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  1. Article: A Rare Congenital Perineal Groove.

    Abate, Enyew

    Case reports in obstetrics and gynecology

    2022  Volume 2022, Page(s) 8797205

    Abstract: Background: Perineal groove is a rare congenital anomaly characterized by nonepithelialized mucous membrane that appears as an erythematous sulcus in the perineal midline, extending from the posterior vaginal fourchette to the anterior anal orifice. It ... ...

    Abstract Background: Perineal groove is a rare congenital anomaly characterized by nonepithelialized mucous membrane that appears as an erythematous sulcus in the perineal midline, extending from the posterior vaginal fourchette to the anterior anal orifice. It is one of the uncommon anomalies of anogenital region that is unknown to many clinicians, and it is usually misdiagnosed as an anal fissure, perineal trauma, diaper dermatitis, infection, or sexual abuse.
    Conclusions: Recognition of the congenital perineal groove at birth is important for the health care providers to deliver an appropriate parental counseling and appropriate follow-up.
    Language English
    Publishing date 2022-10-27
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2627654-9
    ISSN 2090-6692 ; 2090-6684
    ISSN (online) 2090-6692
    ISSN 2090-6684
    DOI 10.1155/2022/8797205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A structured 2-week follow-up visit in the cascade of care for TB increases case detection.

    Rudolf, F / Abate, E / Moges, B / Gomes, V F / Mendes, A M / Sifna, A / Fekadu, H / Bizuneh, S / Wejse, C / Schön, T

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

    2024  Volume 28, Issue 3, Page(s) 148–153

    Abstract: ... OBJECTIVES ... Delayed detection in TB due to structural and diagnostic shortcomings is pivotal for disease transmission, morbidity and mortality. We investigated whether an inclusive screening, followed by a structured clinical ... ...

    Abstract <sec id="st1"><title>OBJECTIVES</title>Delayed detection in TB due to structural and diagnostic shortcomings is pivotal for disease transmission, morbidity and mortality. We investigated whether an inclusive screening, followed by a structured clinical follow-up (FU) could improve case-finding.</sec><sec id="st2"><title>METHODS</title>Patients were recruited from health centres in Bissau, Guinea-Bissau, and Gondar, Ethiopia. A routine FU was done at Week 2. If persisting symptoms were found, patients were investigated using chest X-ray (CXR) and Xpert
    MeSH term(s) Adult ; Humans ; Tuberculosis/diagnosis ; Tuberculosis/prevention & control ; Follow-Up Studies ; Delivery of Health Care ; Cough ; Ethiopia ; Mycobacterium tuberculosis
    Language English
    Publishing date 2024-03-07
    Publishing country France
    Document type Journal Article
    ZDB-ID 1385624-8
    ISSN 1815-7920 ; 1027-3719
    ISSN (online) 1815-7920
    ISSN 1027-3719
    DOI 10.5588/ijtld.23.0435
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Haematological Parameters in People with Atherosclerotic Cardiovascular Disease versus Those Who are Only at Risk for Cardiovascular Disease

    Abate E / Degef M / Melkie A / Gnanasekeran N / Mehdi M / Tolcha Y / Chala D

    Diabetes, Metabolic Syndrome and Obesity, Vol Volume 16, Pp 1869-

    A Comparative Cross-Sectional Study

    2023  Volume 1883

    Abstract: Ebsitu Abate,1 Maria Degef,1 Addisu Melkie,2 Natesan Gnanasekeran,1 Mohammed Mehdi,1 Yosef Tolcha,3 Dawit Chala3 1Department of Medical Biochemistry Addis Ababa University, Addis Ababa, Ethiopia; 2Department of Internal Medicine, Addis Ababa University, ... ...

