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MeSH term(s)	Humans ; Cardiac Surgical Procedures ; Renal Replacement Therapy ; Continuous Renal Replacement Therapy ; Acute Kidney Injury
Language	English
Publishing date	2022-12-26
Publishing country	United States
Document type	Letter
ZDB-ID	1067317-9
ISSN	1532-8422 ; 1053-0770
ISSN (online)	1532-8422
ISSN	1053-0770
DOI	10.1053/j.jvca.2022.12.021
Database	MEDical Literature Analysis and Retrieval System OnLINE

Article ; Online: STUDY THE EFFECT OF EXOGENOUS AND ENDOGENOUS IRISIN ON OBESITY AND TYPE II DIABETES MELLITUS IN MALE ALBINO RATS

Hanan Mostafa Abdallah , Sahar Ahmed Elsawy , Abeer Abed Ahmed and Rizk Mahmoud Elkholy

2020

Abstract: Irisin is a myokine secreted from muscle cells and other organs and it has multiple endocrinal effects on other body systems. The exact relationship of irisin in diabetes and obesity is still not completely understood. Aim of the work: Is to study the ... ...

Abstract	Irisin is a myokine secreted from muscle cells and other organs and it has multiple endocrinal effects on other body systems. The exact relationship of irisin in diabetes and obesity is still not completely understood. Aim of the work: Is to study the effect of exogenous and endogenous irisin on obesity and type II diabetes mellitus in male albino rats. Methods: 90 male albino rats divided into 3 groups. Control group;10 rats that fed with a regular diet. Obese group; 40 rats that fed with high fat diet for 8 weeks then subdivided into 4 equal groups 10 rats each. Control obese group; treated by intraperitoneal (ip) injection of 150 μl saline daily for 8 weeks. Irisin treated obese group;treated by ip injection of 150 μl of prepared irisin solution daily for 8 weeks. Exercise treated obese group;treated by moderate intensity swimming exercise for 30 min per day 5 days a week for 8 successive weeks. Irisin and exercise treated obese group;treated as before. Diabetic group; 40 rats that fed with high fat diet for 4 weeks then injected with a single ip streptozotocin (STZ) in a dose of 30 mg/kg body weight. After one week, diabetic group subdivided into 4 equal groups 10 rats each. Control diabetic group, irisin treated diabetic group, exercise treated diabetic group and irisin and exercise treated diabetic group;treated as before. Results:Non treated obese and diabetic groups showed significant increase in body weight gain, body mass index, serum insulin level, fasting glucose level,(HOMA-IR), osteopontin level, triglycerides level and atherogenic index of plasma.While, showed significant decrease in serum nitrite/ nitrate level,HDL cholesterol level,irisin level and (HOMA-S) when compared to the control group.In contrast, irisin treated obese and diabetic groups showed significant decrease in body weight gain, body mass index, serum insulin level, fasting glucose level,(HOMA-IR), osteopontin level, triglycerides level and atherogenic index of plasma. Whileit showed significant increase in serum nitrite/ nitrate ...
Keywords	Irisin Exercise Diabetes HOMA-IR HOMA-S Body Mass Index (BMI) Dyslipidemia Atherogenic Index Oxidative Stress Osteopontin Nitrite/ Nitrate
Subject code	796
Publishing date	2020-05-14
Publishing country	eu
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Deciding When to Start Renal Replacement Therapy After Cardiac Surgery in Real Life.

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