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  1. Article ; Online: Metabolomic Profiling and Identification of Antioxidant and Antidiabetic Compounds from Leaves of Different Varieties of

    Jan, Bisma / Zahiruddin, Sultan / Basist, Parakh / Irfan, Mohammad / Abass, Sageer / Ahmad, Sayeed

    ACS omega

    2022  Volume 7, Issue 28, Page(s) 24317–24328

    Abstract: Mulberry ( ...

    Abstract Mulberry (
    Language English
    Publishing date 2022-07-08
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.2c01623
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Receptor-Mediated Targeting in Breast Cancer through Solid Lipid Nanoparticles and Its Mechanism.

    Malik, Zoya / Parveen, Rabea / Abass, Sageer / Irfan, Mohammad / Husain, Syed Akhtar / Ahmad, Sayeed

    Current drug metabolism

    2022  

    Abstract: Nanoparticles have gained prominence in many areas and domains world-wide such as metallic NP, carbon-dots, quantum dots, polymeric NP, nano-suspension, nanocrystals, solid lipid nanoparticles (SLN), etc. and have been applied in the field of medicine as ...

    Abstract Nanoparticles have gained prominence in many areas and domains world-wide such as metallic NP, carbon-dots, quantum dots, polymeric NP, nano-suspension, nanocrystals, solid lipid nanoparticles (SLN), etc. and have been applied in the field of medicine as nanomedicine with promising results. Rise in global cancer mortality rate has been an issue since long with female breast cancer as one of the most detected cancers. No permanent treatment has been developed till date that could combat breast cancer with minimum side effects that are not long-lasting as there is not any proper technique through which the anticancer drugs can recognize benign or malignant or normal cells that causes systematic toxicity. Advancement in technology has led to the discovery of many biological pathways and mechanisms. Tumor cells or cancer cells overexpress some high-affinity receptors that can be targeted to deliver the anticancer drugs at specific site using these pathways and mechanisms. Solid lipid nanoparticles (SLN) are among some of the excellent drug delivery systems, especially stealth SLN (sSLN). SLN when conjugated with a ligand (called as sSLN) has affinity and specificity towards a specific receptor, and can deliver the drug in breast cancer cells overexpressing the receptors. Using this technique, various investigations have reported better anti-breast cancer activity than simple SLN (non-conjugated to ligand or no receptor targeting). This review includes the investigations and data on receptor-mediated targeting in breast cancer from 2010 to 2021 by searching different databases. Overall, information on SLN in different cancers are reviewed. Effectiveness of sSLN is discussed with in vivo studies, pharmacokinetics, biodistribution, and stability. Investigations included in this review demonstrate that sSLN delivers the drug by overcoming the biological barriers and shows enhanced and better activity than non-conjugated SLN that also verifies that lesser concentration of drug can show anti-breast cancer activity. The efficacy of medicines could be increased with lower cancer deaths through stealth-SLN. Due to the low cost of synthesis, biocompatibility and easy to formulate, more study is needed in vitro and in vivo so that this novel technique could be utilized in the treatment of human breast cancer.
    Language English
    Publishing date 2022-04-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2064815-7
    ISSN 1875-5453 ; 1389-2002
    ISSN (online) 1875-5453
    ISSN 1389-2002
    DOI 10.2174/1389200223666220416213639
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5584: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Synergy based Extracts of Medicinal Plants: Future Antimicrobials to Combat Multidrug Resistance.

    Abass, Sageer / Parveen, Rabea / Irfan, Mohammad / Jan, Bisma / Husain, Syed Akhtar / Ahmad, Sayeed

    Current pharmaceutical biotechnology

    2022  Volume 23, Issue 13, Page(s) 1527–1540

    Abstract: The use of herbal medicines and supplements in the last thirty years has increased enormously. Herbal medication has demonstrated promising and effective potential against various diseases. Herbal and phytoconstituent medications are gaining popularity ... ...

    Abstract The use of herbal medicines and supplements in the last thirty years has increased enormously. Herbal medication has demonstrated promising and effective potential against various diseases. Herbal and phytoconstituent medications are gaining popularity globally and many people are adopting herbal remedies to deal with different health issues. The indiscriminate use of antibiotics, due to the development of antimicrobial resistance, poses an unprecedented problem for human civilization. Bacterial infections are difficult to cure because of the propensity of microbes to acquire resistance to a wide range of antimicrobial drugs. New compounds are being explored and quantified for possible antibacterial activity with little or no side effects. Researchers are investigating the range of therapeutic plants mentioned in Unani, Ayurveda, and Siddha around the globe. Known and commonly acclaimed global databases such as PubMed, Research Gate, Science Direct, Google Scholar were searched using different search strings such as Indian medicinal plants, multidrug resistance (MDR), thin layer chromatography (TLC), antimicrobials, and Synergism were used in diverse combinations to reclaim numerous citations associated with this area. Thus, the current review aims to shed a light on the information of medicinal plants as a potential foundation of herbal drugs and elucidate how synergism and TLC bioautography play a crucial role in finding antimicrobial compounds.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Infective Agents/pharmacology ; Anti-Infective Agents/therapeutic use ; Drug Resistance, Multiple ; Humans ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Plants, Medicinal/chemistry
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents ; Plant Extracts
    Language English
    Publishing date 2022-01-21
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2132197-8
    ISSN 1873-4316 ; 1389-2010
    ISSN (online) 1873-4316
    ISSN 1389-2010
    DOI 10.2174/1389201023666220126115656
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6212: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Development of Synergy-Based Combination of Methanolic Extract of Andrographis paniculata and Berberis aristata Against E. coli and S. aureus.

