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  1. Article ; Online: The pulmonary effects of STAT3 deficiency.

    Gilje, Elizabeth A / Abbott, Jordan K

    The Journal of allergy and clinical immunology

    2023  Volume 152, Issue 2, Page(s) 368–370

    MeSH term(s) Humans ; Job Syndrome ; Immunoglobulin E ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/metabolism ; Mutation
    Chemical Substances Immunoglobulin E (37341-29-0) ; STAT3 Transcription Factor ; STAT3 protein, human
    Language English
    Publishing date 2023-06-16
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2023.06.003
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    Uh III Zs.92: Show issues Location:
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  2. Article ; Online: Registries are shaping how we think about primary immunodeficiency diseases.

    Abbott, Jordan K / Gelfand, Erwin W

    The Journal of allergy and clinical immunology

    2022  Volume 149, Issue 6, Page(s) 1943–1945

    MeSH term(s) Genetic Diseases, Inborn ; Humans ; Primary Immunodeficiency Diseases ; Registries
    Language English
    Publishing date 2022-04-26
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2022.04.019
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  3. Article ; Online: "Common variable immunodeficiency: Challenges for diagnosis".

    Wang, Laura A / Abbott, Jordan K

    Journal of immunological methods

    2022  Volume 509, Page(s) 113342

    Abstract: Common variable immunodeficiency is a heterogeneous condition characterized by B cell dysfunction with reduced serum immunoglobulin levels and a highly variable spectrum of clinical manifestations ranging from recurrent infections to autoimmune disease. ... ...

    Abstract Common variable immunodeficiency is a heterogeneous condition characterized by B cell dysfunction with reduced serum immunoglobulin levels and a highly variable spectrum of clinical manifestations ranging from recurrent infections to autoimmune disease. The diagnosis of CVID is often challenging due to the diverse clinical presentation of patients and the existence of multiple diagnostic criteria without a universally adopted consensus. Laboratory evaluation to assist with diagnosis currently includes serum immunoglobulin testing, immunophenotyping, assessment of vaccine response, and genetic testing. Additional emerging techniques include investigation of the B cell repertoire and the use of machine learning algorithms. Advances in our understanding of common variable immunodeficiency will ultimately contribute to earlier diagnosis and novel interventions with the goal of improving prognosis for these patients.
    MeSH term(s) B-Lymphocytes ; Common Variable Immunodeficiency/diagnosis ; Flow Cytometry/methods ; Humans ; Immunoglobulins ; Immunophenotyping
    Chemical Substances Immunoglobulins
    Language English
    Publishing date 2022-08-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 120142-6
    ISSN 1872-7905 ; 0022-1759
    ISSN (online) 1872-7905
    ISSN 0022-1759
    DOI 10.1016/j.jim.2022.113342
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    Zs.A 795: Show issues Location:
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  4. Article ; Online: The Immune Status of Patients with 16p11.2 Deletion Syndrome.

    Wang, Laura A / Larson, Austin / Abbott, Jordan K

    Journal of clinical immunology

    2023  Volume 43, Issue 8, Page(s) 1792–1795

    MeSH term(s) Humans ; Chromosome Deletion ; Chromosome Disorders ; Autistic Disorder ; Intellectual Disability
    Language English
    Publishing date 2023-10-09
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 779361-3
    ISSN 1573-2592 ; 0271-9142
    ISSN (online) 1573-2592
    ISSN 0271-9142
    DOI 10.1007/s10875-023-01597-2
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  5. Article: Composition of the CD27+ Memory-B-Cell Compartment Delineates Immunoglobulin Deficiency Endotypes.

    Starich, Oliva / Rieck, Jared M / Tarter, Wyatt J / Hochheimer, Camille J / Knight, Vijaya / Abbott, Jordan K

    Research square

    2024  

    Abstract: Abstract purpose: The finding of reduced numbers of class-switched memory B cells (CSM) in peripheral blood is widely used to assist the diagnosis and subclassification of CVID. Limited data exists on this finding in relation to the entire class of PADs. ...

