LIVIVO - Search results -

Search results

Result 1 - 10 of total 11

Search options

Article: Performance of 11 Host Biomarkers Alone or in Combination in the Diagnosis of Late-Onset Sepsis in Hospitalized Neonates: The Prospective EMERAUDE Study.

Pons, Sylvie / Trouillet-Assant, Sophie / Subtil, Fabien / Abbas-Chorfa, Fatima / Cornaton, Elise / Berthiot, Amélie / Galletti, Sonia / Plat, Aurélie / Rapin, Stephanie / Trapes, Laurene / Generenaz, Laurence / Brengel-Pesce, Karen / Callies, Arnaud / Plaisant, Franck / Claris, Olivier / Portefaix, Aurelie / Flamant, Cyril / Butin, Marine

Biomedicines

2023 Volume 11, Issue 6

Abstract: Despite the high prevalence of late-onset sepsis (LOS) in neonatal intensive care units, a reliable diagnosis remains difficult. This prospective, multicenter cohort study aimed to identify biomarkers early to rule out the diagnosis of LOS in 230 ... ...

Abstract	Despite the high prevalence of late-onset sepsis (LOS) in neonatal intensive care units, a reliable diagnosis remains difficult. This prospective, multicenter cohort study aimed to identify biomarkers early to rule out the diagnosis of LOS in 230 neonates ≥7 days of life with signs of suspected LOS. Blood levels of eleven protein biomarkers (PCT, IL-10, IL-6, NGAL, IP-10, PTX3, CD14, LBP, IL-27, gelsolin, and calprotectin) were measured. Patients received standard of care blinded to biomarker results, and an independent adjudication committee blinded to biomarker results assigned each patient to either infected, not infected, or unclassified groups. Performances of biomarkers were assessed considering a sensitivity of at least 0.898. The adjudication committee classified 22% of patients as infected and all of these received antibiotics. A total of 27% of the not infected group also received antibiotics. The best biomarkers alone were IL-6, IL-10, and NGAL with an area under the curve (95% confidence interval) of 0.864 (0.798-0.929), 0.845 (0.777-0.914), and 0.829 (0.760-0.898), respectively. The best combinations of up to four biomarkers were PCT/IL-10, PTX3/NGAL, and PTX3/NGAL/gelsolin. The best models of biomarkers could have identified not infected patients early on and avoided up to 64% of unjustified antibiotics. At the onset of clinical suspicion of LOS, additional biomarkers could help the clinician in identifying non-infected patients.
Language	English
Publishing date	2023-06-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11061703
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: The French Pregnancy Cohort: Medication use during pregnancy in the French population.

Bérard, Anick / Abbas-Chorfa, Fatima / Kassai, Behrouz / Vial, Thierry / Nguyen, Kim An / Sheehy, Odile / Schott, Anne-Marie

PloS one

2019 Volume 14, Issue 7, Page(s) e0219095

Abstract: Purpose: We described the medication use during pregnancy in the French population using the French Pregnancy Cohort (FPC).: Methods: The FPC was built with the sampling of all pregnant women included in the French Echantillon généraliste des ... ...

