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  1. Article: Otosyphilis with Clinical and Serologic Responses with Weekly Intramuscular Penicillin: A Case Report and Literature Review.

    Etemady-Deylamy, Ali / Abate, Getahun

    Case reports in infectious diseases

    2022  Volume 2022, Page(s) 3152383

    Abstract: With the increasing prevalence of syphilis in different parts of the world, it is important to be cognizant of serious forms of syphilis. Otosyphilis is a rare form of syphilis with an extremely high rate of complications. Early diagnosis is essential to ...

    Abstract With the increasing prevalence of syphilis in different parts of the world, it is important to be cognizant of serious forms of syphilis. Otosyphilis is a rare form of syphilis with an extremely high rate of complications. Early diagnosis is essential to prevent a complete loss of hearing and decrease mortality. We present a unique case of otosyphilis who presented with left hearing loss, tinnitus, and vertigo, with audiometric findings confirming the hearing loss. An MRI brain showed asymmetric enhancement of the left cochlea and vestibular apparatus. She initially received oral steroids and trans-tympanic steroid injections with transient improvement of symptoms. She was diagnosed with syphilis through contact tracing after her ex-boyfriend tested positive. She received three weekly doses of intramuscular penicillin. Interestingly, her symptoms, rapid plasma regain (RPR) titer, and audiometry findings markedly improved. Once a diagnosis of otosyphilis was established, she received 14 days of intravenous penicillin.
    Language English
    Publishing date 2022-02-25
    Publishing country Egypt
    Document type Case Reports
    ZDB-ID 2627642-2
    ISSN 2090-6633 ; 2090-6625
    ISSN (online) 2090-6633
    ISSN 2090-6625
    DOI 10.1155/2022/3152383
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Usefulness of Routine Laboratory Tests for Follow up of Patients Receiving Outpatient Parenteral Antimicrobial Therapy Run by Infectious Diseases Fellows.

    Frisby, Jared / Ali, Naureen / Niemotka, Samson / Abate, Getahun

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 2

    Abstract: Background: The infectious disease society of America (IDSA) recommends routine laboratory tests for all patients receiving outpatient parenteral antimicrobial therapy (OPAT) to monitor for adverse events. There are no data to support how often patients ...

    Abstract Background: The infectious disease society of America (IDSA) recommends routine laboratory tests for all patients receiving outpatient parenteral antimicrobial therapy (OPAT) to monitor for adverse events. There are no data to support how often patients should take monitoring laboratory tests. In addition, the relevance of different laboratory tests commonly used for OPAT follow up is not clearly known.
    Methods: We conducted a retrospective observational cohort study over a 7-year study interval (1 January 2014 to 31 December 2021). Clinical data were obtained to identify the risk factors associated with abnormal laboratory tests and determine if abnormal laboratory tests led to antibiotic change or hospital readmission.
    Results: Two hundred and forty-six patients met the inclusion criteria for this study. In our multivariate analysis, the Charlson comorbidity index (CCI) of 0-4 (aOR 0.39, 95%Cl 0.18-0.86), the use of ceftriaxone without vancomycin (aOR 0.47, 95%Cl 0.24-0.91) and an OPAT duration of 2-4 weeks (aOR 0.47, 95%Cl 0.24-0.91) were associated with a lower risk of OPAT complications. A CCI of 5 or more (aOR 2.5, 95%Cl (1.1-5.7)) and an OPAT duration of 5 or more weeks (aOR 2.7, 95% Cl 1.3-5.6) were associated with a higher risk of OPAT complications. An abnormal complete metabolic panel or vancomycin levels, but not an abnormal complete blood count, were associated with antibiotic change or readmission.
    Conclusion: Patients with fewer comorbidities, ceftriaxone and short OPAT durations are at lower risk for OPAT complications. These patients could be followed with less frequent laboratory monitoring.
    Language English
    Publishing date 2023-02-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12020330
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Ceftaroline: Systematic Review of Clinical Uses and Emerging Drug Resistance.

    Abate, Getahun / Wang, Grace / Frisby, Jared

    The Annals of pharmacotherapy

    2022  Volume 56, Issue 12, Page(s) 1339–1348

    Abstract: Objective: To assess the success rates of off-label uses of ceftaroline for infections caused by methicillin-resistant : Data sources: We queried PubMed/MEDLINE, with the search term "Ceftaroline." Articles were restricted to the English language and ...

