Article: Crossroads of Antimicrobial and Diagnostic Stewardship: Assessing Risks to Develop Clinical Decision Support to Combat Multidrug-Resistant
Open forum infectious diseases
2023 Volume 10, Issue 10, Page(s) ofad512
Abstract: Background: Early detection of multidrug-resistant : Methods: This was a mixed-methods study. We conducted a split-sample cohort study of adult critical care patients with : Results: The 2 previous risk prediction tools demonstrated similar ... ...
| Abstract | Background: Early detection of multidrug-resistant Methods: This was a mixed-methods study. We conducted a split-sample cohort study of adult critical care patients with Results: The 2 previous risk prediction tools demonstrated similar accuracy in the derivation cohort (c-statistic of 0.76 [95% confidence interval {CI}, .69-.83] and 0.73 [95% CI, .66-.8]). A simplified tool based on 4 variables demonstrated reasonable accuracy (c-statistic of 0.71 [95% CI, .57-.85]) without significant overprescribing in the validation cohort. The risk factors were prior MDRP infection, ≥4 antibiotics prior to culture, infection >3 days after admission, and dialysis. Fourteen clinicians completed the survey. An alert providing context regarding individual patient risk factors for MDRP was preferred. Conclusions: These results can be used to develop a local EMR-integrated tool to improve timeliness of effective therapy in those at risk of MDRP infections. |
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| Language | English |
| Publishing date | 2023-10-12 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 2757767-3 |
| ISSN | 2328-8957 |
| ISSN | 2328-8957 |
| DOI | 10.1093/ofid/ofad512 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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