Abstract	Purpose: We described the medication use during pregnancy in the French population using the French Pregnancy Cohort (FPC). Methods: The FPC was built with the sampling of all pregnant women included in the French Echantillon généraliste des bénéficiaires (EGB), which is a 1/97th representative sample of the population covered by the French health insurance. The EGB includes anonymized information on the socio-demographic and medical characteristics of beneficiaries, and the health care services they have received such as diagnoses and procedure codes as well as data on filled reimbursed medication; EGB also includes data on hospital stays in all public and private French health facilities. Each filled prescription record contains information on drug brand and generic names, date of prescription and date of dispensing, quantity dispensed, mode of administration, duration of prescription, dosage, and prescribing physician specialty. FPC includes data on all pregnancies of women in the EGB (2010-2013). Date of entry in the FPC is the first day of pregnancy regardless of pregnancy outcome (spontaneous abortions or planned abortions (with or without medical reasons), deliveries), and data on women are collected retrospectively for a period of one year before pregnancy, and prospectively during pregnancy, and up to one year after delivery. The prevalence of prescribed medications before, during and after pregnancy was compared; comparison was also done between trimesters. Pregnancy outcomes are described and include spontaneous and planned abortions, livebirths, and stillbirths. Results: FPC includes data on 36,065 pregnancies. Among them, 27,253 (75.6%) resulted in a delivery including 201 stillbirths (0.7%). The total number of spontaneous abortions was 6,718 (18.6%), and planned abortions 2,094 (5.8%). The prevalence of filled medication use was 91.1%, 89.9%, and 95.6% before, during and after pregnancy, respectively. Although there was a statistically significant decrease in the proportion of use once the pregnancy was diagnosed (first trimester exposure, 76.4% vs. exposure in the year prior to pregnancy, 91.1% (p < .01)), post-pregnancy medication use was above the pre-pregnancy level (95.6%). Maternal depression was the most prevalent comorbidity during pregnancy (20%), and post-partum depression was higher in those who delivered a stillborn infant (38.8%) as well as in those with a spontaneous (19.5%) or planned abortion (22.4%) compared to those with a liveborn (12.0%). Conclusion: FPC is an excellent tool for the study of the risk and benefit of drug use during the perinatal period. FPC has the advantage of including a representative sample of French pregnant women, and study medications only available in France in addition to others available worldwide.
MeSH term(s)	Abortion, Induced/statistics & numerical data ; Abortion, Spontaneous/epidemiology ; Adult ; Cohort Studies ; Comorbidity ; Databases, Factual ; Drug Therapy/statistics & numerical data ; Drug-Related Side Effects and Adverse Reactions/epidemiology ; Female ; France/epidemiology ; Humans ; Insurance, Health ; Pregnancy ; Pregnancy Complications/drug therapy ; Pregnancy Outcome ; Prevalence ; Retrospective Studies ; Young Adult
Language	English
Publishing date	2019-07-17
Publishing country	United States
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0219095
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Performance Evaluation of Host Biomarker Combinations for the Diagnosis of Serious Bacterial Infection in Young Febrile Children: A Double-Blind, Multicentre, Observational Study.

Portefaix, Aurélie / Pons, Sylvie / Ouziel, Antoine / Basmaci, Romain / Rebaud, Philippe / Delafay, Marie-Caroline / Generenaz, Laurence / Oriol, Guy / Meunier, Boris / Abbas-Chorfa, Fatima / Trouillet-Assant, Sophie / Ginhoux, Tiphanie / Subtil, Fabien / Gillet, Yves / Brengel-Pesce, Karen / Javouhey, Etienne

Journal of clinical medicine

2022 Volume 11, Issue 21

Abstract: The diagnosis of serious bacterial infection (SBI) in young febrile children remains challenging. This prospective, multicentre, observational study aimed to identify new protein marker combinations that can differentiate a bacterial infection from a ... ...

Abstract	The diagnosis of serious bacterial infection (SBI) in young febrile children remains challenging. This prospective, multicentre, observational study aimed to identify new protein marker combinations that can differentiate a bacterial infection from a viral infection in 983 children, aged 7 days-36 months, presenting with a suspected SBI at three French paediatric emergency departments. The blood levels of seven protein markers (CRP, PCT, IL-6, NGAL, MxA, TRAIL, IP-10) were measured at enrolment. The patients received the standard of care, blinded to the biomarker results. An independent adjudication committee assigned a bacterial vs. viral infection diagnosis based on clinical data, blinded to the biomarker results. Computational modelling was applied to the blood levels of the biomarkers using independent training and validation cohorts. Model performances (area under the curve (AUC), positive and negative likelihood ratios (LR+ and LR-)) were calculated and compared to those of the routine biomarkers CRP and PCT. The targeted performance for added value over CRP or PCT was LR+ ≥ 5.67 and LR- ≤ 0.5. Out of 652 analysed patients, several marker combinations outperformed CRP and PCT, although none achieved the targeted performance criteria in the 7 days-36 months population. The models seemed to perform better in younger (7-91 day-old) patients, with the CRP/MxA/TRAIL combination performing best (AUC 0.895, LR+ 10.46, LR- 0.16). Although computational modelling using combinations of bacterial- and viral-induced host-protein markers is promising, further optimisation is necessary to improve SBI diagnosis in young febrile children.
Language	English
Publishing date	2022-11-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11216563
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Elderly patients hospitalized in the ICU in France: a population-based study using secondary data from the national hospital discharge database.

