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  1. Article: The heat is on: Killing blacklegged ticks in residential washers and dryers to prevent tickborne diseases

    Nelson, Christina A / Alan C. Graham / Catherine M. Hayes / Jacqueline J. Flynn / Marc C. Dolan / Mark J. Delorey / Molly A. Markowitz / Paul S. Mead

    Ticks and tick-borne diseases. 2016 July, v. 7, no. 5

    2016  

    Abstract: Reducing exposure to ticks can help prevent Lyme disease and other tickborne diseases. Although it is currently recommended to dry clothes on high heat for one hour to kill ticks on clothing after spending time outdoors, this recommendation is based on a ...

    Abstract Reducing exposure to ticks can help prevent Lyme disease and other tickborne diseases. Although it is currently recommended to dry clothes on high heat for one hour to kill ticks on clothing after spending time outdoors, this recommendation is based on a single published study of tick survival under various washing conditions and a predetermined one-hour drying time. We conducted a series of tests to investigate the effects of temperature, humidity, and drying time on killing nymphal and adult blacklegged ticks (Ixodes scapularis). Muslin bags containing 5 ticks each were washed then dried or dried only with six cotton towels during each drying cycle. All nymphal and adult ticks were killed when exposed to wash cycles when the water temperature reached ≥54°C (≥130°F); however, 50% of ticks survived hot water washes when the water temperature was <54°C. The majority (94%) of ticks survived warm washes [temperature range, 27–46°C (80–115°F)] and all ticks survived cold washes [15–27°C (59–80°F)]. When subsequently dried on high heat setting [54–85°C (129–185°F)], it took 50min to kill all ticks (95% confidence limit, 55min). Most significantly, we found that all adult and nymphal ticks died when placed directly in the dryer with dry towels and dried for 4min on high heat (95% confidence limit, 6min). We have identified effective, easily implemented methods to rid clothing of ticks after spending time outdoors. Placing clothing directly in a dryer and drying for a minimum of 6min on high heat will effectively kill ticks on clothing. If clothing is soiled and requires washing first, our results indicate clothing should be washed with water temperature ≥54°C (≥130°F) to kill ticks. When practiced with other tick-bite prevention methods, these techniques could further reduce the risk of acquiring tickborne diseases.
    Keywords adults ; bags ; clothing ; cold ; cotton ; dryers ; drying ; heat ; humidity ; Ixodes scapularis ; Lyme disease ; risk reduction ; ticks ; washing ; water temperature
    Language English
    Dates of publication 2016-07
    Size p. 958-963.
    Publishing place Elsevier GmbH
    Document type Article
    ZDB-ID 2541872-5
    ISSN 1877-9603 ; 1877-959X
    ISSN (online) 1877-9603
    ISSN 1877-959X
    DOI 10.1016/j.ttbdis.2016.04.016
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Model of transcriptional activation by MarA in Escherichia coli.

    Michael E Wall / David A Markowitz / Judah L Rosner / Robert G Martin

    PLoS Computational Biology, Vol 5, Iss 12, p e

    2009  Volume 1000614

    Abstract: The AraC family transcription factor MarA activates approximately 40 genes (the marA/soxS/rob regulon) of the Escherichia coli chromosome resulting in different levels of resistance to a wide array of antibiotics and to superoxides. Activation of marA/ ... ...

    Abstract The AraC family transcription factor MarA activates approximately 40 genes (the marA/soxS/rob regulon) of the Escherichia coli chromosome resulting in different levels of resistance to a wide array of antibiotics and to superoxides. Activation of marA/soxS/rob regulon promoters occurs in a well-defined order with respect to the level of MarA; however, the order of activation does not parallel the strength of MarA binding to promoter sequences. To understand this lack of correspondence, we developed a computational model of transcriptional activation in which a transcription factor either increases or decreases RNA polymerase binding, and either accelerates or retards post-binding events associated with transcription initiation. We used the model to analyze data characterizing MarA regulation of promoter activity. The model clearly explains the lack of correspondence between the order of activation and the MarA-DNA affinity and indicates that the order of activation can only be predicted using information about the strength of the full MarA-polymerase-DNA interaction. The analysis further suggests that MarA can activate without increasing polymerase binding and that activation can even involve a decrease in polymerase binding, which is opposite to the textbook model of activation by recruitment. These findings are consistent with published chromatin immunoprecipitation assays of interactions between polymerase and the E. coli chromosome. We find that activation involving decreased polymerase binding yields lower latency in gene regulation and therefore might confer a competitive advantage to cells. Our model yields insights into requirements for predicting the order of activation of a regulon and enables us to suggest that activation might involve a decrease in polymerase binding which we expect to be an important theme of gene regulation in E. coli and beyond.
    Keywords Biology (General) ; QH301-705.5
    Subject code 570
    Language English
    Publishing date 2009-12-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Search for Gravitational Waves Associated with Gamma-Ray Bursts Detected by Fermi and Swift During the LIGO-Virgo Run O3a

