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  1. Article ; Online: Use of a Therapeutic Trial of Graduated Neoadjuvant Radiation Therapy for Locally Advanced Esophageal Cancer in a Patient With Fanconi Anemia

    Ulysses G. Gardner, Jr, MD, MBA / Stephanie G. Wood, MD / Emerson Y. Chen, MD / Joel S. Greenberger, MD / Aaron J. Grossberg, MD, PhD

    Advances in Radiation Oncology, Vol 7, Iss 1, Pp 100810- (2022)

    2022  

    Keywords Medical physics. Medical radiology. Nuclear medicine ; R895-920 ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Muscle and adipose tissue segmentations at the third cervical vertebral level in patients with head and neck cancer

    Kareem A. Wahid / Brennan Olson / Rishab Jain / Aaron J. Grossberg / Dina El-Habashy / Cem Dede / Vivian Salama / Moamen Abobakr / Abdallah S. R. Mohamed / Renjie He / Joel Jaskari / Jaakko Sahlsten / Kimmo Kaski / Clifton D. Fuller / Mohamed A. Naser

    Scientific Data, Vol 9, Iss 1, Pp 1-

    2022  Volume 6

    Abstract: Measurement(s) skeletal muscle • adipose tissue Technology Type(s) computed ... ...

    Abstract Measurement(s) skeletal muscle • adipose tissue Technology Type(s) computed tomography
    Keywords Science ; Q
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Lipocalin 2 mediates appetite suppression during pancreatic cancer cachexia

    Brennan Olson / Xinxia Zhu / Mason A. Norgard / Peter R. Levasseur / John T. Butler / Abigail Buenafe / Kevin G. Burfeind / Katherine A. Michaelis / Katherine R. Pelz / Heike Mendez / Jared Edwards / Stephanie M. Krasnow / Aaron J. Grossberg / Daniel L. Marks

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 15

    Abstract: Lipocalin 2 (LCN2) has been recently identified as an endogenous regulator of appetite. Here, using pancreatic cancer as a model of cachexia, the authors demonstrate that LCN2 is a critical mediator of cancer-associated anorexia and may be ... ...

    Abstract Lipocalin 2 (LCN2) has been recently identified as an endogenous regulator of appetite. Here, using pancreatic cancer as a model of cachexia, the authors demonstrate that LCN2 is a critical mediator of cancer-associated anorexia and may be therapeutically targeted to improve patient outcomes.
    Keywords Science ; Q
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Muscle atrophy in response to cytotoxic chemotherapy is dependent on intact glucocorticoid signaling in skeletal muscle.

    Theodore P Braun / Marek Szumowski / Peter R Levasseur / Aaron J Grossberg / XinXia Zhu / Anupriya Agarwal / Daniel L Marks

    PLoS ONE, Vol 9, Iss 9, p e

    2014  Volume 106489

    Abstract: Cancer cachexia is a syndrome of weight loss that results from the selective depletion of skeletal muscle mass and contributes significantly to cancer morbidity and mortality. The driver of skeletal muscle atrophy in cancer cachexia is systemic ... ...

    Abstract Cancer cachexia is a syndrome of weight loss that results from the selective depletion of skeletal muscle mass and contributes significantly to cancer morbidity and mortality. The driver of skeletal muscle atrophy in cancer cachexia is systemic inflammation arising from both the cancer and cancer treatment. While the importance of tumor derived inflammation is well described, the mechanism by which cytotoxic chemotherapy contributes to cancer cachexia is relatively unexplored. We found that the administration of chemotherapy to mice produces a rapid inflammatory response. This drives activation of the hypothalamic-pituitary-adrenal axis, which increases the circulating level of corticosterone, the predominant endogenous glucocorticoid in rodents. Additionally, chemotherapy administration results in a significant loss of skeletal muscle mass 18 hours after administration with a concurrent induction of genes involved with the ubiquitin proteasome and autophagy lysosome systems. However, in mice lacking glucocorticoid receptor expression in skeletal muscle, chemotherapy-induced muscle atrophy is completely blocked. This demonstrates that cytotoxic chemotherapy elicits significant muscle atrophy driven by the production of endogenous glucocorticoids. Further, it argues that pharmacotherapy targeting the glucocorticoid receptor, given in concert with chemotherapy, is a viable therapeutic strategy in the treatment of cancer cachexia.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Quantitative 3-Dimensional Photographic Assessment of Breast Cosmesis After Whole Breast Irradiation for Early Stage Breast Cancer

    Bhavana V. Chapman, MD / Xiudong Lei, PhD / Prithvi Patil, MS / Shikha Tripathi, MS / Krista M. Nicklaus, MS / Aaron J. Grossberg, MD, PhD / Simona F. Shaitelman, MD, EdM / Alastair M. Thompson, MD / Kelly K. Hunt, MD / Thomas A. Buchholz, MD, FASTRO / Fatima Merchant, PhD / Mia K. Markey, PhD / Benjamin D. Smith, MD, FASTRO / Jay P. Reddy, MD, PhD

    Advances in Radiation Oncology, Vol 5, Iss 5, Pp 824-

    A Secondary Analysis of a Randomized Clinical Trial

    2020  Volume 833

    Abstract: Purpose: Our purpose was to use 3-dimensional (3D) surface photography to quantitatively measure breast cosmesis within the framework of a randomized clinical trial of conventionally fractionated (CF) and hypofractionated (HF) whole breast irradiation ( ... ...