Fassier, Thomas / Duclos, Antoine / Abbas-Chorfa, Fatima / Couray-Targe, Sandrine / West, T Eoin / Argaud, Laurent / Colin, Cyrille

Journal of evaluation in clinical practice

2016 Volume 22, Issue 3, Page(s) 378–386

Abstract: Rationale, aims and objectives: In the global context of population ageing, understanding and monitoring intensive care use by the elderly is a strategic issue. National-level data are needed to overcome sampling biases that often limit epidemiologic ... ...

Abstract	Rationale, aims and objectives: In the global context of population ageing, understanding and monitoring intensive care use by the elderly is a strategic issue. National-level data are needed to overcome sampling biases that often limit epidemiologic studies of the critically ill elderly. The objective of this study was to describe intensive care use for hospitalized elderly patients using secondary data from the French national hospital discharge database. Method: Structured assessment of the national database coverage and accuracy; cross-sectional analysis of hospitalizations including at least one admission in an intensive care unit (ICU) for patients aged ≥ 80 years from 1 January to 31 December 2009. Results: In 2009, people aged ≥ 80 years accounted for 5.4% of the population but 15.3% of the 215 210 adult hospitalizations involving intensive care in France. In this elderly group, the mean age was 84.0 (± 3.56) years, and 51.6% were male. In-hospital mortality was 33.9%. The median time spent in the ICU was 3 [interquartile range (IQR), 2-8] days, the median time spent in hospital was 14 (IQR, 8-24) days and 9% of hospitalizations ended by the patient's death involved intensive care. A surgical procedure was included in 43% of hospitalizations. Medical and surgical diagnosis-related group hospitalizations were characterized by significant differences in volume, mortality, ICU days and costs. Conclusions: There was marked clinical heterogeneity in the population of elderly patients hospitalized in the ICU. These data provide baseline information and prompt further studies comparing intensive care utilization across age groups, between countries and over time.
MeSH term(s)	Aged, 80 and over ; Cross-Sectional Studies ; Databases, Factual ; Female ; France ; Hospitalization ; Humans ; Intensive Care Units/utilization ; Male ; Patient Discharge
Language	English
Publishing date	2016-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1327355-3
ISSN	1365-2753 ; 1356-1294
ISSN (online)	1365-2753
ISSN	1356-1294
DOI	10.1111/jep.12497
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 4464: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Impact of thyroid surgery volume and pathologic detection on risk of thyroid cancer: A geographical analysis in the Rhône-Alpes region of France.

Hafdi-Nejjari, Zakia / Abbas-Chorfa, Fatima / Decaussin-Petrucci, Myriam / Berger, Nicole / Couray-Targe, Sandrine / Schott, Anne-Marie / Sturm, Nathalie / Dumollard, Jean Marc / Roux, Jean Jacques / Beschet, Isabelle / Colonna, Marc / Delafosse, Patricia / Lifante, Jean Christophe / Borson-Chazot, Françoise / Sassolas, Geneviève

Clinical endocrinology

2018 Volume 89, Issue 6, Page(s) 824–833

Abstract: Objective: To investigate the impact of the volume of thyroid surgery and pathologic detection on the risk of thyroid cancer.: Methods: We investigated the influence of the volume of thyroid surgery in a first study that included 23 384 thyroid ... ...

