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Article: A Rare Congenital Perineal Groove.

Abate, Enyew

Case reports in obstetrics and gynecology

2022 Volume 2022, Page(s) 8797205

Abstract: Background: Perineal groove is a rare congenital anomaly characterized by nonepithelialized mucous membrane that appears as an erythematous sulcus in the perineal midline, extending from the posterior vaginal fourchette to the anterior anal orifice. It ... ...

Abstract	Background: Perineal groove is a rare congenital anomaly characterized by nonepithelialized mucous membrane that appears as an erythematous sulcus in the perineal midline, extending from the posterior vaginal fourchette to the anterior anal orifice. It is one of the uncommon anomalies of anogenital region that is unknown to many clinicians, and it is usually misdiagnosed as an anal fissure, perineal trauma, diaper dermatitis, infection, or sexual abuse. Conclusions: Recognition of the congenital perineal groove at birth is important for the health care providers to deliver an appropriate parental counseling and appropriate follow-up.
Language	English
Publishing date	2022-10-27
Publishing country	United States
Document type	Case Reports
ZDB-ID	2627654-9
ISSN	2090-6692 ; 2090-6684
ISSN (online)	2090-6692
ISSN	2090-6684
DOI	10.1155/2022/8797205
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Article ; Online: Electronic maternal and child health application usability, feasibility and acceptability among healthcare providers in Amhara region, Ethiopia.

Alemneh, Esubalew / Kebebaw, Tegegn / Nigatu, Dabere / Azage, Muluken / Misgan, Eyaya / Abate, Enyew

PLOS digital health

2024 Volume 3, Issue 5, Page(s) e0000494

Abstract: An innovative electronic Maternal and Child Health (eMCH) application was developed to support operational and clinical decision-making in maternal and child health services. End-user-based evaluation of eHealth application is a critical step to ... ...

Abstract	An innovative electronic Maternal and Child Health (eMCH) application was developed to support operational and clinical decision-making in maternal and child health services. End-user-based evaluation of eHealth application is a critical step to ascertain how successfully users can learn and use it, and improve the technology. Therefore, this study aimed to evaluate the eMCH tool usability, feasibility, and acceptability among healthcare providers (HCPs) in the Amhara region, Ethiopia. A cross-sectional study was conducted among HCPs working in six public healthcare facilities. The usability evaluation was done on 24 HCPs across three professional categories using the ISO 9241-11 usability guideline. One hundred nine HCPs were participated in the feasibility and acceptability study. Data were collected using a standard usability tool, think-aloud protocol, a self-administered approach, and Open Broadcaster Software Studio version 26.1.1 video recorder. Descriptive statistics were used to describe the data. A Kruskal-Wallis test was used to measure the association between mean scores and categories of HCPs. The recorded videos were used for the log file analysis method. None of the HCP categories were able to complete all the tasks without errors. The average number of errors and restarts were 7.5 and 2.8, respectively. The average number of restarts was directly proportional to the average number of errors. The participants successfully completed more than 70% of the tasks without requiring any assistance or guidance. Forty-seven comments or errors were identified from the think-aloud analysis and 22 comments from the usability metrics analysis. Overall, statistically significant performance differences were observed among the three HCP groups across the majority of the usability evaluation metrics. Fifty-seven percent of HCPs scored higher than the mean on the feasibility study. Slightly higher than half, 56 (51.4%), of the HCPs scored higher than the mean score on the acceptability study. The usability evaluation identified vital comments and usability flaws that were essential for the eMCH tool to be upgraded. The tool was feasible and acceptable as reported by end-users. Therefore, the errors and usability flaws of the tool should be fixed before deployment to other healthcare settings.
Language	English
Publishing date	2024-05-13
Publishing country	United States
Document type	Journal Article
ISSN	2767-3170
ISSN (online)	2767-3170
DOI	10.1371/journal.pdig.0000494
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Article ; Online: Haematological Parameters in People with Atherosclerotic Cardiovascular Disease versus Those Who are Only at Risk for Cardiovascular Disease

Abate E / Degef M / Melkie A / Gnanasekeran N / Mehdi M / Tolcha Y / Chala D

Diabetes, Metabolic Syndrome and Obesity, Vol Volume 16, Pp 1869-

A Comparative Cross-Sectional Study

2023 Volume 1883

Abstract: Ebsitu Abate,1 Maria Degef,1 Addisu Melkie,2 Natesan Gnanasekeran,1 Mohammed Mehdi,1 Yosef Tolcha,3 Dawit Chala3 1Department of Medical Biochemistry Addis Ababa University, Addis Ababa, Ethiopia; 2Department of Internal Medicine, Addis Ababa University, ... ...