    Abstract Purpose: Our purpose was to use 3-dimensional (3D) surface photography to quantitatively measure breast cosmesis within the framework of a randomized clinical trial of conventionally fractionated (CF) and hypofractionated (HF) whole breast irradiation (WBI); to identify how 3D measurements are associated with patient- and physician-reported cosmesis; and to determine whether objective measures of breast symmetry varied by WBI treatment arm or transforming growth factor β 1 (TGFβ1) status. Methods and Materials: From 2011 to 2014, 287 women age ≥40 with ductal carcinoma in situ or early-stage invasive breast cancer were enrolled in a multicenter trial and randomized to HF-WBI or CF-WBI with a boost. Three-dimensional surface photography was performed at 3 years posttreatment. Patient-reported cosmetic outcomes were recorded with the Breast Cancer Treatment Outcome Scale. Physician-reported cosmetic outcomes were assessed by the Radiation Therapy Oncology Group scale. Volume ratios and 6 quantitative measures of breast symmetry, termed F1-6C, were calculated using the breast contour and fiducial points assessed on 3D surface images. Associations between all metrics, patient- and physician-reported cosmesis, treatment arm, and TGFβ1 genotype were performed using the Kruskal-Wallis test and multivariable logistic regression models. Results: Among 77 (39 CF-WBI and 38 HF-WBI) evaluable patients, both patient- and physician-reported cosmetic outcomes were significantly associated with the F1C vertical symmetry measure (both P < .05). Higher dichotomized F1C and volumetric symmetry measures were associated with improved patient- and physician-reported cosmesis on multivariable logistic regression (both P ≤ .05). There were no statistically significant differences in vertical symmetry or volume measures between treatment arms. Increased F6C horizontal symmetry was observed in the CF-WBI arm (P = .05). Patients with the TGFβ1 C-509T variant allele had lower F2C vertical symmetry measures (P = .02). Conclusions: Quantitative 3D image-derived measures revealed comparable cosmetic outcomes with HF-WBI compared with CF-WBI. Our findings suggest that 3D surface imaging may be a more sensitive method for measuring subtle cosmetic changes than global patient- or physician-reported assessments.
    Keywords Medical physics. Medical radiology. Nuclear medicine ; R895-920 ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
    Subject code 616
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  6. Article ; Online: Author Correction

    Aaron J. Grossberg / Abdallah S. R. Mohamed / Hesham Elhalawani / William C. Bennett / Kirk E. Smith / Tracy S. Nolan / Bowman Williams / Sasikarn Chamchod / Jolien Heukelom / Michael E. Kantor / Theodora Browne / Katherine A. Hutcheson / G. Brandon Gunn / Adam S. Garden / William H. Morrison / Steven J. Frank / David I. Rosenthal / John B. Freymann / Clifton D. Fuller

    Scientific Data, Vol 5, Iss 1, Pp 1-

    Imaging and clinical data archive for head and neck squamous cell carcinoma patients treated with radiotherapy

    2018  Volume 1

    Abstract: In the original version of the Data Descriptor the surname of author Hesham Elhalawani was misspelled. This has now been corrected in the HTML and PDF versions. ...

    Abstract In the original version of the Data Descriptor the surname of author Hesham Elhalawani was misspelled. This has now been corrected in the HTML and PDF versions.
    Keywords Science ; Q
    Language English
    Publishing date 2018-11-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Cancer exosomes induce tumor innervation

    Marianna Madeo / Paul L. Colbert / Daniel W. Vermeer / Christopher T. Lucido / Jacob T. Cain / Elisabeth G. Vichaya / Aaron J. Grossberg / DesiRae Muirhead / Alex P. Rickel / Zhongkui Hong / Jing Zhao / Jill M. Weimer / William C. Spanos / John H. Lee / Robert Dantzer / Paola D. Vermeer

    Nature Communications, Vol 9, Iss 1, Pp 1-

    2018  Volume 15

    Abstract: Tumors can induce axonogenesis which is commonly associated with worse outcomes. Here, the authors show that this phenomenon is mediated by cancer exosomes. ...

    Abstract Tumors can induce axonogenesis which is commonly associated with worse outcomes. Here, the authors show that this phenomenon is mediated by cancer exosomes.
    Keywords Science ; Q
    Language English
    Publishing date 2018-10-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Cancer exosomes induce tumor innervation

    Marianna Madeo / Paul L. Colbert / Daniel W. Vermeer / Christopher T. Lucido / Jacob T. Cain / Elisabeth G. Vichaya / Aaron J. Grossberg / DesiRae Muirhead / Alex P. Rickel / Zhongkui Hong / Jing Zhao / Jill M. Weimer / William C. Spanos / John H. Lee / Robert Dantzer / Paola D. Vermeer

    Nature Communications, Vol 9, Iss 1, Pp 1-

    2018  Volume 15

    Abstract: Tumors can induce axonogenesis which is commonly associated with worse outcomes. Here, the authors show that this phenomenon is mediated by cancer exosomes. ...

    Abstract Tumors can induce axonogenesis which is commonly associated with worse outcomes. Here, the authors show that this phenomenon is mediated by cancer exosomes.
    Keywords Science ; Q
    Language English
    Publishing date 2018-10-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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