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  1. Article: Fertility Preserving Surgery Outcomes for Ovarian Malignancy: Data from a Tertiary Cancer Centre in Central London.

    Gaughran, Jonathan / Rosen O'Sullivan, Hannah / Lyne, Tom / Abdelbar, Ahmed / Abdalla, Mostafa / Sayasneh, Ahmad

    Journal of clinical medicine

    2022  Volume 11, Issue 11

    Abstract: Fertility Sparing Surgery (FSS) appears to be a safe means of treating early-stage ovarian cancer based on relatively limited evidence. However, there is currently insufficient evidence to aid women in counselling about their potential fertility outcomes. ...

    Abstract Fertility Sparing Surgery (FSS) appears to be a safe means of treating early-stage ovarian cancer based on relatively limited evidence. However, there is currently insufficient evidence to aid women in counselling about their potential fertility outcomes. The aim of this study was to assess the reproductive outcomes and prognosis of women who have undergone FSS for ovarian malignancy. Between 1 June 2008 and 1 June 2018, a retrospective review of a clinical database was conducted to identify all consecutive patients who underwent FSS in a central London gynaecological oncology centre. All patients with a histological diagnosis of ovarian malignancy (excluding borderline ovarian tumours) were eligible. All identified patients were then prospectively called into a follow up and asked to complete a questionnaire about their fertility outcomes. A total of 47 women underwent FSS; 36 were included in this study. The mean age was 30.3 years (95% Confidence Interval [CI]: 27.6 to 33.0 years). During the study period, 17/36 (47.2%) of the women had attempted to conceive following surgery, with a successful live birth rate of 52.9% (9/17). The mean time of recurrence was 125.3 months (95% CI: 106.5−144.1 months). The mean time to death was 139.5 months (95% CI: 124.3−154.8). The cancer grade, tumour stage and use of Assisted Reproductive Technology (ART) were the main factors significantly associated with the risk of recurrence and death. In conclusion, this study suggests that a large proportion of women will not attempt to conceive following FSS. For those who do attempt to conceive, the likelihood of achieving a live birth is high. However, careful counselling about the higher risk of recurrence and worse survival for women with high grade cancer, disease Stage > IA and potentially those who undergo ART is essential before contemplating FFS.
    Language English
    Publishing date 2022-06-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11113195
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: A Geometric Approach to Modeling, Simulation and Control

    Abdelgalil, Mahmoud / Eldesoukey, Asmaa / Elshabrawy, Esraa / Abdalla, Mostafa

    2020  

    Abstract: In this work, we utilize discrete geometric mechanics to derive a 2nd-order variational integrator so as to simulate rigid body dynamics. The developed integrator is to simulate the motion of a free rigid body and a quad-rotor. We demonstrate the ... ...

    Abstract In this work, we utilize discrete geometric mechanics to derive a 2nd-order variational integrator so as to simulate rigid body dynamics. The developed integrator is to simulate the motion of a free rigid body and a quad-rotor. We demonstrate the effectiveness of the simulator and its accuracy in long term integration of mechanical systems without energy damping. Furthermore, this work deals with the geometric nonlinear control problem for rigid bodies where backstepping controller is designed for full tracking of position and orientation. The attitude dynamics and control are defined on \textbf{SO(3)} to avoid singularities associated with Euler angles or ambiguities accompanying quaternion representation. The controller is shown to track large rotation attitude signals close to $180^\circ$ achieving almost globally asymptotic stability for rotations. A Quad-rotor is presented as an example of an under-actuated system with nonlinear model on which we apply the backstepping control law. In addition, an aerodynamic model aiming at deriving the aerodynamic forces and torques acting on rotors is added for realistic simulation purposes and to testify the effectiveness of the derived control method.
    Keywords Mathematics - Optimization and Control
    Subject code 629
    Publishing date 2020-05-14
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Mixed Endometrial Epithelial Carcinoma: Epidemiology, Treatment and Survival Rates-A 10-Year Retrospective Cohort Study from a Single Institution.

    Pappa, Christina / Le Thanh, Valentina / Smyth, Sarah Louise / Zouridis, Andreas / Kashif, Ammara / Sadeghi, Negin / Sattar, Alisha / Damato, Stephen / Abdalla, Mostafa / Laganà, Antonio Simone / Ferrari, Federico / Kehoe, Sean / Addley, Susan / Soleymani Majd, Hooman

    Journal of clinical medicine

    2023  Volume 12, Issue 19

    Abstract: Mixed endometrial carcinoma (MEEC) refers to rare endometrial tumours that are composed of two or more distinct histotypes, at least one of which is serous or clear cell. The aim of this study was to evaluate the epidemiology, treatment outcomes and ... ...

    Abstract Mixed endometrial carcinoma (MEEC) refers to rare endometrial tumours that are composed of two or more distinct histotypes, at least one of which is serous or clear cell. The aim of this study was to evaluate the epidemiology, treatment outcomes and survival rates of patients with mixed endometrial carcinoma. The medical records of 34 patients diagnosed with MEEC between March 2010 and January 2020 were reviewed retrospectively. Clinicopathological variables and treatment strategies were assessed, and overall survival and disease-free survival rates were evaluated. The histology of endometrioid and serous component was found in 26 (76.5%) patients, followed by serous and clear-cell components (5/34, 14.5%) and mixed endometrioid serous and clear-cell components (3/34, 8.8%). The median age at diagnosis was 70 years (range 52-84), and the median follow-up time was 55 months. The 5-year disease-free survival and the 5-year overall survival were 50.4% and 52.4%, respectively. Advanced disease stage was identified as an independent predictor of inferior disease-free (<0.003) and overall survival (
    Language English
    Publishing date 2023-10-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12196373
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The Prognostic Characteristics and Recurrence Patterns of High Grade Endometrioid Endometrial Cancer: A Large Retrospective Analysis of a Tertiary Center.

    Zouridis, Andreas / Zarrindej, Kianoush / Rencher, Joshua / Pappa, Christina / Kashif, Ammara / Smyth, Sarah Louise / Sadeghi, Negin / Sattar, Alisha / Damato, Stephen / Ferrari, Federico / Laganà, Antonio Simone / Abdalla, Mostafa / Kehoe, Sean / Addley, Susan / Soleymani Majd, Hooman

    Journal of clinical medicine

    2023  Volume 12, Issue 9

    Abstract: High grade endometrioid endometrial cancer (HGEEC) is a heterogeneous group of tumors with unclear prognostic features. The aim of the present study is to evaluate the independent risk factors for recurrence and mortality and to describe the recurrence ... ...

    Abstract High grade endometrioid endometrial cancer (HGEEC) is a heterogeneous group of tumors with unclear prognostic features. The aim of the present study is to evaluate the independent risk factors for recurrence and mortality and to describe the recurrence patterns of HGEEC. Ninety-six consecutive cases of HGEEC treated with primary surgery in a single Tertiary Center were retrospectively reviewed. Clinicopathological and treatment details were recorded, and all patients were closely followed up. Disease-free, overall and cancer-specific survival rates were 83.8%, 77.8% and 83.6%, respectively. Cervical stromal involvement was independently related to recurrence (HR = 25.67; 95%CI 2.95-223.30;
    Language English
    Publishing date 2023-04-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12093141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Kasr Alainy simplified uterine preserving surgery for conservative management of placenta accreta spectrum (PAS): A modified surgical approach.

    Mousa, Abdalla / Elkhateb, Islam T / Gaafar, Hassan M / Elsherbini, Moutaz M / Mousa, Hatem / Abdalla, Mostafa / Abdelbar, Ahmed / Rida, Dana / Majd, Hooman Soleymani / Collins, Sally L

    European journal of obstetrics, gynecology, and reproductive biology

    2023  Volume 284, Page(s) 150–161

    Abstract: Objective: The incidence of placenta accreta spectrum (PAS) is rising rapidly due to the global surge in Caesarean delivery. It is associated with significant maternal morbidity and mortality. It is usually managed with Caesarean hysterectomy. However, ... ...

    Abstract Objective: The incidence of placenta accreta spectrum (PAS) is rising rapidly due to the global surge in Caesarean delivery. It is associated with significant maternal morbidity and mortality. It is usually managed with Caesarean hysterectomy. However, uterine preserving surgeries can have advantages over Caesarean hysterectomy and intentional placental retention techniques.
    Study design: We present a modified technique of uterine preserving surgery that uses a safe approach for placental bed surgical devascularization. This is followed by resection of the invaded uterine segment and uterine wall reconstruction.
    Results: The technique was used in the management of 20 patients with antenatally suspected PAS that were confirmed at laparotomy. It was successful in preserving the uterus in 18/20 (90 %) women. The mean intraoperative blood loss in was 1305 CC (SD: +361.6) with a mean operative time of 123 min (SD: ±38.7). There was only one urinary bladder injury and no other maternal morbidity.
    Conclusion: Our surgical technique is safe and may be useful for conservative surgical management of PAS, particularly in low- and middle-income countries, where access to complex resources, such as interventional radiology, is limited.
    MeSH term(s) Pregnancy ; Female ; Humans ; Male ; Placenta Accreta/surgery ; Placenta Accreta/epidemiology ; Conservative Treatment ; Retrospective Studies ; Placenta ; Hysterectomy/methods
    Language English
    Publishing date 2023-03-24
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2023.03.026
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