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  1. AU="Abdallah, Hussein"
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  1. Book ; Online: Towards a GML-Enabled Knowledge Graph Platform

    Abdallah, Hussein / Mansour, Essam

    2023  

    Abstract: This vision paper proposes KGNet, an on-demand graph machine learning (GML) as a service on top of RDF engines to support GML-enabled SPARQL queries. KGNet automates the training of GML models on a KG by identifying a task-specific subgraph. This helps ... ...

    Abstract This vision paper proposes KGNet, an on-demand graph machine learning (GML) as a service on top of RDF engines to support GML-enabled SPARQL queries. KGNet automates the training of GML models on a KG by identifying a task-specific subgraph. This helps reduce the task-irrelevant KG structure and properties for better scalability and accuracy. While training a GML model on KG, KGNet collects metadata of trained models in the form of an RDF graph called KGMeta, which is interlinked with the relevant subgraphs in KG. Finally, all trained models are accessible via a SPARQL-like query. We call it a GML-enabled query and refer to it as SPARQLML. KGNet supports SPARQLML on top of existing RDF engines as an interface for querying and inferencing over KGs using GML models. The development of KGNet poses research opportunities in several areas, including meta-sampling for identifying task-specific subgraphs, GML pipeline automation with computational constraints, such as limited time and memory budget, and SPARQLML query optimization. KGNet supports different GML tasks, such as node classification, link prediction, and semantic entity matching. We evaluated KGNet using two real KGs of different application domains. Compared to training on the entire KG, KGNet significantly reduced training time and memory usage while maintaining comparable or improved accuracy. The KGNet source-code is available for further study

    Comment: 9 pages, 15 figures, accepted at ICDE 2023
    Keywords Computer Science - Databases ; Computer Science - Artificial Intelligence ; Computer Science - Machine Learning
    Subject code 004
    Publishing date 2023-03-03
    Publishing country us
    Document type Book ; Online
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  2. Article ; Online: Clinical characteristics of familial and sporadic pediatric cerebral cavernous malformations and outcomes.

    Jaman, Emade / Abdallah, Hussein M / Zhang, Xiaoran / Greene, Stephanie

    Journal of neurosurgery. Pediatrics

    2023  Volume 32, Issue 4, Page(s) 506–513

    Abstract: Objective: Cerebral cavernous malformation (CCM) is a subtype of the vascular malformations found within the cerebral cortex. Although rare and usually discovered incidentally, these vascular abnormalities can predispose patients to spontaneous cerebral ...

    Abstract Objective: Cerebral cavernous malformation (CCM) is a subtype of the vascular malformations found within the cerebral cortex. Although rare and usually discovered incidentally, these vascular abnormalities can predispose patients to spontaneous cerebral hemorrhage and subsequently lead to a myriad of neurological symptoms at presentation such as seizures and other focal neurological deficits. Although the symptoms and presentations of CCM have been adequately described in the adult population, disease characteristics and outcomes have not been extensively described in the pediatric population. Furthermore, the etiology of CCM-e.g., familial versus sporadic disease, as well as the risk factors for hemorrhage and neurological deficits and predictors of clinical and surgical outcomes-has not been adequately explored in the pediatric population. The current study attempts to classify and characterize differences in the clinical presentation, characteristics, and outcomes of CCMs between familial and sporadic cases within the pediatric population.
    Methods: A retrospective review identified 131 pediatric patients with radiographically confirmed diagnosis of CCM. All pertinent demographic and clinical variables were collected. CCM lesions were characterized using T2-weighted and susceptibility-weighted angiography (SWAN) MRI. Statistical analysis was conducted using the t-test for continuous variables, whereas categorical variables were analyzed with the Fisher exact test or chi-square test. Multivariate analysis was performed using a Cox proportional hazards model with R version 4.2.0.
    Results: This retrospective study identified 131 pediatric CCM patients with a mean age of 8.4 years, and 54% (n = 71) were male. Twenty-seven percent (n = 35) were identified as cases with familial CCM, with the remainder classified as sporadic. The most common symptoms at presentation included generalized symptoms (headaches, nausea, and vomiting) or seizures, with a large proportion of patients also presenting as asymptomatic. No significant differences were observed in severity of symptoms between patients harboring different forms of the disease. Patients with familial CCM were noted to have a larger lesion size on average (5.26 cm3 vs 1.6 cm3, p = 0.047). These patients also had a shorter progression-free follow-up interval, with 50% of patients showing progression by 888 days, compared with only 15% of sporadic CCM patients during the same period (p = 0.0019). Familial etiology of the disease and larger average lesion volume were independent, significant predictors of disease progression (p = 0.001, HR 3.29, 95% CI 1.65-6.54) and future hemorrhage (p = 0.023, HR 1.1, 95% CI 1.01-1.10), respectively.
    Conclusions: Familial and sporadic CCMs tend to present with similar characteristics within the pediatric population. Patients with the familial form of the disease have an increased risk of progressive disease in terms of further hemorrhagic events.
    MeSH term(s) Adult ; Child ; Humans ; Male ; Female ; Hemangioma, Cavernous, Central Nervous System/diagnostic imaging ; Hemangioma, Cavernous, Central Nervous System/genetics ; Retrospective Studies ; Magnetic Resonance Imaging ; Seizures
    Language English
    Publishing date 2023-07-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2403985-8
    ISSN 1933-0715 ; 1933-0707
    ISSN (online) 1933-0715
    ISSN 1933-0707
    DOI 10.3171/2023.5.PEDS22397
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  3. Article ; Online: Zinc Ions Affect Siderophore Production by Fungi Isolated from the