    Abstract Ebsitu Abate,1 Maria Degef,1 Addisu Melkie,2 Natesan Gnanasekeran,1 Mohammed Mehdi,1 Yosef Tolcha,3 Dawit Chala3 1Department of Medical Biochemistry Addis Ababa University, Addis Ababa, Ethiopia; 2Department of Internal Medicine, Addis Ababa University, Addis Ababa, Ethiopia; 3Department of Diagnostic Laboratory, Ethiopian Public Health Institute, Addis Ababa, EthiopiaCorrespondence: Ebsitu Abate, Tel +251 912632054, Email ebsitu.abate@aau.edu.etIntroduction: Cardiovascular disease (CVD) is the foremost killer disease worldwide. ASCVD is one of the most common types of CVD. It is mainly associated with a condition called atherosclerosis. Its occurrence is linked to several risk factors. Hypertension, diabetes, dyslipidemia, smoking, genetic factors, and so on are examples. The presence of ASCVD, as well as its risk factors, causes a variety of disruptions in the body’s physiological and biological functions. The presence of abnormal physiological and biological functions, for example, tends to disrupt hematological parameters.Purpose: The study’s aim was to assess and compare the pattern of hematological parameters in people with established atherosclerotic cardiovascular disease (ASVD) versus people with ASCVD risks alone who attended TASH Addis Ababa, Ethiopia, as well as to correlate hematological parameters with the novel inflammatory marker hs-CRP.Methods: A prospective cross-sectional comparative study with 100 study participants was conducted during where October 2019-March 2020 proposal development, sample collection, and lab analysis period, and from March 2020-June to 2021 data entry, analysis, and writing period. A serum sample was collected from each study participant for the lipid and hsCRP analyses and whole blood for hematological parameter determination. The socio-demographic characteristics of the study participants were obtained through a well-structured questionnaire.Results: The ASCVD-risk group had significantly higher mean platelet volume (MPV), which was associated with the presence of the ...
    Keywords ascvd ; hematological parameters ; hs-crp ; hypertension ; diabetes ; Specialties of internal medicine ; RC581-951
    Subject code 610
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Dove Medical Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Neglected Tropical Diseases: responding to calls for action from the front lines in Ethiopia.

    Abate, Ebba / Reeder, John C

    Journal of infection in developing countries

    2020  Volume 14, Issue 6.1, Page(s) 1S–2S

    MeSH term(s) Ethiopia/epidemiology ; Humans ; Neglected Diseases/epidemiology ; Tropical Medicine
    Language English
    Publishing date 2020-06-29
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2394024-4
    ISSN 1972-2680 ; 2036-6590
    ISSN (online) 1972-2680
    ISSN 2036-6590
    DOI 10.3855/jidc.12790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Critical water contents at leaf, stem and root level leading to irreversible drought-induced damage in two woody and one herbaceous species.

    Trifilò, Patrizia / Abate, Elisa / Petruzzellis, Francesco / Azzarà, Maria / Nardini, Andrea

    Plant, cell & environment

    2022  Volume 46, Issue 1, Page(s) 119–132

    Abstract: Plant water content is a simple and promising parameter for monitoring drought-driven plant mortality risk. However, critical water content thresholds leading to cell damage and plant failure are still unknown. Moreover, it is unclear whether whole-plant ...

    Abstract Plant water content is a simple and promising parameter for monitoring drought-driven plant mortality risk. However, critical water content thresholds leading to cell damage and plant failure are still unknown. Moreover, it is unclear whether whole-plant or a specific organ water content is the most reliable indicator of mortality risk. We assessed differences in dehydration thresholds in leaf, stem and root samples, hampering the organ-specific rehydration capacity and increasing the mortality risk. We also tested eventual differences between a fast experimental dehydration of uprooted plants, compared to long-term water stress induced by withholding irrigation in potted plants. We investigated three species with different growth forms and leaf habits i.e., Helianthus annuus (herbaceous), Populus nigra (deciduous tree) and Quercus ilex (evergreen tree). Results obtained by the two dehydration treatments largely overlapped, thus validating bench dehydration as a fast but reliable method to assess species-specific critical water content thresholds. Regardless of the organ considered, a relative water content value of 60% induced significant cell membrane damage and loss of rehydration capacity, thus leading to irreversible plant failure and death.
    MeSH term(s) Plant Leaves
    Language English
    Publishing date 2022-11-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391893-2
    ISSN 1365-3040 ; 0140-7791
    ISSN (online) 1365-3040
    ISSN 0140-7791
    DOI 10.1111/pce.14469
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Too dry to survive: Leaf hydraulic failure in two Salvia species can be predicted on the basis of water content.

    Abate, Elisa / Nardini, Andrea / Petruzzellis, Francesco / Trifilò, Patrizia

    Plant physiology and biochemistry : PPB

    2021  Volume 166, Page(s) 215–224

    Abstract: Global warming is exposing plants to increased risks of drought-driven mortality. Recent advances suggest that hydraulic failure is a key process leading to plant death, and the identification of simple and reliable proxies of species-specific risk of ... ...