Abstract	Ebsitu Abate,1 Maria Degef,1 Addisu Melkie,2 Natesan Gnanasekeran,1 Mohammed Mehdi,1 Yosef Tolcha,3 Dawit Chala3 1Department of Medical Biochemistry Addis Ababa University, Addis Ababa, Ethiopia; 2Department of Internal Medicine, Addis Ababa University, Addis Ababa, Ethiopia; 3Department of Diagnostic Laboratory, Ethiopian Public Health Institute, Addis Ababa, EthiopiaCorrespondence: Ebsitu Abate, Tel +251 912632054, Email ebsitu.abate@aau.edu.etIntroduction: Cardiovascular disease (CVD) is the foremost killer disease worldwide. ASCVD is one of the most common types of CVD. It is mainly associated with a condition called atherosclerosis. Its occurrence is linked to several risk factors. Hypertension, diabetes, dyslipidemia, smoking, genetic factors, and so on are examples. The presence of ASCVD, as well as its risk factors, causes a variety of disruptions in the body’s physiological and biological functions. The presence of abnormal physiological and biological functions, for example, tends to disrupt hematological parameters.Purpose: The study’s aim was to assess and compare the pattern of hematological parameters in people with established atherosclerotic cardiovascular disease (ASVD) versus people with ASCVD risks alone who attended TASH Addis Ababa, Ethiopia, as well as to correlate hematological parameters with the novel inflammatory marker hs-CRP.Methods: A prospective cross-sectional comparative study with 100 study participants was conducted during where October 2019-March 2020 proposal development, sample collection, and lab analysis period, and from March 2020-June to 2021 data entry, analysis, and writing period. A serum sample was collected from each study participant for the lipid and hsCRP analyses and whole blood for hematological parameter determination. The socio-demographic characteristics of the study participants were obtained through a well-structured questionnaire.Results: The ASCVD-risk group had significantly higher mean platelet volume (MPV), which was associated with the presence of the ...
Keywords	ascvd ; hematological parameters ; hs-crp ; hypertension ; diabetes ; Specialties of internal medicine ; RC581-951
Subject code	610
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Dove Medical Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A structured 2-week follow-up visit in the cascade of care for TB increases case detection.

Rudolf, F / Abate, E / Moges, B / Gomes, V F / Mendes, A M / Sifna, A / Fekadu, H / Bizuneh, S / Wejse, C / Schön, T

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

2024 Volume 28, Issue 3, Page(s) 148–153

Abstract: ... OBJECTIVES ... Delayed detection in TB due to structural and diagnostic shortcomings is pivotal for disease transmission, morbidity and mortality. We investigated whether an inclusive screening, followed by a structured clinical ... ...

Abstract	<sec id="st1"><title>OBJECTIVES</title>Delayed detection in TB due to structural and diagnostic shortcomings is pivotal for disease transmission, morbidity and mortality. We investigated whether an inclusive screening, followed by a structured clinical follow-up (FU) could improve case-finding.</sec><sec id="st2"><title>METHODS</title>Patients were recruited from health centres in Bissau, Guinea-Bissau, and Gondar, Ethiopia. A routine FU was done at Week 2. If persisting symptoms were found, patients were investigated using chest X-ray (CXR) and Xpert
MeSH term(s)	Adult ; Humans ; Tuberculosis/diagnosis ; Tuberculosis/prevention & control ; Follow-Up Studies ; Delivery of Health Care ; Cough ; Ethiopia ; Mycobacterium tuberculosis
Language	English
Publishing date	2024-03-07
Publishing country	France
Document type	Journal Article
ZDB-ID	1385624-8
ISSN	1815-7920 ; 1027-3719
ISSN (online)	1815-7920
ISSN	1027-3719
DOI	10.5588/ijtld.23.0435
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Article ; Online: Neglected Tropical Diseases: responding to calls for action from the front lines in Ethiopia.