    Collaboration, The LIGO Scientific / R.Abbott, the Virgo Collaboration / T.D.Abbott, / S.Abraham, / F.Acernese, / K.Ackley, / C.Adams, / R.X.Adhikari, / V.B.Adya, / C.Affeldt, / M.Agathos, / K.Agatsuma, / N.Aggarwal, / O.D.Aguiar, / A.Aich, / L.Aiello, / A.Ain, / P.Ajith, / G.Allen, /
    A.Allocca, / P.A.Altin, / A.Amato, / S.Anand, / A.Ananyeva, / S.B.Anderson, / W.G.Anderson, / S.V.Angelova, / S.Ansoldi, / S.Antier, / S.Appert, / K.Arai, / M.C.Araya, / J.S.Areeda, / M.Arene, / N.Arnaud, / S.M.Aronson, / Y.Asali, / S.Ascenzi, / G.Ashton, / M.Assiduo, / S.M.Aston, / P.Astone, / F.Aubin, / P.Aufmuth, / K.AultONeal, / C.Austin, / V.Avendano, / S.Babak, / P.Bacon, / F.Badaracco, / M.K.M.Bader, / S.Bae, / A.M.Baer, / J.Baird, / F.Baldaccini, / G.Ballardin, / S.W.Ballmer, / A.Bals, / A.Balsamo, / G.Baltus, / S.Banagiri, / D.Bankar, / R.S.Bankar, / J.C.Barayoga, / C.Barbieri, / B.C.Barish, / D.Barker, / K.Barkett, / P.Barneo, / F.Barone, / B.Barr, / L.Barsotti, / M.Barsuglia, / D.Barta, / J.Bartlett, / I.Bartos, / R.Bassiri, / A.Basti, / M.Bawaj, / J.C.Bayley, / M.Bazzan, / B.B'ecsy, / M.Bejger, / I.Belahcene, / A.S.Bell, / D.Beniwal, / M.G.Benjamin, / J.D.Bentley, / F.Bergamin, / B.K.Berger, / G.Bergmann, / S.Bernuzzi, / C.P.L.Berry, / D.Bersanetti, / A.Bertolini, / J.Betzwieser, / R.Bhandare, / A.V.Bhandari, / A.Bianchi, / J.Bidler, / E.Biggs, / I.A.Bilenko, / G.Billingsley, / R.Birney, / O.Birnholtz, / S.Biscans, / M.Bischi, / S.Biscoveanu, / A.Bisht, / G.Bissenbayeva, / M.Bitossi, / M.A.Bizouard, / J.K.Blackburn, / J.Blackman, / C.D.Blair, / D.G.Blair, / R.M.Blair, / F.Bobba, / N.Bode, / M.Boer, / Y.Boetzel, / G.Bogaert, / F.Bondu, / E.Bonilla, / R.Bonnand, / P.Booker, / B.A.Boom, / R.Bork, / V.Boschi, / S.Bose, / V.Bossilkov, / J.Bosveld, / Y.Bouffanais, / A.Bozzi, / C.Bradaschia, / P.R.Brady, / A.Bramley, / M.Branchesi, / J.E.Brau, / M.Breschi, / T.Briant, / J.H.Briggs, / F.Brighenti, / A.Brillet, / M.Brinkmann, / P.Brockill, / A.F.Brooks, / J.Brooks, / D.D.Brown, / S.Brunett, / G.Bruno, / R.Bruntz, / A.Buikema, / T.Bulik, / H.J.Bulten, / A.Buonanno, / D.Buskulic, / R.L.Byer, / M.Cabero, / L.Cadonati, / G.Cagnoli, / C.Cahillane, / Bustillo, J.Calder'on / J.D.Callaghan, / T.A.Callister, / E.Calloni, / J.B.Camp, / M.Canepa, / Santoro, G.Caneva / K.C.Cannon, / H.Cao, / J.Cao, / G.Carapella, / F.Carbognani, / S.Caride, / M.F.Carney, / G.Carullo, / T.L.Carver, / Diaz, J.Casanueva / C.Casentini, / J.Castaneda, / S.Caudill, / M.Cavaglia, / F.Cavalier, / R.Cavalieri, / G.Cella, / P.Cerd'a-Dur'an, / E.Cesarini, / O.Chaibi, / K.Chakravarti, / C.Chan, / M.Chan, / S.Chao, / P.Charlton, / E.A.Chase, / E.Chassande-Mottin, / D.Chatterjee, / M.Chaturvedi, / H.Y.Chen, / X.Chen, / Y.Chen, / H.-P.Cheng, / C.K.Cheong, / H.Y.Chia, / F.Chiadini, / R.Chierici, / A.Chincarini, / A.Chiummo, / G.Cho, / H.S.Cho, / M.Cho, / N.Christensen, / Q.Chu, / S.Chua, / K.W.Chung, / S.Chung, / G.Ciani, / P.Ciecielag, / M.Cie'slar, / A.A.Ciobanu, / R.Ciolfi, / F.Cipriano, / A.Cirone, / F.Clara, / J.A.Clark, / P.Clearwater, / S.Clesse, / F.Cleva, / E.Coccia, / P.