Abstract	Objective: To investigate the impact of the volume of thyroid surgery and pathologic detection on the risk of thyroid cancer. Methods: We investigated the influence of the volume of thyroid surgery in a first study that included 23 384 thyroid surgeries and 5302 thyroid cancers collected between 2008 and 2013. Standardized incidence ratios (SIRs) and thyroid intervention rates (STIRs) were used as indicators of cancer risk and surgery volume, respectively. The influence of pathologic detection, using the number of cuts per gram of tissue as the indicator, was studied in a second study that included 1257 thyroid specimens, collected in 2014. Results: We found departmental variations in SIRs and a significant effect of the STIR on the SIR (men, P = 0.0008; women, P < 0.0001). A 1/100 000 increase in the STIR resulted in a 3% and 1.3% increase in the SIR in men and women, respectively. This effect was greatest for microcancers and absent for tumours >4 cm. The risk of cancer diagnosis was significantly associated with the number of cuts per gram of tissue (OR 6.1, P < 0.001), and was greater for total thyroidectomy than for lobectomy (P = 0.014) and when FNA cytology had been preoperatively performed (P < 0.001). The prevalence of incidental microcancers was highest in the centres performing the highest number of cuts per gram. Conclusions: The risk of thyroid cancer, particularly microcancer, is related to the volume of surgery and to the level of pathologist scrutiny. Both factors contribute to the increase in overdiagnosis. This further advocates for appropriate selection of patients for thyroid surgery.
MeSH term(s)	Adult ; Aged ; Female ; France/epidemiology ; Humans ; Incidence ; Male ; Middle Aged ; Retrospective Studies ; Thyroid Gland/pathology ; Thyroid Gland/surgery ; Thyroid Neoplasms/diagnosis ; Thyroid Neoplasms/epidemiology ; Thyroid Neoplasms/surgery ; Young Adult
Language	English
Publishing date	2018-09-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	121745-8
ISSN	1365-2265 ; 0300-0664
ISSN (online)	1365-2265
ISSN	0300-0664
DOI	10.1111/cen.13833
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 814: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Promotion of WHO feeding recommendations: a model evaluating the effects on HIV-free survival in African children.

David, Sandra / Abbas-Chorfa, Fatima / Vanhems, Philippe / Vallin, Béatrice / Iwaz, Jean / Ecochard, René

Journal of human lactation : official journal of International Lactation Consultant Association

2008 Volume 24, Issue 2, Page(s) 140–149

Abstract: In Africa, HIV and feeding practices deeply affect child mortality. To prevent mother-to-child transmission, the World Health Organization recommends exclusive breastfeeding for 6 months and replacement feeding when acceptable, feasible, affordable, and ... ...

Abstract	In Africa, HIV and feeding practices deeply affect child mortality. To prevent mother-to-child transmission, the World Health Organization recommends exclusive breastfeeding for 6 months and replacement feeding when acceptable, feasible, affordable, and sustainable. Determining the proportion and number of children saved with exclusive breastfeeding and replacement feeding is essential to design and implement crucial nationwide policies. Using data on 31 sub-Saharan countries and a decision tree for risk assessment, the authors estimated the number of children's lives potentially saved according to 6 scenarios that combine exclusive breastfeeding for 6 months or replacement feeding with 3 promotion strategies. Among all HIV-negative children born to HIV-positive mothers who die in sub-Saharan Africa per year, 52,315 (9.6%) would be saved yearly with exclusive breastfeeding versus 21,638 (4.0%) with replacement feeding. Promotion support would double these numbers (110,625 vs 45,330; ie, 20.3% vs 8.3%), and with additional prenatal group education, 132,633 versus 54,192 lives would be saved (24.3% vs 9.9%). Wherever replacement feeding is not possible, exclusive breastfeeding with promotion support and prenatal group education would save 1 of 4 exposed children.
MeSH term(s)	Africa South of the Sahara ; Breast Feeding ; Diarrhea, Infantile/mortality ; Female ; HIV Infections/prevention & control ; HIV Infections/transmission ; Health Promotion ; Humans ; Infant ; Infant Mortality ; Infant, Newborn ; Infectious Disease Transmission, Vertical/prevention & control ; Male ; Safety ; Time Factors ; World Health Organization
Language	English
Publishing date	2008-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1138470-0
ISSN	0890-3344
ISSN	0890-3344
DOI	10.1177/0890334408315330
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3580: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Influence of perinatal care regionalisation on the referral patterns of intermediate- and high-risk pregnancies.

