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Article ; Online: Unveiling the Anti-Cholera and Active Diabetic Renoprotective Compounds of Maqian Essential Oil: A Computational and Molecular Dynamics Study.

Dahab, Mahmoud / Zhang, Ping / Al-Mijalli, Samiah Hamad / Abdallah, Emad M

2023 Volume 28, Issue 24

Abstract: Cholera is an exceptionally aggressive infectious disease characterized by the potential to induce acute, copious, watery diarrhea of considerable severity and renal inflammation. Diabetic nephropathy is a serious complication of diabetes mellitus that ... ...

Abstract	Cholera is an exceptionally aggressive infectious disease characterized by the potential to induce acute, copious, watery diarrhea of considerable severity and renal inflammation. Diabetic nephropathy is a serious complication of diabetes mellitus that can lead to kidney failure through inflammation; thus, anti-inflammatory agents are promising therapies for diabetic nephropathy. Previous studies have shown that the essential oil of
MeSH term(s)	Mice ; Animals ; Diabetic Nephropathies/metabolism ; Oils, Volatile/pharmacology ; Oils, Volatile/therapeutic use ; Cholera Toxin/chemistry ; Cholera Toxin/metabolism ; Cholera Toxin/therapeutic use ; Diabetes Mellitus, Experimental/drug therapy ; Cholera/complications ; Cholera/drug therapy ; Molecular Dynamics Simulation ; NF-E2-Related Factor 2/metabolism ; Inflammation/drug therapy ; Anti-Inflammatory Agents/pharmacology
Chemical Substances	alpha-terpineol (21334LVV8W) ; Oils, Volatile ; Cholera Toxin (9012-63-9) ; NF-E2-Related Factor 2 ; Anti-Inflammatory Agents
Language	English
Publishing date	2023-12-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28247954
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Zs.MO 81: Show issues

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Article: Antibacterial efficiency of the Sudanese Roselle (Hibiscus sabdariffa L.), a famous beverage from Sudanese folk medicine.

Abdallah, Emad Mohamed

Journal of intercultural ethnopharmacology

2016 Volume 5, Issue 2, Page(s) 186–190

Abstract: Background: Hibiscus sabdariffa L. is a plant native to tropical Africa and intensively cultivated in Sudan. Its calyces are widely consumed with many uses in Sudanese folk medicine.: Materials and methods: The dried calyces of H. sabdariffa were ... ...

Abstract	Background: Hibiscus sabdariffa L. is a plant native to tropical Africa and intensively cultivated in Sudan. Its calyces are widely consumed with many uses in Sudanese folk medicine. Materials and methods: The dried calyces of H. sabdariffa were subjected to soak in 80% v/v methanol to get the methanolic extract, which was tested against five Gram-negative and three Gram-positive referenced bacterial strains using disc diffusion method. Selected bioactive phytochemical compounds were also investigated using qualitative methods. Results: The results of the antibacterial test indicate that the methanol extract of H. sabdariffa calyces contained effective antibacterial agent(s), revealed a considerable zone of inhibition against all tested Gram-negative and Gram-positive bacteria, and it was a competitor to gentamicin and greatly higher than penicillin which showed weak or no effect. Conclusion: The results of current investigation support the folk medicine application of this plant against different microbial ailments and suggest it as a promising source for new antibacterial agents.
Language	English
Publishing date	2016-03-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2721488-6
ISSN	2146-8397
ISSN	2146-8397
DOI	10.5455/jice.20160320022623
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Article: Back to Nature: Medicinal Plants as Promising Sources for Antibacterial Drugs in the Post-Antibiotic Era.

Abdallah, Emad M / Alhatlani, Bader Y / de Paula Menezes, Ralciane / Martins, Carlos Henrique Gomes

Plants (Basel, Switzerland)

2023 Volume 12, Issue 17

Abstract: Undoubtedly, the advent of antibiotics in the 19th century had a substantial impact, increasing human life expectancy. However, a multitude of scientific investigations now indicate that we are currently experiencing a phase known as the post-antibiotic ... ...

