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Article: Acute Disseminated Encephalomyelitis Following COVID-19 Infection.

Assi, Farah / Abdallah, Rim / Mecheik, Ali / Rahhal, Hassan H / Wazne, Jaafar

2023 Volume 15, Issue 1, Page(s) e33365

Abstract: Acute disseminated encephalomyelitis (ADEM) is a relatively rare, post-inflammatory, immune-mediated demyelinating central nervous system disease that is predominantly reported in pediatric populations. Following the emergence of severe acute respiratory ...

Abstract	Acute disseminated encephalomyelitis (ADEM) is a relatively rare, post-inflammatory, immune-mediated demyelinating central nervous system disease that is predominantly reported in pediatric populations. Following the emergence of severe acute respiratory syndrome coronavirus 2, cases of ADEM are being reported following infection with this virus. Our case report describes a male patient in his early 40s who developed severe coronavirus disease 2019 (COVID-19) that rapidly progressed to a critical disease requiring invasive mechanical ventilation and high positive end-expiratory pressure, which was complicated by extensive neurological involvement and quadriplegia. MRI of the brain showed characteristic demyelinating lesions, suggestive of ADEM. As other entities were ruled out, our patient was treated using pulse steroids and intravenous immunoglobulins. The patient showed a good response to treatment and had an overall good prognosis, despite the severity of his condition. ADEM following COVID-19 is a rare entity worldwide.
Language	English
Publishing date	2023-01-04
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.33365
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The First Documented Ibuprofen-Induced Toxic Epidermal Necrolysis in the Middle East and North Africa Region: A Case Report, Complications, and Management.

Kheir, Karim / Abdallah, Rim M / Sleiman, Ziad / Mallat, Hassan / Haddad, Fady

Cureus

2023 Volume 15, Issue 11, Page(s) e49608

Abstract: Introduction: Stevens-Johnson syndrome (SJS), Stevens-Johnson/toxic epidermal necrolysis overlap syndrome (SJS/TEN) and toxic epidermal necrolysis (TEN) are rare, acute, potentially lethal conditions, considered to be part of the severe cutaneous ... ...

Abstract	Introduction: Stevens-Johnson syndrome (SJS), Stevens-Johnson/toxic epidermal necrolysis overlap syndrome (SJS/TEN) and toxic epidermal necrolysis (TEN) are rare, acute, potentially lethal conditions, considered to be part of the severe cutaneous adverse reactions (SCARs) spectrum, with TEN being the most life-threatening. The distinction between these three entities is based on the extent of total skin surface involvement, with SJS involving < 10%, SJS/TEN involving 10-30% and TEN involving > 30% of total body surface area. These mucocutaneous reactions are most commonly caused by a hypersensitivity reaction to a drug, with infections and vaccines being possible, less common etiologies. Case presentation: In the following case report, we summarize a rare case of a 43-year-old, previously healthy male patient who presented with TEN after taking ibuprofen, a non-steroidal anti-inflammatory drug. According to PubMed literature, this is the first documented case of ibuprofen-induced TEN in the Middle East and North Africa (MENA) region. Discussion: TEN is an autoimmune bullous disorder that results in the death of keratinocytes, leading to complete dermo-epidermal separation. In the case of our patient, the desquamation was extensive, involving 70% of the total body surface area, and was complicated by a triple bacterial infection with Conclusion: In the case of TEN, early diagnosis and hospitalization in a burn centre are crucial to allow rapid healing, and improve the quality of life of the affected patients. Immediate cessation of the causative mediation is critical. Supportive management, hydration, nutritional support, and maintenance of aseptic conditions are highly encouraged to reduce the mortality and morbidity associated with TEN.
Language	English
Publishing date	2023-11-28
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.49608
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Article ; Online: Transfusion Reactions and Adverse Events.

Abdallah, Rim / Rai, Herleen / Panch, Sandhya R

Clinics in laboratory medicine

2021 Volume 41, Issue 4, Page(s) 669–696

Abstract: Blood transfusions are generally safe but can carry considerable risks. This review summarizes the different types of transfusion reactions and ways to diagnose and manage them. Symptoms are often overlapping and nonspecific. When a reaction is suspected, ...