Abate, Ebba / Reeder, John C

Journal of infection in developing countries

2020 Volume 14, Issue 6.1, Page(s) 1S–2S

MeSH term(s)	Ethiopia/epidemiology ; Humans ; Neglected Diseases/epidemiology ; Tropical Medicine
Language	English
Publishing date	2020-06-29
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2394024-4
ISSN	1972-2680 ; 2036-6590
ISSN (online)	1972-2680
ISSN	2036-6590
DOI	10.3855/jidc.12790
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Article: When Water Availability Is Low, Two Mediterranean Salvia Species Rely on Root Hydraulics

Abate, Elisa / Azzarà, Maria / Trifilò, Patrizia

Plants. 2021 Sept. 13, v. 10, no. 9

2021

Abstract: Increase in severity and frequency of drought events is altering plant community composition, exposing biomes to a higher risk of biodiversity losses. This is exacerbated in the most fragile areas as Mediterranean biome. Thus, identifying plant traits ... ...

Abstract	Increase in severity and frequency of drought events is altering plant community composition, exposing biomes to a higher risk of biodiversity losses. This is exacerbated in the most fragile areas as Mediterranean biome. Thus, identifying plant traits for forecasting species with a high risk of drought-driven mortality is particularly urgent. In the present study, we investigated the drought resistance strategy of two Mediterranean native species: Salvia ceratophylloides Ard. (Sc) and Salvia officinalis L. (So) by considering the impact of drought-driven water content decline on plant hydraulics. Well-watered samples of Sc displayed higher leaf and stemsaturated water content and lower shoot biomass than So samples, but similar root biomass. In response to drought, Sc showed a conservative water use strategy, as the prompt stomatal closure and leaves shedding suggested. A drought-tolerant mechanism was confirmed in So samples. Nevertheless, Sc and So showed similar drought-driven plant hydraulic conductance (Kₚₗₐₙₜ) recover ability. Root hydraulic traits played a key role to reach this goal. Relative water content as well as loss of cell rehydration capability and membrane damages, especially of stem and root, were good proxies of drought-driven Kₚₗₐₙₜ decline.
Keywords	Salvia officinalis ; biomass ; botanical composition ; decline ; drought ; drought tolerance ; ecosystems ; fluid mechanics ; hydraulic conductivity ; indigenous species ; leaves ; mortality ; rehydration ; risk ; stomatal movement ; water content
Language	English
Dates of publication	2021-0913
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants10091888
Database	NAL-Catalogue (AGRICOLA)

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Article: Too dry to survive: Leaf hydraulic failure in two Salvia species can be predicted on the basis of water content

Abate, Elisa / Nardini, Andrea / Petruzzellis, Francesco / Trifilò, Patrizia

Plant physiology and biochemistry. 2021 Sept., v. 166

2021

Abstract: Global warming is exposing plants to increased risks of drought-driven mortality. Recent advances suggest that hydraulic failure is a key process leading to plant death, and the identification of simple and reliable proxies of species-specific risk of ... ...

Abstract	Global warming is exposing plants to increased risks of drought-driven mortality. Recent advances suggest that hydraulic failure is a key process leading to plant death, and the identification of simple and reliable proxies of species-specific risk of irreversible hydraulic damage is urgently required.We assessed the predictive power of leaf water content and shrinkage for monitoring leaf hydraulic failure in two Mediterranean native species, Salvia ceratophylloides (Sc) and S. officinalis (So).The study species showed significant differences in relative water content (RWC) thresholds inducing loss of rehydration capacity, as well as leaf hydraulic conductance (KL) impairment. Sc turned out to be more resistant to drought than So. However, Sc and So showed different leaf saturated water content values, so that different RWC values actually corresponded to similar absolute leaf water content. Our findings suggest that absolute leaf water content and leaf water potential, but not RWC, are reliable parameters for predicting the risk of leaf hydraulic impairment of two Salvia species, and their potential risk of irreversible damage under severe drought. Moreover, the lack of any KL decline until the turgor loss point in Sc, coupled to consistent leaf shrinkage, rejects the hypothesis to use leaf shrinkage as a proxy to predict KL vulnerability, at least in species with high leaf capacitance. Robust linear correlations between KL decline and electrolyte leakage measurements suggested a role of membrane damage in driving leaf hydraulic collapse.
Keywords	biochemistry ; capacitance ; death ; decline ; drought ; electrolyte leakage ; hydraulic conductivity ; indigenous species ; leaf water potential ; leaves ; mortality ; rehydration ; risk ; shrinkage ; turgor ; water content
Language	English
Dates of publication	2021-09
Size	p. 215-224.
Publishing place	Elsevier Masson SAS
Document type	Article
ZDB-ID	742978-2
ISSN	1873-2690 ; 0981-9428
ISSN (online)	1873-2690
ISSN	0981-9428
DOI	10.1016/j.plaphy.2021.05.046
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Helminth species-specific effects on IFN-γ producing T cells during active and latent tuberculosis.

