    Keywords нейрогенное воспаление ; генетика ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Siberian State Medical University (Tomsk)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Phenotype variation of hypertrophic cardiomyopathy in carriers of the p.Arg870His pathogenic variant in the MYH7 gene

    A. N. Kucher / N. R. Valiakhmetov / R. R. Salakhov / M. V. Golubenko / E. N. Pavlyukova / M. S. Nazarenko

    Бюллетень сибирской медицины, Vol 21, Iss 3, Pp 205-

    2022  Volume 216

    Abstract: The review analyzes variability of clinical manifestations of p.Arg870His in the MYH7 gene, which is repeatedly registered in patients with hypertrophic cardiomyopathy (HCM). The analysis involves the data from scientific publications obtained as a ... ...

    Abstract The review analyzes variability of clinical manifestations of p.Arg870His in the MYH7 gene, which is repeatedly registered in patients with hypertrophic cardiomyopathy (HCM). The analysis involves the data from scientific publications obtained as a search result in the PubMed, СlinVar, and eLibrary.ru databases, as well as authors’ own results. A wide range of phenotypic manifestations have been revealed in carriers of p.Arg870His, from the asymptomatic to severe course, rapid progression, and early death. The review considers possible factors that modify the effect of the pathogenic variant (i.e. dosage of the pathogenic variant, the presence of other unfavorable genetic variants, etc.). The importance of accumulating information on the clinical features of HCM in the carriers of specific gene variants is emphasized in order to clarify their pathogenicity and to identify factors modifying the clinical outcome, which is important for the choice of the treatment strategy for HCM.
    Keywords гипертрофическая кардиомиопатия (гкмп) ; ген тяжелой цепи миозина (myh7) ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-10-01T00:00:00Z
    Publisher Siberian State Medical University (Tomsk)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article: Sequence of the mrjp3 Microsatellite Locus in Honeybees of Different Origin

    Ostroverkhova, N.V / A. N. Kucher / N. P. Babushkina / O. L. Konusova

    Russian journal of genetics. 2018 Mar., v. 54, no. 3

    2018  

    Abstract: The sequencing of the nucleotide sequences of the mrjp3 repetitive region (mrjp3 microsatellite locus) in Siberian honeybees was carried out. A high similarity of the studied nucleotide sequences (≥99% identity) with reference sequences was observed, ... ...

    Abstract The sequencing of the nucleotide sequences of the mrjp3 repetitive region (mrjp3 microsatellite locus) in Siberian honeybees was carried out. A high similarity of the studied nucleotide sequences (≥99% identity) with reference sequences was observed, which indicates a high conservation of the mrjp3 repetitive region in different Apis mellifera subspecies.
    Keywords Apis mellifera ; honey bees ; nucleotide sequences
    Language English
    Dates of publication 2018-03
    Size p. 322-327.
    Publishing place Pleiades Publishing
    Document type Article
    ZDB-ID 1195858-3
    ISSN 1608-3369 ; 1022-7954
    ISSN (online) 1608-3369
    ISSN 1022-7954
    DOI 10.1134/S1022795418030109
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 80/727: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article: Investigation of polyandry in honey bees (Apis mellifera) using microsatellites

    Ostroverkhova, N. V / A. N. Kucher / O. L. Konusova / T. N. Kireeva

    Entomological revue. 2016 July, v. 96, no. 4

    2016  

    Abstract: Polyandry is a specific phenomenon increasing genetic diversity. To analyze the level of polyandry and to assess the contribution of drones to the genetic diversity of honey bee colonies, three microsatellite loci (A008, Ap049, and AC117) were studied in ...

    Abstract Polyandry is a specific phenomenon increasing genetic diversity. To analyze the level of polyandry and to assess the contribution of drones to the genetic diversity of honey bee colonies, three microsatellite loci (A008, Ap049, and AC117) were studied in honey bees from colonies of different origin (Middle Russian race, Carpathian race, and hybrids) in Tomsk Province. The share of the introduced paternal alleles varied between colonies from 6.67 to 28.00%. The highest genetic diversity was observed in hybrid colonies (25–28% of introduced paternal alleles).
    Keywords alleles ; Apis mellifera ; genetic variation ; honey bee colonies ; honey bees ; hybrids ; microsatellite repeats ; polyandry
    Language English
    Dates of publication 2016-07
    Size p. 389-394.
    Publishing place Pleiades Publishing
    Document type Article
    ISSN 0013-8738
    DOI 10.1134/S0013873816040011
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article: Ethnic and Geographical Aspects of the Prevalence of the Polymorphic Variants of Genes Associated with Tuberculosis

    Babushkina, N. P / A. N. Kucher / E. Yu. Bragina / A. F. Garaeva / I. A. Goncharova / D. Yu. Tcitrikov / D. E. Gomboeva / A. A. Rudko / M. B. Freidin

    Russian journal of genetics. 2018 Sept., v. 54, no. 9

    2018  

    Abstract: Specificity of the structure of gene pools of different ethno-territorial groups of the human population can underlie the epidemiological features of the spread of tuberculosis (TB) and the structure of the genetic component of the susceptibility to the ... ...