Abstract	Undoubtedly, the advent of antibiotics in the 19th century had a substantial impact, increasing human life expectancy. However, a multitude of scientific investigations now indicate that we are currently experiencing a phase known as the post-antibiotic era. There is a genuine concern that we might regress to a time before antibiotics and confront widespread outbreaks of severe epidemic diseases, particularly those caused by bacterial infections. These investigations have demonstrated that epidemics thrive under environmental stressors such as climate change, the depletion of natural resources, and detrimental human activities such as wars, conflicts, antibiotic overuse, and pollution. Moreover, bacteria possess a remarkable ability to adapt and mutate. Unfortunately, the current development of antibiotics is insufficient, and the future appears grim unless we abandon our current approach of generating synthetic antibiotics that rapidly lose their effectiveness against multidrug-resistant bacteria. Despite their vital role in modern medicine, medicinal plants have served as the primary source of curative drugs since ancient times. Numerous scientific reports published over the past three decades suggest that medicinal plants could serve as a promising alternative to ineffective antibiotics in combating infectious diseases. Over the past few years, phenolic compounds, alkaloids, saponins, and terpenoids have exhibited noteworthy antibacterial potential, primarily through membrane-disruption mechanisms, protein binding, interference with intermediary metabolism, anti-quorum sensing, and anti-biofilm activity. However, to optimize their utilization as effective antibacterial drugs, further advancements in omics technologies and network pharmacology will be required in order to identify optimal combinations among these compounds or in conjunction with antibiotics.
Language	English
Publishing date	2023-08-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants12173077
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Article ; Online: Pharmacoinformatics and Breed-Based De Novo Hybridization Studies to Develop New Neuraminidase Inhibitors as Potential Anti-Influenza Agents.

Lotfi, Bourougaa / Mebarka, Ouassaf / Alhatlani, Bader Y / Abdallah, Emad M / Kawsar, Sarkar M A

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 18

Abstract: Influenza represents a profoundly transmissible viral ailment primarily afflicting the respiratory system. Neuraminidase inhibitors constitute a class of antiviral therapeutics employed in the management of influenza. These inhibitors impede the ... ...

Abstract	Influenza represents a profoundly transmissible viral ailment primarily afflicting the respiratory system. Neuraminidase inhibitors constitute a class of antiviral therapeutics employed in the management of influenza. These inhibitors impede the liberation of the viral neuraminidase protein, thereby impeding viral dissemination from the infected cell to host cells. As such, neuraminidase has emerged as a pivotal target for mitigating influenza and its associated complications. Here, we apply a de novo hybridization approach based on a breed-centric methodology to elucidate novel neuraminidase inhibitors. The breed technique amalgamates established ligand frameworks with the shared target, neuraminidase, resulting in innovative inhibitor constructs. Molecular docking analysis revealed that the seven synthesized breed molecules (designated Breeds 1-7) formed more robust complexes with the neuraminidase receptor than conventional clinical neuraminidase inhibitors such as zanamivir, oseltamivir, and peramivir. Pharmacokinetic evaluations of the seven breed molecules (Breeds 1-7) demonstrated favorable bioavailability and optimal permeability, all falling within the specified parameters for human application. Molecular dynamics simulations spanning 100 nanoseconds corroborated the stability of these breed molecules within the active site of neuraminidase, shedding light on their structural dynamics. Binding energy assessments, which were conducted through MM-PBSA analysis, substantiated the enduring complexes formed by the seven types of molecules and the neuraminidase receptor. Last, the investigation employed a reaction-based enumeration technique to ascertain the synthetic pathways for the synthesis of the seven breed molecules.
MeSH term(s)	Humans ; Neuraminidase/genetics ; Influenza, Human/drug therapy ; Influenza, Human/genetics ; Molecular Docking Simulation ; Hybridization, Genetic ; Antiviral Agents/pharmacology ; Enzyme Inhibitors/pharmacology ; Central Nervous System Depressants
Chemical Substances	Neuraminidase (EC 3.2.1.18) ; Antiviral Agents ; Enzyme Inhibitors ; Central Nervous System Depressants
Language	English
Publishing date	2023-09-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28186678
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Article ; Online: Plicated Sleeve Gastrectomy with Combined Mesocolon and Greater Omentum Fixation After T-Shaped Omentoplasty: How to Do it?

Abdallah, Emad / Fikry, Mohamed / Rady, Omar / Elfeki, Hossam

Obesity surgery

2020 Volume 30, Issue 3, Page(s) 1173–1174

Abstract: Introduction: This technique aims to evaluate fixation of the sleeved distal part of the stomach to the root of the transverse mesocolon and greater omentum after its shortening in a T-shaped design.: Methods: Sleeve gastrectomy is done in a standard ...