Abstract	Blood transfusions are generally safe but can carry considerable risks. This review summarizes the different types of transfusion reactions and ways to diagnose and manage them. Symptoms are often overlapping and nonspecific. When a reaction is suspected, it is critical to stop the transfusion immediately and report the reaction to the blood bank, as this can affect the patient's outcome. New evidence-based algorithms of transfusion, newer blood screening methods and donor policies and deferrals, new laboratory testing, electronic verification systems, and improved hemovigilance lead to the avoidance of unnecessary transfusions and decrease the incidence of serious transfusion reactions.
MeSH term(s)	Blood Banks ; Blood Safety ; Blood Transfusion ; Humans ; Transfusion Reaction
Language	English
Publishing date	2021-09-29
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	604580-7
ISSN	1557-9832 ; 0272-2712
ISSN (online)	1557-9832
ISSN	0272-2712
DOI	10.1016/j.cll.2021.07.009
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Article ; Online: The risk of pig and chicken farming for carriage and transmission of

Sudatip, Duangdao / Mostacci, Nadezda / Tiengrim, Surapee / Thamlikitkul, Visanu / Chasiri, Kittipong / Kritiyakan, Anamika / Phanprasit, Wantanee / Thinphovong, Chuanphot / Abdallah, Rim / Baron, Sophie Alexandra / Rolain, Jean-Marc / Morand, Serge / Oppliger, Anne / Hilty, Markus

Microbial genomics

2023 Volume 9, Issue 3

Abstract: South-East Asian countries report a high prevalence of extended-spectrum cephalosporin- (ESC-) and colistin- ... ...

Abstract	South-East Asian countries report a high prevalence of extended-spectrum cephalosporin- (ESC-) and colistin-resistant
MeSH term(s)	Animals ; Humans ; Escherichia coli/genetics ; Colistin/pharmacology ; Chickens ; Escherichia coli Proteins/genetics ; Thailand/epidemiology ; beta-Lactamases/genetics ; Farms
Chemical Substances	Colistin (Z67X93HJG1) ; Escherichia coli Proteins ; beta-Lactamases (EC 3.5.2.6) ; MCR-1 protein, E coli
Language	English
Publishing date	2023-03-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2835258-0
ISSN	2057-5858 ; 2057-5858
ISSN (online)	2057-5858
ISSN	2057-5858
DOI	10.1099/mgen.0.000951
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Article: A molecular study of Tunisian populations of Dugesia sicula (Plathelminthes, Tricladida) through an identification of a set of genes

Meddeb, Emna / Charni, Mohamed / Ben Abdallah, Rim / Raboudi, Faten / Fattouch, Sami

Comptes rendus. 2019 Nov., Dec., v. 342, no. 9-10

2019

Abstract: Cell regeneration is a natural repair of different types of tissue after an injury or a lesion, and is associated with asexual reproduction in some animals such as planarians. Its understanding and improvement could have repercussions for tissue repair ... ...

Abstract	Cell regeneration is a natural repair of different types of tissue after an injury or a lesion, and is associated with asexual reproduction in some animals such as planarians. Its understanding and improvement could have repercussions for tissue repair and regeneration as far as humans are concerned. In this context, we have proceeded to an essential step, which is the identification of the genes involved in planarian regeneration in the model species. Dugesia sicula Lepori (D. sicula) is distributed around the Mediterranean Sea, and this population is found in most of Tunisian dams. The collection of identified genes is already known in other species. DjFoxG, DjPC2, DjotxA, and Cathepsin-D were identified by the PCR technique and their expression was confirmed by RT-PCR and in situ hybridization. DjFoxG gene, the FoxG1 homolog, is expressed throughout the planarian body, abundantly on stem cells. Consecutively, we choose a central nervous system (CNS) marker; the prohormone convertase 2 (DjPC2) gene. DjotxA was observed in the brain and especially in the region surrounding the eyes (visual cells). The regenerative cells of the gut of D. sicula were scored by the Cathepsin-D gene expression, which belongs to the aspartyl protease family. We found significant results through RT-PCR and In Situ Hybridization (ISH) techniques, confirming the expression of DjFoxG, DjPC2, DjotxA and Cathepsin-D genes in our specimens.
Keywords	Dugesia ; asexual reproduction ; brain ; cathepsin D ; digestive system ; eyes ; gene expression ; genes ; humans ; in situ hybridization ; models ; reverse transcriptase polymerase chain reaction ; stem cells ; tissue repair ; Mediterranean Sea
Language	English
Dates of publication	2019-11
Size	p. 291-298.
Publishing place	Elsevier Masson SAS
Document type	Article
ZDB-ID	2072863-3
ISSN	1768-3238 ; 1631-0691
ISSN (online)	1768-3238
ISSN	1631-0691
DOI	10.1016/j.crvi.2019.10.005
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Article ; Online: SCA Medium: A New Culture Medium for the Isolation of All

Ibrahim, Ahmad / Peyclit, Lucie / Abdallah, Rim / Khelaifia, Saber / Chamieh, Amanda / Rolain, Jean-Marc / Bittar, Fadi

Journal of fungi (Basel, Switzerland)

2021 Volume 7, Issue 6

Abstract: ... Candida ... ...

