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  1. Article ; Online: Notes from the Field: Scrub Typhus Outbreak - Los Lagos Region, Chile, January-February 2023.

    Weitzel, Thomas / Martínez-Valdebenito, Constanza / Acosta-Jamett, Gerardo / Abarca, Katia

    MMWR. Morbidity and mortality weekly report

    2023  Volume 72, Issue 27, Page(s) 753–754

    MeSH term(s) Humans ; Scrub Typhus/epidemiology ; Chile/epidemiology ; Disease Outbreaks
    Language English
    Publishing date 2023-07-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 412775-4
    ISSN 1545-861X ; 0149-2195
    ISSN (online) 1545-861X
    ISSN 0149-2195
    DOI 10.15585/mmwr.mm7227a4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Asthma and the Risk of Invasive Pneumococcal Disease: A Meta-analysis.

    Castro-Rodriguez, Jose A / Abarca, Katia / Forno, Erick

    Pediatrics

    2019  Volume 145, Issue 1

    Abstract: Context: Invasive pneumococcal disease (IPD) and pneumonia are a leading cause of morbidity and mortality throughout the world, and asthma is the most common chronic disease of childhood.: Objective: To evaluate the risk of IPD or pneumonia among ... ...

    Abstract Context: Invasive pneumococcal disease (IPD) and pneumonia are a leading cause of morbidity and mortality throughout the world, and asthma is the most common chronic disease of childhood.
    Objective: To evaluate the risk of IPD or pneumonia among children with asthma after the introduction of pneumococcal conjugate vaccines (PCVs).
    Data sources: Four electronic databases were searched.
    Study selection: We selected all cohorts or case-control studies of IPD and pneumonia in populations who already received PCV (largely 7-valent pneumococcal conjugate vaccine), but not 23-valent pneumococcal polysaccharide, in which authors reported data for children with asthma and in which healthy controls were included, without language restriction.
    Data extraction: Two reviewers independently reviewed all studies. Primary outcomes were occurrence of IPD and pneumonia. Secondary outcomes included mortality, hospital admissions, hospital length of stay, ICU admission, respiratory support, costs, and additional medication use.
    Results: Five studies met inclusion criteria; of those, 3 retrospective cohorts (∼26 million person-years) and 1 case-control study (
    Limitations: None of the identified studies had information of asthma therapy or compliance.
    Conclusions: Despite PCV vaccination, children with asthma continue to have a higher risk of IPD than children without asthma. Further research is needed to assess the need for supplemental 23-valent pneumococcal polysaccharide vaccination in children with asthma, regardless of their use of oral steroids.
    MeSH term(s) Asthma/complications ; Case-Control Studies ; Child ; Humans ; Pneumococcal Infections/etiology ; Pneumococcal Infections/prevention & control ; Pneumococcal Vaccines/administration & dosage ; Pneumonia, Pneumococcal/etiology ; Pneumonia, Pneumococcal/prevention & control ; Retrospective Studies ; Streptococcus pneumoniae ; Vaccines, Conjugate/administration & dosage
    Chemical Substances Pneumococcal Vaccines ; Vaccines, Conjugate
    Language English
    Publishing date 2019-12-16
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2019-1200
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Scrub typhus in Chile.

    Concha-Rogazy, Marcela / Kinzel-Maluje, Francisca / Pinto-Santana, Cristián / Sánchez-Sánchez, Nicolás / Abarca, Katia

    Cutis

    2021  Volume 107, Issue 1, Page(s) E35–E38

    MeSH term(s) Chile/epidemiology ; Humans ; Scrub Typhus/diagnosis ; Scrub Typhus/epidemiology
    Language English
    Publishing date 2021-02-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391840-3
    ISSN 2326-6929 ; 0011-4162 ; 0151-9522
    ISSN (online) 2326-6929
    ISSN 0011-4162 ; 0151-9522
    DOI 10.12788/cutis.0181
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: An Update on Host-Pathogen Interplay and Modulation of Immune Responses during Orientia tsutsugamushi Infection.

    Díaz, Fabián E / Abarca, Katia / Kalergis, Alexis M

    Clinical microbiology reviews

    2018  Volume 31, Issue 2

    Abstract: The obligate intracellular ... ...

    Abstract The obligate intracellular bacterium
    MeSH term(s) Host-Pathogen Interactions/immunology ; Humans ; Immunomodulation/immunology ; Models, Animal ; Orientia tsutsugamushi/immunology ; Scrub Typhus/immunology ; Scrub Typhus/microbiology
    Language English
    Publishing date 2018-01-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 645015-5
    ISSN 1098-6618 ; 0893-8512
    ISSN (online) 1098-6618
    ISSN 0893-8512
    DOI 10.1128/CMR.00076-17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Development of a New Genus-Specific Quantitative Real-Time PCR Assay for the Diagnosis of Scrub Typhus in South America.