    Abdallah Hussein, Khalid / Joo, Jin Ho

    Journal of microbiology and biotechnology

    2018  Volume 29, Issue 1, Page(s) 105–113

    Abstract: Although siderophore compounds are mainly biosynthesized as a response to iron deficiency in the environment, they also bind with other metals. A few studies have been conducted on the impact of heavy metals on the siderophore-mediated iron uptake by ... ...

    Abstract Although siderophore compounds are mainly biosynthesized as a response to iron deficiency in the environment, they also bind with other metals. A few studies have been conducted on the impact of heavy metals on the siderophore-mediated iron uptake by microbiome. Here, we investigated siderophore production by a variety of rhizosphere fungi under different concentrations of Zn²⁺ ion. These strains were specifically isolated from the rhizosphere of
    MeSH term(s) Biodegradation, Environmental ; Chemistry Techniques, Analytical/methods ; Fungi/classification ; Fungi/metabolism ; Iron/metabolism ; Panax/microbiology ; Rhizosphere ; Siderophores/biosynthesis ; Siderophores/chemistry ; Soil Microbiology ; Soil Pollutants/metabolism ; Zinc/metabolism
    Chemical Substances Siderophores ; Soil Pollutants ; Iron (E1UOL152H7) ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2018-10-10
    Publishing country Korea (South)
    Document type Journal Article
    ISSN 1738-8872
    ISSN (online) 1738-8872
    DOI 10.4014/jmb.1712.12026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Laparoscopic extended right colectomy and splenectomy for splenic flexure cancer with isolated synchronous splenic metastases - A video vignette.

    Abdallah, Hussein / Nagliati, Carlo / Troian, Marina / Pennisi, Damiano / Balani, Alessandro

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2022  Volume 24, Issue 7, Page(s) 885–887

    MeSH term(s) Colectomy ; Colon, Transverse/surgery ; Colonic Neoplasms/surgery ; Humans ; Laparoscopy ; Neoplasms/surgery ; Splenectomy
    Language English
    Publishing date 2022-03-24
    Publishing country England
    Document type Letter ; Video-Audio Media
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.16115
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  5. Article ; Online: Expression of SidD gene and physiological characterization of the rhizosphere plant growth-promoting yeasts

    Saad S. El-Maraghy / Tohamy Anwar Tohamy / Khalid Abdallah Hussein

    Heliyon, Vol 6, Iss 7, Pp e04384- (2020)

    2020  

    Abstract: There is increasing evidence that rhizosphere microbes contribute to the stress mitigation process, but the mechanisms of this plant-microbe interaction are not yet understood. Siderophores-producing microorganisms have been considered important for ... ...

