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Article ; Online: Osteoporosis Risk Prediction Using Data Mining Algorithms

efat jabarpour / amin Abedini / abbasali keshtkar

Journal of Community Health Research, Vol 9, Iss 2, Pp 69-

2020 Volume 80

Abstract: Abstract Introduction: Osteoporosis is a disease that reduces bone density and loses the quality of bone microstructure leading to an increased risk of fractures. It is one of the major causes of inability and death in elderly people. The current study ... ...

Abstract	Abstract Introduction: Osteoporosis is a disease that reduces bone density and loses the quality of bone microstructure leading to an increased risk of fractures. It is one of the major causes of inability and death in elderly people. The current study aims at determining the factors influencing the incidence of osteoporosis and providing a predictive model for the disease diagnosis to increase the diagnostic speed and reduce diagnostic costs. Methods: An Individual's data including personal information, lifestyle, and disease information were reviewed. A new model has been presented based on the Cross-Industry Standard Process CRISP methodology. Besides, Support Vector Machine (SVM) and Bayes methods (Tree Augmented Naïve Bayes (TAN)) and Clementine12 have been used as data mining tools. Results: Some features have been detected to affect this disease. The rules have been extracted that can be used as a pattern for the prediction of the patients' status. Classification precision was calculated to be 88.39% for SVM, and 91.29% for (TAN) when the precision of TAN is higher comparing to other methods. Conclusion: The most effective factors concerning osteoporosis are detected and can be used for a new sample with defined characteristics to predict the possibility of osteoporosis in a person.
Keywords	osteoporosis ; data mining ; support vector machine ; bayes network ; Public aspects of medicine ; RA1-1270
Subject code	006
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	Shahid Sadoughi University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The worldwide prevalence of burnout syndrome among bank employees

Sharareh Azedi Tehrani / Abbasali Keshtkar / Akilesh Ramasamy / Majid Fadaei

Systematic Reviews, Vol 10, Iss 1, Pp 1-

a systematic review and meta-analysis protocol

2021 Volume 6

Abstract: Abstract Background Burnout is a syndrome caused by chronic stress in the workplace that has not been successfully managed. Although prevalence of burnout is well documented in different fields, little is known about this syndrome in the context of ... ...

Abstract	Abstract Background Burnout is a syndrome caused by chronic stress in the workplace that has not been successfully managed. Although prevalence of burnout is well documented in different fields, little is known about this syndrome in the context of banking work. The objective of this review will be to assess worldwide pooled prevalence of burnout syndrome among bank employees. Methods This is a study protocol for a systematic review. We will search the following electronic databases (from their inception onwards): PubMed/MEDLINE, SCOPUS, Web of Science, PsycINFO, ERIC, EBSCOhost, Emerald Insight, and Google Scholar. Grey literature will be identified through searching SCOPUS, Google Scholar, ProQuest databases, and websites of related organizations. We will consider studies that include any type of employee in the banking industry and report extractable prevalence estimates of burnout. Two reviewers will independently screen all citations, full-text articles, and abstract data. The study methodological quality (or bias) will be appraised using an appropriate tool. If feasible, we will conduct random effect meta-analysis of prevalence data. Additional analyses will be conducted to explore the potential sources of heterogeneity (e.g., setting, sex, burnout assessment method, country, and work hours). Discussion This systematic review will assess the worldwide prevalence of burnout syndrome among bank employees. The results of this study will be published in a peer-reviewed journal. As it presents an analysis of published literature, the study does not require ethical approval. Systematic review registration PROSPERO CRD42020213565
Keywords	Burnout ; Prevalence ; Maslach burnout inventory (MBI) ; Banking industry ; Medicine ; R
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Safety and efficacy of pulmonary physiotherapy in hospitalized patients with severe COVID-19 pneumonia (PPTCOVID study)

Mohammad Javaherian / Azadeh Shadmehr / Abbasali Keshtkar / Mohammad Taghi Beigmohammadi / Narges Dabbaghipour / Aabis Syed / Behrouz Attarbashi Moghadam

PLoS ONE, Vol 18, Iss 1, p e

A prospective, randomised, single-blind, controlled trial.

2023 Volume 0268428

Abstract: Background Pulmonary physiotherapy (PPT) is an important treatment in the management of patients with different types of pulmonary disorders. We aimed to evaluate safety and efficacy of PPT in hospitalized patients with severe COVID-19 pneumonia. Methods ...