    Abstract Global warming is exposing plants to increased risks of drought-driven mortality. Recent advances suggest that hydraulic failure is a key process leading to plant death, and the identification of simple and reliable proxies of species-specific risk of irreversible hydraulic damage is urgently required. We assessed the predictive power of leaf water content and shrinkage for monitoring leaf hydraulic failure in two Mediterranean native species, Salvia ceratophylloides (Sc) and S. officinalis (So). The study species showed significant differences in relative water content (RWC) thresholds inducing loss of rehydration capacity, as well as leaf hydraulic conductance (K
    MeSH term(s) Droughts ; Plant Leaves ; Salvia ; Species Specificity ; Water
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2021-06-02
    Publishing country France
    Document type Journal Article
    ZDB-ID 742978-2
    ISSN 1873-2690 ; 0981-9428
    ISSN (online) 1873-2690
    ISSN 0981-9428
    DOI 10.1016/j.plaphy.2021.05.046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Prevalence and Factors Associated with Meconium-Stained Amniotic Fluid in a Tertiary Hospital, Northwest Ethiopia: A Cross-Sectional Study.

    Abate, Enyew / Alamirew, Kassahun / Admassu, Eleni / Derbie, Awoke

    Obstetrics and gynecology international

    2021  Volume 2021, Page(s) 5520117

    Abstract: Background: Methods: A cross-sectional study was conducted from 1 June to 31 August 2018 among 606 labouring mothers at Felege Hiwot Referral Hospital, northwest Ethiopia. Study participants were selected using a systematic random sampling technique. ... ...

    Abstract Background
    Methods: A cross-sectional study was conducted from 1 June to 31 August 2018 among 606 labouring mothers at Felege Hiwot Referral Hospital, northwest Ethiopia. Study participants were selected using a systematic random sampling technique. Data were collected using an interviewer-administered pretested questionnaire and data checklist. Factors associated with MSAF were explored using multivariable logistic regression analysis.
    Results: MSAF occurred in 24.6% (149/606) of pregnancies. Nonreassuring fetal heart rate patterns (Adjusted Odds Ratio [AOR]: 21.9, 95% Confidence interval [95% CI]: 10.96-43.83), postterm pregnancy (AOR: 4.54, 95% CI: 2.24-9.20), duration of labour more than 15 hours (AOR: 2.83, 95% CI: 1.76-4.53), pregnancy-induced hypertension (AOR: 2.43, 95% CI: 1.45-4.05), oligohydramnios (AOR: 2.53, 95% CI: 1.25-5.12), interpregnancy interval less than 2 years (AOR: 2.24, 95% CI: 1.12-4.51), and monthly family income less than 5000 Ethiopian Birr (185 USD) (AOR: 2.03, 95% CI: 1.18-3.51) were significantly associated with MSAF.
    Conclusions: In this study, the proportion of MSAF was at 24.6% which was higher than a previous report in Ethiopia. Nonreassuring fetal heart rate pattern, postterm pregnancy, duration of labour more than 15 hours, pregnancy-induced hypertension, oligohydramnios, interpregnancy interval less than 2 years, and monthly family income less than 5000 Ethiopian Birr were factors associated with an increased risk for MSAF. Therefore, interventions aimed at detecting MSAF early should consider these factors.
    Language English
    Publishing date 2021-05-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2495157-2
    ISSN 1687-9597 ; 1687-9589
    ISSN (online) 1687-9597
    ISSN 1687-9589
    DOI 10.1155/2021/5520117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: When Water Availability Is Low, Two Mediterranean

    Abate, Elisa / Azzarà, Maria / Trifilò, Patrizia

    Plants (Basel, Switzerland)

    2021  Volume 10, Issue 9

    Abstract: Increase in severity and frequency of drought events is altering plant community composition, exposing biomes to a higher risk of biodiversity losses. This is exacerbated in the most fragile areas as Mediterranean biome. Thus, identifying plant traits ... ...

    Abstract Increase in severity and frequency of drought events is altering plant community composition, exposing biomes to a higher risk of biodiversity losses. This is exacerbated in the most fragile areas as Mediterranean biome. Thus, identifying plant traits for forecasting species with a high risk of drought-driven mortality is particularly urgent. In the present study, we investigated the drought resistance strategy of two Mediterranean native species:
    Language English
    Publishing date 2021-09-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants10091888
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Helminth species-specific effects on IFN-γ producing T cells during active and latent tuberculosis.

    Kiflie, Amare / Bewket, Gezahegn / Tajebe, Fitsumbrhan / Abate, Ebba / Schӧn, Thomas / Blomgran, Robert

    PLoS neglected tropical diseases

    2023  Volume 17, Issue 1, Page(s) e0011094

    Abstract: Background: Interferon-γ (IFN-γ) is a key cytokine inducing protective immune responses during tuberculosis (TB) infection. Helminth-induced immune responses may affect IFN-γ production by T cells, although its connection with disease severity and ... ...