Abstract	Candida auris
Language	English
Publishing date	2021-05-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2784229-0
ISSN	2309-608X ; 2309-608X
ISSN (online)	2309-608X
ISSN	2309-608X
DOI	10.3390/jof7060433
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Article ; Online: A molecular study of Tunisian populations of Dugesia sicula (Plathelminthes, Tricladida) through an identification of a set of genes.

Meddeb, Emna / Charni, Mohamed / Ben Abdallah, Rim / Raboudi, Faten / Fattouch, Sami

Comptes rendus biologies

2019 Volume 342, Issue 9-10, Page(s) 291–298

Abstract	Cell regeneration is a natural repair of different types of tissue after an injury or a lesion, and is associated with asexual reproduction in some animals such as planarians. Its understanding and improvement could have repercussions for tissue repair and regeneration as far as humans are concerned. In this context, we have proceeded to an essential step, which is the identification of the genes involved in planarian regeneration in the model species. Dugesia sicula Lepori (D. sicula) is distributed around the Mediterranean Sea, and this population is found in most of Tunisian dams. The collection of identified genes is already known in other species. DjFoxG, DjPC2, DjotxA, and Cathepsin-D were identified by the PCR technique and their expression was confirmed by RT-PCR and in situ hybridization. DjFoxG gene, the FoxG1 homolog, is expressed throughout the planarian body, abundantly on stem cells. Consecutively, we choose a central nervous system (CNS) marker; the prohormone convertase 2 (DjPC2) gene. DjotxA was observed in the brain and especially in the region surrounding the eyes (visual cells). The regenerative cells of the gut of D. sicula were scored by the Cathepsin-D gene expression, which belongs to the aspartyl protease family. We found significant results through RT-PCR and In Situ Hybridization (ISH) techniques, confirming the expression of DjFoxG, DjPC2, DjotxA and Cathepsin-D genes in our specimens.
MeSH term(s)	Animals ; Brain/physiology ; Eye/metabolism ; Mediterranean Sea ; Planarians/genetics ; Regeneration/genetics ; Tunisia
Language	English
Publishing date	2019-11-27
Publishing country	France
Document type	Journal Article
ZDB-ID	2072863-3
ISSN	1768-3238 ; 1631-0691
ISSN (online)	1768-3238
ISSN	1631-0691
DOI	10.1016/j.crvi.2019.10.005
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Article: Population Diversity of Antibiotic Resistant

Abdallah, Rim / Kuete Yimagou, Edmond / Hadjadj, Linda / Mediannikov, Oleg / Ibrahim, Ahmad / Davoust, Bernard / Barciela, Amanda / Hernandez-Aguilar, R Adriana / Diatta, Georges / Sokhna, Cheikh / Raoult, Didier / Rolain, Jean-Marc / Baron, Sophie Alexandra

Frontiers in microbiology

2022 Volume 13, Page(s) 838392

Abstract: Introduction: The role of wildlife in the transmission of antimicrobial resistant (AMR) is suspected but scarcely reported in current studies. Therefore, we studied the dynamics and prevalence of antibiotic-resistant : Materials and methods: We ... ...

Abstract	Introduction: The role of wildlife in the transmission of antimicrobial resistant (AMR) is suspected but scarcely reported in current studies. Therefore, we studied the dynamics and prevalence of antibiotic-resistant Materials and methods: We collected fecal samples from monkeys and apes (N = 226) and non-fecal environmental samples (N = 113) from Senegal in 2015 and 2019. We grew the samples on selective media, subsequently isolated AMR Results: We isolated 72 different Conclusion: Wildlife constitutes a rich, unexplored reservoir of natural microbial diversity, AMR genes and international resistant clones pathogenic in humans. The presence of a transposon that carries AMR genes is intriguing since no antibiotics are used in the non-human primates we studied.
Language	English
Publishing date	2022-03-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2022.838392
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Article ; Online: A One Health approach to assessing occupational exposure to antimicrobial resistance in Thailand: The FarmResist project.

Sudatip, Duangdao / Chasiri, Kittipong / Kritiyakan, Anamika / Phanprasit, Wantanee / Thinphovong, Chuanphot / Tiengrim, Surapee / Thamlikitkul, Visanu / Abdallah, Rim / Baron, Sophie Alexandra / Rolain, Jean-Marc / Morand, Serge / Hilty, Markus / Oppliger, Anne

PloS one

2021 Volume 16, Issue 1, Page(s) e0245250

Abstract: This Southeast Asia-Europe research project will use a One Health approach to identify the major parameters responsible for the presence of animal-associated antimicrobial resistant bacteria in animal production facilities in Thailand and the risk of ... ...

