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  1. Article ; Online: Central composite design driven optimization of sustainable stability indicating HPLC method for the determination of Tigecycline and greenness assessment.

    Hafez, Hani Mohammed / Barghash, Sona Soliman / Soliman, Marwa M / Soltan, Moustafa K / Abd Elrahman, Mohamed / Katamesh, Noha Salah

    F1000Research

    2023  Volume 12, Page(s) 341

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Tigecycline ; Chromatography, High Pressure Liquid/methods ; Anti-Bacterial Agents ; Ethanol ; Water
    Chemical Substances Tigecycline (70JE2N95KR) ; Anti-Bacterial Agents ; Ethanol (3K9958V90M) ; Water (059QF0KO0R)
    Language English
    Publishing date 2023-08-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2699932-8
    ISSN 2046-1402 ; 2046-1402
    ISSN (online) 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.130861.2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Application of different counseling strategies for better adult asthma control.

    Mohamed, Basma M E / Laz, Nabila / Saeed, Haitham / Alghamdi, Saleh / AbdElrahman, Mohamed / Abdelrahim, Mohamed E A / Rabea, Hoda

    The Journal of asthma : official journal of the Association for the Care of Asthma

    2023  , Page(s) 1–8

    Abstract: Objective: We aimed to compare the effectiveness of three distinct counseling methods to determine the most effective approach.: Methods: In this prospective cohort study with a two-month follow-up, A group of non-smoking adults, aged 19-60 years, ... ...

    Abstract Objective: We aimed to compare the effectiveness of three distinct counseling methods to determine the most effective approach.
    Methods: In this prospective cohort study with a two-month follow-up, A group of non-smoking adults, aged 19-60 years, were randomly collected at outpatients clinic with prior asthma diagnosis, based on the forced expiratory volume in one seconds to forced vital capacity ratio (FEV1/FVC) and the guidelines outlined by the Global Initiative for Asthma (GINA), At the baseline assessment, all patients, underwent FEV1/FVC measurements, asthma symptom evaluations using Asthma Control Test (ACT), Asthma Control Questionnaire (ACQ), and GINA symptoms control assessment questionnaire, and assessment of pressurized metered-dose inhaler (pMDI) usage. The patients were divided into three groups, each assigned a distinct counseling strategy: traditional verbal counseling, advanced counseling utilizing the Asthma smartphone-application, and a combination of advanced-verbal counseling. We conducted a two-month monitoring period for all three groups.
    Results: Significant differences (
    Conclusion: The study findings indicate that the combining advanced-verbal counseling by incorporating the Asthma smartphone-application alongside traditional verbal counseling is a more effective approach for improving asthma control in adults.
    Language English
    Publishing date 2023-12-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 603816-5
    ISSN 1532-4303 ; 0277-0903
    ISSN (online) 1532-4303
    ISSN 0277-0903
    DOI 10.1080/02770903.2023.2300709
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Functional Bi

    Cendrowski, Krzysztof / Federowicz, Karol / Techman, Mateusz / Chougan, Mehdi / El-Khayatt, Ahmed M / Saudi, H A / Kędzierski, Tomasz / Mijowska, Ewa / Strzałkowski, Jarosław / Sibera, Daniel / Abd Elrahman, Mohamed / Sikora, Pawel

    Nanomaterials (Basel, Switzerland)

    2024  Volume 14, Issue 2

    Abstract: This study presents a new approach towards the production of sol-gel silica-coated ... ...

    Abstract This study presents a new approach towards the production of sol-gel silica-coated Bi
    Language English
    Publishing date 2024-01-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano14020168
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The Effect of Lightweight Concrete Cores on the Thermal Performance of Vacuum Insulation Panels.

    Chung, Sang-Yeop / Sikora, Pawel / Stephan, Dietmar / Abd Elrahman, Mohamed

    Materials (Basel, Switzerland)

    2020  Volume 13, Issue 11

    Abstract: The performance of vacuum insulation panels (VIPs) is strongly affected by several factors, such as panel thickness, design, quality of vacuum, and material type. In particular, the core materials inside VIPs significantly influence their overall ... ...

    Abstract The performance of vacuum insulation panels (VIPs) is strongly affected by several factors, such as panel thickness, design, quality of vacuum, and material type. In particular, the core materials inside VIPs significantly influence their overall performance. Despite their superior insulation performance, VIPs are limited in their widespread use as structural materials, because of their low material strength and the relatively expensive core materials. As an alternative core material that can compensate these limitations, foamed concrete, a type of lightweight concrete with very low density, can be used. In this study, two different types of foamed concrete were used as VIP core materials, with their effects on the thermal behavior of the VIPs having been evaluated using experimental and numerical methods. To confirm and generate numerical models for VIP analysis, micro-computed tomography (micro-CT) was utilized. The obtained results show that insulation effects increase effectively when panels with lightweight concrete are in a vacuum, and both foamed concrete types can be effectively used as VIP core materials.
    Language English
    Publishing date 2020-06-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma13112632
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Accuracy and safety of CO2 digital subtraction angiography during endovascular treatment of symptomatic peripheral artery occlusive disease. A prospective study on Egyptian patients

    Mohammed H. Abdelbary / Abd Elrahman Mohamed / Atef Abdel-Hamid

    The Egyptian Journal of Radiology and Nuclear Medicine, Vol 49, Iss 1, Pp 76-

    2018  Volume 84

    Abstract: Purpose: To study the efficacy, safety and clinical outcome of carbon dioxide DSA during angioplasty procedures for patients with predominant femoropopliteal segment occlusive lesions, aiming to reduce possible allergic reactions and potential ... ...

    Abstract Purpose: To study the efficacy, safety and clinical outcome of carbon dioxide DSA during angioplasty procedures for patients with predominant femoropopliteal segment occlusive lesions, aiming to reduce possible allergic reactions and potential nephrotoxicity. Materials and methods: The study included eighteen Egyptian patients in a prospective manner, with evidence of predominant femoropopliteal arterial occlusive disease by Duplex study. All the selected patients had borderline renal functions with serum creatinine levels between 1.5 mg/dL and 2 mg/dL. Every patient was scheduled for a percutaneous endovascular therapy during which CO2 DSA and small volume injections of ICM DSA of the diseased segment and distal arterial tree were done. We analyzed our results emphasizing the technical success, CO2 DSA related complications, allergic reactions and intolerance. We also correlated the amount of contrast injected with the serum creatinine levels as well as the degree of opacification of the diseased segment. Results: We were able to achieve technical success in 88% of our cases except in two patients who had TASC D lesions. The average fluoroscopy time in our study was about 100 min. There were no CO2 related complications or allergic reactions. Five patients were intolerant to CO2 injection related pains and repeated injections were performed with smaller volumes. The injected mean volume of CO2 was 76.1 mL while the mean volume of ICM used per patient was 24 mL. Most patients showed non-significant rise of serum creatinine levels at both samples. Moreover, the results of the “Good” score & the “Fair” score for the CO2 DSA image quality plotted by the interobserver agreement was about 40% & 33% respectively from the total number of patients included in the study. Conclusion: CO2 DSA is a non-nephrotoxic alternative to traditional ICM DSA that could be safely used and well tolerated during endovascular management of lower extremity symptomatic arterial disease. When selectively delivered to the ...
    Keywords Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Subject code 610 ; 616
    Language English
    Publishing date 2018-03-01T00:00:00Z
    Publisher SpringerOpen
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: The Influence of Nanomaterials on the Thermal Resistance of Cement-Based Composites-A Review.

    Sikora, Pawel / Abd Elrahman, Mohamed / Stephan, Dietmar

    Nanomaterials (Basel, Switzerland)

    2018  Volume 8, Issue 7

    Abstract: Exposure to elevated temperatures has detrimental effects on the properties of cementitious composites, leading to irreversible changes, up to total failure. Various methods have been used to suppress the deterioration of concrete under elevated ... ...

    Abstract Exposure to elevated temperatures has detrimental effects on the properties of cementitious composites, leading to irreversible changes, up to total failure. Various methods have been used to suppress the deterioration of concrete under elevated temperature conditions. Recently, nanomaterials have been introduced as admixtures, which decrease the thermal degradation of cement-based composites after exposure to high temperatures. This paper presents a comprehensive review of recent developments related to the effects of nanoparticles on the thermal resistance of cementitious composites. The review provides an updated report on the effects of temperature on the properties of cement-based composites, as well as a detailed analysis of the available literature regarding the inclusion of nanomaterials and their effects on the thermal degradation of cementitious composites. The data from the studies reviewed indicate that the inclusion of nanoparticles in composites protects from strength loss, as well as contributing to a decrease in disruptive cracking, after thermal exposure. From all the nanomaterials presented, nanosilica has been studied the most extensively. However, there are other nanomaterials, such as carbon nanotubes, graphene oxide, nanoclays, nanoalumina or nano-iron oxides, that can be used to produce heat-resistant cementitious composites. Based on the data available, it can be concluded that the effects of nanomaterials have not been fully explored and that further investigations are required, so as to successfully utilize them in the production of heat-resistant cementitious composites.
    Language English
    Publishing date 2018-06-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano8070465
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The diagnostic utility of microRNA 222-3p, microRNA 21-5p, and microRNA 122-5p for HCV-related hepatocellular carcinoma and its relation to direct-acting antiviral therapy.

    Khairy, Ahmed / Ibrahim, Marwa K / AbdElrahman, Mohamed / Fouad, Rabab / Zayed, Naglaa / Ayman, Yosra / Abdellatef, Zeinab / Yosry, Ayman

    Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology

    2022  Volume 23, Issue 2, Page(s) 108–114

    Abstract: Background and study aims: Recent reports have emphasized the increased risk of hepatocellular carcinoma (HCC) post direct-acting antiviral (DAAs) therapy in chronic hepatitis C virus (HCV) patients. Unfortunately, reliable diagnostic markers for HCC ... ...

    Abstract Background and study aims: Recent reports have emphasized the increased risk of hepatocellular carcinoma (HCC) post direct-acting antiviral (DAAs) therapy in chronic hepatitis C virus (HCV) patients. Unfortunately, reliable diagnostic markers for HCC are still lacking. In this context, serum microRNAs have become promising diagnostic targets. Thus, the current study aims to elaborate the diagnostic utility of microRNA 122-5p, microRNA 21-5p, and microRNA 222-3p in the serum of Egyptian patients presenting with HCV infection and HCC post DAA therapy.
    Patients and methods: Qiagen specific microRNA assays were utilized to assess the expression levels of the chosen microRNAs in the serum samples collected from 3 groups: (1) 50 patients with HCV-related HCC, (2) 50 patients with HCC post DAA therapy, and 20 healthy control.
    Results: The mean serum values of microRNA 21-5p and microRNA 122-5p were significantly lower in the HCC post DAA therapy group than in both the group with HCC without prior exposure to DAAs (P < 0.001) and control group (P 0.05 and 0.02, respectively). A significant upregulation was observed for both microRNA 21-5p and microRNA 122-5p in the HCV-related HCC group compared with the control group (P < 0.001 and = 0.011, respectively). On the other hand, the mean serum value of microRNA 222-3p was significantly raised in the HCC post DAA therapy group than in the control group (P = 0.007), whereas no statistically significant difference was observed between both groups with HCC and between the group with HCV-related HCC without prior exposure to DAAs and control group.
    Conclusion: This is the first study to introduce microRNA 21-5p, microRNA 122-5p and microRNA 222-3p as noninvasive biomarker candidates for HCC post DAA therapy. Their altered expression among treatment-naive HCC and HCC post DAA therapy might assume a different microRNA profiling in both HCC groups.
    MeSH term(s) Antiviral Agents/therapeutic use ; Carcinoma, Hepatocellular/virology ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/drug therapy ; Hepatitis C, Chronic/pathology ; Humans ; Liver Neoplasms/virology ; MicroRNAs/genetics
    Chemical Substances Antiviral Agents ; MIRN122 microRNA, human ; MIRN21 microRNA, human ; MIRN222 microRNA, human ; MicroRNAs
    Language English
    Publishing date 2022-05-21
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2502114-X
    ISSN 2090-2387 ; 1687-1979
    ISSN (online) 2090-2387
    ISSN 1687-1979
    DOI 10.1016/j.ajg.2022.04.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Salivary α2-macroglobulin as a marker for glycemic control in patients with type 2 diabetes mellitus

    Ayman Abd-Elrahman Mohamed Nsr-Allah / Saad El-Osh / Azza M Ahmed / Sara Hazem

    The Egyptian Journal of Internal Medicine, Vol 31, Iss 2, Pp 155-

    2019  Volume 163

    Abstract: Introduction Panic from needle and the cost can discourage some diabetic patients from monitoring their blood glucose levels in a regular manner, so there is a critical need to find a new cost-effective, painless, and sensitive glucose-detection method. ... ...

    Abstract Introduction Panic from needle and the cost can discourage some diabetic patients from monitoring their blood glucose levels in a regular manner, so there is a critical need to find a new cost-effective, painless, and sensitive glucose-detection method. Many studies have found that α2-macroglobulin (A2MG) concentrations are increased in the blood of both type 1 and type 2 diabetic patients. Aim The aim of the article is to study the salivary A2MG value as a marker for glycemic control in patients with type 2 diabetes mellitus (DM). Patients and methods A total of 60 patients were included and divided into three groups. Group 1 included patients with type 2 DM with glycosylated hemoglobin (HbA1c) levels more than or equal to 7% (inadequate glycemic control). Group 2 included patients with type 2 DM with HbA1c levels less than 7% (adequate glycemic control). Group 3 included healthy persons (control group). All patients were subjected to the following: thorough history taking, full physical examination, and laboratory investigations, including fasting blood glucose, cholesterol, triglycerides, HbA1c, and salivary A2MG. Results There were statistical significant relations between salivary A2MG and both BMI and duration of diabetes (P<0.05) in type 2 uncontrolled diabetes group but not in controlled group (P>0.05). There were statistically significant positive correlations between levels of salivary A2MG and HbA1c, cholesterol, triglycerides, fasting blood sugar, duration of DM, BMI, and age. The best cutoff value of salivary A2MG as a predictor of bad glycemic control, in relation to HbA1c, was more than or equal to 645 ng/ml, with area under the receiver operating characteristic curve of 0.92, sensitivity of 91.7%, specificity of 90%, and P value of less than 0.001. Conclusion and recommendation With the advantages of rapid, accessible, sensitive, cost-effective, and noninvasive method, salivary A2MG is a promising biological marker for glycemic control in patients with type 2 DM.
    Keywords α2-macroglobulin ; salivary α2-macroglobulin ; type 2 diabetes mellitus ; Internal medicine ; RC31-1245
    Subject code 616
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher SpringerOpen
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Can lung ultrasound assist in the decision of weaning mechanically ventilated neonates?

    Mohamed Adel Eltomey / Ahmed Hany Shehata / Mohamed Abd Ellatiff Nassar / Abd Elrahman Mohamed Elmashad

    The Egyptian Journal of Radiology and Nuclear Medicine, Vol 50, Iss 1, Pp 1-

    2019  Volume 7

    Abstract: Abstract Background Mechanical ventilation is widely used in neonates presenting with respiratory distress; however, it is not without complications. Early weaning of neonates is vital however the process of extubation is difficult to determine precisely. ...

    Abstract Abstract Background Mechanical ventilation is widely used in neonates presenting with respiratory distress; however, it is not without complications. Early weaning of neonates is vital however the process of extubation is difficult to determine precisely. The use of lung ultrasound in neonates is recently accepted as a reliable tool in the assessment of several lung conditions. The aim of this study was to assess the use of lung ultrasound score as a quantitative method to assist in the decision of weaning mechanically ventilated neonates. Results The study was conducted on 40 neonates admitted to the NICU with different causes of respiratory distress needing respiratory support by mechanical ventilation. Lung ultrasound was performed using a linear superficial probe at least three times, at admission, before switching mechanical ventilation mode and before weaning. The initial lung ultrasound score for all patients was between 9 and 36 (mean 25 ± 6.97, median 26) with the 11 patients initiated on Sync. Intermittent ventilation (SIMV) showing significantly lower scores than those initiated on assist/control ventilation (ACV). Patients successfully switched from ACV to SIMV showed significantly lower scores than those who failed. Patients successfully weaned from SIMV showed significantly lower scores than those who failed. ROC analysis showed a cut-off score of ≤ 14 had 85% sensitivity and 100% specificity for a successful switch between ACV to SIMV. It also showed that a score ≤ 6 had 87.5% sensitivity and 100% specificity for successful extubation. Conclusion The use of quantitative lung ultrasound scores in assessment of mechanically ventilated neonates shows a great potential in aiding the process of weaning.
    Keywords Lung ; Ultrasound ; Mechanical ventilation ; Neonates ; Weaning ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Subject code 610
    Language English
    Publishing date 2019-11-01T00:00:00Z
    Publisher SpringerOpen
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Stability indicating liquid chromatography method for the analysis of Vecuronium bromide: study of the degradation profile.

    Abd Elrahman, Mohamed K / El Houssini, Ola M / Fahem, Diana K / Zaazaa, Hala E

    Heliyon

    2020  Volume 6, Issue 3, Page(s) e03530

    Abstract: Neuromuscular blocker agent namely; Vecuronium bromide (VEC) was quantified through developing a simple reversed phase liquid chromatographic (RP-LC) method, in drug substance and in drug product. The proposed method could quantify VEC in the presence of ...

    Abstract Neuromuscular blocker agent namely; Vecuronium bromide (VEC) was quantified through developing a simple reversed phase liquid chromatographic (RP-LC) method, in drug substance and in drug product. The proposed method could quantify VEC in the presence of its degradation products produced from exposing VEC to different stress conditions as recommended by the International Conference on harmonization (ICH) guidelines. Acidic (2M HCl), basic (2MNaOH) hydrolysis, oxidation (3% H
    Language English
    Publishing date 2020-03-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2020.e03530
    Database MEDical Literature Analysis and Retrieval System OnLINE

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