Abstract	Introduction: This technique aims to evaluate fixation of the sleeved distal part of the stomach to the root of the transverse mesocolon and greater omentum after its shortening in a T-shaped design. Methods: Sleeve gastrectomy is done in a standard five-port technique. Then, we fix the distal end of the staple line using an inverting interrupted 2/0 Ticron suture. We plicate the anterior and posterior walls to invert the staple line and then fix it to the mesocolic fat below the pancreas and to the edge of the disconnected distal omentum close to the antrum. Proceeding caudally, we shorten the greater omentum in the form of a T-shaped suture that forms an omental window between the two edges of the omentum. Plication and fixation are continued upwards until the lower border of the pancreas. Then, we plicate the sleeved stomach using a 2/0 Ticron suture starting cranially near the angle of His. Results: All patients are discharged from the hospital the next day and followed-up at the clinic after the end of first and second weeks, then after 3, 6, and 12 months postoperatively. Conclusion: Plicated sleeve gastrectomy combined with mesocolon and greater omentum fixation after T-Shaped omentoplasty is safe and feasible. Long-term follow-up study is required to validate our results.
MeSH term(s)	Follow-Up Studies ; Gastrectomy ; Humans ; Laparoscopy ; Mesocolon/surgery ; Obesity, Morbid/surgery ; Omentum/surgery
Language	English
Publishing date	2020-01-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1070827-3
ISSN	1708-0428 ; 0960-8923
ISSN (online)	1708-0428
ISSN	0960-8923
DOI	10.1007/s11695-019-04382-6
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Zs.A 3381: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
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Article ; Online: Effect of body posture on stability and balance of occlusal contacts.

Abe, Ken-Ichi / Sakaguchi, Kiwamu / Mehta, Noshir R / Correa, Leopoldo P / Abdallah, Emad F / Yokoyama, Atsuro

Cranio : the journal of craniomandibular practice

2022 , Page(s) 1–11

Abstract: Objective: To evaluate the effect of body posture on occlusal contact.: Methods: A total of 30 healthy subjects were evaluated. T-Scan™ III was used to analyze the center of occlusal force (COF) and occlusal force distribution while subjects remained ...

Abstract	Objective: To evaluate the effect of body posture on occlusal contact. Methods: A total of 30 healthy subjects were evaluated. T-Scan™ III was used to analyze the center of occlusal force (COF) and occlusal force distribution while subjects remained supine (SP), upright sitting with the head fixed (UP-HFI), upright sitting with the head free (UP-HFR), and natural standing (NS). Results: The total trajectory length of COF was significantly longer in NS than in SP, UP-HFI, and UP-HFR. The COF area was significantly larger in UP-HFR than in SP and UP-HFI and also significantly larger in NS than in SP, UP-HFI, and UP-HFR. The anteroposterior occlusal force distribution (AOD) in NS shifted significantly forward, compared to SP, UP-HFI, and UP-HFR. AOD in UP-HFI and UP-HFR shifted significantly forward, compared to the SP position. Conclusion: Changes in body posture affect the stability and anteroposterior balance of occlusal contacts.
Language	English
Publishing date	2022-09-13
Publishing country	England
Document type	Journal Article
ZDB-ID	632570-1
ISSN	2151-0903 ; 0886-9634
ISSN (online)	2151-0903
ISSN	0886-9634
DOI	10.1080/08869634.2022.2119301
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Zs.A 2071: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
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Article ; Online: Exploring Cinnamoyl-Substituted Mannopyranosides: Synthesis, Evaluation of Antimicrobial Properties, and Molecular Docking Studies Targeting H5N1 Influenza A Virus.

Akter, Sabina / Alhatlani, Bader Y / Abdallah, Emad M / Saha, Supriyo / Ferdous, Jannatul / Hossain, Md Emdad / Ali, Ferdausi / Kawsar, Sarkar M A

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 24

Abstract: The pursuit of innovative combinations for the development of novel antimicrobial and antiviral medications has garnered worldwide interest among scientists in recent times. Monosaccharides and their glycosides, such as methyl α-d-mannopyranoside ... ...

Abstract	The pursuit of innovative combinations for the development of novel antimicrobial and antiviral medications has garnered worldwide interest among scientists in recent times. Monosaccharides and their glycosides, such as methyl α-d-mannopyranoside derivatives, play a significant role in the potential treatment of viral respiratory pathologies. This study was undertaken to investigate and assess the synthesis and spectral characterization of methyl α-d-mannopyranoside derivatives
MeSH term(s)	Molecular Docking Simulation ; Mannose ; Influenza A Virus, H5N1 Subtype ; Anti-Infective Agents/chemistry ; Anti-Bacterial Agents/chemistry ; Antifungal Agents/chemistry ; Molecular Structure ; Structure-Activity Relationship
Chemical Substances	Mannose (PHA4727WTP) ; Anti-Infective Agents ; Anti-Bacterial Agents ; Antifungal Agents
Language	English
Publishing date	2023-12-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28248001
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Article: Inhibitory Activity of

Idriss, Hajo / Siddig, Babeker / González-Maldonado, Pamela / Elkhair, H M / Alakhras, Abbas I / Abdallah, Emad M / Elzupir, Amin O / Sotelo, Pablo H

Plants (Basel, Switzerland)

2023 Volume 12, Issue 3

Abstract: Medicinal herbs have long been utilized to treat various diseases or to relieve the symptoms of some ailments for extended periods. The present investigation demonstrates the phytochemical profile, molecular docking, anti- ...