Abstract	This Southeast Asia-Europe research project will use a One Health approach to identify the major parameters responsible for the presence of animal-associated antimicrobial resistant bacteria in animal production facilities in Thailand and the risk of their transmission from animals to humans. We will focus on traditional, small, extensive pig and poultry farms where information on antibiotic use is scarce and animals live in close contact with humans. This cross-sectional study will be based on the epidemiological analysis of the antimicrobial resistance (AMR) present in fecal samples from animals and humans. Extended spectrum beta-lactamase producing Enterobacteriaceae (ESBL-E) and Enterobacteriaceae resistant to colistin will be actively searched in the feces of farm animals (pigs and poultry), small wild rodents and farmers. Phenotypic (selective plating) and genotypic (multilocus seuquence typing and sequencing) methods will be used for the detection of AMR, the identification of antibiotic resistance genes (ARGs) and the characterization of strains carrying resistance genes. Questionnaires will be administered to investigate the effects of antibiotic use, farm characteristics and biosecurity measures on the occurrence of AMR in animals. Subsequently, the fecal carriage of AMR and ARGs in farmers will be compared to a control population with no occupational contacts with animals, thus enabling an estimation of the risk of transmission of AMR/ARGs from animals to farmers.
MeSH term(s)	Animals ; Anti-Bacterial Agents/pharmacology ; Chickens ; Colistin/pharmacology ; Cross-Sectional Studies ; DNA, Bacterial/chemistry ; DNA, Bacterial/metabolism ; Drug Resistance, Bacterial/drug effects ; Drug Resistance, Bacterial/genetics ; Enterobacteriaceae/drug effects ; Enterobacteriaceae/enzymology ; Enterobacteriaceae/isolation & purification ; Enterobacteriaceae Infections/microbiology ; Enterobacteriaceae Infections/transmission ; Farmers/psychology ; Feces/microbiology ; Humans ; Multilocus Sequence Typing ; Occupational Exposure ; Surveys and Questionnaires ; Swine ; Thailand ; Whole Genome Sequencing ; beta-Lactamases/genetics
Chemical Substances	Anti-Bacterial Agents ; DNA, Bacterial ; beta-Lactamases (EC 3.5.2.6) ; Colistin (Z67X93HJG1)
Language	English
Publishing date	2021-01-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0245250
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Proteolytic regulation of the extent of dietary proteins with skin grape proanthocyanidin and anthocyanidin's interactions

Ben Abdallah, Rim / Bautista‐Ortin, Ana Belén / Ghazouani, Tesnime / Talbi, Wafa / Jiménez‐Martinez, Maria D / Gómez‐Plaza, Encarna / Fattouch, Sami

International journal of food science & technology. 2019 May, v. 54, no. 5

2019

Abstract: During technological processing, proanthocyanidins and anthocyanidins could be partly lost due to the complexation phenomena, affecting food and beverage nutritional properties, organoleptic properties and health‐promoting potentials. A common issue is ... ...

Abstract	During technological processing, proanthocyanidins and anthocyanidins could be partly lost due to the complexation phenomena, affecting food and beverage nutritional properties, organoleptic properties and health‐promoting potentials. A common issue is encountered when processing food and beverage which is binding of phenolics to dietary proteins. The present investigation aims at evaluating the proteolysis contribution, using pure protease (Pepsin, 3000 units g−1), to protein–anthocyanidin and protein–proanthocyanidin interactions. Bovine serum albumin (BSA), ovalbumin (OVA) and casein (CAS) dietary protein models were used. High‐performance liquid chromatography coupled to diode array detector (HPLC‐DAD) and size exclusion chromatography analyses proved that pepsin treatment significantly (P > 0.05) decreased the ratio of flavonoids’ interaction with tested proteins . The proteolysis reduced anthocyanidin interactions with CAS, OVA and BSA by 64.88%, 57.37% and 42.87% respectively. Similarly, proanthocyanidins interaction with CAS, OVA and BSA were reduced by 34.23%, 13.74% and 2.39% respectively. This study provides the basis to develop innovative technologies to limit protein–flavonoid complexation during food and beverage processing.
Keywords	anthocyanidins ; beverages ; bovine serum albumin ; casein ; diodes ; gel chromatography ; grapes ; health promotion ; high performance liquid chromatography ; model food systems ; nutritive value ; ovalbumin ; pepsin ; proanthocyanidins ; proteolysis ; sensory properties ; technology
Language	English
Dates of publication	2019-05
Size	p. 1633-1641.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	883561-5
ISSN	0950-5423
ISSN	0950-5423
DOI	10.1111/ijfs.14038
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