    Abstract Abstract purpose: The finding of reduced numbers of class-switched memory B cells (CSM) in peripheral blood is widely used to assist the diagnosis and subclassification of CVID. Limited data exists on this finding in relation to the entire class of PADs. In this study, consecutive 8-marker comprehensive B-cell panel results were analyzed to determine how reduced CSM quantities might inform the pathophysiology of CVID and other humoral immunodeficiencies.
    Methods: Subpopulations of CD27+ memory B cells from 64 consecutive subjects with or without humoral immunodeficiency were examined to identify associations with diagnosis and serum immunoglobulin level. Results: CD27+IgM-IgD- percentage (CSM%) was correlated with IgG level in a discontinuous manner with an estimated change point of 9.7% (95% CI: 4.7, 12.4). All subjects with a CSM% below 9.7% had substantially lower serum IgG and IgA levels compared with those above 9.7. CSM% below 9.7% is not associated with serum IgM level. Rather, the proportion of CD27+IgMonly B cells (IgMonly or IgMonly%) is correlated with serum IgM.
    Conclusion: Low CSM% may mark an endotype of humoral immune dysfunction defined by either loss of class switching or critical failure of the coordinated production of both memory cells and long-lived plasma cells responsible for adequate immunoglobulin levels in humans. In patients with low CSM%, maintenance or expansion of IgMonly cells and IgM production suggests the former explanation, while concomitant loss of IgMonly cells suggests the latter. These findings provide a simple endotypic stratification method for future studies on the failed coordinated B cell response in humans with PAD.
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-3838482/v1
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  6. Article: “Common variable immunodeficiency: Challenges for diagnosis”

    Wang, Laura A. / Abbott, Jordan K.

    Journal of immunological methods. 2022 Oct., v. 509

    2022  

    Abstract: Common variable immunodeficiency is a heterogeneous condition characterized by B cell dysfunction with reduced serum immunoglobulin levels and a highly variable spectrum of clinical manifestations ranging from recurrent infections to autoimmune disease. ... ...

    Abstract Common variable immunodeficiency is a heterogeneous condition characterized by B cell dysfunction with reduced serum immunoglobulin levels and a highly variable spectrum of clinical manifestations ranging from recurrent infections to autoimmune disease. The diagnosis of CVID is often challenging due to the diverse clinical presentation of patients and the existence of multiple diagnostic criteria without a universally adopted consensus. Laboratory evaluation to assist with diagnosis currently includes serum immunoglobulin testing, immunophenotyping, assessment of vaccine response, and genetic testing. Additional emerging techniques include investigation of the B cell repertoire and the use of machine learning algorithms. Advances in our understanding of common variable immunodeficiency will ultimately contribute to earlier diagnosis and novel interventions with the goal of improving prognosis for these patients.
    Keywords B-lymphocytes ; autoimmune diseases ; blood serum ; immunoglobulins ; immunophenotyping ; immunosuppression ; prognosis ; vaccines
    Language English
    Dates of publication 2022-10
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 120142-6
    ISSN 1872-7905 ; 0022-1759
    ISSN (online) 1872-7905
    ISSN 0022-1759
    DOI 10.1016/j.jim.2022.113342
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Fluctuations in quality of life and immune responses during intravenous immunoglobulin infusion cycles.

    Abbott, Jordan K / Chan, Sanny K / MacBeth, Morgan / Crooks, James L / Hancock, Cathy / Knight, Vijaya / Gelfand, Erwin W

    PloS one

    2022  Volume 17, Issue 3, Page(s) e0265852

    Abstract: Despite adequate infection prophylaxis, variation in self-reported quality of life (QOL) throughout the intravenous immunoglobulin (IVIG) infusion cycle is a widely reported but infrequently studied phenomenon. To better understand this phenomenon, ... ...

    Abstract Despite adequate infection prophylaxis, variation in self-reported quality of life (QOL) throughout the intravenous immunoglobulin (IVIG) infusion cycle is a widely reported but infrequently studied phenomenon. To better understand this phenomenon, subjects with humoral immunodeficiency receiving replacement doses of IVIG were studied over 3 infusion cycles. Questionnaire data from 6 time points spread over 3 IVIG infusions cycles (infusion day and 7 days after each infusion) were collected in conjunction with monitoring the blood for number of regulatory T-cells (Treg) and levels of 40 secreted analytes: primarily cytokines, chemokines, and growth factors. At day 7, self-reported well-being increased, and self-reported fatigue decreased, reflecting an overall improvement in QOL 7 days after infusion. Over the same period, percentage of Treg cells in the blood increased (p<0.01). Multiple inflammatory chemokine and cytokine levels increased in the blood by 1 hour after infusion (CCL4 (MIP-1b), CCL3 (MIP-1a), CCL2 (MCP-1), TNF-α, granzyme B, IL-10, IL-1RA, IL-8, IL-6, GM-CSF, and IFN- γ). The largest changes in analytes occurred in subjects initiated on IVIG during the study. A significant decrease in IL-25 (IL-17E) following infusion was seen in most intervals among subjects already receiving regular infusions prior to study entry. These findings reveal several short-term effects of IVIG given in replacement doses to patients with humoral immunodeficiency: QOL consistently improves in the first week of infusion, levels of a collection of monocyte-associated cytokines increase immediately after infusion whereas IL-25 levels decrease, and Treg levels increase. Moreover, patients that are new to IVIG experience more significant fluctuations in cytokine levels than those receiving it regularly.
    MeSH term(s) Cytokines/metabolism ; Humans ; Immunity ; Immunoglobulins, Intravenous/pharmacology ; Immunoglobulins, Intravenous/therapeutic use ; Quality of Life ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances Cytokines ; Immunoglobulins, Intravenous ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2022-03-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0265852
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  8. Article ; Online: Common Variable Immunodeficiency: Diagnosis, Management, and Treatment.

    Abbott, Jordan K / Gelfand, Erwin W

    Immunology and allergy clinics of North America

    2015  Volume 35, Issue 4, Page(s) 637–658

    Abstract: Common variable immunodeficiency (CVID) refers to a grouping of antibody deficiencies that lack a more specific genetic or phenotypic classification. It is the immunodeficiency classification with the greatest number of constituents, likely because of ... ...

    Abstract Common variable immunodeficiency (CVID) refers to a grouping of antibody deficiencies that lack a more specific genetic or phenotypic classification. It is the immunodeficiency classification with the greatest number of constituents, likely because of the numerous ways in which antibody production can be impaired and the frequency in which antibody production becomes impaired in human beings. CVID comprises a heterogeneous group of rare diseases. Consequently, CVID presents a significant challenge for researchers and clinicians. Despite these difficulties, both our understanding of and ability to manage this grouping of complex immune diseases has advanced significantly over the past 60 years.
    MeSH term(s) Common Variable Immunodeficiency/diagnosis ; Common Variable Immunodeficiency/etiology ; Common Variable Immunodeficiency/metabolism ; Common Variable Immunodeficiency/therapy ; Diagnosis, Differential ; Disease Management ; Humans
    Language English
    Publishing date 2015-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 92606-1
    ISSN 1557-8607 ; 0889-8561
    ISSN (online) 1557-8607
    ISSN 0889-8561
    DOI 10.1016/j.iac.2015.07.009
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  9. Article ; Online: Use of Bortezomib in the Treatment of C3 Glomerulonephritis Refractory to Eculizumab and Rituximab.

    Hui, Jessica W / Banks, Mindy / Nadasdy, Tibor / Rovin, Brad H / Abbott, Jordan K

    Kidney international reports

    2020  Volume 5, Issue 6, Page(s) 951–954

    Language English
    Publishing date 2020-03-30
    Publishing country United States
    Document type Case Reports
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2020.03.022
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  10. Article ; Online: Cytotoxic T-Lymphocyte-Associated Antigen 4 Haploinsufficiency Mimics Difficult-to-Treat Inflammatory Bowel Disease.

    Constant, Brad D / Dutmer, Cullen M / Arnold, Michael A / Hall, Caroline / Abbott, Jordan K / de Zoeten, Edwin F

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2021  Volume 20, Issue 4, Page(s) e696–e702

    MeSH term(s) CTLA-4 Antigen/genetics ; Colitis ; Haploinsufficiency ; Humans ; Inflammatory Bowel Diseases/diagnosis ; Inflammatory Bowel Diseases/genetics
    Chemical Substances CTLA-4 Antigen
    Language English
    Publishing date 2021-05-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2021.05.001
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