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  1. AU="Abazi, Sokol"
  2. AU="Cook, Rebecca"
  3. AU=Martin Flavius
  4. AU="Cipriani, Raffaela"
  5. AU="Levin, Michael E."
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  1. Article: Vasorelaxant Effects of the

    Thaçi, Shpëtim / Krasniqi, Berat / Dërmaku-Sopjani, Miribane / Rifati-Nixha, Arleta / Abazi, Sokol / Sopjani, Mentor

    Evidence-based complementary and alternative medicine : eCAM

    2022  Volume 2022, Page(s) 7708781

    Abstract: This study was undertaken to describe and characterize the relaxing effects of the medicinal ... ...

    Abstract This study was undertaken to describe and characterize the relaxing effects of the medicinal plant
    Language English
    Publishing date 2022-03-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2022/7708781
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Insight into the Mechanisms Underlying the Tracheorelaxant Properties of the

    Krasniqi, Berat / Thaçi, Shpëtim / Dërmaku-Sopjani, Miribane / Rifati-Nixha, Arleta / Abazi, Sokol / Sopjani, Mentor

    Evidence-based complementary and alternative medicine : eCAM

    2020  Volume 2020, Page(s) 6510708

    Abstract: Sideritis ... ...

    Abstract Sideritis raeseri
    Language English
    Publishing date 2020-08-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2020/6510708
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Antioxidant Activity and Chemical Composition of Essential Oils of some Aromatic and Medicinal Plants from Albania.

    Hodaj-Çeliku, Entela / Tsiftsoglou, Olga / Shuka, Lulëzim / Abazi, Sokol / Hadjipavlou-Litina, Dimitra / Lazari, Diamanto

    Natural product communications

    2018  Volume 12, Issue 5, Page(s) 785–790

    Abstract: The chemical compositions have been investigated of the volatile oils of nine populations of six species from Albania, namely Artemisia absinthium, Calamintha nepeta, Hypericum perforatum, Sideritis raeseri subsp. raeseri, Origanum vulgare subsp. hirtum ... ...

    Abstract The chemical compositions have been investigated of the volatile oils of nine populations of six species from Albania, namely Artemisia absinthium, Calamintha nepeta, Hypericum perforatum, Sideritis raeseri subsp. raeseri, Origanum vulgare subsp. hirtum from two wild .populations, and Salvia officinalis (sage) from two wild and one cultivated population,. The essential oils were obtained by hydrodistillation and their analyses were performed by GC-MS. The major constituents were: A. absinthium: neryl isovalerate (19.5%), geranyl isobutanoate (16.4%) and carvacrol (8.8%); C. nepeta: pulegone (31.7%), spathulenol (20.0%) and isomenthone (12.7%); H. perforatum: caryophyllene oxide (31.0%), δ-selinene (10.5%) and carvacrol (10.4%); O. vulgare: carvacrol (81.0, 78.6%), y-terpinene (5.5, 7.1%) and p-cymene (4.9, 4.1%) for 0. vulgare originating from Tepelena. and.Vlora, respectively; S. raeseri: carvacrol (36.7%), caryophyllene oxide (17.8%), p-caryphyllene (8.7%), spathulenol (7.7%) and myrtenol (6.4%); S. officinalis: camphor (40.2, 47.8, 45.9%), c-thujone .(19.2, 22.2, 13.7%), eucalyptol (5.4, 2.6, 6.0%), camphene (5.8, 6.1, 3.9, %), borneol (2.1, 2.9, 5.7%) and bornyl acetate (3.3, 1.4, 5.6%) for samples originating from Tepelena, Tirana and Vlora, respectively. The essential oils were also tested for their free radical scavenging activity using the following in vitro assays: i) interaction with the free stable radical of DPPH (1,1-diphenyl-2-picrylhydrazyl), and ii) inhibition of linoleic acid-peroxidation with 2,2'-azobis- 2-methyl-propanimidamide, dihydrochloride (AAPH). Finally, their inhibitory activity toward soybean lipoxygenase was evaluated, using linoleic acid as substrate.The essential oil of 0. vulgare (OV-VL) presented the highest interaction with the stable radical DPPH (76.5%), followed by that of A. absinthium (54.7%). O. vulgare (OV-TP) and A. absinthium showed high anti-lipid peroxidation activity, 97.5% and 96.5%, respectively, higher than that of the reference compound trolox (73.0%). Only the tested sample of O. vulgare (OV-VL) significantly inhibited soybean lipoxygenase (54.2%).
    MeSH term(s) Albania ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Biphenyl Compounds ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Lipoxygenase/metabolism ; Oils, Volatile/chemistry ; Oils, Volatile/pharmacology ; Picrates ; Plant Oils/chemistry ; Plant Oils/pharmacology ; Plants, Medicinal/chemistry
    Chemical Substances Antioxidants ; Biphenyl Compounds ; Enzyme Inhibitors ; Oils, Volatile ; Picrates ; Plant Oils ; 1,1-diphenyl-2-picrylhydrazyl (DFD3H4VGDH) ; lipoxygenase L-1 (EC 1.13.11.-) ; Lipoxygenase (EC 1.13.11.12)
    Language English
    Publishing date 2018-11-29
    Publishing country United States
    Document type Journal Article
    ISSN 1934-578X
    ISSN 1934-578X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Lignans and indole alkaloids from the seeds of Centaurea vlachorum Hartvig (Asteraceae), growing wild in Albania and their biological activity.