    Jiang, Ju / Martínez-Valdebenito, Constanza / Weitzel, Thomas / Farris, Christina M / Acosta-Jamett, Gerardo / Abarca, Katia / Richards, Allen L

    Frontiers in medicine

    2022  Volume 9, Page(s) 831045

    Abstract: Scrub typhus is a potentially severe rickettsiosis, caused ... ...

    Abstract Scrub typhus is a potentially severe rickettsiosis, caused by
    Language English
    Publishing date 2022-04-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.831045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Prevalence and Risk Factors of Antibodies to Anaplasma spp. in Chile: A Household-Based Cross-Sectional Study in Healthy Adults and Domestic Dogs

    Acosta-Jamett, Gerardo / Weitzel, Thomas / López, Javier / Alvarado, Doris / Abarca, Katia

    Vector borne and zoonotic diseases. 2020 Apr. 01,

    2020  

    Abstract: Background: Pet-related tick-borne infections constitute an emerging problem in human and veterinary medicine worldwide. In Chile, two pathogens of the Anaplasmataceae family, Anaplasma platys and Ehrlichia canis, have been identified in recent years in ... ...

    Abstract Background: Pet-related tick-borne infections constitute an emerging problem in human and veterinary medicine worldwide. In Chile, two pathogens of the Anaplasmataceae family, Anaplasma platys and Ehrlichia canis, have been identified in recent years in dogs and vectors. This epidemiological survey aimed to determine the human and canine seroprevalence of Anaplasma spp. in urban and rural areas of different regions in Chile and to analyze the factors associated with seropositivity. Methods: We performed a cross-sectional household-based study in four regions, where healthy adults and their household dogs were included. Households were chosen by double stratified random sampling in urban areas and by convenience sampling in rural areas. Anaplasma seroreactivity was determined by a commercial microimmunofluorescence assay using Anaplasma phagocytophilum antigens. A questionnaire survey was applied to assess risk factors for Anaplasma seropositivity. Results: A total of 1105 persons and 905 dogs were included. The overall seroprevalence in humans was 9.4%, ranging from 5.6% in central Chile to 13.7% in the extreme north; in dogs the overall prevalence was 44.0% and ranged from 37.2% in the northern region to 61.1% in central Chile. Risk factors for human seropositivity were lower education and external deworming of dogs, whereas canine seropositivity was associated to urban site, mixed-breed, older animals, and tick infestation. Conclusions: This cross-sectional study suggests a broad exposure of both dogs and dog owners to Anaplasma or related agents in Chile. Further epidemiological and clinical studies are necessary to understand the complete spectrum and epidemiology of tick-borne zoonotic infections in the different ecoclimatic regions of Chile.
    Keywords Anaplasma phagocytophilum ; Anaplasma platys ; Ehrlichia canis ; adults ; antibodies ; antigens ; clinical trials ; cross-sectional studies ; deworming ; dogs ; epidemiological studies ; households ; humans ; mixed breeds ; pathogens ; pet ownership ; questionnaires ; risk factors ; rural areas ; seroprevalence ; tick infestations ; tick-borne diseases ; urban areas ; veterinary medicine ; zoonoses ; Chile
    Language English
    Dates of publication 2020-0401
    Publishing place Mary Ann Liebert, Inc.
    Document type Article
    ZDB-ID 2047199-3
    ISSN 1557-7759 ; 1530-3667
    ISSN (online) 1557-7759
    ISSN 1530-3667
    DOI 10.1089/vbz.2019.2587
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Yellow fever vaccination for Chilean tourists visiting Brazil. Practical considerations.

    Weitzel, Thomas / Perret, Cecilia / Valdivieso, Francisca / Abarca, Katia / Vial, Pablo

    Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia

    2019  Volume 35, Issue 5, Page(s) 587–590

    Abstract: Due to the recent yellow fever outbreak affecting the costal region of Brazil, including main touristic destinations, there is a high demand of yellow fever vaccination. This publication addresses the most relevant practical issues regarding this vaccine ...

    Title translation Vacuna contra fiebre amarilla para viajeros chilenos a Brasil. Consideraciones prácticas.
    Abstract Due to the recent yellow fever outbreak affecting the costal region of Brazil, including main touristic destinations, there is a high demand of yellow fever vaccination. This publication addresses the most relevant practical issues regarding this vaccine for tourists visiting Brazil and aims to serve as a guideline for non-expert physicians in Chile and elsewhere.
    MeSH term(s) Brazil ; Chile ; Humans ; Travel ; Yellow Fever/prevention & control ; Yellow Fever Vaccine/administration & dosage
    Chemical Substances Yellow Fever Vaccine
    Language Spanish
    Publishing date 2019-03-20
    Publishing country Chile
    Document type Journal Article
    ZDB-ID 2048815-4
    ISSN 0717-6341 ; 0716-1018
    ISSN (online) 0717-6341
    ISSN 0716-1018
    DOI 10.4067/s0716-10182018000500587
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Tifus de los matorrales, una enfermedad emergente en Chile.

