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  1. Article ; Online: Epidemiology of pathogens causing acute diarrhea in patients presenting to the emergency departments in 4 hospitals in Lebanon.

    Helou, Mariana / Nasr, Janane / Hajjar, Micheline / Bourji, Alaa / Feghaly, Rita / Jabbour, Elsy / Abboud, Edmond / Abboud, Emma / Mahdi, Ahmad / Mina, Jonathan / Asmar, Alain / Husni, Rola

    Medicine

    2024  Volume 103, Issue 9, Page(s) e37316

    Abstract: Acute diarrhea is a prevalent disease worldwide and a cause of mortality in low and middle-income countries. In previous studies, the causative enteropathogen is found in 38% to 58% of patients, leaving a considerable diagnostic gap. In this study, we ... ...

    Abstract Acute diarrhea is a prevalent disease worldwide and a cause of mortality in low and middle-income countries. In previous studies, the causative enteropathogen is found in 38% to 58% of patients, leaving a considerable diagnostic gap. In this study, we intend to determine the pathogenic agents responsible for acute diarrhea in patients presenting to the Emergency Departments of several Lebanese hospitals. A total of 100 stool samples were collected between June 2022 and June 2023 from patients presenting with acute diarrhea to the Emergency Departments. Pathogens were detected by multiplex polymerase chain reaction. The average age for the patients was 53 years old. All patients presented with diarrhea, 15 of them had fever associated. In total, 46 patients were admitted to the hospital (70%), among them 80% received Intravenous antibiotics. Campylobacter was the most common agent detected in 36%, followed by Rotavirus 19%, and Noroviruses 15%. The rest was detected at lower percentages. Bacteria accounted for 49% of cases, viruses for 39%, and parasitic infection 6%. Acute diarrhea epidemiology is understudied in Lebanon. This study is the first Lebanese data about acute diarrhea pathogens. Avoiding overuse of antibiotics in bacterial versus viral infections can be achieved while prevention campaigns can raise awareness about food and water safety at the community level.
    MeSH term(s) Humans ; Infant ; Middle Aged ; Lebanon/epidemiology ; Diarrhea/etiology ; Rotavirus ; Bacteria ; Anti-Bacterial Agents/therapeutic use ; Hospitals ; Emergency Service, Hospital ; Feces/microbiology
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000037316
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.171: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Characterization and susceptibility of non-albicans

    Husni, Rola / Bou Zerdan, Maroun / Samaha, Nadia / Helou, Mariana / Mahfouz, Youssef / Saniour, Rim / Hourani, Sawsan / Kolanjian, Harout / Afif, Claude / Azar, Eid / El Jisr, Tamima / Mokhbat, Jacques / Abboud, Emma / Feghali, Rita / Abboud, Edmond / Matta, Hiam / Karayakouboglo, Gilbert / Matar, Madonna / Moghnieh, Rima /
    Daoud, Ziad

    Frontiers in public health

    2023  Volume 11, Page(s) 1115055

    Abstract: Background: Invasive fungal infections have presented a challenge in treatment. In the past, it was known that the frontrunner in such infections is : Methods: This is a two-year observational multi-central descriptive study. Between September 2016 ... ...

    Abstract Background: Invasive fungal infections have presented a challenge in treatment. In the past, it was known that the frontrunner in such infections is
    Methods: This is a two-year observational multi-central descriptive study. Between September 2016 and May of 2018, a total of 1000 isolates were collected from 10 different hospitals distributed all over the country. For the culture, Sabouraud Dextrose Agar was used. Antifungal Susceptibility was evaluated by determining the Minimum Inhibitory Concentration (MIC) in broth (microdilution) of the different antifungal treatments.
    Results: Out of the 1000 collected isolates,
    Conclusion: The change of etiology of fungal infections involving a significant increase in NAC cases is alarming due to the different antifungal susceptibility patterns and the lack of local guidelines to guide the treatment. In this context, proper identification of such organisms is of utmost importance. The data presented here can help in establishing guidelines for the treatment of candida infections to decrease morbidity and mortality. Future surveillance data are needed.
    MeSH term(s) Humans ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Candida ; Microbial Sensitivity Tests ; Hospitals ; Mycoses/drug therapy
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2023-03-10
    Publishing country Switzerland
    Document type Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1115055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Epidemiology and susceptibility profiles of diabetic foot infections in five hospitals in Lebanon.

    Obeid, Michele / Moughames, Eric / Aboulhosn, Petra / Madi, Rashad / Farah, Maya / Feghali, Jinia / Mokhbat, Jacques / Farra, Anna / Moughnieh, Rima / Daoud, Ziad / Feghaleh, Rita / Abboud, Edmond / Abboud, Emma / Husni-Samaha, Rola

    Journal of infection in developing countries

    2018  Volume 12, Issue 5, Page(s) 347–351

    Abstract: Introduction: Approximately 80% of diabetes-related lower extremity amputations are preceded by a foot ulcer. Global studies on the epidemiology of diabetic foot ulcer (DFU) infections and guidelines detailing the most common pathogens and their ... ...

