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Article ; Online: Oscillometric devices vs. arterial Doppler in measuring the ankle-arm index for the diagnosis of peripheral arterial disease.

Martín-Rubio, Irene / Marín-García, Beatriz / Romero-Velasco, Elisa / Thuissard-Vasallo, Israel John / Bautista-Hernández, Azucena / Abad-Pérez, Daniel

Medicina clinica

2024

Abstract: Introduction: Peripheral arterial disease is a marker of vascular damage that is diagnosed by measuring the ankle-brachial index. The aim of this study was to determine the validity and agreement of the MESI ABPI-MD and Microlife WatchBP® office-ABI ... ...

Title translation	Dispositivos oscilométricos frente a Doppler arterial en la medida del índice tobillo-brazo para el diagnóstico de la enfermedad arterial periférica.
Abstract	Introduction: Peripheral arterial disease is a marker of vascular damage that is diagnosed by measuring the ankle-brachial index. The aim of this study was to determine the validity and agreement of the MESI ABPI-MD and Microlife WatchBP® office-ABI oscillometric devices with respect to the gold standard arterial Doppler. Materials and methods: Observational, cross-sectional, descriptive study of inpatients who underwent ABI measurement with the three devices. Values are considered normal between 1-1.4, indeterminate between 0.91-0.99 and pathological ≤0.9 and >1.4. Results: A total of 187 patients (54.4% male) with a mean age of 66 years were included. The Doppler results were inferior to those of the oscillometric devices (median [IQR] 1.1 [0.2] vs. 1.2 [0.2], P<.05), with no significant differences between the automated devices (P=.29 for the right lower limb and P=.342 for the left lower limb). Both devices had high specificity (96.5-99.2%) and low sensitivity (29.5-45.4%). The correlation of the results was good-moderate for MESI and moderate for Microlife. The agreement between the two was acceptable-moderate. Conclusion: Automated oscillometric devices could be useful in asymptomatic patients as an alternative to arterial Doppler.
Language	Spanish
Publishing date	2024-04-19
Publishing country	Spain
Document type	Journal Article
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2024.02.003
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Article ; Online: Sustained-release isosorbide mononitrate as adjuvant treatment in isolated systolic hypertension in the elderly.

Abad Pérez, Daniel / García Polo, Iluminada / Rodríguez Salvanés, Francisco José / Bellisco Roncal, Sara / Ibáñez Sanz, Patricia / Suárez Fernández, Carmen

Journal of human hypertension

2021 Volume 36, Issue 2, Page(s) 163–170

Abstract: Hypertension is one of the main cardiovascular risk factors. In the elderly, the most common form is isolated systolic hypertension, a consequence of the increase in arterial stiffness. None of the antihypertensives currently used affects arterial ... ...

Abstract	Hypertension is one of the main cardiovascular risk factors. In the elderly, the most common form is isolated systolic hypertension, a consequence of the increase in arterial stiffness. None of the antihypertensives currently used affects arterial stiffness, whereas nitrates seem to have an effect. The aim of this work was to assess their effect on elderly patients with uncontrolled isolated systolic hypertension, defined as systolic blood pressure over 140 mmHg and diastolic blood pressure under 90 mmHg. The present study is a phase III, randomized, multicenter, double-blind, placebo-controlled clinical trial, conducted at the University Hospital La Princesa in Madrid. Patients of both sexes, aged 65 years or older, with poorly controlled isolated systolic hypertension, were treated with 40-60 mg of sustained-release isosorbide mononitrate or matching placebo for 12 weeks. The main objective was to assess the effect on clinical pulse pressure (PP); in addition, its effect on vascular function was evaluated. Analysis was performed by intention to treat. The study was registered at the European Union Clinical Trials Register (EUDRACT 2012-002988-10) and was funded by the Spanish Ministry of Health. A total of 58 patients with an average age of 77 years were enrolled, 32 were treated with nitrate, and 26 with placebo. No significant differences were found either in PP decline (5.28 vs 7.49 mmHg, p = 0.79) or in other variables, including parameters of vascular function. There were no differences in adverse events. The results of this study have not confirmed the benefit of nitrate treatment in isolated systolic hypertension or the improvement of vascular function.
MeSH term(s)	Aged ; Antihypertensive Agents/therapeutic use ; Blood Pressure ; Delayed-Action Preparations/pharmacology ; Delayed-Action Preparations/therapeutic use ; Double-Blind Method ; Female ; Humans ; Hypertension/diagnosis ; Hypertension/drug therapy ; Isosorbide Dinitrate/analogs & derivatives ; Isosorbide Dinitrate/pharmacology ; Isosorbide Dinitrate/therapeutic use ; Male
Chemical Substances	Antihypertensive Agents ; Delayed-Action Preparations ; Isosorbide Dinitrate (IA7306519N) ; isosorbide-5-mononitrate (LX1OH63030)
Language	English
Publishing date	2021-04-13
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	639472-3
ISSN	1476-5527 ; 0950-9240
ISSN (online)	1476-5527
ISSN	0950-9240
DOI	10.1038/s41371-021-00498-4
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Article ; Online: Usefulness of the ankle-brachial index as a survey method for subclinical vascular disease in patients with rheumatoid arthritis.