    Hodaj, Entela / Tsiftsoglou, Olga / Abazi, Sokol / Hadjipavlou-Litina, Dimitra / Lazari, Diamanto

    Natural product research

    2017  Volume 31, Issue 10, Page(s) 1195–1200

    Abstract: The present phytochemical investigation of the seeds of Centaurea vlachorum led to the isolation and characterisation of four compounds including two indole alkaloids N-(p-coumaroyl) serotonin (1) and moschamine (2) and two dibenzylbutyrolactone lignans ... ...

    Abstract The present phytochemical investigation of the seeds of Centaurea vlachorum led to the isolation and characterisation of four compounds including two indole alkaloids N-(p-coumaroyl) serotonin (1) and moschamine (2) and two dibenzylbutyrolactone lignans matairesinol (3) and arctiin (4). This is the first report on the isolation of non-volatile secondary metabolites from C. vlachorum. The chemataxonomic significance of these compounds was summarised. Moreover, the isolated compounds were tested for their free radical scavenging activity using the following in vitro assays: (i) interaction with the free stable radical of DPPH (1,1-diphenyl-2-picrylhydrazyl), (ii) inhibition of linoleic acid peroxidation with the dihydrochloric acid of 2,2-Azobis-2-amidinopropane (AAPH). Finally, their inhibitory activity towards soybean lipoxygenase was evaluated, using linoleic acid as substrate.
    MeSH term(s) Antioxidants/pharmacology ; Centaurea/chemistry ; Centaurea/growth & development ; Indole Alkaloids/analysis ; Indole Alkaloids/pharmacology ; Lignans/analysis ; Lignans/pharmacology ; Lipoxygenase Inhibitors/pharmacology ; Seeds/chemistry
    Chemical Substances Antioxidants ; Indole Alkaloids ; Lignans ; Lipoxygenase Inhibitors
    Language English
    Publishing date 2017-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2016.1226823
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Diastereoselective radical mediated alkylation of a chiral glycolic acid derivative.

    Abazi, Sokol / Rapado, Liliana Parra / Renaud, Philippe

    Organic & biomolecular chemistry

    2011  Volume 9, Issue 16, Page(s) 5773–5777

    Abstract: Radical alkylation of 2-(tert-butyl)-2-methyldioxolan-4-one, a chiral equivalent of glycolic acid, occurs with good to high diastereoselectivity that compares favorably with the corresponding enolate alkylation. The importance of the position of the ... ...

    Abstract Radical alkylation of 2-(tert-butyl)-2-methyldioxolan-4-one, a chiral equivalent of glycolic acid, occurs with good to high diastereoselectivity that compares favorably with the corresponding enolate alkylation. The importance of the position of the transition state position, early or late, is highlighted.
    Language English
    Publishing date 2011-08-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/c1ob05230f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Significance of the anti-aging protein Klotho.

    Dërmaku-Sopjani, Miribane / Kolgeci, Selim / Abazi, Sokol / Sopjani, Mentor

    Molecular membrane biology

    2013  Volume 30, Issue 8, Page(s) 369–385

    Abstract: The Klotho gene was identified as an 'aging suppressor' in mice. Overexpression of the Klotho gene extends lifespan and defective Klotho results in rapid aging and early death. Both the membrane and secreted forms of Klotho have biological activity that ... ...