    Abstract Introduction: Approximately 80% of diabetes-related lower extremity amputations are preceded by a foot ulcer. Global studies on the epidemiology of diabetic foot ulcer (DFU) infections and guidelines detailing the most common pathogens and their respective antimicrobial susceptibilities are available. While Gram-positive cocci, mainly Staphylococcus species (spp.), were the most common organisms cultured from DFU in the United States, the Gram-negative Pseudomonas spp. were found to be the most common in some Middle Eastern countries. In Lebanon, however, such studies remain scarce. This study, conducted in Lebanon, investigated the most common organisms in DFU infections and their antimicrobial profiles.
    Methodology: We collected data from all documented diabetic foot infections between January 2015 and March 2016, 128 participants total, from 5 different hospitals in various regions of Lebanon.
    Results: Among all isolates, Enterobacteriaceae (42%), Pseudomonas spp. (18.6%) and methicillin-sensitive Staphylococcus aureus (MSSA) (15.3%) were the most frequent bacteria. In addition, 72% of Pseudomonas spp. were susceptible to ciprofloxacin and 63.6% of Enterobacteriaceae were susceptible to either amoxicillin/clavulanate or ciprofloxacin, 91% were susceptible to piperacillin/tazobactam. Methicillin-resistant Staphylococcus aureus (MRSA) was only found in hospitalized patients or those who received prior antibiotics. Polymicrobial infections were documented in only 38% of patients.
    Conclusion: In Lebanon, the most appropriate empirical oral outpatient treatment would be a combination of amoxicillin/clavulanate and ciprofloxacin. As for admitted patients who have failed the oral regimen, piperacillin/tazobactam would then be the treatment of choice.
    Language English
    Publishing date 2018-05-31
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2394024-4
    ISSN 1972-2680 ; 2036-6590
    ISSN (online) 1972-2680
    ISSN 2036-6590
    DOI 10.3855/jidc.10063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: E. coli, K. pneumoniae and K. oxytoca community-acquired infections susceptibility to cephalosporins and other antimicrobials in Lebanon.

    Moghnieh, Rima A / Musharrafieh, Umayya M / Husni, Rola N / Abboud, Edmond / Haidar, Mohammed / Abboud, Emma / Abou Shakra, Diaa

    Le Journal medical libanais. The Lebanese medical journal

    2014  Volume 62, Issue 2, Page(s) 107–112

    Abstract: Objectives: Cephalosporin resistance in Enterobacteriaceae has become an international concern. This article studies the distribution and trends of resistance of E. coli and Klebsiella species isolated from clinical specimens representing community- ... ...

    Abstract Objectives: Cephalosporin resistance in Enterobacteriaceae has become an international concern. This article studies the distribution and trends of resistance of E. coli and Klebsiella species isolated from clinical specimens representing community-acquired infections.
    Methods: E. coli, K. pneumoniae and K. oxytoca specimen strains were collected from patients presenting to three acute care hospitals in Lebanon. The study period extended from January 2010 to January 2011 and included patients presenting with community-acquired infections only. Automated microbiological system (VITEK 2) was used for identification and antimicrobial susceptibilities.
    Results: Data from consecutive non-duplicate 589 E. coli, 54 K. pneumoniae and 40 K. oxytoca strains were collected of which 69.5%, 74.0% and 67.5% were susceptible to 3rd generation cephalosporins (3GC), respectively. Out of the 3GC-resistant E. coli strains, around 90% were susceptible to nitrofurantoin, 46% were susceptible to trimethoprim/sulfamethoxazole (TMP/SMX) and 53% to ciprofloxacin. The patterns of antimicrobial susceptibility in the two Klebsiella species did not parallel those in the E. coli strains. Yet, the number of Klebsiella strains was much lower than that of E. coli. Of note is that the 3GC-resistant strains of both Klebsiella species were less susceptible to nitrofurantoin compared to the overall groups reaching a maximum of 30%. However, susceptibility to TMP/SMX was much higher reaching 79% and that of ciprofloxacin reaching 86%.
    Conclusion: Clinical specimens of E. coli, Klebsiella pneumoniae and Klebsiella oxytoca, causing community-acquired infections in Lebanon showed that these organisms are significantly resistant to many antibiotics. These patterns of resistance were mainly to internationally recommended drugs for empiric treatment of community-acquired infections like community-acquired urinary tract infections (UTIs) and intra-abdominal infections. Therefore, continuous antimicrobial susceptibility surveillance is advisable to track emerging resistance in Enterobacteriaceae and national guidelines would be tailored accordingly.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Cephalosporins/pharmacology ; Cephalosporins/therapeutic use ; Community-Acquired Infections/drug therapy ; Community-Acquired Infections/microbiology ; Drug Resistance, Bacterial ; Escherichia coli/drug effects ; Escherichia coli Infections/drug therapy ; Escherichia coli Infections/microbiology ; Humans ; Klebsiella Infections/drug therapy ; Klebsiella Infections/microbiology ; Klebsiella oxytoca/drug effects ; Klebsiella pneumoniae/drug effects ; Lebanon ; Microbial Sensitivity Tests
    Chemical Substances Anti-Bacterial Agents ; Cephalosporins
    Language English
    Publishing date 2014-07-08
    Publishing country Lebanon
    Document type Journal Article
    ZDB-ID 412536-8
    ISSN 0023-9852
    ISSN 0023-9852
    DOI 10.12816/0004106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 296: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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