Marcos de Frutos, Cristina / Abad Pérez, Daniel / Suárez Fernández, Carmen

Reumatologia clinica

2014 Volume 10, Issue 4, Page(s) 268–269

MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Ankle Brachial Index ; Arthritis, Rheumatoid/complications ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Vascular Diseases/diagnosis ; Vascular Diseases/etiology
Language	Spanish
Publishing date	2014-07
Publishing country	Spain
Document type	Letter
ZDB-ID	2477196-X
ISSN	1885-1398 ; 1699-258X
ISSN (online)	1885-1398
ISSN	1699-258X
DOI	10.1016/j.reuma.2013.11.003
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Article ; Online: Endobronchial tuberculosis simulating lung cancer.

Cadiñanos Loidi, Julen / Abad Pérez, Daniel / de Miguel Buckley, Rosa

Archivos de bronconeumologia

2014 Volume 50, Issue 3, Page(s) 126–127

MeSH term(s)	Biopsy ; Bronchial Diseases/diagnostic imaging ; Bronchial Diseases/etiology ; Bronchial Diseases/microbiology ; Bronchial Diseases/pathology ; Bronchoscopy ; Diagnosis, Differential ; Emigrants and Immigrants ; Female ; Fever/etiology ; Humans ; India/ethnology ; Lung Neoplasms/diagnostic imaging ; Middle Aged ; Mycobacterium tuberculosis/isolation & purification ; Sputum/microbiology ; Tomography, X-Ray Computed ; Tuberculosis/diagnostic imaging ; Tuberculosis/microbiology ; Tuberculosis/pathology ; Tuberculosis, Pulmonary/complications
Language	Spanish
Publishing date	2014-03
Publishing country	Spain
Document type	Case Reports ; Letter
ZDB-ID	733126-5
ISSN	1579-2129 ; 0300-2896
ISSN (online)	1579-2129
ISSN	0300-2896
DOI	10.1016/j.arbres.2013.07.003
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Article ; Online: Ambulatory Blood Pressure Monitoring in HIV-Infected Patients: Usefulness for Cardiovascular Risk Assessment.

Gómez-Berrocal, Ana / De Los Santos-Gil, Ignacio / Abad-Pérez, Daniel / Gutiérrez-Liarte, Ángela / Ibáñez-Sanz, Patricia / Sanz-Sanz, Jesús / Suárez, Carmen

Journal of the International Association of Providers of AIDS Care

2020 Volume 19, Page(s) 2325958220935693

Abstract: Background: There is a lack of consensus regarding the risk of hypertension in HIV-infected patients compared to the general population. Ambulatory blood pressure monitoring (ABPM) is the most accurate method for the hypertension diagnosis. Nevertheless, ...