    Abstract The Klotho gene was identified as an 'aging suppressor' in mice. Overexpression of the Klotho gene extends lifespan and defective Klotho results in rapid aging and early death. Both the membrane and secreted forms of Klotho have biological activity that include regulatory effects on general metabolism and a more specific effect on mineral metabolism that correlates with its effect on aging. Klotho serves as a co-receptor for fibroblast growth factor (FGF), but it also functions as a humoral factor that regulates cell survival and proliferation, vitamin D metabolism, and calcium and phosphate homeostasis and may serve as a potential tumor suppressor. Moreover, Klotho protects against several pathogenic processes in a FGF23-independent manner. These processes include cancer metastasis, vascular calcification, and renal fibrosis. This review covers the recent advances in Klotho research and discusses novel Klotho-dependent mechanisms that are clinically relevant in aging and age-related diseases.
    MeSH term(s) Aging/physiology ; Animals ; Calcium/metabolism ; Cell Proliferation ; Cell Survival ; Fibroblast Growth Factors/genetics ; Fibroblast Growth Factors/metabolism ; Glucuronidase/chemistry ; Glucuronidase/genetics ; Glucuronidase/metabolism ; Glucuronidase/physiology ; Homeostasis ; Humans ; Kidney Diseases/physiopathology ; Membrane Proteins/chemistry ; Membrane Proteins/physiology ; Mice ; Neoplasm Metastasis ; Neoplasms/metabolism ; Neoplasms/physiopathology ; Phosphates/metabolism ; Signal Transduction ; Vascular Calcification/metabolism ; Vascular Calcification/physiopathology
    Chemical Substances Membrane Proteins ; Phosphates ; fibroblast growth factor 23 ; Fibroblast Growth Factors (62031-54-3) ; Glucuronidase (EC 3.2.1.31) ; klotho protein (EC 3.2.1.31) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2013-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1186324-9
    ISSN 1464-5203 ; 0968-7688
    ISSN (online) 1464-5203
    ISSN 0968-7688
    DOI 10.3109/09687688.2013.837518
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: AMPK-sensitive cellular transport.

    Dërmaku-Sopjani, Miribane / Abazi, Sokol / Faggio, Caterina / Kolgeci, Jehona / Sopjani, Mentor

    Journal of biochemistry

    2014  Volume 155, Issue 3, Page(s) 147–158

    Abstract: The energy sensing AMP-activated protein kinase (AMPK) regulates cellular and whole-body energy balance through stimulating catabolic ATP-generating and suppressing anabolic ATP-consuming pathways thereby helping cells survive during energy depletion. ... ...

    Abstract The energy sensing AMP-activated protein kinase (AMPK) regulates cellular and whole-body energy balance through stimulating catabolic ATP-generating and suppressing anabolic ATP-consuming pathways thereby helping cells survive during energy depletion. The kinase has previously been reported to be either directly or indirectly involved in the regulation of several carriers, channels and pumps of high significance in cellular physiology. Thus AMPK provides a necessary link between cellular energy metabolism and cellular transport activity. Better understanding of the AMPK role in cellular transport offers a potential for improved therapies in various human diseases and disorders. In this review, we discuss recent advances in understanding the role and function of AMPK in transport regulation under physiological and pathological states.
    MeSH term(s) AMP-Activated Protein Kinases/metabolism ; Animals ; Biological Transport ; Humans ; Ion Channels/metabolism ; Models, Biological
    Chemical Substances Ion Channels ; AMP-Activated Protein Kinases (EC 2.7.11.31)
    Language English
    Publishing date 2014-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 218073-x
    ISSN 1756-2651 ; 0021-924X
    ISSN (online) 1756-2651
    ISSN 0021-924X
    DOI 10.1093/jb/mvu002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Use of O,Se-Acetals for Radical-Mediated Phenylseleno Group Transfer Reactions

    Renaud, Philippe / Abazi, Sokol

    Synthesis

    1996  Volume 1996, Issue 02, Page(s) 253–258

    Keywords radicals ; selenium ; phenylseleno transfer
    Language English
    Publishing date 1996-01-01
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2033062-5
    ISSN 1437-210X ; 0039-7881
    ISSN (online) 1437-210X
    ISSN 0039-7881
    DOI 10.1055/s-1996-4182
    Database Thieme publisher's database

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