    Abass, Sageer / Zahiruddin, Sultan / Ali, Asghar / Irfan, Mohammad / Jan, Bisma / Haq, Qazi Mohd Rizwanul / Husain, Syed Akhtar / Ahmad, Sayeed

    Current microbiology

    2022  Volume 79, Issue 8, Page(s) 223

    Abstract: This study evaluates the antibacterial activity and phytochemical characterizations of Andrographis paniculata extract (APE) and Berberis aristata extract (BAE). The stem of Andrographis paniculata (AP) and root of Berberis aristata (BA) were extracted ... ...

    Abstract This study evaluates the antibacterial activity and phytochemical characterizations of Andrographis paniculata extract (APE) and Berberis aristata extract (BAE). The stem of Andrographis paniculata (AP) and root of Berberis aristata (BA) were extracted with methanol. The results confirmed that APE and BAE possess high phenolic and flavonoid content. The antioxidant activity of the APE and BAE showed an elevated potential to scavenge DPPH (2,2-diphenyl-1-picrylhydrazyl) radicals with IC
    MeSH term(s) Andrographis paniculata ; Anti-Bacterial Agents/pharmacology ; Berberis/chemistry ; Escherichia coli ; Methanol ; Methicillin-Resistant Staphylococcus aureus ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Staphylococcus aureus
    Chemical Substances Anti-Bacterial Agents ; Plant Extracts ; Methanol (Y4S76JWI15)
    Language English
    Publishing date 2022-06-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 134238-1
    ISSN 1432-0991 ; 0343-8651
    ISSN (online) 1432-0991
    ISSN 0343-8651
    DOI 10.1007/s00284-022-02911-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1446: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Development of Synergy-Based Combination of Methanolic Extract of Andrographis paniculata and Berberis aristata Against E. coli and S. aureus

    Abass, Sageer / Zahiruddin, Sultan / Ali, Asghar / Irfan, Mohammad / Jan, Bisma / Haq, Qazi Mohd Rizwanul / Husain, Syed Akhtar / Ahmad, Sayeed

    Current microbiology. 2022 Aug., v. 79, no. 8

    2022  

    Abstract: This study evaluates the antibacterial activity and phytochemical characterizations of Andrographis paniculata extract (APE) and Berberis aristata extract (BAE). The stem of Andrographis paniculata (AP) and root of Berberis aristata (BA) were extracted ... ...

    Abstract This study evaluates the antibacterial activity and phytochemical characterizations of Andrographis paniculata extract (APE) and Berberis aristata extract (BAE). The stem of Andrographis paniculata (AP) and root of Berberis aristata (BA) were extracted with methanol. The results confirmed that APE and BAE possess high phenolic and flavonoid content. The antioxidant activity of the APE and BAE showed an elevated potential to scavenge DPPH (2,2-diphenyl-1-picrylhydrazyl) radicals with IC₅₀ of 95.03 μg/mL and 256.26 μg/mL, respectively. A total of 35 and 32 metabolites in APE and BAE, respectively, were identified through mass spectrometry analysis, whereas 17 and 12 metabolites in APE and BAE, respectively, were detected through high-performance thin-layer chromatography (HPTLC) fingerprinting profiling. Antibacterial activity of the extracts was performed by the well diffusion and microdilution method, and the findings showed that APE and BAE had antibacterial activities against E. coli and S. aureus. The growth curve and time-kill study showed that the extracts had a bacteriostatic effect. A combination study with the standard drug was carried out using the microdilution checkerboard method in which most of the combinations showed synergistic interactions. The findings of this study have shown that APE and BAE are good sources of antibacterial compounds and can be used for treating infectious diseases caused by E. coli and S. aureus.
    Keywords 2,2-diphenyl-1-picrylhydrazyl ; Andrographis paniculata ; Berberis aristata ; Escherichia coli ; antibacterial properties ; antioxidant activity ; drugs ; flavonoids ; growth curves ; mass spectrometry ; metabolites ; methanol ; microbiology ; thin layer chromatography
    Language English
    Dates of publication 2022-08
    Size p. 223.
    Publishing place Springer US
    Document type Article
    ZDB-ID 134238-1
    ISSN 1432-0991 ; 0343-8651
    ISSN (online) 1432-0991
    ISSN 0343-8651
    DOI 10.1007/s00284-022-02911-8
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 80/708: Show issues

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  6. Article: Heartwood Extract of

    Dar, Mohammad Irfan / Rafat, Sahar / Dev, Kapil / Abass, Sageer / Khan, Mohammad Umar / Abualsunun, Walaa A / Murshid, Samar S / Ahmad, Sayeed / Qureshi, Mohammad Irfan

    Metabolites

    2022  Volume 12, Issue 10

    Abstract: Diabetes mellitus leads to cellular damage and causes apoptosis by oxidative stress. Heartwood extract ... ...

    Abstract Diabetes mellitus leads to cellular damage and causes apoptosis by oxidative stress. Heartwood extract of
    Language English
    Publishing date 2022-10-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo12100947
    Database MEDical Literature Analysis and Retrieval System OnLINE

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