Kiflie, Amare / Bewket, Gezahegn / Tajebe, Fitsumbrhan / Abate, Ebba / Schӧn, Thomas / Blomgran, Robert

PLoS neglected tropical diseases

2023 Volume 17, Issue 1, Page(s) e0011094

Abstract: Background: Interferon-γ (IFN-γ) is a key cytokine inducing protective immune responses during tuberculosis (TB) infection. Helminth-induced immune responses may affect IFN-γ production by T cells, although its connection with disease severity and ... ...

Abstract	Background: Interferon-γ (IFN-γ) is a key cytokine inducing protective immune responses during tuberculosis (TB) infection. Helminth-induced immune responses may affect IFN-γ production by T cells, although its connection with disease severity and immune recovery during treatment is unexplored. We investigated the species-specific effect of helminths on the IFN-γ production by T cells in relation to disease severity during active and latent TB infection (LTBI). Methods: In this study, 69 active pulmonary TB patients (PTB), 28 with LTBI and 66 healthy controls were included. Active TB was diagnosed using GenXpert MTB/RIF while QuantiFERON test (QFT) was used for the screening of healthy community controls (CCs) and for the diagnosis of LTBI. Helminth infection was identified by routine diagnosis whereas clinical disease severity was evaluated by the TB score. Intracellular IFN-γ production of T cells in stimulated peripheral blood mononuclear cells (PBMCs) was analyzed by flow cytometry using TB antigens (PPD), the polyclonal T cell activator staphylococcal enterotoxin B (SEB), or medium as unstimulated control. Results: Helminth infected CCs and LTBI subjects showed a significant reduction of IFN-γ+ CD4+ T cells by PPD-stimulation compared to non-helminth infected control groups. The significant reduction in the frequency of IFN-γ+ T cells in both latent and active PTB patients following SEB stimulation was mostly attributed to Schistosoma mansoni infection, whereas Ascaris lumbricoides, Schistosoma mansoni, and hookworm infection contributed equally in CCs. Following anti-helminthic and anti-TB treatment for 2 months, the frequency of IFN-γ+ CD4 T cells in helminth coinfected PTB was restored to levels of helminth negative PTB before treatment. Helminth coinfected PTB patients with an intermediate and severe clinical course had reduced capacity for production of IFN-γ+ T cells compared to the corresponding non-helminth infected PTB. Conclusion: We found a reduction in IFN-γ producing T cells by helminth coinfection which was restored following anti-helminthic treatment. This reduction was helminth species-dependent in an exploratory sub-analysis and correlated to increased disease severity.
MeSH term(s)	Humans ; Animals ; Latent Tuberculosis ; Interferon-gamma ; Mycobacterium tuberculosis ; Tuberculin ; Leukocytes, Mononuclear ; Tuberculosis/diagnosis ; CD4-Positive T-Lymphocytes ; Helminths ; Antigens, Bacterial
Chemical Substances	Interferon-gamma (82115-62-6) ; Tuberculin ; Antigens, Bacterial
Language	English
Publishing date	2023-01-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2429704-5
ISSN	1935-2735 ; 1935-2735
ISSN (online)	1935-2735
ISSN	1935-2735
DOI	10.1371/journal.pntd.0011094
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Article ; Online: Emerging roles of cytosolic phosphoenolpyruvate kinase 1 (PCK1) in cancer.