Abstract	Medicinal herbs have long been utilized to treat various diseases or to relieve the symptoms of some ailments for extended periods. The present investigation demonstrates the phytochemical profile, molecular docking, anti-
Language	English
Publishing date	2023-01-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants12030460
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Article ; Online: Marine-Derived Compounds as Potential Inhibitors of Hsp90 for Anticancer and Antimicrobial Drug Development: A Comprehensive In Silico Study.

Ouassaf, Mebarka / Bourougaa, Lotfi / Al-Mijalli, Samiah Hamad / Abdallah, Emad M / Bhat, Ajmal R / A Kawsar, Sarkar M

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 24

Abstract: Marine compounds constitute a diverse and invaluable resource for the discovery of bioactive substances with promising applications in the pharmaceutical development of anti-inflammatory and antibacterial agents. In this study, a comprehensive ... ...

Abstract	Marine compounds constitute a diverse and invaluable resource for the discovery of bioactive substances with promising applications in the pharmaceutical development of anti-inflammatory and antibacterial agents. In this study, a comprehensive methodology was employed, encompassing pharmacophore modeling, virtual screening, in silico ADMET assessment (encompassing aspects of absorption, distribution, metabolism, excretion, and toxicity), and molecular dynamics simulations. These methods were applied to identify new inhibitors targeting the Hsp90 protein (heat shock protein 90), commencing with a diverse assembly of compounds sourced from marine origins. During the virtual screening phase, an extensive exploration was conducted on a dataset comprising 31,488 compounds sourced from the CMNPD database, characterized by a wide array of molecular structures. The principal objective was the development of structure-based pharmacophore models, a valuable approach when the pool of known ligands is limited. The pharmacophore model DDRRR was successfully constructed within the active sites of the Hsp90 crystal structure. Subsequent docking studies led to the identification of six compounds (CMNPD
MeSH term(s)	Molecular Docking Simulation ; Molecular Structure ; Molecular Dynamics Simulation ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Anti-Infective Agents/pharmacology ; Ligands
Chemical Substances	Antineoplastic Agents ; Anti-Infective Agents ; Ligands
Language	English
Publishing date	2023-12-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28248074
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Article: Rheumatic heart disease associated with secondary renal amyloidosis.

Abdallah, Emad Ali

Arab journal of nephrology and transplantation

2012 Volume 5, Issue 3, Page(s) 149–152

Abstract: Introduction: Amyloidosis is a disorder of protein folding in which normally soluble proteins undergo conformational changes and are deposited in the extracellular space in an abnormal fibrillar form. Accumulation of these fibrils causes progressive ... ...

Abstract	Introduction: Amyloidosis is a disorder of protein folding in which normally soluble proteins undergo conformational changes and are deposited in the extracellular space in an abnormal fibrillar form. Accumulation of these fibrils causes progressive disruption of the structure and function of tissues and organs, and the systemic forms of amyloidosis are frequently fatal. The conditions that underlie amyloid deposition may be either acquired or hereditary. Amyloid-A (AA) amyloidosis is the most common form of systemic amyloidosis worldwide, AA amyloidosis occurs in the course of chronic inflammatory diseases, hereditary periodic fevers, and with certain neoplasms such as Hodgkin disease and renal cell carcinoma. Amyloidosis due to rheumatic heart disease (RHD) is not common but can be seen. We report here a patient with RHD and AA renal amyloidosis. Case report: we present a 30 year-old Egyptian male with a history of RHD, accidently discovered to have nephrotic range proteinuria and rising serum creatinine. Serology studies were negative or normal, including antinuclear antibody (ANA) and antineutrophil cytoplasmic antibody (ANCA). C3 and C4 complement levels were normal. Kidney biopsy revealed AA renal amyloidosis. CT chest and abdomen revealed bilateral hilar and mediastinal lymphadenopathy and para-aortic lymph nodes. Endobronchial biopsy and bronchoalveolar lavage revealed non-specific chronic inflammatory changes. The patient's secondary amyloidosis was presumed to be related to the long standing RHD after exclusion of other causes of secondary amyloidosis. The patient finally died due to heart failure and acute pulmonary edema. Conclusion: Long standing RHD can lead to secondary AA amyloidosis.
MeSH term(s)	Adult ; Amyloidosis/etiology ; Humans ; Male ; Rheumatic Heart Disease/complications
Language	English
Publishing date	2012-09
Publishing country	Sudan
Document type	Case Reports ; Journal Article
ZDB-ID	2603800-6
ISSN	1858-554X
ISSN	1858-554X
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