Abstract	Background Pulmonary physiotherapy (PPT) is an important treatment in the management of patients with different types of pulmonary disorders. We aimed to evaluate safety and efficacy of PPT in hospitalized patients with severe COVID-19 pneumonia. Methods In this randomised, single-blind, controlled trial, we enrolled hospitalized, non-intubated patients (18 to 75 years with oxygen saturation (Spo2) in free-air breathing ≤90%) with COVID-19 pneumonia at a referral hospital. Participants were randomly assigned (1:1) to receive PPT (six sessions PPT with breathing exercises and airway clearance techniques) or basic care. The primary outcomes were venous blood O2 (pO2) and CO2 (pCO2) pressures, Spo2, and three-minute walking test (3MWT) that were assessed before and end of sixth session. Secondary outcomes included level of dyspnea, venous blood PH, one-month mortality, three-month mortality and short form-36 (SF-36) after one and three months. The assessor was blinded to the assignment. This trial is registered with ClinicalTrials.gov (NCT04357340). Findings In April-May 2020, 40 participants were randomly assigned to PPT or basic care groups. While at the end of intervention, pO2 (adjusted mean difference to baseline measure (AMD) 6.43 mmHg [95%CI 2.8, 10.07], P<0.01), Spo2 (AMD 4.43% [95%CI 2.04, 6.83], P = 0.0011), and 3MTW (AMD 91.44 m [95%CI 68.88, 113.99], P<0.01) were higher in PPT group and basic care group, pCO2 was not improved (AMD -2.1 mmHg [95%CI-6.36, 2.21], P = 0.33). Based on the logistic model adjusted to baseline Spo2, the risks of mortality were reduced 81% ([95%CI: 97% reduction to 30% increase], P = .09) and 84% ([95%CI 74% reduction to 5% increase], P = .06) at one-month and three-month, respectively. There were no significant differences in most SF-36 domains scores after one and three months. No serious adverse event was observed during PPT sessions. Conclusion Early PPT can be considered a safe and relatively effective therapeutic choice for patients with severe COVID-19.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Safety and efficacy of pulmonary physiotherapy in hospitalized patients with severe COVID-19 pneumonia (PPTCOVID study)

Mohammad Javaherian / Azadeh Shadmehr / Abbasali Keshtkar / Mohammad Taghi Beigmohammadi / Narges Dabbaghipour / Aabis Syed / Behrouz Attarbashi Moghadam

PLoS ONE, Vol 18, Iss

A prospective, randomised, single-blind, controlled trial

2023 Volume 1

Abstract	Background Pulmonary physiotherapy (PPT) is an important treatment in the management of patients with different types of pulmonary disorders. We aimed to evaluate safety and efficacy of PPT in hospitalized patients with severe COVID-19 pneumonia. Methods In this randomised, single-blind, controlled trial, we enrolled hospitalized, non-intubated patients (18 to 75 years with oxygen saturation (Spo2) in free-air breathing ≤90%) with COVID-19 pneumonia at a referral hospital. Participants were randomly assigned (1:1) to receive PPT (six sessions PPT with breathing exercises and airway clearance techniques) or basic care. The primary outcomes were venous blood O2 (pO2) and CO2 (pCO2) pressures, Spo2, and three-minute walking test (3MWT) that were assessed before and end of sixth session. Secondary outcomes included level of dyspnea, venous blood PH, one-month mortality, three-month mortality and short form-36 (SF-36) after one and three months. The assessor was blinded to the assignment. This trial is registered with ClinicalTrials.gov (NCT04357340). Findings In April-May 2020, 40 participants were randomly assigned to PPT or basic care groups. While at the end of intervention, pO2 (adjusted mean difference to baseline measure (AMD) 6.43 mmHg [95%CI 2.8, 10.07], P<0.01), Spo2 (AMD 4.43% [95%CI 2.04, 6.83], P = 0.0011), and 3MTW (AMD 91.44 m [95%CI 68.88, 113.99], P<0.01) were higher in PPT group and basic care group, pCO2 was not improved (AMD -2.1 mmHg [95%CI-6.36, 2.21], P = 0.33). Based on the logistic model adjusted to baseline Spo2, the risks of mortality were reduced 81% ([95%CI: 97% reduction to 30% increase], P = .09) and 84% ([95%CI 74% reduction to 5% increase], P = .06) at one-month and three-month, respectively. There were no significant differences in most SF-36 domains scores after one and three months. No serious adverse event was observed during PPT sessions. Conclusion Early PPT can be considered a safe and relatively effective therapeutic choice for patients with severe COVID-19.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Associations between XRCC3 Thr241Met polymorphisms and breast cancer risk

Sepideh Dashti / Zahra Taherian-Esfahani / Abbasali Keshtkar / Soudeh Ghafouri-Fard

BMC Medical Genetics, Vol 20, Iss 1, Pp 1-

systematic-review and meta-analysis of 55 case-control studies

2019 Volume 17

Abstract: Abstract Background The X-ray repair cross-complementing group 3 (XRCC3) is an efficient component of homologous recombination and is required for the preservation of chromosomal integrity in mammalian cells. The association between Thr241Met single- ... ...

