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  1. AU="Aanchal Gupta"
  2. AU="Nguyen, Hang Minh"
  3. AU="Ceasar, M"
  4. AU="López-Cotarelo, Pilar"
  5. AU="Lenc, E"
  6. AU="Brabcova, Zuzana"
  7. AU="Bayırlı Turan, Derya"
  8. AU=Sleigh James N
  9. AU="Thanee, Malinee"
  10. AU="Watchara Fongkum"

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  1. Artikel ; Online: Omicron sub-variants

    Amit Aggarwal / Ashutosh Nirola / Ravinder Singh / Richa Goel / Aanchal Gupta / Ramandeep Singh Gambhir

    Roczniki Panstwowego Zakladu Higieny, Vol 73, Iss 2, Pp 159-

    is the world going to witness another wave?

    2022  Band 162

    Abstract: Omicron, the new ‘Variant of Concern’ of SARS-CoV-2, is rapidly evolving into new sub-variants or sub-lineages (BA.1, BA.2 etc.). These sub-variants have higher transmissibility, decreased vaccine effectiveness and increased risk of reinfection. As a ... ...

    Abstract Omicron, the new ‘Variant of Concern’ of SARS-CoV-2, is rapidly evolving into new sub-variants or sub-lineages (BA.1, BA.2 etc.). These sub-variants have higher transmissibility, decreased vaccine effectiveness and increased risk of reinfection. As a result, many nations across the globe are reporting surge in infections which is a matter of concern. Understanding Omicron and its sub-variants is vital for development of public health policy and preventing disease transmission. The present paper throws a spotlight on the newly detected sub-variants of Omicron as reported in ongoing researches which are available only in pre-print form and also the importance of a booster dose of the vaccine. Information regarding recent research on a new nasal vaccine formulation, which may be effective against the new variants, is also highlighted in the paper.
    Schlagwörter omicron ; sub-variants ; transmission ; vaccine ; genome ; Nutrition. Foods and food supply ; TX341-641 ; Industrial medicine. Industrial hygiene ; RC963-969 ; Public aspects of medicine ; RA1-1270
    Sprache Englisch
    Erscheinungsdatum 2022-06-01T00:00:00Z
    Verlag National Institute of Public Health - National Institute of Hygiene
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Neuroimaging Spectrum in COVID-19 Infection

    Sarbesh Tiwari / Pawan Kumar Garg / Samhita Panda / Aanchal Gupta / Adarsh Hegde / Deepak Kumar / Daisy Khera / Pradeep Kumar Bhatia / Mayank Garg / Taruna Yadav

    Indian Journal of Radiology and Imaging (2023)

    A Single-Center Experience

    2023  

    Abstract: Background and Purpose The ongoing coronavirus disease 2019 (COVID-19) pandemic is a multisystemic disease and involvement of the nervous system is well established. The neurological and neuroimaging features of the disease have been extensively ... ...

    Abstract Background and Purpose The ongoing coronavirus disease 2019 (COVID-19) pandemic is a multisystemic disease and involvement of the nervous system is well established. The neurological and neuroimaging features of the disease have been extensively evaluated. Our study aimed to elucidate the neuroradiological findings in COVID-19 infected patients admitted to our institute during the first and second waves of the pandemic in India. Methods This was a single-center retrospective study of all COVID-19 positive patients who underwent neuroimaging between March 2020 and May 2021. The presenting neurological complaints, the imaging findings in computed tomography (CT) imaging, and/or magnetic resonance imaging (MRI) were recorded. They recorded the findings in the subheadings of ischemic stroke, hemorrhagic stroke, parainfectious demyelination, acute encephalitis syndrome, and changes of global hypoxic changes. Patients with age-related, chronic, and incidental findings were excluded. Results The study comprised of 180 COVID-19 positive patients who underwent neuroimaging. CT scan was performed for 169 patients, MRI for 28, and a combination of both CT and MRI was performed for 17 patients. Seventy percent of patients were males, and median age was 61.5 years (interquartile range: 48.25–70.75). Out of the 180 patients, 66 patients had nonspecific findings that could not be attributed to COVID-19 infection. In the remaining 114 patients, 77 (42.7%) had ischemic findings, while 22 (12.2%) had hemorrhagic stroke. Hypoxic ischemic changes were noted in five patients. The rest of the patients had a spectrum of changes including, cerebellitis (3), tumefactive demyelination (1), COVID-19-associated encephalitis (1), hemorrhagic acute demyelinating encephalomyelitis (1), transverse myelitis (1), cytotoxic lesions of corpus callosum (1), Guillain-Barre syndrome (1), and COVID-19-associated microhemorrhages (1). Conclusion Neurological manifestations of COVID-19 infection are not uncommon, and our understanding of this topic is ...
    Schlagwörter cerebellitis ; covid-19 ; covid-19-associated encephalitis ; neuroimaging ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-04-01T00:00:00Z
    Verlag Thieme Medical and Scientific Publishers Pvt. Ltd.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Applying Channel Estimation in MIMO Network Coding Protocol

    Aanchal Gupta / Tripti Choudhary

    International Journal of Electronics and Computer Science Engineering, Vol 1, Iss 1, Pp 42-

    2012  Band 51

    Abstract: in this paper, a combination of MIMO and network coding, based on MINEC protocol, is used for improving the performance of the relay networks in fading environments. We have introduced the concept of channel estimation into the proposed three-node ... ...

    Abstract — in this paper, a combination of MIMO and network coding, based on MINEC protocol, is used for improving the performance of the relay networks in fading environments. We have introduced the concept of channel estimation into the proposed three-node relay network. When the receiver is having no knowledge of the channel, then the Rayleigh fading channel has to be estimated using some technique, as the channel state information is required at the receiver for the decoding process. In this brief, Least Square Channel Estimation is presented to estimate the channel for Maximum Likelihood Decoding at the detector. Thus, a comparison of the Probability of Error verses SNR characteristic is shown when the channel is assumed to be known at the receiver and when it is estimated. Also an improvement in the error performance is depicted when MIMO is used with network coding and when MIMO is not employed and only network coding is used
    Schlagwörter Alamouti Code ; MIMO ; Network Coding ; Pilot symbol based Least Square Channel Estimation ; Relay Network ; Spatial Diversity ; Spatial Multiplexing ; STBC. ; Electronic computers. Computer science ; QA75.5-76.95 ; Instruments and machines ; QA71-90 ; Mathematics ; QA1-939 ; Science ; Q ; DOAJ:Computer Science ; DOAJ:Technology and Engineering
    Thema/Rubrik (Code) 003
    Sprache Englisch
    Erscheinungsdatum 2012-01-01T00:00:00Z
    Verlag Buldanshahr : IJECSE
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Tocilizumab therapy for COVID-19

    Monica A. Kaminski / Subin Sunny / Khayala Balabayova / Avneet Kaur / Aanchal Gupta / Marie Abdallah / John Quale

    International Journal of Infectious Diseases, Vol 101, Iss , Pp 59-

    A comparison of subcutaneous and intravenous therapies

    2020  Band 64

    Abstract: Background: The release of pro-inflammatory cytokines, resulting in cytokine storm syndrome, contributes to the morbidity and mortality associated with COVID-19 disease. This study aimed to compare the effects of intravenous (IV) and subcutaneous (SC) ... ...

    Abstract Background: The release of pro-inflammatory cytokines, resulting in cytokine storm syndrome, contributes to the morbidity and mortality associated with COVID-19 disease. This study aimed to compare the effects of intravenous (IV) and subcutaneous (SC) tocilizumab, an IL-6 receptor antagonist, on respiratory parameters and clinical outcome in patients with COVID 19. Methods: We performed a retrospective cohort study of hospitalized patients with COVID-19 treated with either IV or SC tocilizumab from March 26, 2020, to May 18, 2020. Respiratory parameters seven days after receiving tocilizumab therapy were compared to baseline measurements. All patients were assessed until discharged from the hospital. Results: Tocilizumab was administered to 125 patients: 65 received IV, and 60 received SC therapy. At day seven, 52% of the IV group patients demonstrated improvement in respiratory parameters, compared to 28% in the SC group (P = 0.01). Mortality rates at days seven and 28 were 15% and 37%, respectively, in the IV group and 17% and 50%, respectively, in the SC group (PNS). The in-hospital mortality rate was 38% for the IV group versus 57% for the SC group (P = 0.04). More than 90% of patients in each group received corticosteroids; however, significantly more patients received convalescent plasma in the IV group. Conclusions: At the doses used in this study, IV tocilizumab is preferred over SC therapy to treat cytokine storm syndrome due to COVID-19.
    Schlagwörter COVID-19 ; Cytokine storm ; Tocilizumab ; Infectious and parasitic diseases ; RC109-216 ; covid19
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2020-12-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Comparative Efficacy of Two Different Dosages of Intrathecal Magnesium Sulphate Supplementation in Subarachnoid Block

    Binesh Kathuria / Neeru Luthra / Aanchal Gupta / Anju Grewal / Dinesh Sood

    Journal of Clinical and Diagnostic Research, Vol 8, Iss 6, Pp GC01-GC

    2014  Band 05

    Abstract: Background: Spinal anaesthesia is the primary anaesthetic technique for many types of surgeries. Adjuncts to the local anaesthetics (LA) used in spinal anaesthesia can exhibit undesirable side-effects like respiratory depression, urinary retention, ... ...

    Abstract Background: Spinal anaesthesia is the primary anaesthetic technique for many types of surgeries. Adjuncts to the local anaesthetics (LA) used in spinal anaesthesia can exhibit undesirable side-effects like respiratory depression, urinary retention, pruritis, haemodynamic instability and nausea and vomiting, limiting their use. Magnesium when used in therapeutic doses avoids all of these side-effects. Materials and Methods: We conducted a randomized double blind study on 90 patients, 30 in each group, scheduled for orthopaedic lower limb surgery under subarachnoid block. Group I: received bupivacaine (0.5%), 12.5 mg + 0.5 ml of preservative free 0.9% normal saline, Group II received bupivacaine (0.5%), 12.5 mg + 0.2 ml (50 mg) of preservative free 25 % magnesium sulphate + 0.3 ml of preservative free 0.9% normal saline Group III: received bupivacaine (0.5%) 12.5 mg + 0.3 ml (75 mg) of 25 % magnesium sulphate + 0.2 ml of preservative free 0.9% normal saline for subarachnoid block. The onset and duration of sensory block, the highest dermatomal level of sensory block, motor block, time to complete motor block recovery and duration of spinal anaesthesia were recorded. Statistical Analysis: ANOVA was applied to determine the significance of difference between different groups. If p-value was significant then Turkey’s Post Hoc Multicomparison test was applied. Values of p<0.05 were considered to be statistically significant. Results: The time of maximum sensory block, time of onset of motor block, duration of sensory block, duration of motor block and time of analgesia request were prolonged in patients given magnesium 50mg and 75mg along with local anaesthetic intrathecally. Conclusion: N-methyl-D-aspartate (NMDA) receptor antagonist, magnesium when administered intrathecally along with local anaesthetics prolongs the duration of spinal analgesia without adverse effects.
    Schlagwörter anaesthesia duration ; local anaesthetic ; magnesium ; opioid ; spinal ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2014-06-01T00:00:00Z
    Verlag JCDR Research and Publications Private Limited
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel: Mineral pitch induces apoptosis and inhibits proliferation via modulating reactive oxygen species in hepatic cancer cells

    Pant, Kishor / Parul Gupta / Preeti Damania / Ajay K. Yadav / Aanchal Gupta / Anam Ashraf / Senthil K. Venugopal

    BMC complementary and alternative medicine. 2016 Dec., v. 16, no. 1

    2016  

    Abstract: BACKGROUND: Mineral Pitch (MP) is a dark brown coloured humic matter originating from high altitude rocks. It is an Ayurvedic medicinal food, commonly used by the people of the Himalayan regions of Nepal and India for various body ailments. METHODS: The ... ...

    Abstract BACKGROUND: Mineral Pitch (MP) is a dark brown coloured humic matter originating from high altitude rocks. It is an Ayurvedic medicinal food, commonly used by the people of the Himalayan regions of Nepal and India for various body ailments. METHODS: The Huh-7 cells were treated with different concentrations of MP for 24 h, and both apoptosis and proliferation was determined by the TUNEL and MTT assays respectively. The formation of ROS and nitric oxide was analysed by DCFH-DA and Griess reagent respectively. The expression of miRNA-21 and miRNA-22 were checked by the real time PCR. Effect of miRNA-22 on proliferation and c-myc was studied by over-expressing miRNA-22 premiRs in Huh-7 cells. RESULTS: We found that MP enhanced anti-cancer effects by inducing apoptosis and inhibiting proliferation. MP induced both ROS and NO, upon neutralizing them, there was a partial recovery of apoptosis and proliferation. MP also induced miRNA-22 expression, while miRNA-21 expression was inhibited. Over-expression of miRNA-22 resulted in a significant inhibition of proliferation. miRNA-22 directly targeted c-myc gene, thereby inhibited proliferation. These results clearly show that MP induces its anti-cancer activity by more than one pathway. CONCLUSION: The data clearly indicate that MP induced apoptosis via the production of ROS, and inhibited proliferation by inducing miRNA-22 and inhibiting miRNA-21 in Huh-7 cells.
    Schlagwörter alternative medicine ; altitude ; antineoplastic activity ; apoptosis ; color ; functional foods ; genes ; liver neoplasms ; neoplasm cells ; neutralization ; nitric oxide ; people ; quantitative polymerase chain reaction ; reactive oxygen species ; rocks ; Himalayan region ; India ; Nepal
    Sprache Englisch
    Erscheinungsverlauf 2016-12
    Umfang p. 148.
    Erscheinungsort BioMed Central
    Dokumenttyp Artikel
    ZDB-ID 2050429-9
    ISSN 1472-6882
    ISSN 1472-6882
    DOI 10.1186/s12906-016-1131-z
    Datenquelle NAL Katalog (AGRICOLA)

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