Artikel ; Online: Managing Hepatotoxicity Caused by Anti-tuberculosis Drugs: A Comparative Study of Approaches.
2024 Band 27, Heft 3, Seite(n) 122–126
Abstract: Background: Tuberculosis (TB) is one of the oldest and most well-known diseases that has been associated with humans for many years and remains a global health challenge today. Timely diagnosis and proper treatment are crucial for controlling and ... ...
Abstract | Background: Tuberculosis (TB) is one of the oldest and most well-known diseases that has been associated with humans for many years and remains a global health challenge today. Timely diagnosis and proper treatment are crucial for controlling and preventing the spread of the disease. While anti-TB drugs offer many benefits, inadequate monitoring can lead to a range of side effects, including hepatotoxicity, which is a major concern and can cause treatment discontinuation. The aim of this study was to determine the approach to the hepatotoxicity of anti-TB drugs and to investigate potential relationships between demographic factors, underlying medical conditions, and successful retreatment outcomes for hepatotoxicity induced by anti-TB drugs. Methods: For this study, we reviewed the medical records of patients who experienced hepatotoxicity due to anti-TB treatment and were admitted to the infectious ward of Imam Khomeini Hospital between April 2015 and February 2019. The data were collected using a questionnaire. Results: The findings indicated that the female gender, weight loss at the beginning of hospitalization, Conclusion: Drug-induced hepatotoxicity is a common occurrence that often results in treatment discontinuation. Understanding the prevalence of this complication and identifying appropriate methods of rechallenge treatment is crucial to reducing complications and mortality rates. |
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Mesh-Begriff(e) | Humans ; Chemical and Drug Induced Liver Injury/etiology ; Antitubercular Agents/adverse effects ; Female ; Male ; Middle Aged ; Adult ; Retrospective Studies ; Risk Factors ; Aged ; Tuberculosis/drug therapy ; Alanine Transaminase/blood ; Aspartate Aminotransferases/blood ; Iran |
Chemische Substanzen | Antitubercular Agents ; Alanine Transaminase (EC 2.6.1.2) ; Aspartate Aminotransferases (EC 2.6.1.1) |
Sprache | Englisch |
Erscheinungsdatum | 2024-03-01 |
Erscheinungsland | Iran |
Dokumenttyp | Journal Article ; Comparative Study |
ZDB-ID | 2204979-4 |
ISSN | 1735-3947 ; 1029-2977 |
ISSN (online) | 1735-3947 |
ISSN | 1029-2977 |
DOI | 10.34172/aim.2024.19 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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