-F.Cohadon, / D.Cohen, / M.Colleoni, / C.G.Collette, / C.Collins, / M.Colpi, / M.Constancio, / L.Conti, / S.J.Cooper, / P.Corban, / T.R.Corbitt, / I.Cordero-Carri'on, / S.Corezzi, / K.R.Corley, / N.Cornish, / D.Corre, / A.Corsi, / S.Cortese, / C.A.Costa, / R.Cotesta, / M.W.Coughlin, / S.B.Coughlin, / J.-P.Coulon, / S.T.Countryman, / P.Couvares, / P.B.Covas, / D.M.Coward, / M.J.Cowart, / D.C.Coyne, / R.Coyne, / J.D.E.Creighton, / T.D.Creighton, / J.Cripe, / M.Croquette, / S.G.Crowder, / J.-R.Cudell, / T.J.Cullen, / A.Cumming, / R.Cummings, / L.Cunningham, / E.Cuoco, / M.Curylo, / Canton, T.Dal / G.D'alya, / A.Dana, / L.M.Daneshgaran-Bajastani, / B.D'Angelo, / S.L.Danilishin, / S.D'Antonio, / K.Danzmann, / C.Darsow-Fromm, / A.Dasgupta, / L.E.H.Datrier, / V.Dattilo, / I.Dave, / M.Davier, / G.S.Davies, / D.Davis, / E.J.Daw, / D.DeBra, / M.Deenadayalan, / J.Degallaix, / Laurentis, M.De / S.Del'eglise, / M.Delfavero, / Lillo, N.De / Pozzo, W.Del / L.M.DeMarchi, / V.D'Emilio, / N.Demos, / T.Dent, / Pietri, R.De / Rosa, R.De / Rossi, C.De / R.DeSalvo, / Varona, O.de / S.Dhurandhar, / M.C.D'iaz, / M.Diaz-Ortiz, / T.Dietrich, / Fiore, L.Di / Fronzo, C.Di / Giorgio, C.Di / Giovanni, F.Di / Giovanni, M.Di / Girolamo, T.Di / Lieto, A.Di / B.Ding, / Pace, S.Di / Palma, I.Di / Renzo, F.Di / A.K.Divakarla, / A.Dmitriev, / Z.Doctor, / F.Donovan, / K.L.Dooley, / S.Doravari, / I.Dorrington, / T.P.Downes, / M.Drago, / J.C.Driggers, / Z.Du, / J.-G.Ducoin, / P.Dupej, / O.Durante, / D.D'Urso, / S.E.Dwyer, / P.J.Easter, / G.Eddolls, / B.Edelman, / T.B.Edo, / O.Edy, / A.Effler, / P.Ehrens, / J.Eichholz, / S.S.Eikenberry, / M.Eisenmann, / R.A.Eisenstein, / A.Ejlli, / L.Errico, / R.C.Essick, / H.Estelles, / D.Estevez, / Z.B.Etienne, / T.Etzel, / M.Evans, / T.M.Evans, / B.E.Ewing, / V.Fafone, / S.Fairhurst, / X.Fan, / S.Farinon, / B.Farr, / W.M.Farr, / E.J.Fauchon-Jones, / M.Favata, / M.Fays, / M.Fazio, / J.Feicht, / M.M.Fejer, / F.Feng, / E.Fenyvesi, / D.L.Ferguson, / A.Fernandez-Galiana, / I.Ferrante, / E.C.Ferreira, / T.A.Ferreira, / F.Fidecaro, / I.Fiori, / D.Fiorucci, / M.Fishbach, / R.P.Fisher, / R.Fittipaldi, / M.Fitz-Axen, / V.Fiumara, / R.Flaminio, / E.Floden, / E.Flynn, / H.Fong, / J.A.Font, / P.W.F.Forsyth, / J.-D.Fournier, / S.Frasca, / F.Frasconi, / Z.Frei, / A.Freise, / R.Frey, / V.Frey, / P.Fritschel, / V.V.Frolov, / G.Fronze, / P.Fulda, / M.Fyffe, / H.A.Gabbard, / B.U.Gadre, / S.M.Gaebel, / J.R.Gair, / S.Galaudage, / D.Ganapathy, / S.G.Gaonkar, / C.Garc'ia-Quir'os, / F.Garufi, / B.Gateley, / S.Gaudio, / V.Gayathri, / G.Gemme, / E.Genin, / A.Gennai, / D.George, / J.George, / L.Gergely, / S.Ghonge, / Ghosh, Abhirup / Ghosh, Archisman / S.Ghosh, / B.Giacomazzo, / J.A.Giaime, / K.D.Giardina, / D.R.Gibson, / C.Gier, / K.Gill, / J.Glanzer, / J.Gniesmer, / P.Godwin, / E.Goetz, / R.Goetz, / N.Gohlke, / B.Goncharov, / G.Gonz'alez, / A.Gopakumar, / S.E.Gossan, / M.Gosselin, / R.Gouaty, / B.Grace, / A.Grado, / M.Granata, / A.Grant, / S.Gras, / P.Grassia, / C.Gray, / R.Gray, / G.Greco, / A.C.Green, / R.Green, / E.M.Gretarsson, / H.L.Griggs, / G.Grignani, / A.Grimaldi, / S.J.Grimm, / H.Grote, / S.Grunewald, / P.Gruning, / G.M.Guidi, / A.R.Guimaraes, / G.Guix'e, / H.K.Gulati, / Y.Guo, / A.Gupta, / Gupta, Anchal / P.Gupta, / E.K.Gustafson, / R.Gustafson, / L.Haegel, / O.Halim, / E.D.Hall, / E.Z.Hamilton, / G.Hammond, / M.Haney, / M.M.Hanke, / J.Hanks, / C.Hanna, / M.D.Hannam, / O.A.Hannuksela, / T.J.Hansen, / J.Hanson, / T.Harder, / T.Hardwick, / K.Haris, / J.Harms, / G.M.Harry, / I.W.Harry, / R.K.Hasskew, / C.-J.Haster, / K.Haughian, / F.J.Hayes, / J.Healy, / A.Heidmann, / M.C.Heintze, / J.Heinze, / H.Heitmann, / F.Hellman, / P.Hello, / G.Hemming, / M.Hendry, / I.S.Heng, / E.Hennes, / J.Hennig, / M.Heurs, / S.Hild, / T.Hinderer, / S.Y.Hoback, / S.Hochheim, / E.Hofgard, / D.Hofman, / A.M.Holgado, / N.A.Holland, / K.Holt, / D.E.Holz, / P.Hopkins, / C.Horst, / J.Hough, / E.J.Howell, / C.G.Hoy, / Y.Huang, / M.T.Hubner, / E.A.Huerta, / D.Huet, / B.Hughey, / V.Hui, / S.Husa, / S.H.Huttner, / R.Huxford, / T.Huynh-Dinh, / B.Idzkowski, / A.Iess, / H.Inchauspe, / C.Ingram, / G.Intini, / J.-M.Isac, / M.Isi, / B.R.Iyer, / T.Jacqmin, / S.J.Jadhav, / S.P.Jadhav, / A.L.James, / K.Jani, / N.N.Janthalur, / P.Jaranowski, / D.Jariwala, / R.Jaume, / A.C.Jenkins, / J.Jiang, / G.R.Johns, / A.W.Jones, / D.I.Jones, / J.D.Jones, / P.Jones, / R.Jones, / R.J.G.Jonker, / L.Ju, / J.Junker, / C.V.Kalaghatgi, / V.Kalogera, / B.Kamai, / S.Kandhasamy, / G.Kang, / J.B.Kanner, / S.J.Kapadia, / S.Karki, / R.Kashyap, / M.Kasprzack, / W.Kastaun, / S.Katsanevas, / E.Katsavounidis, / W.Katzman, / S.Kaufer, / K.Kawabe, / F.K'ef'elian, / D.Keitel, / A.Keivani, / R.Kennedy, / J.S.Key, / S.Khadka, / F.Y.Khalili, / I.Khan, / S.Khan, / Z.A.Khan, / E.A.Khazanov, / N.Khetan, / M.Khursheed, / N.Kijbunchoo, / Kim, Chunglee / G.J.Kim, / J.C.Kim, / K.Kim, / W.Kim, / W.S.Kim, / Y.-M.Kim, / C.Kimball, / P.J.King, / M.Kinley-Hanlon, / R.Kirchhoff, / J.S.Kissel, / L.Kleybolte, / S.Klimenko, / T.D.Knowles, / E.Knyazev, / P.Koch, / S.M.Koehlenbeck, / G.Koekoek, / S.Koley, / V.Kondrashov, / A.Kontos, / N.Koper, / M.Korobko, / W.Z.Korth, / M.Kovalam, / D.B.Kozak, / V.Kringel, / N.V.Krishnendu, / A.Kr'olak, / N.Krupinski, / G.Kuehn, / A.Kumar, / P.Kumar, / Kumar, Rahul / Kumar, Rakesh / S.Kumar, / L.Kuo, / A.Kutynia, / B.D.Lackey, / D.Laghi, / E.Lalande, / T.L.Lam, / A.Lamberts, / M.Landry, / B.B.Lane, / R.N.Lang, / J.Lange, / B.Lantz, / R.K.Lanza, / Rosa, I.La / A.Lartaux-Vollard, / P.D.Lasky, / M.Laxen, / A.Lazzarini, / C.Lazzaro, / P.Leaci, / S.Leavey, / Y.K.Lecoeuche, / C.H.Lee, / H.M.Lee, / H.W.Lee, / J.Lee, / K.Lee, / J.Lehmann, / N.Leroy, / N.Letendre, / Y.Levin, / A.K.Y.Li, / J.Li, / K.li, / T.G.F.Li, / X.Li, / F.Linde, / S.D.Linker, / J.N.Linley, / T.B.Littenberg, / J.Liu, / X.Liu, / M.Llorens-Monteagudo, / R.K.L.Lo, / A.Lockwood, / L.T.London, / A.Longo, / M.Lorenzini, / V.Loriette, / M.Lormand, / G.Losurdo, / J.D.Lough, / C.O.Lousto, / G.Lovelace, / H.Luck, / D.Lumaca, / A.P.Lundgren, / Y.Ma, / R.Macas, / S.Macfoy, / M.MacInnis, / D.M.Macleod, / I.A.O.MacMillan, / A.Macquet, / Hernandez, I.Magana / F.Magana-Sandoval, / R.M.Magee, / E.Majorana, / I.Maksimovic, / A.Malik, / N.Man, / V.Mandic, / V.Mangano, / G.L.Mansell, / M.Manske, / M.Mantovani, / M.Mapelli, / F.Marchesoni, / F.Marion, / S.M'arka, / Z.M'arka, / C.Markakis, / A.S.Markosyan, / A.Markowitz, / E.Maros, / A.Marquina, / S.Marsat, / F.Martelli, / I.W.Martin, / R.M.Martin, / V.Martinez, / D.V.Martynov, / H.Masalehdan, / K.Mason, / E.Massera, / A.Masserot, / T.J.Massinger, / M.Masso-Reid, / S.Mastrogiovanni, / A.Matas, / F.Matichard, / N.Mavalvala, / E.Maynard, / J.J.McCann, / R.McCarthy, / D.E.McClelland, / S.McCormick, / L.McCuller, / S.C.McGuire, / C.McIsaac, / J.McIver, / D.J.McManus, / T.McRae, / S.T.McWilliams, / D.Meacher, / G.D.Meadors, / M.Mehmet, / A.K.Mehta, / Villa, E.Mejuto / A.Melatos, / G.Mendell, / R.A.Mercer, / L.Mereni, / K.Merfeld, / E.L.Merilh, / J.D.Merritt, / M.Merzougui, / S.Meshkov, / C.Messenger, / C.Messick, / R.Metzdorff, / P.M.Meyers, / F.Meylahn, / A.Mhaske, / A.Miani, / H.Miao, / I.Michaloliakos, / C.Michel, / H.Middleton, / 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    Abstract: We search for gravitational-wave transients associated with gamma-ray bursts detected by the Fermi and Swift satellites during the first part of the third observing run of Advanced LIGO and Advanced Virgo (1 April 2019 15:00 UTC - 1 October 2019 15:00 ... ...

    Abstract We search for gravitational-wave transients associated with gamma-ray bursts detected by the Fermi and Swift satellites during the first part of the third observing run of Advanced LIGO and Advanced Virgo (1 April 2019 15:00 UTC - 1 October 2019 15:00 UTC). 105 gamma-ray bursts were analyzed using a search for generic gravitational-wave transients; 32 gamma-ray bursts were analyzed with a search that specifically targets neutron star binary mergers as short gamma-ray burst progenitors. We describe a method to calculate the probability that triggers from the binary merger targeted search are astrophysical and apply that method to the most significant gamma-ray bursts in that search. We find no significant evidence for gravitational-wave signals associated with the gamma-ray bursts that we followed up, nor for a population of unidentified subthreshold signals. We consider several source types and signal morphologies, and report for these lower bounds on the distance to each gamma-ray burst.
    Keywords covid19
    Publisher ArXiv
    Document type Article
    Database COVID19

    Kategorien

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