Abstract	Abstract Background The X-ray repair cross-complementing group 3 (XRCC3) is an efficient component of homologous recombination and is required for the preservation of chromosomal integrity in mammalian cells. The association between Thr241Met single-nucleotide polymorphism (SNP) in this gene and susceptibility to breast cancer has been assessed in several studies. Yet, reports are controversial. The present meta-analysis has been designed to identify whether this SNP is associated with susceptibility to breast cancer. Methods We performed a systematic review and meta-analysis for retrieving the case-control studies on the associations between T241 M SNP and the risk of breast cancer. Crude odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to verify the association in dominant, recessive, and homozygote inheritance models. Results We included 55 studies containing 30,966 sporadic breast cancer cases, 1174 familial breast cancer cases and 32,890 controls in the meta-analysis. In crude analyses, no association was detected between the mentioned SNP and breast cancer risk in recessive, homozygote or dominant models. However, ethnic based analysis showed that in sporadic breast cancer, the SNP was associated with breast cancer risk in Arab populations in homozygous (OR (95% CI) = 3.649 (2.029–6.563), p = 0.0001) and recessive models (OR (95% CI) = 4.092 (1.806–9.271), p = 0.001). The association was significant in Asian population in dominant model (OR (95% CI) = 1.296, p = 0.029). However, the associations was significant in familial breast cancer in mixed ethnic-based subgroup in homozygote and recessive models (OR (95% CI) = 0.451 (0.309–0.659), p = 0.0001, OR (95% CI) = 0.462 (0.298–0.716), p = 0.001 respectively). Conclusions Taken together, our results in a large sample of both sporadic and familial cases of breast cancer showed insignificant role of Thr241Met in the pathogenesis of this type of malignancy. Such results were more conclusive in sporadic cases. In familial cases, future studies are needed to verify our results.
Keywords	Genes ; Neoplasm ; Single nucleotide polymorphism ; Breast Cancer ; Internal medicine ; RC31-1245 ; Genetics ; QH426-470
Subject code	616
Language	English
Publishing date	2019-05-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Investigating Effects of Vitamin D Injection during a Course of Endurance Training On Anthropometrical Parameters of Wistar Rats with High-Fat Diet-Induced Obesity

Seyed Javad Mirghani / Mohammad Ali Azarbayjani / Maghsood Peeri / Abbasali keshtkar

Medical Laboratory Journal, Vol 13, Iss 6, Pp 36-

2019 Volume 43

Abstract: ABSTRACT Background and Objectives: The purpose of this research was to determine effects of vitamin D supplementation during a course of endurance training on anthropometrical parameters of Wistar rats exposed to a high-fat diet. Methods: In this ... ...

Abstract	ABSTRACT Background and Objectives: The purpose of this research was to determine effects of vitamin D supplementation during a course of endurance training on anthropometrical parameters of Wistar rats exposed to a high-fat diet. Methods: In this experimental study, 38 Wistar rats aged 5-6 weeks were assigned to five groups: 1. Control with normal diet (n=5), 2. Control with high-fat diet (n=5), 3. High-fat diet and vitamin D supplementation (n=10), 4. High-fat diet and endurance training (n=10), and 5. High-fat diet, endurance training and vitamin D supplementation (n=10). The animals were subjected to a high-fat diet (40%) for 13 weeks, followed by 12 weeks of exercise and vitamin D supplementation. Results: Weight (P=0.02), BMI (P=0.001), Lee index (P=0.01) and energy efficiency (P=0.001) differed significantly between groups 1 and 2. Feed efficiency (P=0.03) and energy efficiency (P=0.01) of groups 2, 3 and 4 were significantly different from that of the control group. Conclusion: The results of the present study indicate that endurance training and vitamin D supplementation could significantly decrease some anthropometric indices. Keywords: Endurance Training, Vitamin D, High Fat Diet, Anthropometric Indices.
Keywords	endurance training ; vitamin d ; high fat diet ; anthropometric indices ; Medicine ; R
Subject code	796
Language	English
Publishing date	2019-11-01T00:00:00Z
Publisher	Golestan University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Subtypes of Benign Breast Disease as a Risk Factor of Breast Cancer