Abstract	Background: There is a lack of consensus regarding the risk of hypertension in HIV-infected patients compared to the general population. Ambulatory blood pressure monitoring (ABPM) is the most accurate method for the hypertension diagnosis. Nevertheless, it is rarely used in HIV clinical care. Materials and methods: All HIV-infected patients who underwent 24 hours ABPM were included. The agreement between office blood pressure (BP) readings and ABPM was analyzed. The rate of patients with masked hypertension (MH), isolated clinical hypertension, and nocturnal hypertension was obtained. Furthermore, it was analyzed if the differences between both methods may affect the cardiovascular risk (CVR) assessment. Results: A total of 116 patients were included. The κ coefficient between office BP and ABPM was 0.248. Over a quarter of the cohort was diagnosed with MH-25.8% (CI 95% 17.7%-34.0%), and 12% (CI 95%: 6.1%-16.1%) was diagnosed with ICH. Moreover, 19% of patients had hypertension exclusively during the night. The patients classified as low risk according to the CVR scores had a different diagnosis with ABPM than with office BP ( Conclusions: The agreement between office BP and ABPM was low in HIV-infected patients. Ambulatory BP monitoring is useful in HIV-infected patients as a hypertension diagnosis method, especially among patients classified as low risk.
MeSH term(s)	Adult ; Aged ; Blood Pressure Monitoring, Ambulatory ; Cardiovascular Diseases/diagnosis ; Cohort Studies ; Female ; HIV Infections/complications ; HIV Infections/diagnosis ; Heart Disease Risk Factors ; Homosexuality, Male ; Humans ; Hypertension/diagnosis ; Male ; Middle Aged ; Predictive Value of Tests ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2020-08-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2709037-1
ISSN	2325-9582 ; 2325-9574
ISSN (online)	2325-9582
ISSN	2325-9574
DOI	10.1177/2325958220935693
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Article ; Online: Effect of oral nitrates on pulse pressure and arterial elasticity in patients aged over 65 years with refractory isolated systolic hypertension: study protocol for a randomized controlled trial.

Abad-Pérez, Daniel / Novella-Arribas, Blanca / Rodríguez-Salvanés, Francisco J / Sánchez-Gómez, Luis M / García-Polo, Iluminada / Verge-González, Carmen / Suárez-Fernández, Carmen

Trials

2013 Volume 14, Page(s) 388

Abstract: Background: Isolated systolic hypertension is a highly prevalent disease among the elderly. The little available evidence on the efficacy of nitrates for treating the disease is based on small experimental studies.: Methods/design: We performed a ... ...

Abstract	Background: Isolated systolic hypertension is a highly prevalent disease among the elderly. The little available evidence on the efficacy of nitrates for treating the disease is based on small experimental studies. Methods/design: We performed a multicenter, randomized, double-blind, phase III, placebo-controlled trial in 154 patients aged over 65 years with refractory isolated systolic hypertension. Patients were randomized to placebo or 40 mg/day of extended-release isosorbide mononitrate added to standard therapy and titrated to 60 mg/day at week 6 if blood pressure exceeded 140/90 mmHg.The primary objective was to assess the effect on clinical pulse pressure of extended-release isosorbide mononitrate added to standard therapy in patients aged over 65 years with refractory isolated systolic hypertension after 3 months of treatment.The secondary objectives were as follows: to quantify the effect of adding the study drug on central blood pressure and vascular compliance using the augmentation index and pulse wave velocity; to evaluate the safety profile by recording adverse effects (frequency, type, severity) and the percentage of patients who had to withdraw from the trial because of adverse events; to quantify the percentage of patients who reach a clinical systolic blood pressure <140 mmHg or <130 mmHg measured by ambulatory blood pressure monitoring; and to quantify the change in pulse pressure measured by ambulatory blood pressure monitoring. Discussion: Few clinical trials have been carried out to test the effect of oral nitrates on isolated systolic hypertension, even though these agents seem to be effective. Treatment with extended-release isosorbide mononitrate could improve control of systolic blood pressure without severe side effects, thus helping to reduce the morbidity and mortality of the disease. Trial registration: EUDRACT Number: 2012-002988-10.
MeSH term(s)	Administration, Oral ; Aged ; Antihypertensive Agents/administration & dosage ; Blood Pressure/drug effects ; Blood Pressure Monitoring, Ambulatory ; Clinical Protocols ; Delayed-Action Preparations ; Double-Blind Method ; Elasticity ; Humans ; Hypertension/diagnosis ; Hypertension/drug therapy ; Hypertension/physiopathology ; Isosorbide Dinitrate/administration & dosage ; Isosorbide Dinitrate/analogs & derivatives ; Pulse Wave Analysis ; Research Design ; Spain ; Time Factors ; Treatment Outcome ; Vascular Stiffness/drug effects ; Vasodilator Agents/administration & dosage
Chemical Substances	Antihypertensive Agents ; Delayed-Action Preparations ; Vasodilator Agents ; Isosorbide Dinitrate (IA7306519N) ; isosorbide-5-mononitrate (LX1OH63030)
Language	English
Publishing date	2013-11-14
Publishing country	England
Document type	Clinical Trial, Phase III ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1468-6708
ISSN (online)	1745-6215 ; 1468-6694
ISSN	1468-6708
DOI	10.1186/1745-6215-14-388
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Article ; Online: A cluster-randomised clinical trial comparing two cardiovascular health education strategies in a child population