    Abstract Background: Interferon-γ (IFN-γ) is a key cytokine inducing protective immune responses during tuberculosis (TB) infection. Helminth-induced immune responses may affect IFN-γ production by T cells, although its connection with disease severity and immune recovery during treatment is unexplored. We investigated the species-specific effect of helminths on the IFN-γ production by T cells in relation to disease severity during active and latent TB infection (LTBI).
    Methods: In this study, 69 active pulmonary TB patients (PTB), 28 with LTBI and 66 healthy controls were included. Active TB was diagnosed using GenXpert MTB/RIF while QuantiFERON test (QFT) was used for the screening of healthy community controls (CCs) and for the diagnosis of LTBI. Helminth infection was identified by routine diagnosis whereas clinical disease severity was evaluated by the TB score. Intracellular IFN-γ production of T cells in stimulated peripheral blood mononuclear cells (PBMCs) was analyzed by flow cytometry using TB antigens (PPD), the polyclonal T cell activator staphylococcal enterotoxin B (SEB), or medium as unstimulated control.
    Results: Helminth infected CCs and LTBI subjects showed a significant reduction of IFN-γ+ CD4+ T cells by PPD-stimulation compared to non-helminth infected control groups. The significant reduction in the frequency of IFN-γ+ T cells in both latent and active PTB patients following SEB stimulation was mostly attributed to Schistosoma mansoni infection, whereas Ascaris lumbricoides, Schistosoma mansoni, and hookworm infection contributed equally in CCs. Following anti-helminthic and anti-TB treatment for 2 months, the frequency of IFN-γ+ CD4 T cells in helminth coinfected PTB was restored to levels of helminth negative PTB before treatment. Helminth coinfected PTB patients with an intermediate and severe clinical course had reduced capacity for production of IFN-γ+ T cells compared to the corresponding non-helminth infected PTB.
    Conclusion: We found a reduction in IFN-γ producing T cells by helminth coinfection which was restored following anti-helminthic treatment. This reduction was helminth species-dependent in an exploratory sub-analysis and correlated to increased disease severity.
    MeSH term(s) Humans ; Animals ; Latent Tuberculosis ; Interferon-gamma ; Mycobacterium tuberculosis ; Tuberculin ; Leukocytes, Mononuclear ; Tuberculosis/diagnosis ; CD4-Positive T-Lymphocytes ; Helminths ; Antigens, Bacterial
    Chemical Substances Interferon-gamma (82115-62-6) ; Tuberculin ; Antigens, Bacterial
    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2735
    ISSN (online) 1935-2735
    ISSN 1935-2735
    DOI 10.1371/journal.pntd.0011094
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Emerging roles of cytosolic phosphoenolpyruvate kinase 1 (PCK1) in cancer.

    Abate, Ebsitu / Mehdi, Mohammed / Addisu, Sisay / Degef, Maria / Tebeje, Solomon / Kelemu, Tsehayneh

    Biochemistry and biophysics reports

    2023  Volume 35, Page(s) 101528

    Abstract: Although it was traditionally believed that gluconeogenesis enzymes were absent from cancers that did not originate in gluconeogenic organs, numerous investigations have shown that they are functionally expressed in a variety of tumors as mediators of ... ...

    Abstract Although it was traditionally believed that gluconeogenesis enzymes were absent from cancers that did not originate in gluconeogenic organs, numerous investigations have shown that they are functionally expressed in a variety of tumors as mediators of shortened forms of Gluconeogenesis. One of the isomers of PEPCK, the first-rate limiting enzyme in gluconeogenesis, is PCK 1, which catalyzes the conversion of oxaloacetate (OAA) and GTP into PEP, CO2, and GDP. It is also known as PEPCK-C or PCK1, and it is cytosolic. Despite being paradoxical, it has been demonstrated that, in addition to its enzymatic role in normal metabolism, this enzyme also plays a role in tumors that arise in gluconeogenic and non-gluconeogenic organs. According to newly available research, it has metabolic and non-metabolic roles in tumor progression and development. Thus, this review will give insight into
    Language English
    Publishing date 2023-08-18
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2831046-9
    ISSN 2405-5808 ; 2405-5808
    ISSN (online) 2405-5808
    ISSN 2405-5808
    DOI 10.1016/j.bbrep.2023.101528
    Database MEDical Literature Analysis and Retrieval System OnLINE

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