Abate, Ebsitu / Mehdi, Mohammed / Addisu, Sisay / Degef, Maria / Tebeje, Solomon / Kelemu, Tsehayneh

Biochemistry and biophysics reports

2023 Volume 35, Page(s) 101528

Abstract: Although it was traditionally believed that gluconeogenesis enzymes were absent from cancers that did not originate in gluconeogenic organs, numerous investigations have shown that they are functionally expressed in a variety of tumors as mediators of ... ...

Abstract	Although it was traditionally believed that gluconeogenesis enzymes were absent from cancers that did not originate in gluconeogenic organs, numerous investigations have shown that they are functionally expressed in a variety of tumors as mediators of shortened forms of Gluconeogenesis. One of the isomers of PEPCK, the first-rate limiting enzyme in gluconeogenesis, is PCK 1, which catalyzes the conversion of oxaloacetate (OAA) and GTP into PEP, CO2, and GDP. It is also known as PEPCK-C or PCK1, and it is cytosolic. Despite being paradoxical, it has been demonstrated that, in addition to its enzymatic role in normal metabolism, this enzyme also plays a role in tumors that arise in gluconeogenic and non-gluconeogenic organs. According to newly available research, it has metabolic and non-metabolic roles in tumor progression and development. Thus, this review will give insight into
Language	English
Publishing date	2023-08-18
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2831046-9
ISSN	2405-5808 ; 2405-5808
ISSN (online)	2405-5808
ISSN	2405-5808
DOI	10.1016/j.bbrep.2023.101528
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Article: Haematological Parameters in People with Atherosclerotic Cardiovascular Disease versus Those Who are Only at Risk for Cardiovascular Disease: A Comparative Cross-Sectional Study.

Abate, Ebsitu / Degef, Maria / Melkie, Addisu / Gnanasekeran, Natesan / Mehdi, Mohammed / Tolcha, Yosef / Chala, Dawit

Diabetes, metabolic syndrome and obesity : targets and therapy

2023 Volume 16, Page(s) 1869–1883

Abstract: Introduction: Cardiovascular disease (CVD) is the foremost killer disease worldwide. ASCVD is one of the most common types of CVD. It is mainly associated with a condition called atherosclerosis. Its occurrence is linked to several risk factors. ... ...

Abstract	Introduction: Cardiovascular disease (CVD) is the foremost killer disease worldwide. ASCVD is one of the most common types of CVD. It is mainly associated with a condition called atherosclerosis. Its occurrence is linked to several risk factors. Hypertension, diabetes, dyslipidemia, smoking, genetic factors, and so on are examples. The presence of ASCVD, as well as its risk factors, causes a variety of disruptions in the body's physiological and biological functions. The presence of abnormal physiological and biological functions, for example, tends to disrupt hematological parameters. Purpose: The study's aim was to assess and compare the pattern of hematological parameters in people with established atherosclerotic cardiovascular disease (ASVD) versus people with ASCVD risks alone who attended TASH Addis Ababa, Ethiopia, as well as to correlate hematological parameters with the novel inflammatory marker hs-CRP. Methods: A prospective cross-sectional comparative study with 100 study participants was conducted during where October 2019-March 2020 proposal development, sample collection, and lab analysis period, and from March 2020-June to 2021 data entry, analysis, and writing period. A serum sample was collected from each study participant for the lipid and hsCRP analyses and whole blood for hematological parameter determination. The socio-demographic characteristics of the study participants were obtained through a well-structured questionnaire. Results: The ASCVD-risk group had significantly higher mean platelet volume (MPV), which was associated with the presence of the risk. Furthermore, hs-CRPs show a significant correlation with MPV in a correlation analysis of highly sensitive C-reactive protein (hs-CRP) with hematological parameters. Thus, using these affordable, routinely tested, and easily available tests may help to infer future ASCVD risk as well as the presence of ASCVD morbidity while hsCRP level in comparison group vs cases requires further study.
Language	English
Publishing date	2023-06-23
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494854-8
ISSN	1178-7007
ISSN	1178-7007
DOI	10.2147/DMSO.S407480
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