Sánchez-Gómez Luis / Fernández-Luque María / Ruiz-Díaz Lourdes / Sánchez-Alcalde Rosa / Sierra-García Belén / Mayayo-Vicente Soledad / Ruiz-López Marta / Loeches-Belinchón Pilar / López-Gónzález Javier / González-Gamarra Amelia / Gallego-Arenas Angela / Cubillo-Serna Ana / Gil-Juberias Gema / Pérez-Cayuela Pilar / Cañedo-Arguelles Celina / García-Pascual Julia / Ruiz-Chércoles Esther / Suarez-Fernández Carmen / Garcia-Polo Iluminada /

Abad-Perez Daniel / Ballesteros-Arribas Juan M / Izquierdo-Martínez Maravillas / Salvador-Alcaide Elena / Arribas-Vela Ana B / Alonso-Pérez Juan M / Veja-Piris Lorena / Rodríguez-Salvanés Francisco / Novella-Arribas Blanca

BMC Public Health, Vol 12, Iss 1, p

the Savinghearts project

2012 Volume 1024

Abstract: Abstract Background This paper describes a methodology for comparing the effects of an eduentertainment strategy involving a music concert, and a participatory class experience involving the description and making of a healthy breakfast, as educational ... ...

Abstract	Abstract Background This paper describes a methodology for comparing the effects of an eduentertainment strategy involving a music concert, and a participatory class experience involving the description and making of a healthy breakfast, as educational vehicles for delivering obesity-preventing/cardiovascular health messages to children aged 7–8 years. Methods/design This study will involve a cluster-randomised trial with blinded assessment. The study subjects will be children aged 7–8 years of both sexes attending public primary schools in the Madrid Region. The participating schools (n=30) will be randomly assigned to one of two groups: 1) Group MC, in which the children will attend a music concert that delivers obesity-preventing/cardiovascular health messages, or 2) Group HB, in which the children will attend a participatory class providing the same information but involving the description and making of a healthy breakfast. The main outcome measured will be the increase in the number of correct answers scored on a knowledge questionnaire and in an attitudes test administered before and after the above interventions . The secondary outcome recorded will be the reduction in BMI percentile among children deemed overweight/obese prior to the interventions. The required sample size (number of children) was calculated for a comparison of proportions with an α of 0.05 and a β of 0.20, assuming that the Group MC subjects would show values for the measured variables at least 10% higher than those recorded for the subjects of Group HB. Corrections were made for the design effect and assuming a loss to follow-up of 10%. The maximum sample size required will be 2107 children. Data will be analysed using summary measurements for each cluster, both for making estimates and for hypothesis testing. All analyses will be made on an intention-to-treat basis. Discussion The intervention providing the best results could be recommended as part of health education for young schoolchildren. Trial registration Clinicaltrials.gov: NCT01418872
Keywords	Cluster randomised clinical trial ; Cluster analysis ; Cardiovascular diseases ; Child obesity ; Educational concerts ; Healthy strategies ; NAOS strategy ; Public aspects of medicine ; RA1-1270
Subject code	796
Language	English
Publishing date	2012-11-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A cluster-randomised clinical trial comparing two cardiovascular health education strategies in a child population: the Savinghearts project.