Pasquier, Jean-Charles / Rabilloud, Muriel / Janody, Géraldine / Abbas-Chorfa, Fatima / Ecochard, René / Mellier, Georges

European journal of obstetrics, gynecology, and reproductive biology

2005 Volume 120, Issue 2, Page(s) 152–157

Abstract: Objective(s): To use the delivery site according to the birth weight as a marker of changes in the referral practices after regionalisation of perinatal care.: Study design: Analysis of the distribution of low birth weight infants according to the ... ...

Abstract	Objective(s): To use the delivery site according to the birth weight as a marker of changes in the referral practices after regionalisation of perinatal care. Study design: Analysis of the distribution of low birth weight infants according to the level of care in Rhone-Alpes from 1998 to 2000 and analysis of the birth rate heterogeneity according to the delivery site characteristics. Results: The distribution of infants<or=1500 g remained constant at all levels (60% at level 3). That of infants 1500-2000 g born at level 3 dropped in 2000 but raised at levels 1 and 2. For both weight categories, the lower birth rates corresponded to the private, the lower-flow, and the more distant from neonatal intensive care units facilities. For infants<or=1500 g, the level 3 birth rate was four times the level 2 (P=0.0006) and five times the level 1 (P<0.0001) rates. For infants 1500-2000 g, level 3 birth rate was twice the level 2 (P=0.0096) and 3.6 times the level 1 (P<0.0001) rates. Birth rates were always significantly higher in university than in private facilities.<br />Conclusion(s): Supervising level 3 is insufficient to show the effect of regionalisation. A more accurate analysis of intermediate-risk referral determinants is needed to reach a more demand/supply adequacy.
MeSH term(s)	Birth Rate ; Birth Weight ; Female ; France ; Humans ; Intensive Care, Neonatal/statistics & numerical data ; Perinatal Care/statistics & numerical data ; Practice Patterns, Physicians' ; Pregnancy ; Pregnancy, High-Risk ; Referral and Consultation/statistics & numerical data
Language	English
Publishing date	2005-06-01
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	190605-7
ISSN	1872-7654 ; 0301-2115 ; 0028-2243
ISSN (online)	1872-7654
ISSN	0301-2115 ; 0028-2243
DOI	10.1016/j.ejogrb.2004.09.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 837: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: A 7-year longitudinal follow-up of intellectual development in children with congenital hemiplegia.

Gonzalez-Monge, Sibylle / Boudia, Baya / Ritz, Annie / Abbas-Chorfa, Fatima / Rabilloud, Muriel / Iwaz, Jean / Bérard, Carole

Developmental medicine and child neurology

2009 Volume 51, Issue 12, Page(s) 959–967

Abstract: Aims: Our aim was to examine intellectual development in children with congenital hemiplegia from early childhood to adolescence.: Method: Full-scale IQ (FIQ), Verbal IQ (VIQ), and Performance IQ (PIQ) scores were measured in 32 participants (19 ... ...