    Abstract Objective: To assess the success rates of off-label uses of ceftaroline for infections caused by methicillin-resistant
    Data sources: We queried PubMed/MEDLINE, with the search term "Ceftaroline." Articles were restricted to the English language and year of publication (January 1, 2009-January 31, 2022).
    Study selection and data extraction: Clinical trials, observational studies, and case reports that reported efficacy, safety, pharmacokinetics, use in MRSA infections other than acute bacterial skin infection and community-acquired pneumonia, and ceftaroline resistance were selected.
    Data synthesis: The search pooled 103 publications and all abstracts were reviewed. Forty-six articles that reported efficacy, safety, pharmacokinetics, or off-label use in multiple patients and 7 articles on ceftaroline resistance are used in this review. Ceftaroline has been approved for treatment of acute skin/soft tissue infection and community-acquired pneumonia. Ceftaroline's efficacy in off-label infections ranged from 66.7% to 87.3% depending on the types of infection. There were 14 documented cases of ceftaroline resistance associated with PBP2a changes.
    Relevance to patient care and clinical practice: Case series and observational studies have documented success with ceftaroline alone or in combination with vancomycin or daptomycin for treatment of MRSA bone and joint, endovascular, diabetic foot infections, and bacteremia from other causes.
    Conclusion: Despite the lack of randomized controlled trials, ceftaroline is used as salvage therapy for different MRSA infections. The data from case series and observational studies are promising but ceftaroline should be used judiciously as ceftaroline-resistant MRSA begin to emerge.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Cephalosporins/pharmacology ; Cephalosporins/therapeutic use ; Community-Acquired Infections/drug therapy ; Daptomycin/therapeutic use ; Drug Resistance ; Humans ; Methicillin-Resistant Staphylococcus aureus ; Microbial Sensitivity Tests ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/microbiology ; Vancomycin/therapeutic use ; Ceftaroline
    Chemical Substances Anti-Bacterial Agents ; Cephalosporins ; Vancomycin (6Q205EH1VU) ; Daptomycin (NWQ5N31VKK)
    Language English
    Publishing date 2022-03-18
    Publishing country United States
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 1101370-9
    ISSN 1542-6270 ; 1060-0280
    ISSN (online) 1542-6270
    ISSN 1060-0280
    DOI 10.1177/10600280221082326
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 900: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Monkeypox, A New Public Health Threat.

    Hoque, Farzana / Poowanawittayakon, Nongnooch / Abate, Getahun / Nayak, Ravi

    Missouri medicine

    2022  Volume 119, Issue 5, Page(s) 424–425

    MeSH term(s) Humans ; Mpox (monkeypox)/epidemiology ; Public Health ; Disease Outbreaks
    Language English
    Publishing date 2022-10-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 427362-x
    ISSN 0026-6620
    ISSN 0026-6620
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 182: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Candida

    Ali, Naureen / Abate, Getahun

    Case reports in infectious diseases

    2020  Volume 2020, Page(s) 3935691

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2020-04-14
    Publishing country Egypt
    Document type Case Reports
    ZDB-ID 2627642-2
    ISSN 2090-6633 ; 2090-6625
    ISSN (online) 2090-6633
    ISSN 2090-6625
    DOI 10.1155/2020/3935691
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Diagnosis and Management of Pulmonary NTM with a Focus on

    Hendrix, Christian / McCrary, Myah / Hou, Rong / Abate, Getahun

    Microorganisms

    2022  Volume 11, Issue 1

    Abstract: Background: Nontuberculous mycobacteria (NTM) are ubiquitous. NTM can affect different organs and may cause disseminated diseases, but the pulmonary form is the most common form. Pulmonary NTM is commonly seen in patients with underlying diseases. ... ...

    Abstract Background: Nontuberculous mycobacteria (NTM) are ubiquitous. NTM can affect different organs and may cause disseminated diseases, but the pulmonary form is the most common form. Pulmonary NTM is commonly seen in patients with underlying diseases. Pulmonary
    Methods: A literature search was conducted using PubMed/MEDLINE and multiple search terms. The search was restricted to the English language and human studies. The database query resulted in a total of 197 publications. After the title and abstract review, 64 articles were included in this analysis.
    Results: The guidelines by the American Thoracic Society (ATS), European Respiratory Society (ERS), European Society of Clinical Microbiology and Infectious Diseases (ESCMID), and Infectious Diseases Society of America (IDSA) are widely applicable. The guidelines are based on expert opinion and there may be a need to broaden criteria to include those with underlying lung diseases who may not fulfill some of the criteria as 'probable cases' for better follow up and management. Some cases with only one culture-positive sputum sample or suggestive histology without a positive culture may benefit from new methods of confirming NTM infection. Amikacin liposomal inhalation suspension (ALIS), gallium containing compounds and immunotherapies will have potential in the management of pulmonary MAC and MAB.
    Conclusions: the prevalence of pulmonary NTM is increasing. The efforts to optimize diagnosis and treatment of pulmonary NTM are encouraging. There is still a need to develop new diagnostics and therapeutics.
    Language English
    Publishing date 2022-12-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11010047
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  7. Article: Immunotherapy for tuberculosis: future prospects.

    Abate, Getahun / Hoft, Daniel F

    ImmunoTargets and therapy

    2016  Volume 5, Page(s) 37–45

    Abstract: Tuberculosis (TB) is still a major global health problem. A third of the world's population is infected with Mycobacterium tuberculosis. Only ~10% of infected individuals develop TB but there are 9 million TB cases with 1.5 million deaths annually. The ... ...

    Abstract Tuberculosis (TB) is still a major global health problem. A third of the world's population is infected with Mycobacterium tuberculosis. Only ~10% of infected individuals develop TB but there are 9 million TB cases with 1.5 million deaths annually. The standard prophylactic treatment regimens for latent TB infection take 3-9 months, and new cases of TB require at least 6 months of treatment with multiple drugs. The management of latent TB infection and TB has become more challenging because of the spread of multidrug-resistant and extremely drug-resistant TB. Intensified efforts to find new TB drugs and immunotherapies are needed. Immunotherapies could modulate the immune system in patients with latent TB infection or active disease, enabling better control of M. tuberculosis replication. This review describes several types of potential immunotherapies with a focus on those which have been tested in humans.
    Language English
    Publishing date 2016-04-20
    Publishing country New Zealand
    Document type Journal Article ; Review
    ISSN 2253-1556
    ISSN 2253-1556
    DOI 10.2147/ITT.S81892
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Femoral artery aneurysm with large hematoma from Pasteurella: case report and literature review.

    Hanson, Jamie / Etemady-Deylamy, Ali / Frisby, Jared / D'Addario, Justin / Smeds, Matthew / Chamberland, Robin / Guo, Huazhang / Abate, Getahun

    BMC infectious diseases

    2022  Volume 22, Issue 1, Page(s) 170

    Abstract: Background: Pasteurella multocida is a well-known gram-negative facultative anaerobe well known for its ability to cause soft tissue infections following animal bite or scratch. Here we present a case with mycotic aneurysm of the superficial femoral ... ...

    Abstract Background: Pasteurella multocida is a well-known gram-negative facultative anaerobe well known for its ability to cause soft tissue infections following animal bite or scratch. Here we present a case with mycotic aneurysm of the superficial femoral artery due to P. multocida infection.
    Case presentation: A 62 year old male patient presented with worsening right leg pain and swelling. On examination, he was found to have profound swelling and erythema of the right medial thigh and tenderness to palpation. Computerized tomography showed findings suggestive of right femoral pseudoaneurysm with a large right medial thigh hematoma. Blood cultures grew P. multocida. Patient underwent emergent open resection of the mycotic aneurysm and vascular bypass surgery. Intraoperatively, the site was noted to be grossly infected with multiple pockets of pus which were drained and pus cultures grew P. multocida. The diagnosis of P. multocida bacteremia with right femoral mycotic aneurysm and thigh abscess was made. Patient received 6 weeks of intravenous ceftriaxone and recovered.
    Conclusion: Our case is the first report on infection of peripheral vessel with Pasteurella and highlights the importance of prompt surgical intervention and effective antibiotic treatment.
    MeSH term(s) Aneurysm, False/diagnostic imaging ; Aneurysm, False/surgery ; Aneurysm, Infected/diagnostic imaging ; Aneurysm, Infected/surgery ; Animals ; Femoral Artery/diagnostic imaging ; Femoral Artery/surgery ; Hematoma/diagnostic imaging ; Hematoma/surgery ; Humans ; Male ; Middle Aged ; Pasteurella ; Pasteurella Infections/diagnosis ; Pasteurella Infections/etiology
    Language English
    Publishing date 2022-02-21
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 2041550-3
    ISSN 1471-2334 ; 1471-2334
    ISSN (online) 1471-2334
    ISSN 1471-2334
    DOI 10.1186/s12879-022-07136-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: BCG Vaccination Induces

    Abate, Getahun / Hamzabegovic, Fahreta / Eickhoff, Christopher S / Hoft, Daniel F

    Frontiers in immunology

    2019  Volume 10, Page(s) 234

    Abstract: Pulmonary non-tuberculous mycobacterial (NTM) infections particularly caused ... ...

    Abstract Pulmonary non-tuberculous mycobacterial (NTM) infections particularly caused by
    MeSH term(s) Adolescent ; Adult ; Animals ; BCG Vaccine/immunology ; Cells, Cultured ; Cross Reactions/immunology ; Female ; Humans ; Interferon-gamma/immunology ; Leukocytes, Mononuclear/immunology ; Leukocytes, Mononuclear/microbiology ; Male ; Mice ; Mice, Inbred C57BL ; Middle Aged ; Mycobacterium abscessus/immunology ; Mycobacterium avium/immunology ; T-Lymphocytes/immunology ; Tuberculosis/immunology ; Tuberculosis/microbiology ; Vaccination/methods ; Young Adult
    Chemical Substances BCG Vaccine ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2019-02-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.00234
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Flagellin adjuvanted F1/V subunit plague vaccine induces T cell and functional antibody responses with unique gene signatures.

    Hamzabegovic, Fahreta / Goll, Johannes B / Hooper, William F / Frey, Sharon / Gelber, Casey E / Abate, Getahun

    NPJ vaccines

    2020  Volume 5, Issue 1, Page(s) 6

    Abstract: ... Yersinia ... ...

    Abstract Yersinia pestis
    Keywords covid19
    Language English
    Publishing date 2020-01-23
    Publishing country England
    Document type Journal Article
    ISSN 2059-0105
    ISSN (online) 2059-0105
    DOI 10.1038/s41541-020-0156-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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