    Abstract Specificity of the structure of gene pools of different ethno-territorial groups of the human population can underlie the epidemiological features of the spread of tuberculosis (TB) and the structure of the genetic component of the susceptibility to the disease. The variability of 62 genetic variants potentially associated with the risk of the development of TB in the Russian population of the city of Tomsk has been studied and the differentiation of various ethno-territorial groups of the world by these markers has been assessed. The studied sample comprised 445 Russian residents of the city of Tomsk without bronchopulmonary pathology. For comparison, the data on the variability of the genetic markers of interest in 26 populations from the 1000 Genomes Project was involved. In the Tomsk population, only the ancestral allele was found for seven of the 58 SNPs studied; the allele frequencies for 36 markers were within the limits of the values seen in other European populations; for 12 SNPs, the observed frequencies were closer to populations with a significant Mongoloid component. By the total of the SNPs, the Tomsk population, despite the geographical distance from the rest of the European populations, did not differ from them (in genetic distances and Gₛₜ statistics), although it had some features of the gene pool. Intergroup differentiation of the world populations by these SNPs reflects mainly interracial differences. The greatest differences in the genetic structure between the studied populations were seen for the markers localized in intergenic regions. Statistically significant differences were found when comparing the levels of the average expected heterozygosity between groups of “L4 carrier populations” of mycobacteria and “non-L4” populations, which indicates the impact of the prevalence of different pathogenic lineages of M. tuberculosis on the formation of population specificity of the allelic frequencies.
    Keywords Mycobacterium tuberculosis ; alleles ; gene frequency ; gene pool ; genetic distance ; genetic markers ; genetic variation ; heterozygosity ; human population ; intergenic DNA ; risk ; single nucleotide polymorphism ; tuberculosis
    Language English
    Dates of publication 2018-09
    Size p. 1089-1100.
    Publishing place Pleiades Publishing
    Document type Article
    ZDB-ID 1195858-3
    ISSN 1608-3369 ; 1022-7954
    ISSN (online) 1608-3369
    ISSN 1022-7954
    DOI 10.1134/S102279541809003X
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 80/727: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: DISTRIBUTION OF BIOCHEMICAL AND MOLECULAR-GENETIC MARKERS OF GENES IN WORKERS OF COAL MINING ENTERPRISES OF KUZBASS REGION SUFFERING FROM CHRONIC DUST BRONCHITIS

    V. V. Zakharenkov / N. I. Gafarov / N. I. Panev / A. N. Kucher / M. B. Freydin / A. A. Rudko / T. K. Yadikina / A. S. Kazitskaya

    Acta Biomedica Scientifica, Vol 0, Iss 1, Pp 93-

    2012  Volume 97

    Abstract: Distribution of genotypes of biochemical markers of HP, GC, EsD, АсР genes, genotypes on polymorphic variants of the genes coding enzymes of biotransformation GSTT1 (GST-ɵ1) and GSTM1 (GST-μ1) and NOS3 (VNTR4 polymorphism) in the miners with chronic ... ...

    Abstract Distribution of genotypes of biochemical markers of HP, GC, EsD, АсР genes, genotypes on polymorphic variants of the genes coding enzymes of biotransformation GSTT1 (GST-ɵ1) and GSTM1 (GST-μ1) and NOS3 (VNTR4 polymorphism) in the miners with chronic mechanic bronchitis, and in persons without this occupational pathology is investigated. It is shown that the owners of EsD 1-2, АсР bb genotypes are most subject to development of chronic mechanic bronchitis. Endogen factors of resistance to this disease are GC 1-1, EsD 1-1, АсР bc genotypes.
    Keywords genetic markers ; a genotype ; genetic predisposition ; resistance ; Science ; Q
    Language Russian
    Publishing date 2012-02-01T00:00:00Z
    Publisher Scientific Сentre for Family Health and Human Reproduction Problems
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top