Abstract	Aims: Our aim was to examine intellectual development in children with congenital hemiplegia from early childhood to adolescence. Method: Full-scale IQ (FIQ), Verbal IQ (VIQ), and Performance IQ (PIQ) scores were measured in 32 participants (19 males, 13 females) with congenital hemiplegia at mean ages of 4 years 6 months (SD 7mo; 31 participants), 7 years (SD 6mo; 23 participants), and 14 years (SD 1y 5mo; 26 participants). Results: The FIQ and VIQ scores did not change with age, but the PIQ declined significantly (0.7 points per year; p=0.004). The estimated mean (95% confidence intervals) scores in males born at term with right-sided lesions without epilepsy were FIQ 106.5 (95.29-117.74), VIQ 105.9 (95.57-116.24), and PIQ 103.7 (93.19-114.31). Those means were negatively associated with preterm birth. PIQ was negatively associated with epilepsy. VIQ increased more quickly in males and in children with right-sided lesions. Interpretation: The results confirm previous findings of FIQ stability, PIQ decline, the impact of epilepsy, and the status of females with left-sided lesions, and also reveal the effect of gestational age at birth. They underline the importance of management focused on nonverbal functions and further the debate about the early lateralization of language, the 'crowding effect', and the difference in brain plasticity between males and females.
MeSH term(s)	Adolescent ; Cerebral Cortex/physiopathology ; Child ; Child Development ; Child, Preschool ; Cognition Disorders/complications ; Cognition Disorders/physiopathology ; Developmental Disabilities ; Epilepsy/complications ; Epilepsy/physiopathology ; Female ; Follow-Up Studies ; Functional Laterality ; Hemiplegia/complications ; Hemiplegia/congenital ; Hemiplegia/physiopathology ; Humans ; Intelligence ; Male ; Neuronal Plasticity ; Sex Factors ; Wechsler Scales
Language	English
Publishing date	2009-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80369-8
ISSN	1469-8749 ; 0012-1622
ISSN (online)	1469-8749
ISSN	0012-1622
DOI	10.1111/j.1469-8749.2009.03339.x
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.B 5: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Outcome of cystic fibrosis-related diabetes two years after lung transplantation.

Valour, Florent / Brault, Coralie / Abbas-Chorfa, Fatima / Martin, Christine / Kessler, Laurence / Kanaan, Reem / Mosnier-Pudar, Hélène / Coltey, Bérengère / Nove-Josserand, Raphaële / Durupt, Stéphane / Colin, Cyrille / Durieu, Isabelle

Respiration; international review of thoracic diseases

2012 Volume 86, Issue 1, Page(s) 32–38

Abstract: Background: Although transplantation is known to impair glucose tolerance, evolution of pre-existing diabetes after lung transplantation (LT) in cystic fibrosis (CF) has never been described.: Objectives: We aimed to assess the outcome of CF-related ... ...

Abstract	Background: Although transplantation is known to impair glucose tolerance, evolution of pre-existing diabetes after lung transplantation (LT) in cystic fibrosis (CF) has never been described. Objectives: We aimed to assess the outcome of CF-related diabetes (CFRD) after LT, with the hypothesis that suppressing chronic inflammatory foci may improve glucose tolerance in some patients. Methods: In a retrospective study of 29 CF diabetic patients treated with insulin and undergoing LT, CFRD control was assessed 3 months before LT and 1 (n = 27) and 2 (n = 18) years after LT by measuring insulin dosage, fasting blood glucose and glycosylated hemoglobin (HbA1c) levels. Patients with HbA1c ≤7% and an insulin dose ≤1 UI/kg/day were defined as having controlled CFRD (group A). Other patients were assigned to group B. Results: Before LT, 19 (65.5%) patients were in group A. At 2 years, 6 of 10 (60%) patients who were in group B prior to LT had moved into group A, which then comprised 77.8% of all patients. Insulin could have been stopped in 5 patients. Uncontrolled CFRD before LT (OR = 16) and a long delay between the diagnosis of CFRD and LT (OR = 1.3) were significant predictors of uncontrolled CFRD at 1 year. Conclusions: LT does not seem to worsen CFRD in some patients, suggesting that in some cases, glucose tolerance may be improved by the suppression of chronic pulmonary infection.
MeSH term(s)	Adrenal Cortex Hormones/adverse effects ; Adult ; Blood Glucose ; Cystic Fibrosis/complications ; Cystic Fibrosis/surgery ; Diabetes Mellitus/blood ; Diabetes Mellitus/etiology ; Diabetes Mellitus/physiopathology ; Disease Progression ; Exocrine Pancreatic Insufficiency/etiology ; Female ; Glycated Hemoglobin A ; Humans ; Immunosuppressive Agents/adverse effects ; Insulin/metabolism ; Insulin Resistance/physiology ; Insulin Secretion ; Logistic Models ; Lung Transplantation ; Male ; Retrospective Studies ; Treatment Outcome ; Young Adult
Chemical Substances	Adrenal Cortex Hormones ; Blood Glucose ; Glycated Hemoglobin A ; Immunosuppressive Agents ; Insulin ; hemoglobin A1c protein, human
Language	English
Publishing date	2012-08-25
Publishing country	Switzerland
Document type	Journal Article ; Observational Study
ZDB-ID	206674-9
ISSN	1423-0356 ; 0025-7931
ISSN (online)	1423-0356
ISSN	0025-7931
DOI	10.1159/000339928
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uh II Zs.138: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Outcome of Cystic Fibrosis-Related Diabetes Two Years after Lung Transplantation