Fatemeh Salamat / Babak Niakan / Abbasali Keshtkar / Elahe Rafiei / Manoosh Zendehdel

Iranian Journal of Medical Sciences, Vol 43, Iss 4, Pp 355-

A Systematic Review and Meta Analyses

2018 Volume 364

Abstract: Background: Researchers suggest that benign breast disease (BBD) is a key risk factor for breast cancer. The present study aimed to determinate the risk level of breast cancer in terms of various BBD subgroups. Methods: A meta-analysis was performed to ... ...

Abstract	Background: Researchers suggest that benign breast disease (BBD) is a key risk factor for breast cancer. The present study aimed to determinate the risk level of breast cancer in terms of various BBD subgroups. Methods: A meta-analysis was performed to determinate the risk of breast cancer associated with BBD. Observational studies (traditional case-control studies, nested case-control studies, and cohort studies) published from January 2000 to June 2015 were assessed to evaluate the risk of developing breast cancer related to BBD. Various databases such as Medline (PubMed), Web of Science (ISI), Scopus, and Google Scholar were searched. The additional search included the Journal of Breast Cancer Research and Treatment and the Journal of Cancer Research. Results: Twenty studies out of 21 were used to estimate the risk of developing breast cancer related to proliferative disease without atypia versus non-proliferative disease and the reported risk ranged from 1.04 to 1.83. The reported risk of developing breast cancer related to proliferative disease with atypia versus non-proliferative disease in 21 studies ranged from 1.59 to 4.74. Based on 20 studies, the pooled risk estimates for developing breast cancer related to proliferative disease without atypia versus non-proliferative disease was 1.58 (95% CI: 1.51-1.66). Based on 21 studies, the pooled risk estimates for developing breast cancer related to proliferative disease with atypia versus non-proliferative disease was 3.49 (95% CI: 3.23-3.77). Conclusion: The overall result of this review showed an elevated risk for breast cancer related to BBD subtypes. We propose better strategies for screening recommendations for such women.
Keywords	mammary ; Breast neoplasms ; Risk factors ; Review ; Benign breast disease ; Dysplasia ; Medicine (General) ; R5-920
Subject code	610 ; 616
Language	English
Publishing date	2018-07-01T00:00:00Z
Publisher	Shiraz University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Subtypes of Benign Breast Disease as a Risk Factor for Breast Cancer

Manoosh Zendehdel / Babak Niakan / Abbasali Keshtkar / Elahe Rafiei / Fatemeh Salamat

Iranian Journal of Medical Sciences, Vol 43, Iss 1, Pp 1-

A Systematic Review and Meta-Analysis Protocol

2018 Volume 8

Abstract: Breast cancer is a multifactorial disease. Benign breast disease (BBD) is one of the most important risk factors for breast cancer. The etiology of BBD is unknown. It is divided into nonproliferative and proliferative diseases. The selection of studies ... ...

Abstract	Breast cancer is a multifactorial disease. Benign breast disease (BBD) is one of the most important risk factors for breast cancer. The etiology of BBD is unknown. It is divided into nonproliferative and proliferative diseases. The selection of studies will be based on titles, abstract screening, inclusion and exclusion criteria, and quality assessment. Previous studies have shown that all types of BBD increase the risk of breast cancer, but the risk degree is different for each one. Accurate risk estimation of breast cancer in each category can be very important for proper clinical management. This systematic review and meta-analysis will be conducted on observational studies (traditional case control, nested case control, case cohort, and cohort) published in the Web of Science (ISI), PubMed (MEDLINE), Scopus, Google Scholar, and the key journals of this field such as Breast Cancer Research and Treatment and Cancer Research from January 2000 to June 2015. Reference lists and gray literature will be reviewed too. All the initial retrievals will be performed by 2 researchers independently. The data extraction form will consist of general information concerning the studies, study eligibility, method, risk of bias assessment, and results—including odds ratios, risk ratios, rate ratios, and hazard ratios. The PRISMA and MOOSE guidelines will be used to report our findings. Registration Details: PROSPERO-42016035243
Keywords	Fibrocystic breast disease ; Mammary dysplasia ; Breast neoplasms ; Risk factors ; Systematic review ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Shiraz University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Association of osteoporosis with anthropometric measures in a representative sample of Iranian Adults

Shirin Hasani-Ranjbar / Shahrzad Jafari-Adli / Moloud Payab / Mostafa Qorbani / Farzaneh Ahanjideh / Abbasali Keshtkar / Bagher Larijani

International Journal of Preventive Medicine, Vol 10, Iss 1, Pp 157-

The Iranian multicenter osteoporosis study

2019 Volume 157

Abstract: Background: Osteoporosis and obesity are two major public health problems worldwide. Considering the conflicting results about the association between anthropometric measurement and bone mineral density (BMD) and also differences between various races, ... ...

Abstract	Background: Osteoporosis and obesity are two major public health problems worldwide. Considering the conflicting results about the association between anthropometric measurement and bone mineral density (BMD) and also differences between various races, this study was designed to examine the relationship between anthropometric measurements and BMD in a sample of Iranian adults. Methods: This cross-sectional population-based study was conducted on 2625 Iranian adults aged 18 and above who were selected using multistage, cluster sampling method from Sanandaj and Arak (two cities of Iran). The evaluated variables included age, sex, height, weight, body mass index (BMI), BMD, and waist and hip circumferences. The correlations between anthropometric measures and BMD in three bone areas (total hip, femoral neck, and spine) were observed in four sex/age groups (men <50 years, men ≥50 years, and pre- and postmenopausal women). Results: Of all the 2625 participants in the Iranian Multicenter Osteoporosis Study, 2022 (1303 women and 719 men) entered into our survey and were stratified into four sex/age groups. According to the results, increasing BMI was directly associated with BMD increase, while an inverse association was observed between waist-to-hip ratio (WHR) and total hip BMD. In a similar analysis on the femoral neck and WHR, the correlation coefficients in premenopausal women and men ≥50 years were reported as being the highest and the lowest, respectively, among the four groups. Conclusions: Our results showed that high BMI is a protective factor (positive correlation), and high WHR is a risk factor for osteoporosis, although it should be reminded that we could not specifically define which factors including lean tissue mass, fat mass, and total weight are really affecting BMD increase in the overweight/obese participants.
Keywords	abdominal obesity ; body mass index ; bone mineral density ; obesity ; osteoporosis ; waist-to-hip ratio ; Medicine ; R
Subject code	796
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluation of Some Plasma Coagulation Factors in Women with Spontaneous Miscarriage

Mahsa Besharat / Afsane Tabandeh / Abbasali Keshtkar / Elham Mobasheri / Sima Besharat / Hamidreza Joshaghani

International Journal of Fertility & Sterility, Vol 9, Iss 3, Pp 309-

2015 Volume 312

Abstract: Background: It has been reported that 15-20% of parous female have experienced at least one miscarriage, while 3% of them have experienced two miscarriages. The goal of this study was to evaluate the plasma level of coagulation factors in women with a ... ...

Abstract	Background: It has been reported that 15-20% of parous female have experienced at least one miscarriage, while 3% of them have experienced two miscarriages. The goal of this study was to evaluate the plasma level of coagulation factors in women with a history of spontaneous abortions. Materials and Methods: In this case-control study, 82 women with a history of two or more abortions referred to the six private gynecologic clinics in Gorgan city without any structural abnormality were recruited during 2011-2012. Plasma levels of antithrombin III (ATIII) using colorimetric assay, protein C, protein S, factor V Leiden and lupus anticoagulant (LAC) using coagulation method were measured. The control group was women with a history of normal delivery and no abortions. Those under anti-coagulant therapy were excluded from the study. Data were entered into the computer using the Statistical Package for the Social Sciences (SPSS, SPSS Inc., Chicago, IL, USA) version 16 and analyzed by Chi-square, t test and non-parametric tests. Results: At least one abnormality was reported in 35 cases (42.7%). Among them, protein C deficiency was the most prevalent (30.5%). ATIII was abnormal in 17.1% and lupus anti-coagulant was abnormal in 8.5%. Factor V Leiden was normal in all cases and protein S deficiency was only seen in one case. Conclusion: We suggest to perform these tests in regards to the thrombophilia in cases with spontaneous abortions in order to find an early cure for this treatable disorder.
Keywords	Thrombophilia ; Abortion ; Protein C ; Protein S ; Factor V Leiden ; Medicine (General) ; R5-920 ; Medicine ; R
Subject code	150
Language	English
Publishing date	2015-10-01T00:00:00Z
Publisher	Royan Institute (ACECR), Tehran
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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