    Abarca, Katia / Weitzel, Thomas / Martínez-Valdebenito, Constanza / Acosta-Jamett, Gerardo

    Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia

    2019  Volume 35, Issue 6, Page(s) 696–699

    Abstract: Scrub typhus, caused by Orientia tsutsugamushi and transmitted by larvae of trombiculid mites, is an endemic rickettsiosis in the Asia Pacific region. After the first identification of a case in Chile in 2006, more than 30 cases have been diagnosed by ... ...

    Title translation Scrub typhus, an emerging infectious disease in Chile.
    Abstract Scrub typhus, caused by Orientia tsutsugamushi and transmitted by larvae of trombiculid mites, is an endemic rickettsiosis in the Asia Pacific region. After the first identification of a case in Chile in 2006, more than 30 cases have been diagnosed by our group since 2015. Cases were detected predominantly during the Chilean summer months. Patients presented with fever, rash, and a typical eschar at the inoculation site; other frequent findings were intense headache, night sweats, increased laboratory markers of inflammation and transaminases. The vast majority of cases have been diagnosed in southern Chile (mainly Chiloé Island), although recently some cases were also identified in the central Metropolitan Region in patients returning from trips to southern Chile. Physicians attending Chilean patients should be aware of this emerging infection to be able to initiate empirical therapy with doxycycline. The confirmation of cases by the diagnostic methods available in Chile will contribute to a better understanding of the epidemiological and clinical relevance of this emerging infection in South America.
    MeSH term(s) Chile/epidemiology ; Communicable Diseases, Emerging/epidemiology ; Humans ; Orientia tsutsugamushi ; Scrub Typhus/epidemiology ; Seasons
    Language Spanish
    Publishing date 2019-06-06
    Publishing country Chile
    Document type Journal Article
    ZDB-ID 2048815-4
    ISSN 0717-6341 ; 0716-1018
    ISSN (online) 0717-6341
    ISSN 0716-1018
    DOI 10.4067/S0716-10182018000600696
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Aproximación clínica y principales rickettsiosis transmitidas por garrapatas presentes en Latinoamérica.

    Abarca, Katia / Oteo, José A

    Revista chilena de infectología : órgano oficial de la Sociedad Chilena de Infectología

    2014  Volume 31, Issue 5, Page(s) 569–576

    Abstract: Tick-borne rickettsial diseases are potentially life threatening infections that in Latin America have an emerging and reemerging character. Until few years ago, Rickettsia rickettsia was the only tick-borne rickettsia present in America; but nowadays ... ...

    Title translation Clinical approach and main tick-borne rickettsiosis present in Latin America.
    Abstract Tick-borne rickettsial diseases are potentially life threatening infections that in Latin America have an emerging and reemerging character. Until few years ago, Rickettsia rickettsia was the only tick-borne rickettsia present in America; but nowadays several other species such as R. parkeri and R. massiliae are causing disease in humans in the region. In addition, new species are being described; although their pathogenicity has not been confirmed they should be considered as potential pathogens. Since the microbiological diagnosis of rickettsioses can take days or weeks, a high clinical suspicion and early start of appropriate treatment are crucial. In this review the distribution and main clinical manifestations of tick-borne rickettsial diseases in Latin America are detailed. Since R. felis has been found in ticks and the role of this vector has not been clarified, we have included a section about this pathogen.
    MeSH term(s) Animals ; Humans ; Latin America ; Rickettsia/classification ; Rickettsia/isolation & purification ; Rickettsia Infections/classification ; Rickettsia Infections/microbiology ; Tick-Borne Diseases/classification ; Tick-Borne Diseases/microbiology ; Ticks/microbiology
    Language Spanish
    Publishing date 2014-10
    Publishing country Chile
    Document type English Abstract ; Journal Article
    ISSN 0716-1018
    ISSN 0716-1018
    DOI 10.4067/S0716-10182014000500009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Prevalence and Risk Factors of Antibodies to

    Acosta-Jamett, Gerardo / Weitzel, Thomas / López, Javier / Alvarado, Doris / Abarca, Katia

    Vector borne and zoonotic diseases (Larchmont, N.Y.)

    2020  Volume 20, Issue 8, Page(s) 572–579

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Anaplasma/immunology ; Anaplasmosis/blood ; Anaplasmosis/epidemiology ; Animals ; Antibodies, Bacterial/blood ; Chile/epidemiology ; Cross-Sectional Studies ; Dog Diseases/blood ; Dog Diseases/epidemiology ; Dog Diseases/immunology ; Dogs ; Female ; Humans ; Male ; Middle Aged ; Prevalence ; Risk Factors
    Chemical Substances Antibodies, Bacterial
    Language English
    Publishing date 2020-04-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2047199-3
    ISSN 1557-7759 ; 1530-3667
    ISSN (online) 1557-7759
    ISSN 1530-3667
    DOI 10.1089/vbz.2019.2587
    Database MEDical Literature Analysis and Retrieval System OnLINE

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