    Abstract There is increasing evidence that rhizosphere microbes contribute to the stress mitigation process, but the mechanisms of this plant-microbe interaction are not yet understood. Siderophores-producing microorganisms have been considered important for enhancing metal tolerance in plants. In this study, rhizosphere yeasts were isolated from wheat (Triticum aestivum L.) and examined for siderophores production and heavy metal resistance. Out of thirty-five isolates, only eight yeast strains showed heavy metal-resistance and plant-growth promotion properties. The highest inorganic phosphate-solubilization was shown by Trichosporon ovoides IFM 63839 (2.98 mg ml−1) and Saccharomyces cerevisiae FI25-1F (2.54 mg ml−1). Two strains, namely YEAST-6 and YEAST-16 showed high siderophore production and heavy metal-resistance, were investigated for sidD gene expression under different levels of Cd2+ and Pb2+ toxicity stress. The heavy metal-resistant yeast strains were characterized and identified based on the phenotypic characteristics and their 18S rRNA genes sequence. SidD gene expression was induced by yeasts growing under iron-limiting conditions and excess of other heavy metal, suggesting that expression of sidD gene increases in the presence of 600–800 μM heavy metal but under iron limitation. Extensive studies of the microbe-plant micronutrient interactions will enrich our understanding of the rhizosphere role in the terms of plant growth promotion.
    Keywords Microbiology ; Siderophores ; Gene expression ; SidD gene ; Rhizosphere yeasts ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 580
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
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  6. Article ; Online: Indications for upper gastrointestinal endoscopy before bariatric surgery: a multicenter study.

    Abdallah, Hussein / El Skalli, Mehdi / Mcheimeche, Hussein / Casagranda, Biagio / de Manzini, Nicolò / Palmisano, Silvia

    Surgical endoscopy

    2022  Volume 37, Issue 2, Page(s) 1342–1348

    Abstract: Background: The role of preoperative upper gastrointestinal endoscopy before bariatric surgery is still debated, and a consensus among the international scientific community is lacking. The aims of this study, conducted in three different geographic ... ...

    Abstract Background: The role of preoperative upper gastrointestinal endoscopy before bariatric surgery is still debated, and a consensus among the international scientific community is lacking. The aims of this study, conducted in three different geographic areas, were to analyze data regarding the pathological endoscopic findings and report their impact on the decision-making process and surgical management, in terms of delay in surgical operation, modification of the intended bariatric procedure, or contraindication to surgery.
    Methods: This is a multicenter cross-sectional study using data obtained from three prospective databases. The preoperative endoscopic reports, patient demographics, Body Mass Index, type of surgery, and Helicobacter pylori status were collected. Endoscopic findings were categorized into four groups: (1) normal endoscopy, (2) abnormal findings not requiring a change in the surgical approach, (3) clinically important lesions that required a change in surgical management or further investigations or therapy prior to surgery, and (4) findings that contraindicated surgery.
    Results: Between 2006 and 2020, data on 643 patients were analyzed. In all of the enrolled bariatric institutions, preoperative endoscopy was performed routinely. A total of 76.2% patients had normal and/or abnormal findings that did not required a change in surgical management; in 23.8% cases a change or a delay in surgical approach occurred. Helicobacter pylori infection was detected in 15.2% patients. No patient had an endoscopic finding contraindicating surgery.
    Conclusions: The role of preoperative UGE is to identify a wide range of pathological findings in patients with obesity that could influence the therapeutic approach, including the choice of the proper bariatric procedure. Considering the anatomical modifications, the incidence of asymptomatic pathologies, and the risk of malignancy, we support the decision of performing preoperative endoscopy for all patients eligible for bariatric operation.
    MeSH term(s) Humans ; Obesity, Morbid/surgery ; Helicobacter Infections/epidemiology ; Cross-Sectional Studies ; Preoperative Care/methods ; Helicobacter pylori ; Bariatric Surgery/methods ; Endoscopy, Gastrointestinal/methods ; Retrospective Studies
    Language English
    Publishing date 2022-10-06
    Publishing country Germany
    Document type Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639039-0
    ISSN 1432-2218 ; 0930-2794
    ISSN (online) 1432-2218
    ISSN 0930-2794
    DOI 10.1007/s00464-022-09656-2
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    Zs.A 2214: Show issues Location:
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  7. Article ; Online: Polycystic ovary syndrome preceding the diagnosis of acromegaly: a retrospective study in 97 reproductive-aged women.