Respiration

2012 Volume 86, Issue 1, Page(s) 32–38

Abstract: Background: Although transplantation is known to impair glucose tolerance, evolution of pre-existing diabetes after lung transplantation (LT) in cystic fibrosis (CF) has never been described. Objectives: We aimed to assess the outcome of CF-related ... ...

Institution	Departments of Internal Medicine and Diabetology, Adult Cystic Fibrosis Care Center Unité Evaluation Epidémiologie, Pôle Information Médicale Evaluation Recherche, Hospices Civils de Lyon Université de Lyon, EA Santé-Individu, and Université Claude Bernard Lyon 1, Lyon Department of Diabetology, Adult Cystic Fibrosis Care Center, Hôpital de Hautepierre, University of Strasbourg, Strasbourg, Departments of Pneumology and Diabetology, Adult Cystic Fibrosis Care Center, Hôpital Cochin, Paris, and Department of Pneumology, Adult Cystic Fibrosis Care Centre, Grenoble, France
Abstract	Background: Although transplantation is known to impair glucose tolerance, evolution of pre-existing diabetes after lung transplantation (LT) in cystic fibrosis (CF) has never been described. Objectives: We aimed to assess the outcome of CF-related diabetes (CFRD) after LT, with the hypothesis that suppressing chronic inflammatory foci may improve glucose tolerance in some patients. Methods: In a retrospective study of 29 CF diabetic patients treated with insulin and undergoing LT, CFRD control was assessed 3 months before LT and 1 (n = 27) and 2 (n = 18) years after LT by measuring insulin dosage, fasting blood glucose and glycosylated hemoglobin (HbA1c) levels. Patients with HbA1c ≤7% and an insulin dose ≤1 UI/kg/day were defined as having controlled CFRD (group A). Other patients were assigned to group B. Results: Before LT, 19 (65.5%) patients were in group A. At 2 years, 6 of 10 (60%) patients who were in group B prior to LT had moved into group A, which then comprised 77.8% of all patients. Insulin could have been stopped in 5 patients. Uncontrolled CFRD before LT (OR = 16) and a long delay between the diagnosis of CFRD and LT (OR = 1.3) were significant predictors of uncontrolled CFRD at 1 year. Conclusions: LT does not seem to worsen CFRD in some patients, suggesting that in some cases, glucose tolerance may be improved by the suppression of chronic pulmonary infection.
Keywords	Lung transplantation ; Diabetes mellitus ; Cystic fibrosis
Language	English
Publishing date	2012-08-25
Publisher	S. Karger AG
Publishing place	Basel, Switzerland
Document type	Article
Note	Clinical Investigations
ZDB-ID	206674-9
ISSN	1423-0356 ; 0025-7931
ISSN (online)	1423-0356
ISSN	0025-7931
DOI	10.1159/000339928
Database	Karger publisher's database

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uh II Zs.138: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito