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  1. Article ; Online: M cell maturation and cDC activation determine the onset of adaptive immune priming in the neonatal Peyer's patch.

    Torow, Natalia / Li, Ronghui / Hitch, Thomas Charles Adrian / Mingels, Clemens / Al Bounny, Shahed / van Best, Niels / Stange, Eva-Lena / Simons, Britta / Maié, Tiago / Rüttger, Lennart / Gubbi, Narasimha Murthy Keshava Prasad / Abbott, Darryl Adelaide / Benabid, Adam / Gadermayr, Michael / Runge, Solveig / Treichel, Nicole / Merhof, Dorit / Rosshart, Stephan Patrick / Jehmlich, Nico /
    Hand, Timothy Wesley / von Bergen, Martin / Heymann, Felix / Pabst, Oliver / Clavel, Thomas / Tacke, Frank / Lelouard, Hugues / Costa, Ivan Gesteira / Hornef, Mathias Walter

    Immunity

    2023  Volume 56, Issue 6, Page(s) 1220–1238.e7

    Abstract: Early-life immune development is critical to long-term host health. However, the mechanisms that determine the pace of postnatal immune maturation are not fully resolved. Here, we analyzed mononuclear phagocytes (MNPs) in small intestinal Peyer's patches ...

    Abstract Early-life immune development is critical to long-term host health. However, the mechanisms that determine the pace of postnatal immune maturation are not fully resolved. Here, we analyzed mononuclear phagocytes (MNPs) in small intestinal Peyer's patches (PPs), the primary inductive site of intestinal immunity. Conventional type 1 and 2 dendritic cells (cDC1 and cDC2) and RORgt+ antigen-presenting cells (RORgt+ APC) exhibited significant age-dependent changes in subset composition, tissue distribution, and reduced cell maturation, subsequently resulting in a lack in CD4+ T cell priming during the postnatal period. Microbial cues contributed but could not fully explain the discrepancies in MNP maturation. Type I interferon (IFN) accelerated MNP maturation but IFN signaling did not represent the physiological stimulus. Instead, follicle-associated epithelium (FAE) M cell differentiation was required and sufficient to drive postweaning PP MNP maturation. Together, our results highlight the role of FAE M cell differentiation and MNP maturation in postnatal immune development.
    MeSH term(s) M Cells ; Peyer's Patches ; Intestines ; Intestine, Small ; Cell Differentiation ; Intestinal Mucosa
    Language English
    Publishing date 2023-05-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2023.04.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4227: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MG 69: Show issues

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  2. Article ; Online: A novel murine model of differentiation-mediated cytomegalovirus reactivation from latently infected bone marrow haematopoietic cells.

    Liu, Xue-Feng / Swaminathan, Suchitra / Yan, Shixian / Engelmann, Flora / Abbott, Darryl Adelaide / VanOsdol, Luke Andrew / Heald-Sargent, Taylor / Qiu, Longhui / Chen, Qing / Iovane, Andre / Zhang, Zheng / Abecassis, Michael M

    The Journal of general virology

    2019  Volume 100, Issue 12, Page(s) 1680–1694

    Abstract: CD34+ myeloid lineage progenitor cells are an important reservoir of latent human cytomegalovirus (HCMV), and differentiation to macrophages or dendritic cells (DCs) is known to cause reactivation of latent virus. Due to its species-specificity, murine ... ...

    Abstract CD34+ myeloid lineage progenitor cells are an important reservoir of latent human cytomegalovirus (HCMV), and differentiation to macrophages or dendritic cells (DCs) is known to cause reactivation of latent virus. Due to its species-specificity, murine models have been used to study mouse CMV (MCMV) latency and reactivation
    MeSH term(s) Animals ; Biomarkers ; Bone Marrow Cells/drug effects ; Bone Marrow Cells/metabolism ; Bone Marrow Cells/virology ; Cell Differentiation/drug effects ; Cells, Cultured ; Cytomegalovirus/physiology ; Cytomegalovirus Infections/virology ; Disease Models, Animal ; Female ; Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology ; Hematopoietic Stem Cells/metabolism ; Hematopoietic Stem Cells/virology ; Host-Pathogen Interactions ; Interleukin-4/pharmacology ; Kinetics ; Mice ; Myeloid Cells/drug effects ; Myeloid Cells/metabolism ; Myeloid Cells/virology ; Viral Tropism ; Virus Activation ; Virus Latency ; Virus Replication
    Chemical Substances Biomarkers ; Interleukin-4 (207137-56-2) ; Granulocyte-Macrophage Colony-Stimulating Factor (83869-56-1)
    Language English
    Publishing date 2019-10-24
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 219316-4
    ISSN 1465-2099 ; 0022-1317
    ISSN (online) 1465-2099
    ISSN 0022-1317
    DOI 10.1099/jgv.0.001327
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 610: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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