    Khiyami, Anamil M / Jokar, Tahereh Orouji / Abdallah, Hussein M / Gardner, Paul A / Zenonos, Georgios A / Styer, Aaron K / Fazeli, Pouneh K

    Reproductive biology and endocrinology : RB&E

    2023  Volume 21, Issue 1, Page(s) 14

    Abstract: Background: Acromegaly is a disease of growth hormone excess that results in enlargement of extremities, abnormal glucose and lipid metabolism, and gonadal disruption. Manifestations of the disease are insidious and typically lead to a diagnostic delay ... ...

    Abstract Background: Acromegaly is a disease of growth hormone excess that results in enlargement of extremities, abnormal glucose and lipid metabolism, and gonadal disruption. Manifestations of the disease are insidious and typically lead to a diagnostic delay of 7-10 years. Classically the polycystic ovary syndrome (PCOS) phenotype is described in women with irregular menses, clinical or biochemical evidence of androgen excess, and/or multiple ovarian follicles on pelvic ultrasonography. Women with acromegaly may present with some or all of these symptoms. Our objective was to evaluate the prevalence of PCOS in patients with acromegaly and to determine if diagnosis of PCOS results in a delay in diagnosing acromegaly.
    Methods: Using patient databases at two academic health centers, we identified 97 premenopausal women aged 18-49 years old presenting with acromegaly. Data were collected regarding pelvic sonography and reproductive history, including the diagnosis of PCOS. Patients carrying the diagnosis of PCOS before their diagnosis of acromegaly were identified and the remaining patients were screened using the Rotterdam criteria to identify additional patients meeting the criteria for PCOS prior to their diagnosis of acromegaly.
    Results: Mean age of the population (n = 97) at the time of diagnosis of acromegaly was 33.4 ± 7.5 years (SD). Thirty-three percent of patients (n = 32) either carried a diagnosis of PCOS or met diagnostic criteria for PCOS before their diagnosis of acromegaly. In the subset of patients in whom data on symptom onset were available, those who met criteria for PCOS were diagnosed with acromegaly a median of 5 years [4, 9] after the onset of symptoms compared to 2 years [0.92, 3] (p =  0.006) in the patients who did not meet criteria for PCOS.
    Conclusions: Our data demonstrate a high prevalence of signs and symptoms of PCOS in reproductive-aged women with acromegaly and a longer time to diagnosis in women who meet the clinical criteria for PCOS. As screening for acromegaly is relatively simple and done with measurement of a random, non-fasting IGF-1 level that can be drawn at any time during the menstrual cycle, screening patients with PCOS for acromegaly may lessen the delay in diagnosis for reproductive-aged women with this disease.
    MeSH term(s) Female ; Humans ; Acromegaly/complications ; Acromegaly/diagnosis ; Delayed Diagnosis ; Polycystic Ovary Syndrome/complications ; Polycystic Ovary Syndrome/diagnosis ; Polycystic Ovary Syndrome/epidemiology ; Reproduction ; Retrospective Studies ; Adult
    Language English
    Publishing date 2023-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2119215-7
    ISSN 1477-7827 ; 1477-7827
    ISSN (online) 1477-7827
    ISSN 1477-7827
    DOI 10.1186/s12958-023-01057-x
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  8. Article ; Conference proceedings: Changes in Pituitary Adenoma Patient Presentation and Outcomes During the COVID Pandemic at a Pituitary Center of Excellence

    Tang, Anthony / Abdallah, Hussein M. / Chang, Yue-Fang / Zenonos, Georgios A. / Choby, Garret / Wang, Eric W. / Gardner, Paul A. / Snyderman, Carl