Sánchez-Gómez, Luis María / Fernández-Luque, María Jesús / Ruiz-Díaz, Lourdes / Sánchez-Alcalde, Rosa / Sierra-García, Belén / Mayayo-Vicente, Soledad / Ruiz-López, Marta / Loeches-Belinchón, Pilar / López-Gónzález, Javier / González-Gamarra, Amelia / Gallego-Arenas, Angela / Cubillo-Serna, Ana / Gil-Juberias, Gema / Pérez-Cayuela, Pilar / Cañedo-Arguelles, Celina Arana / García-Pascual, Julia Natividad / Ruiz-Chércoles, Esther / Suarez-Fernández, Carmen / Garcia-Polo, Iluminada /

Abad-Perez, Daniel / Ballesteros-Arribas, Juan M / Izquierdo-Martínez, Maravillas / Salvador-Alcaide, Elena / Arribas-Vela, Ana B / Alonso-Pérez, Juan M / Veja-Piris, Lorena / Rodríguez-Salvanés, Francisco / Novella-Arribas, Blanca

BMC public health

2012 Volume 12, Page(s) 1024

Abstract: Background: This paper describes a methodology for comparing the effects of an eduentertainment strategy involving a music concert, and a participatory class experience involving the description and making of a healthy breakfast, as educational vehicles ...

Abstract	Background: This paper describes a methodology for comparing the effects of an eduentertainment strategy involving a music concert, and a participatory class experience involving the description and making of a healthy breakfast, as educational vehicles for delivering obesity-preventing/cardiovascular health messages to children aged 7-8 years. Methods/design: This study will involve a cluster-randomised trial with blinded assessment. The study subjects will be children aged 7-8 years of both sexes attending public primary schools in the Madrid Region. The participating schools (n=30) will be randomly assigned to one of two groups: 1) Group MC, in which the children will attend a music concert that delivers obesity-preventing/cardiovascular health messages, or 2) Group HB, in which the children will attend a participatory class providing the same information but involving the description and making of a healthy breakfast. The main outcome measured will be the increase in the number of correct answers scored on a knowledge questionnaire and in an attitudes test administered before and after the above interventions. The secondary outcome recorded will be the reduction in BMI percentile among children deemed overweight/obese prior to the interventions. The required sample size (number of children) was calculated for a comparison of proportions with an α of 0.05 and a β of 0.20, assuming that the Group MC subjects would show values for the measured variables at least 10% higher than those recorded for the subjects of Group HB. Corrections were made for the design effect and assuming a loss to follow-up of 10%. The maximum sample size required will be 2107 children. Data will be analysed using summary measurements for each cluster, both for making estimates and for hypothesis testing. All analyses will be made on an intention-to-treat basis. Discussion: The intervention providing the best results could be recommended as part of health education for young schoolchildren. Trial registration: Clinicaltrials.gov: NCT01418872.
MeSH term(s)	Breakfast ; Cardiovascular Diseases/prevention & control ; Child ; Cluster Analysis ; Female ; Follow-Up Studies ; Health Education/methods ; Health Knowledge, Attitudes, Practice ; Health Promotion/methods ; Humans ; Male ; Music ; Obesity/prevention & control ; Program Evaluation ; Single-Blind Method
Language	English
Publishing date	2012-11-23
Publishing country	England
Document type	Comparative Study ; Journal Article ; Randomized Controlled Trial
ISSN	1471-2458
ISSN (online)	1471-2458
DOI	10.1186/1471-2458-12-1024
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