    Journal of Neurological Surgery Part B: Skull Base

    2024  Volume 85, Issue S 01

    Event/congress 33rd Annual Meeting North American Skull Base Society, Atlanta Marriott Marquis Atlanta, Georgia, United States, 2024-02-16
    Language English
    Publishing date 2024-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2654269-9
    ISSN 2193-634X ; 2193-6331
    ISSN (online) 2193-634X
    ISSN 2193-6331
    DOI 10.1055/s-0044-1780047
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  9. Article ; Conference proceedings: 30-Day Hospitalization Period for Pituitary Adenoma Patients: Introducing A Novel Outcome Metric

    Tang, Anthony / Abdallah, Hussein M. / Gardner, Paul / Zenonos, Georgios A. / Chang, Yue-Fang / Choby, Garret / Wang, Eric W. / Snyderman, Carl

    Journal of Neurological Surgery Part B: Skull Base

    2024  Volume 85, Issue S 01

    Event/congress 33rd Annual Meeting North American Skull Base Society, Atlanta Marriott Marquis Atlanta, Georgia, United States, 2024-02-16
    Language English
    Publishing date 2024-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2654269-9
    ISSN 2193-634X ; 2193-6331
    ISSN (online) 2193-634X
    ISSN 2193-6331
    DOI 10.1055/s-0044-1779930
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  10. Article ; Online: A Minimal Physiologically-Based Pharmacokinetic Model Demonstrates Role of the Neonatal Fc Receptor (FcRn) Competition in Drug-Disease Interactions With Antibody Therapy.

    Abdallah, Hussein M / Zhu, Andy Z X

    Clinical pharmacology and therapeutics

    2019  Volume 107, Issue 2, Page(s) 423–434

    Abstract: Disease trajectories following antibody therapy can have a significant impact on the pharmacokinetics of the antibody. Although this phenomenon can often be explained by reduced target-expressing cells, other mechanisms may play a role. We use a novel ... ...

    Abstract Disease trajectories following antibody therapy can have a significant impact on the pharmacokinetics of the antibody. Although this phenomenon can often be explained by reduced target-expressing cells, other mechanisms may play a role. We use a novel minimal physiologically-based pharmacokinetic model to evaluate an alternative drug-disease interaction mechanism involving competitive inhibition of neonatal Fc receptor (FcRn)-mediated Immunoglobulin G recycling by paraproteins. The model is validated with clinical data from the anti-FcRn antibody M281 and is used to conduct a scenario test to quantify the interaction among M-protein, the characteristic paraprotein of multiple myeloma (MM), and the anti-CD38 antibody daratumumab indicated for MM treatment. Simulations predict up to a 3.6-fold increase in daratumumab half-life following M-protein reduction, which lends credence to the hypothesis that FcRn competition in MM can manifest as time-dependent reduction of clearance for daratumumab. This model can inform optimal dosing strategies for antibodies in MM and other pathologies of paraprotein excess.
    MeSH term(s) ADP-ribosyl Cyclase 1/immunology ; Antibodies, Monoclonal/pharmacokinetics ; Antibodies, Monoclonal/pharmacology ; Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/pharmacology ; Half-Life ; Histocompatibility Antigens Class I/metabolism ; Humans ; Immunoglobulin G/metabolism ; Metabolic Clearance Rate ; Models, Biological ; Multiple Myeloma/drug therapy ; Myeloma Proteins/metabolism ; Paraproteins/metabolism ; Receptors, Fc/metabolism
    Chemical Substances Antibodies, Monoclonal ; Antineoplastic Agents ; Histocompatibility Antigens Class I ; Immunoglobulin G ; Myeloma Proteins ; Paraproteins ; Receptors, Fc ; multiple myeloma M-proteins ; daratumumab (4Z63YK6E0E) ; ADP-ribosyl Cyclase 1 (EC 3.2.2.6) ; Fc receptor, neonatal (TW3XAW0RCY)
    Language English
    Publishing date 2019-09-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123793-7
    ISSN 1532-6535 ; 0009-9236
    ISSN (online) 1532-6535
    ISSN 0009-9236
    DOI 10.1002/cpt.1619
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